Notice of Intended Changes—4,4′-Methylene bis(2-chloroaniline), Perfluoroisobutylene, and Triethanolamine

References

• DuPont Company, Haskell Laboratory . 1965 . Reports No. MR-815–6, HL-167–65 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• DuPont Company, Haskell Laboratory . 1963 . Reports No. MR-346–15, HL-97–63 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• Brooks , T. M. and Dean , B. J. Progr. Mutat. Res. 1 (Eval. Short-Term-Tests Carcinogen . Rep. Int. Collab. Program) , 261 – 270 . (CA 95:216182) (1981)
   Google Scholar
• Linch , A. L. , O'Connor , G. B. Barnes , J. R. 1971 . Methylene-bis-ortho-Chloroaniline (MOCA): Evaluation of Hazards and Exposure Control . Am. Ind. Hyg. Assoc. J. , 32 ( 12 ) : 802 – 819 .
   PubMed Web of Science ®Google Scholar
• Barnes , J. R. 1964 . Toxicity Study on MOCA 4,4′-Methylene bis(2-chloroaniline) , Newark, DE : DuPont Company, Haskel Laboratory . (unpublished data)
   Google Scholar
• DuPont Company, Haskell Laboratory . 1964 . Report No. MR-652–2 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• Stula , E. F. , Sherman , H. Zapp , J. A. 1975 . Experimental Neoplasia in Rats from Oral Administration of 3,3′-Dichlorobenzidine, 4,4′-Methylene bis(2-chloroaniline), and 4,4′-Methylene bis(2-methylaniline) . Toxicol. Appl. Pharmacol. , 31 : 159 – 176 .
   PubMed Web of Science ®Google Scholar
• Grundmann , E. and Steinhoff , D. 1970 . Leber- und Lungentumoren nach 3,3′-Dichlor-4,4′-diaminodiphenylmethan bei Ratten . Z. Krebsforsch. , 74 : 28 – 39 .
   PubMedGoogle Scholar
• Russfield , A. B. , Homburger , F. Boger , E. 1975 . The Carcinogenic Effect of 4,4′-Methylene-bis-(2-chloroaniline) in Mice and Rats . Toxicol. Appl. Pharmacol. , 31 : 47 – 54 .
   PubMedGoogle Scholar
• Kommineni , C. , Groth , D. H. Frockt , I. J. 1979 . Determination of the Tumorigenic Potential of Methylene-bis-ortho-chloroaniline . J. Environ. Pathol. Toxicol. , 2 ( 5 ) : 149 – 171 .
   PubMedGoogle Scholar
• Steinhoff , D. and Grundmann , E. 1971 . Carcinogenic Action of 3,3′-Dichloro-4,4′-diaminodiphenylmethane in Rats . Naturwissenschaften , 58 ( 11 ) : 578
   PubMedGoogle Scholar
• Stula , E. F. , Sherman , H. Zapp , J. A. 1975 . Urinary Bladder Tumors in Dogs from 4,4′-Methylene-bis (2-chloroaniline) (MOCA) . J. Environ. Pathol. Toxicol. Oncol. , 1 : 31 – 50 .
   Google Scholar
• DuPont Company, Haskell Laboratory . 1976 . Reports No. MR-936, HL-800–76 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• DuPont Company, Haskell Laboratory . 1974 . Reports No. MR-1984–1, HL-676–74 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• DuPont Company, Haskell Laboratory . 1974 . Reports No. MR-1984–1, HL-839–74 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• McCann , J. , Choi , E. , Yamasaki , E. and Ames , B. N. 1975 . Detection of Carcinogens as Mutagens in the Salmonella/Microsome Test: Assay of 300 Chemicals . Proc. Nat. Acad. Sci. , 72 ( 12 ) : 5135 – 5139 .
   PubMed Web of Science ®Google Scholar
• Baker , R. S.U. and Bonin , A. M. 1981 . Study of 42 Coded Compounds with the Salmonella/Mammalian Microsome Assay . Prog. Mutat. Res. , 1 : 249 – 260 .
   Google Scholar
• Garner , R. C. , Welch , A. and Pickering , C. 1981 . Mutagenic Activity of 42 Coded Compounds in the Salmonella/Microsome Assay . Prog. Mutat. Res. , 1 : 280 – 284 .
   Google Scholar
• Hubbard , S. A. , Green , M. H.L. Bridges , B. A. 1981 . Fluctuation Test with S9 and Hepatocyte Activation . Prog. Mutat. Res. , 1 : 361 – 370 .
   Google Scholar
• Ichinotsubo , D. , Mower , H. and Mandel , M. 1981 . Mutagen Testing of a Series of Paired Compounds with the Ames Salmonella Testing System . Prog. Mutat. Res. , 1 : 298 – 301 .
   Google Scholar
• McDonald , D. J. 1981 . Salmonella/Microsomes Tests on 42 Coded Compounds . Prog. Mutat. Res. , 1 : 285 – 297 . (Eval. Short-Term-Tests Carcinogen.: Rep. Int. Collab. Program)
   Google Scholar
• Martire , G. , Vricella , G. , Perfumo , A. M. and De Lorenzo , F. 1981 . Evaluation of the Mutagenic Activity of Coded Compounds in the Salmonella Test . Prog. Mutat. Res. , 1 : 271 – 279 .
   Google Scholar
• Nagao , M. and Takahashi , Y. 1981 . Mutagenic Activity of 42 Coded Compounds in the Salmonella/Microsome Assay . Prog. Mutat. Res. , 1 : 302 – 313 .
   Google Scholar
• Rowland , I. and Severn , B. 1981 . Mutagenicity of Carcinogens and Noncarcinogens in the Salmonella/Microsome Test . Prog. Mutat. Res. , 1 : 323 – 332 .
   Google Scholar
• Simmon , V. F. and Shepherd , G. 1981 . Mutagenic Activity of 42 Coded Compounds in the Salmonella/Microsome Assay . Prog. Mutat. Res. , 1 : 333 – 342 .
   Google Scholar
• Trueman , R. W. 1981 . Activity of 42 Coded Compounds in the Salmonella Reverse Mutation Test . Prog. Mutat. Res. , 1 : 343 – 350 .
   Google Scholar
• Brooks , T. M. and Dean , B. J. 1981 . Mutagenic Activity of 42 Coded Compounds in the Salmonella/Microsome Assay with Preincubation . Prog. Mutat. Res. , 1 : 261 – 270 .
   Google Scholar
• Venitt , S. and Crofton-Sleigh , C. 1981 . Mutagenicity of 42 Coded Compounds in a Bacterial Assay using Escherichia coli and Salmonella typhimurium . Prog. Mutat. Res. , 1 : 351 – 360 .
   Google Scholar
• Gatehouse , D. 1981 . Mutagenic Activity of 42 Coded Compounds in the “Microtiter” Fluctuation Test . Prog. Mutat. Res. , 1 : 376 – 386 .
   Google Scholar
• Takemura , N. and Shimuzu , H. 1978 . Mutagenicity of Some Aromatic Amino-and Nitro-Compounds . Mutat. Res. , 54 : 256 – 257 .
   Web of Science ®Google Scholar
• Purchase , I. F.H. , Longstaff , E. Ashby , J. 1978 . An Evaluation of 6 Short-term Tests for Detection of Organic Chemical Carcinogens . Br. J. Cancer , 37 : 873 – 959 .
   PubMed Web of Science ®Google Scholar
• Ho , T. , Hardigree , A. A. Larimer , F. W. 1979 . Comparative Mutagenicity Study of Potentially Carcinogenic Industrial Compounds . Environ. Mutagen. , 1 : 167 – 168 .
   Google Scholar
• Matsushima , T. , Takamoto , Y. Shirai , A. 1981 . Reverse Mutation Test on 42 Coded Compounds with the Ecoli WP2 System . Prog. Mutat. Res. , 1 : 387 – 395 .
   Google Scholar
• Haworth , S. , Lawlor , T. Mortelmans , K. 1983 . Salmonella Mutagenicity Test Results for 250 Chemicals . Environ. Mol. Mutagen. , 5 ( Suppl. 1 ) : 3 – 142 .
   Google Scholar
• Bridges , B. A. , McGregor , D. Zeiger , E. 1981 . Summary Report on the Performance of Bacterial Mutation Assays . Prog. Mutat. Res. , 1 : 49 – 67 .
   Google Scholar
• Kugler-Steigmeier , M. E. , Friedrich , U. Graf , U. 1989 . Genotoxicity of Aniline Derivatives in Various Short-term Tests . Mutat. Res. , 211 : 279 – 289 .
   PubMedGoogle Scholar
• Rao , T. K. , Dorsey , G. F. , Allen , B. E. and Epler , J. L. 1982 . Mutagenicity of 4,4′-Methylenedianiline Derivatives in the Salmonella Histidine Reversion Assay . Arch. Toxicol. , 49 : 185 – 190 .
   PubMed Web of Science ®Google Scholar
• Herbold , B. 1979 . Report No. 8284 , Wuppertal, FRG : Bayer AG . (unpublished data)
   Google Scholar
• Shimizu , H. , Suzuki , Y. Suzuki , T. 1983 . Mutagenicity of Epoxy Resin Hardeners . Sangyo Igaku , 24 ( 5 ) : 498 – 503 . abstract in CA 98:66866 (1983).
   Google Scholar
• Thomson , J. A. 1981 . Mutagenic Activity of 42 Coded Compounds in the Lambda Induction Assay . Prog. Mutat. Res. , 1 : 224 – 235 .
   Google Scholar
• Rosenkranz , H. S. , Hyman , J. and Leifer , Z. 1981 . DNA Polymerase Deficient Assay . Prog. Mutat. Res. , 1 : 210 – 218 .
   Google Scholar
• Green , M. H.L. 1981 . A Differential Killing Test Using an Improved Repair-deficient Strain of Escherichia coli . Prog. Mutat. Res. , 1 : 183 – 194 .
   Google Scholar
• Tweats , D. J. 1981 . Activity of 42 Coded Compounds in a Differential Killing Test using Escherichia coli Strains WP2, WP67 (uvrA polA), and CM871 (uvrA lexA recA) . Prog. Mutat. Res. , 1 : 199 – 209 .
   Google Scholar
• Kada , T. 1981 . The DNA-damaging Activity of 42 Coded Compounds in the Rec-Assay . Prog. Mutat. Res. , 1 : 175 – 182 .
   Google Scholar
• Jagannath , D. R. , Vultaggio , D. M. and Brusick , D. J. 1981 . Genetic Activity of 42 Coded Compounds in the Mitotic Gene Conversion Assay Using Saccharomyces cerevisiae Strain D4 . Prog. Mutat. Res. , 1 : 456 – 467 .
   Google Scholar
• Sharp , D. C. and Parry , J. M. 1981 . Induction of Mitotic Gene Conversion by 41 Coded Compounds Using the Yeast Culture JD1 . Prog. Mutat. Res. , 1 : 491 – 501 .
   Google Scholar
• Kassinova , G. V. , Kovaltsova , S. V. , Marfin , S. V. and Zakharov , I. A. 1981 . Activity of 40 Coded Compounds in Differential Inhibition and Mitotic Crossing-over Assays in Yeast . Prog. Mutat. Res. , 1 : 434 – 455 .
   Google Scholar
• Mehta , R. D. and von Borstel , R. C. 1981 . Mutagenic Activity of 42 Encoded Compounds in the Haploid Yeast Reversion Assay, Strain XV185–14C . Prog. Mutat. Res. , 1 : 414 – 423 .
   Google Scholar
• Parry , J. M. and Sharp , D. C. 1981 . Induction of Mitotic Aneuploidy in the Yeast Strain D6 by 42 Coded Compounds . Prog. Mutat. Res. , 1 : 468 – 480 .
   Google Scholar
• Zimmermann , F. K. and Scheel , I. 1981 . Induction of Mitotic Gene Conversion in Strain D7 of Saccharomyces cerevisiae by 42 Coded Chemicals . Prog. Mutat. Res. , 1 : 481 – 490 .
   Google Scholar
• De Serres , F. J. and Hoffmann , G. R. 1981 . Summary Report on the Performance of Yeast Assays . Prog. Mutat. Res. , 1 : 68 – 76 .
   Google Scholar
• Huff , J. E. , ed. 1983 . NTP Technical Bulletin No. 9 , 7 U.S. Dept. of Health and Human Services, Public Health Service .
   Google Scholar
• Perry , P. E. and Thomson , E. J. 1981 . Evaluation of the Sister Chromatid Exchange Method in Mammalian Cells as a Screening System for Carcinogens . Prog. Mutat. Res. , 1 : 560 – 569 .
   Google Scholar
• Galloway , S. M. , Bloom , A. D. Resnik , M. 1985 . Development of a Standard Protocol for in vitro Cytogenetic Testing with Chinese Hamster Ovary Cells: Comparison of Results for 22 Compounds in Two Laboratories . Environ. Mol. Mutagen. , 7 : 1 – 51 .
   Google Scholar
• Mori , H. , Yoshimi , N. Sugie , S. 1988 . Genotoxicity of Epoxy Resin Hardeners in the Hepatocyte Primary Culture/DNA Repair Test . Mutat. Res. , 204 : 683 – 688 .
   PubMedGoogle Scholar
• McQueen , C. A. , Maslansky , C. J. , Crescenzi , S. B. and Williams , G. M. 1981 . Genotoxicity of 4,4′-Methylenebis-2-chloroaniline in Rat, Mouse, and Hamster Hepatocytes . Toxicol. Appl. Pharmacol. , 58 : 231 – 235 .
   PubMed Web of Science ®Google Scholar
• McQueen , C. A. and Williams , G. M. 1982 . Cytotoxicity of Xenobiotics in Adult Rat Hepatocytes in Primary Culture . Fundam. Appl. Toxicol. , 2 : 139 – 144 .
   PubMedGoogle Scholar
• Williams , G. M. , Laspia , M. F. and Dunkel , V. C. 1982 . Reliability of the Hepatocyte Primary Culture/DNA Repair Test in Testing of Coded Carcinogens and Noncarcinogens . Mutat. Res. , 97 : 359 – 370 .
   PubMed Web of Science ®Google Scholar
• Martin , C. N. and McDermid , A. C. 1981 . Testing of 42 Coded Compounds for Their Ability to Induce Unscheduled DNA Repair Synthesis in HeLa Cells . Prog. Mutat. Res. , 1 : 533 – 537 .
   Google Scholar
• Daniel , M. R. and Dehnel , J. M. 1981 . Cell Transformation Test with Baby Hamster Kidney Cells . Prog. Mutat. Res. , 1 : 626 – 637 .
   Google Scholar
• Styles , J. A. 1981 . Activity of 42 Coded Compounds in the BHK-21 Cell Transformation Test . Prog. Mutat. Res. , 1 : 638 – 646 .
   Google Scholar
• Dunkel , V. C. , Pienta , R. J. , Sivak , A. and Traul , K. A. 1981 . Comparative Neoplastic Transformation Responses of Balb/3T3 Cells, Syrian Hamster Embryo Cells, and Rauscher Murine Leukemia Virus-infected Fischer 344 Rat Embryo Cells to Chemical Carcinogens . J. Nat. Cancer Inst. , 67 ( 6 ) : 1303 – 1315 .
   PubMedGoogle Scholar
• Traul , K. A. , Takayama , K. Kachevsky , V. 1981 . A Rapid in vitro Assay for Carcinogenicity of Chemical Substances in Mammalian Cells Utilizing an Attachment-Independence-Endpoint . J. Appl. Toxicol. , 1 ( 3 ) : 190 – 195 .
   PubMedGoogle Scholar
• Yoshikura , H. and Matsushima , T. 1981 . MLV Test (Integration Enhancement Test) of 42 Coded Compounds in Mouse Kidney Cells . Prog. Mutat. Res. , 1 : 647 – 650 .
   Google Scholar
• Fey , E. G. , White , H. A. and Rabin , B. R. 1981 . Development of the Degranulation System . Prog. Mutat. Res. , 1 : 236 – 244 .
   Google Scholar
• Shivapurkar , N. , Lehman , T. A. , Schut , H. A.J. and Stoner , G. D. 1987 . DNA Binding of 4,4′-Methylene-bis (2-chloroaniline) (MOCA) in Explant Cultures of Human and Dog Bladder . Cancer Lett. , 38 : 41 – 48 .
   PubMedGoogle Scholar
• Vogel , E. , Blijleven , W. G.H. , Kortselius , M. J.H. and Zijlstra , J. A. 1981 . Mutagenic Activity of 17 Coded Compounds in the Sex-Linked-Recessive Lethal Test in Drosophila melanogaster . Prog. Mutat. Res. , 1 : 660 – 665 .
   Google Scholar
• Salamone , M. F. , Heddle , J. A. and Katz , M. 1981 . Mutagenic Activity of 41 Compounds in the in vivo Micronucleus Assay . Prog. Mutat. Res. , 1 : 686 – 697 .
   Google Scholar
• Tsuchimoto , T. and Matter , B. E. 1981 . Activity of Coded Compounds in the Micronucleus Test . Prog. Mutat. Res. , 1 : 705 – 711 .
   Google Scholar
• Morton , K. C. 1983 . Metabolism of 4,4′-Methylenebis (2-chloroaniline) (MOCA) in Rats . Proc. Am. Assoc. Cancer Res. , 24 : 83
   Google Scholar
• Ducos , P. , Maire , C. and Gaudin , R. 1985 . Assessment of Occupational Exposure to 4,4′-methylenebis(2-chloroaniline) (MOCA) by a New Sensitive Method for Biological Monitoring . Int. Arch. Occup. Environ. Health , 55 : 159 – 167 .
   PubMed Web of Science ®Google Scholar
• Groth , D. H. , Wiegel , W. W. Tolos , W. P. 1984 . 4,4′-Methylene-bis-orthochloro-aniline (MBOCA): Absorption and Excretion after Skin Application and Gavage . Environ. Res. , 34 : 38 – 54 .
   PubMedGoogle Scholar
• Manis , M. O. and Braselton , W. E. 1984 . Structure Elucidation and in vitro Reactivity of the Major Metabolite of 4,4′-methylenebis-(2-chloroaniline) (MBOCA) in Canine Urine . Fund. Appl. Toxicol. , 4 : 1000 – 1008 .
   PubMedGoogle Scholar
• Manis , M. O. , Williams , D. E. McCormack , K. M. 1984 . Percutaneous Absorption, Disposition and Excretion of 4,4′-Methylenebis-(2-chloroaniline) in Dogs . Environ. Res. , 33 : 234 – 245 .
   PubMedGoogle Scholar
• Tobes , M. C. , Brown , L. E. Chin , B. 1983 . Kinetics of Tissue Distribution and Elimination of 4,4′-Methylene-bis (2-chloroaniline) in Rats . Toxicol. Lett. , 14 : 69 – 75 .
   Google Scholar
• Farmer , P. B. , Rickard , J. and Robertson , S. 1981 . The Metabolism and Distribution of 4,4′-Methylene-bis (2-chloroaniline) (MBOCA) in Rats . J. Appl. Toxicol. , 1 : 317 – 322 .
   PubMedGoogle Scholar
• Manis , M. O. and Braselton , W. E. 1986 . Metabolism of 4,4′-Methylenebis-(2-chloroaniline) by Canine Liver and Kidney Slices . Drug. Metab. Dispos. , 14 : 166 – 174 .
   PubMedGoogle Scholar
• DuPont Company, Haskell Laboratory . 1978 . Reports No. MR-2865–1, HL-377–78 , Newark, DE : DuPont Company . (unpublished data)
   Google Scholar
• National Research Council . 1981 . Aromatic Amines: An Assessment of the Biological and Environmental Effects, Chap 7. Committee on Amines, Board of Toxicology and Environmental Health Hazards, Assembly of Life Sciences , Washington, DC : National Academy Press .
   Google Scholar
• Chin , B. , Tobes , M. C. and Han , S. S. 1983 . Absorption of 4,4′-Methylenebis (2-chloroaniline) by Human Skin . Environ. Res. , 32 : 167 – 178 .
   PubMed Web of Science ®Google Scholar
• Glowinski , J. B. , Radtke , H. E. and Weber , W. W. 1978 . Genetic Variation in N-Acetylation of Carcinogenic Arylamines by Human and Rabbit Liver . Mol. Pharmacol. , 14 : 940 – 949 .
   PubMed Web of Science ®Google Scholar
• Morton , K. C. , Lee , M. S. Siedlik , P. 1988 . Metabolism of 4,4′-Methylenebis-2-chloroaniline (MOCA) by Rats in vivo and Formation of N-Hydroxy MOCA by Rat and Human Liver Microsomes . Carcinogenesis , 9 ( 5 ) : 731 – 739 .
   PubMedGoogle Scholar
• Mastromatteo , E. 1965 . Recent Occupational Experiences in Ontario . J. Occup. Med. , 7 : 502 – 511 .
   PubMedGoogle Scholar
• Hosein , H. R. and Van Roosmalen , P. B. 1978 . Summary Report: Acute Exposure to Methylene-bis-o-chloroaniline (MOCA) . Am. Ind. Hyg. Assoc. J. , 39 : 496 – 497 .
   PubMed Web of Science ®Google Scholar
• Linch , A. L. , O'Conner , G. B. Barnes , J. R. 1971 . Methylene-bis-orthochloroaniline (MOCA): Evaluation of Hazards and Exposure Control . Am. Ind. Hyg. Assoc. J. , 32 : 802 – 819 .
   PubMed Web of Science ®Google Scholar
• Ward , E. , Smith , A. B. and Halperin , W. 1987 . 4,4′-Methylenebis (2-chloroaniline): An Unregulated Carcinogen . Am. J. Ind. Med. , 12 : 537 – 549 .
   PubMed Web of Science ®Google Scholar
• Ward , E. , Halperin , W. Thun , M. 1988 . Bladder Tumors in Two Young Males Occupationally Exposed to MBOCA . Am. J. Ind. Med. , 14 : 267 – 272 .
   PubMed Web of Science ®Google Scholar
• U.S. Dept. of Labor, Occupational Safety and Health Administration . 1989 . 29 CFR Part 1910, Air Contaminants . Final Rule. Fed. Reg. , 54 ( 12 ) January 19 : 2562
   Google Scholar
• Kel'man , G. Y. , Mashbits , F. D. and Eisengart , R. S. Comparative Toxicological and Hygienic Evaluation of Four Chemical Additives for Cured Rubber . Kauch. Rezina , 26 ( 9 ) 29 – 30 . abstracted in CA 67:120013 1967
   Google Scholar
• Salamone , M. F. 1981 . Toxicity of 41 Carcinogens and Noncarcinogenic Analogs . Prog. Mutat. Res. , 1 : 682 – 685 .
   Google Scholar