Notice of Intended Change—4-Vinylcyclohexene

References

• Sandmeyer , E. E. 1981 . “ Alicyclic Hydrocarbons. ” . In Patty's Industrial Hygiene and Toxicology, 3rd Rev. ed., Vol. 2B, Toxicology Edited by: Clayton , G.D. and Clayton , F.E. 3221 – 3251 . New York : John Wiley & Sons .
   Google Scholar
• Van Duuren , B. 1965 . “ Carcinogenic Epoxides, Lactones, and Hydroperoxides. ” . In Mycotoxins in Foodstuffs Edited by: Wogan , G. 275 – 285 . Cambridge, MA : MIT Press .
   Google Scholar
• International Agency for Research on Cancer . 1976 . IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Vol. 11, Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anesthetics, pp. 141–145, 277–281 Lyon, , France : IARC .
   Google Scholar
• Rappaport , S. M. and Fraser , D. A. 1976 . Gas Chromatographic-Mass Spectrometric Identification of Volatiles Released from a Rubber Stock During Simulated Vulcanization . Anal. Chem. , 48 : 476 – 481 .
   Web of Science ®Google Scholar
• Rappaport , S. M. and Fraser , D. A. 1977 . Air Sampling and Analysis in a Rubber Vulcanization Area . Am. Ind. Hyg. Assoc. J. , 38 : 205 – 210 .
   PubMed Web of Science ®Google Scholar
• Cocheo , V. , Bellomo , M. L. and Bombi , G. G. 1983 . Rubber Manufacture: Sampling and Identification of Volatile Pollutants . Am. Ind. Hyg. Assoc. J. , 44 : 521 – 527 .
   PubMed Web of Science ®Google Scholar
• Smyth , H.F. Jr. , Carpenter , C. P. and Weil , C. S. 1969 . Range-Finding Toxicity Data: List VII . Am. Ind. Hyg. Assoc. J. , 30 : 470 – 476 .
   PubMedGoogle Scholar
• Collins , J. J. and Manus , A. G. 1987 . Toxicological Evaluation of 4-Vinylcyclohexene . I. Prechronic (14-Day) and Subchronic (13-Week) Gavage Studies in Fischer 344 Rats and B6C3F1 Mice. J. Toxicol. Environ. Health , 21 : 493 – 505 .
   Google Scholar
• Collins , J. J. , Montali , R. J. and Manus , A. G. 1987 . Toxicological Evaluation of 4-Vinylcyclohexene . II. Induction of Ovarian Tumors in Female B6C3F1 Mice by Chronic Oral Administration of 4-Vinylcyclohexene. J. Toxicol. Environ. Health , 21 : 507 – 524 .
   Google Scholar
• Bykov , L. Maximum Permissible Concentration of Vinylcyclohexene in the Air of Industrial Buildings . Proceedings of the Conference on Toxicology and Hygiene in Petrochemical Industrial Products . pp. 32 – 34 . Moscow
   Google Scholar
• Van Duuren , B. L. , Nelson , N. and Orris , L. 1963 . Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds . J. Natl. Cancer Inst. , 31 : 41 – 55 .
   PubMed Web of Science ®Google Scholar
• Van Duuren , B. L. , Langseth , L. , Goldschmidt , B. and Orris , L. 1967 . Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds . VI. Structure and Carcinogenic Activity. J. Natl. Cancer Inst. , 39 : 1217 – 1228 .
   PubMed Web of Science ®Google Scholar
• Hendry , J. A. , Homer , R. F. , Rose , F. L. and Walpole , A. L. 1951 . Cytotoxic Agents . II. Bis-Epoxides and Related Compounds. Br. J. Pharmacol. , 6 : 235 – 255 .
   PubMed Web of Science ®Google Scholar
• Rose , F. L. , Hendry , J. A. and Walpole , A. L. 1950 . New Cytotoxic Agents with Tumour-Inhibitory Activity . Nature , 165 : 993 – 996 .
   PubMed Web of Science ®Google Scholar
• National Toxicology Program . 1986 . Toxicology and Carcinogenesis Studies of 4-Vinylcyclohexene [CAS No. 100–40–3] in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP TR 303 Research Triangle Park, NC : NTP . DHHS (NIH) Pub. No. 86–2559.
   Google Scholar
• Hooser , S. B. , Parola , L. R. and Douds , D. A. 1991 . Reproductive Toxicity of 4-Vinylcyclohexene and 4-Phenylcyclohexene in Mice . Toxicologist , 11 : 110
   Google Scholar
• Fail , P. A. , George , J. D. and Grizzle , T. B. 1991 . Reproductive Toxicity of 4-Vinylcyclohexene (VCH) in Mice as Evaluated by the Continuous Breeding Protocol . Toxicologist , 11 : 113
   Google Scholar
• Turchi , G. , Bonatti , S. and Citti , L. 1981 . Alkylating Properties and Genetic Activity of 4-Vinylcyclohexene Metabolites and Structurally Related Epoxides . Mutat. Res. , 83 : 419 – 430 .
   PubMed Web of Science ®Google Scholar
• Wade , M. J. , Moyer , J. W. and Hine , C. H. 1979 . Mutagenic Action of a Series of Epoxides . Mutat. Res. , 66 : 367 – 371 .
   PubMed Web of Science ®Google Scholar
• Murray , M. P. and Cummins , J. E. 1979 . Mutagenic Activity of Epoxy Embedding Reagents Employed in Electron Microscopy . Environ. Mutagen. , 1 : 307 – 313 .
   PubMedGoogle Scholar
• Simmon , V. F. and Baden , J. M. 1980 . Mutagenic Activity of Vinyl Compounds and Derived Epoxides . Mutat. Res. , 78 : 227 – 231 .
   PubMed Web of Science ®Google Scholar
• El-Tantawy , M. A. and Hammock , B. D. 1980 . The Effect of Hepatic Microsomal and Cytosolic Subcellular Fractions on the Mutagenic Activity of Epoxide-Containing Compounds in the Salmonella Assay . Mutat. Res. , 79 : 59 – 71 .
   PubMed Web of Science ®Google Scholar
• Mortelmans , K. , Haworth , S. and Lawlor , T. 1986 . Salmonella Mutagenicity Tests: II . Results from the Testing of 270 Chemicals. Environ. Mutagen. , 8 : 1 – 119 . Suppl. 7
   PubMedGoogle Scholar
• Voogd , C. E. , van der Stel , J. J. and Jacobs , J. A. 1981 . The Mutagenic Action of Aliphatic Epoxides . Mutat. Res. , 89 : 269 – 282 .
   PubMed Web of Science ®Google Scholar
• Gervasi , P. , Abbondandolo , A. , Citti , L. and Turchi , G. 1981 . “ Microsomal 4-Vinylcyclohexene Mono-Oxygenase and Mutagenic Activity of Metabolic Intermediates. ” . In Industrial and Environmental Xenobiotics. Metabolism and Pharmacokinetics of Organic Chemicals and Metals Edited by: Gut , I. , Cikrt , M. and Plaa , G.L. 205 – 210 . Berlin : Springer-Verlag .
   Google Scholar
• Watabe , T. , Hiratsuka , A. , Isobe , M. and Ozawa , N. 1980 . Metabolism of d-Limonene by Hepatic Microsomes to Non-mutagenic Epoxides Towards Salmonella typhimurium. Biochem . Pharmacol. , 29 : 1068 – 1071 .
   Web of Science ®Google Scholar
• Watabe , T. , Hiratsuka , A. , Ozawa , N. and Isobe , M. 1981 . A Comparative Study on the Metabolism of d-Limonene and 4-Vinylcyclohex-1-ene by Hepatic Microsomes . Xenobiotica , 11 : 333 – 344 .
   PubMed Web of Science ®Google Scholar
• Giannarini , C. , Citti , L. , Gervasi , P. G. and Turchi , G. 1981 . Effects of 4-Vinylcyclohexene and Its Main Oxirane Metabolite on Mouse Hepatic Microsomal Enzymes and Glutathione Levels . Toxicol. Lett. , 8 : 115 – 121 .
   PubMed Web of Science ®Google Scholar
• Smith , B. J. , Carter , D. E. and Sipes , I. G. 1990 . Comparison of the Disposition and In Vitro Metabolism of 4-Vinylcyclohexene in the Female Mouse and Rat . Toxicol. Appl. Pharmacol. , 105 : 364 – 371 .
   PubMed Web of Science ®Google Scholar
• Smith , B. J. , Mattison , D. R. and Sipes , I. G. 1990 . The Role of Epoxidation in 4-Vinylcyclohexene-Induced Ovarian Toxicity . Toxicol. Appl. Pharmacol. , 105 : 372 – 381 .
   PubMed Web of Science ®Google Scholar
• Smith , B. J. , Sipes , I. G. , Stevens , J. C. and Halpert , J. R. 1990 . The Biochemical Basis for the Species Difference in Hepatic Microsomal 4-Vinylcyclohexene Epoxidation Between Female Mice and Rats . Carcinogenesis , 11 : 1951 – 1957 .
   PubMed Web of Science ®Google Scholar
• Smith , B. J. , Mattison , D. R. and Sipes , I. G. 1990 . “ Hepatic Bioactivation of 4-Vinylcyclohexene to Ovotoxic Epoxides. ” . In Biological Reactive Intermediates. IV. Implications in Human Health Edited by: Witmer , C. , Snyder , R. and Sipes , I.G. New York : Plenum Press . (in press)
   Google Scholar
• Maronpot , R. P. 1987 . Ovarian Toxicity and Carcinogenicity in Eight Recent National Toxicology Program Studies . Environ. Health Perspect. , 73 : 125 – 130 .
   PubMed Web of Science ®Google Scholar
• 1990–1991 Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices . American Conference of Governmental Industrial Hygienists . Cincinnati, OH : ACGIH .
   Google Scholar
• 1984 . National Toxicology Program, Board of Scientific Counselors: Report of the NTP Ad Hoc Panel on Chemical Carcinogenicity Testing and Evaluation, pp. 143–145, 184–187, 248–254 Washington, DC : U.S. Government Printing Office .
   Google Scholar
• Nebert , D. W. , Nelson , D. R. and Adesnik , M. 1986 . The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci . DNA , 8 : 1 – 13 .
   Google Scholar