Characterization of Growth and Reproduction Performance, Transgene Integration, Expression, and Transmission Patterns in Transgenic Pigs Produced by piggyBac Transposition-Mediated Gene Transfer

References

• Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle FH. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 1980; 77:7380–7384.
   PubMed Web of Science ®Google Scholar
• Perry AC, Wakayama T, Kishikawa H, et al. Mammalian transgenesis by intracytoplasmic sperm injection. Science 1999; 284:1180–1183.
   PubMed Web of Science ®Google Scholar
• Moreira PN, Pozueta J, Giraldo P, Gutierrez-Adan A, Montoliu L. Generation of yeast artificial chromosome transgenic mice by intracytoplasmic sperm injection. Methods Mol Biol 2006; 349:151–161.
   PubMedGoogle Scholar
• Perry AC. Hijacking oocyte DNA repair machinery in transgenesis? Mol Reprod Dev 2000; 56:319–324.
   PubMed Web of Science ®Google Scholar
• Smith K. Theoretical mechanisms in targeted and random integration of transgene DNA. Reprod Nutr Dev 2001; 41:465–485.
   PubMedGoogle Scholar
• Uchida M, Shimatsu Y, Onoe K, et al. Production of transgenic miniature pigs by pronuclear microinjection. Transgenic Res 2001; 10:577–582.
   PubMed Web of Science ®Google Scholar
• Kurome M, Ueda H, Tomii R, Naruse K, Nagashima H. Production of transgenic-clone pigs by the combination of ICSI-mediated gene transfer with somatic cell nuclear transfer. Transgenic Res 2006; 15:229–240.
   PubMed Web of Science ®Google Scholar
• Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 2002; 295:868–872.
   PubMed Web of Science ®Google Scholar
• Hofmann A, Kessler B, Ewerling S, et al. Efficient transgenesis in farm animals by lentiviral vectors. EMBO Rep 2003; 4:1054–1060.
   PubMed Web of Science ®Google Scholar
• Hofmann A, Zakhartchenko V, Weppert M, et al. Generation of transgenic cattle by lentiviral gene transfer into oocytes. Biol Reprod 2004; 71:405–409.
   PubMed Web of Science ®Google Scholar
• Page DC, Silber S, Brown LG. Men with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertility. Hum Reprod 1999; 14:1722–1726.
   PubMed Web of Science ®Google Scholar
• Park F. Lentiviral vectors: are they the future of animal transgenesis? Physiol Genomics 2007; 31:159–173.
   PubMed Web of Science ®Google Scholar
• Katter K, Geurts AM, Hoffmann O, et al. Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J 2013; 27:930–941.
   PubMed Web of Science ®Google Scholar
• Marh J, Stoytcheva Z, Urschitz J, et al. Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis. Proc Natl Acad Sci USA 2012; 109:19184–19189.
   PubMed Web of Science ®Google Scholar
• Garrels W, Mates L, Holler S, et al. Germline transgenic pigs by Sleeping Beauty transposition in porcine zygotes and targeted integration in the pig genome. PLoS One 2011; 6:e23573.
   PubMed Web of Science ®Google Scholar
• Li Z, Zeng F, Meng F, et al. Generation of transgenic pigs by cytoplasmic injection of piggyBac transposase-based pmGENIE-3 plasmids. Biol Reprod 2014; 90:93.
   PubMed Web of Science ®Google Scholar
• Garrels W, Holler S, Cleve N, Niemann H, Ivics Z, Kues WA. Assessment of fecundity and germ line transmission in two transgenic pig lines produced by sleeping beauty transposition. Genes (Basel) 2012; 3:615–633.
   PubMed Web of Science ®Google Scholar
• Urschitz J, Moisyadi S. Transpositional transgenesis with piggyBac. Mob Genet Elements 2013; 3:e25167.
   Google Scholar
• Ivics Z, Garrels W, Mates L, et al. Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons. Nat Protoc 2014; 9:810–827.
   PubMed Web of Science ®Google Scholar
• Wu Z, Xu Z, Zou X, et al. Pig transgenesis by piggyBac transposition in combination with somatic cell nuclear transfer. Transgenic Res 2013; 22:1107–1118.
   PubMed Web of Science ®Google Scholar
• Urschitz J, Kawasumi M, Owens J, et al. Helper-independent piggyBac plasmids for gene delivery approaches: strategies for avoiding potential genotoxic effects. Proc Natl Acad Sci USA 2010; 107:8117–8122.
   PubMed Web of Science ®Google Scholar
• Marh J, Stoytcheva Z, Urschitz J, et al. Hyperactive self-inactivating piggyBac for transposase-enhanced pronuclear microinjection transgenesis. Proc Natl Acad Sci USA 2012; 109:19184–19189.
   PubMed Web of Science ®Google Scholar
• Steger K. Haploid spermatids exhibit translationally repressed mRNAs. Anat Embryol (Berl) 2001; 203:323–334.
   PubMedGoogle Scholar
• Ward WS, Zalensky AO. The unique, complex organization of the transcriptionally silent sperm chromatin. Crit Rev Eukaryot Gene Expr 1996; 6:139–147.
   PubMed Web of Science ®Google Scholar
• Peters HL, Pitt JJ, Wood LR, Hamilton NJ, Sarsero JP, Buck NE. Mouse models for methylmalonic aciduria. PLoS One 2012; 7:e40609.
   PubMed Web of Science ®Google Scholar
• Yang D, Xu J, Zhu T, et al. Effective gene targeting in rabbits using RNA-guided Cas9 nucleases. J Mol Cell Biol 2014; 6:97–99.
   PubMed Web of Science ®Google Scholar
• Kong Q, Wu M, Huan Y, et al. Transgene expression is associated with copy number and cytomegalovirus promoter methylation in transgenic pigs. PLoS One 2009; 4:e6679.
   Google Scholar
• Rostovskaya M, Fu J, Obst M, et al. Transposon-mediated BAC transgenesis in human ES cells. Nucleic Acids Res 2012; 40:e150.
   PubMed Web of Science ®Google Scholar
• Suster ML, Abe G, Schouw A, Kawakami K. Transposon-mediated BAC transgenesis in zebrafish. Nat Protoc 2011; 6:1998–2021.
   PubMed Web of Science ®Google Scholar
• Zhao L, Ng ET, Koopman P. A piggyBac transposon- and gateway-enhanced system for efficient BAC transgenesis. Dev Dyn 2014; 243:1086–1094.
   PubMed Web of Science ®Google Scholar