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Articles

Detecting novel Indel variants within the GHR gene and their associations with growth traits in Luxi Blackhead sheep

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References

  • Abousoliman I, Reyer H, Oster M, et al. Analysis of candidate genes for growth and milk performance traits in the Egyptian Barki sheep. Animals. 2020;10(2):197–116.
  • Rupp R, Mucha S, Larroque H, McEwan J, Conington J. Genomic application in sheep and goat breeding. Animal Frontiers. 2016;6(1):39–44.
  • Bolormaa S, Swan AA, Brown DJ, Hatcher S, et al. Multiple trait QTL mapping and genomic prediction for wool traits in sheep. Genet Sel Evol. 2017;49(1):62.
  • Kominakis A, Hager-Theodorides AL, Zoidis E, Saridaki A, Antonakos G, Tsiamis G. Combined GWAS and 'guilt by association'-based prioritization analysis identifies functional candidate genes for body size in sheep . Genet Sel Evol. 2017;49(1):41.
  • Cui XK, Wang JW, Zhang GP, et al. Researches on growth and development law of Luxi Blackhead sheep. Mod J Anim Husband Vet Med. 2017;3:1–5. (in Chinese).
  • Yang Q, Zhang S, Li J, et al. Development of a touch-down multiplex PCR method for simultaneously rapidly detecting three novel insertion/deletions (indels) within one gene: an example for goat GHR gene. Anim Biotechnol. 2019;30(4):366–371.
  • Renaville R, Hammadi M, Portetelle D. Role of the somatotropic axis in the mammalian metabolism. Domest Anim Endocrinol. 2002;23(1–2):351–360.
  • Wang K, Kang Z, Jiang E, et al. Genetic effects of DSCAML1 identified in genome-wide association study revealing strong associations with litter size and semen quality in goat (Capra hircus). Theriogenology. 2020;146:20–25.
  • Valeh MV, Tahmoorespour M, Ansari M, Nassiry MR, Karimi D, Taheri A. Association of growth traits with SSCP polymorphisms at the growth hormone receptor (GHR) and growth hormone releasing hormone receptor (GHRHR) genes in the Baluchi sheep. J Anim Vet Adv. 2009;8(6):1063–1069.
  • Dettori ML, Pazzola M, Paschino P, Amills M, Vacca GM. Association between the GHR, GHRHR, and IGF1 gene polymorphisms and milk yield and quality traits in Sarda sheep. J Dairy Sci. 2018;101(11):9978–9986.
  • Lu M, Flanagan JU, Langley RJ, Hay MP, Perry JK. Targeting growth hormone function: strategies and therapeutic applications. Signal Transduct Target Ther. 2019;4:3.
  • Carter-Su C, Schwartz J, Argetsinger LS. Growth hormone signaling pathways. Growth Horm Igf Res. 2016;28:11–15.
  • Jia JL, Zhang LP, Wu JP, Ha ZJ, Li WW. Study of the correlation between GH gene polymorphism and growth traits in sheep. Genet Mol Res. 2014;13(3):7190–7200.
  • Gorlov IF, Kolosov YA, Shirokova NV, et al. Association of the growth hormone gene polymorphism with growth traits in Salsk sheep breed. Small Ruminant Research. 2017;150:11–14.
  • Pantel J, Grulich-Henn J, Bettendorf M, Strasburger CJ, Heinrich U, Amselem S. Heterozygous nonsense mutation in exon 3 of the growth hormone receptor (GHR) in severe GH insensitivity (Laron syndrome) and the issue of the origin and function of the GHRD3 isoform. J Clin Endocrinol Metab. 2003;88(4):1705–1710.
  • Ko JM, Park JY, Yoo HW. Common exon 3 polymorphism of the GH receptor (GHR) gene and effect of GH therapy on growth in Korean children with idiopathic short stature (ISS). Clin Endocrinol (Oxf)). 2009;70(1):82–87.
  • Yang Q, Yan H, Li J, et al. A novel 14-bp duplicated deletion within goat GHR gene is significantly associated with growth traits and litter size. Anim Genet. 2017;48(4):499–500.
  • Parra-Bracamonte GM, Lopez-Villalobos N, Sifuentes-Rincon AM, Morris S, Lopez-Bustamante LA, Meza-Garcia LA. Single and composite influence of growth-related candidate gene polymorphisms on additive genetic variation of birth weight in Charolais beef cattle. Trop Anim Health Prod. 2014;46(3):509–512.
  • Cardoso DF, de Souza FRP, de Camargo GMF, et al. Polymorphism analysis in genes of the somatotropic axis in Nellore cattle selected for growth. Gene. 2014;545(2):215–219.
  • Li H, Zhu W, Chen K, Song W, Shu J, Han W. Effects of the polymorphisms of GHR gene and IGF-1 gene on egg quality in Wenchang chicken. Res J Poult Sci. 2010;3(2):19–22.
  • Crisà A, Marchitelli C, Pariset L, et al. Exploring polymorphisms and effects of candidate genes on milk fat quality in dairy sheep. J Dairy Sci. 2010;93(8):3834–3845.
  • Xu S-S, Gao L, Xie X-L, et al. Genome-wide association analyses highlight the potential for different genetic mechanisms for litter size among sheep breeds. Front Genet. 2018;9:118.
  • Bahrami A, Behzadi S, Miraei-Ashtiani SR, Roh SG, Katoh K. Genetic polymorphisms and protein structures in growth hormone, growth hormone receptor, ghrelin, insulin-like growth factor 1 and leptin in Mehraban sheep. Gene. 2013;527(1):397–404.
  • Hui Y, Zhang Y, Wang K, et al. Goat DNMT3B: An indel mutation detection, association analysis with litter size and mRNA expression in gonads. Theriogenology. 2020;147:108–115.
  • Wu X, Jia W, Zhang J, et al. Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds. Small Ruminant Research. 2014;121(2–3):232–243.
  • Wang Z, Zhang X, Jiang E, et al. InDels within caprine IGF2BP1 intron 2 and the 3′-untranslated regions are associated with goat growth traits. Anim Genet. 2020;51(1):117–121.
  • Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005;15(2):97–98.
  • Zhang S, Jiang E, Wang K, et al. Two insertion/deletion variants within SPAG17 gene are associated with goat body measurement traits. Animals (Basel). 2019;9(6):379.
  • Cui Y, Yan H, Wang K, et al. Insertion/deletion within the KDM6A gene is significantly associated with litter size in goat. Front Genet. 2018;9(MAR):1–11.
  • Ardlie KG, Kruglyak L, Seielstad M. Patterns of linkage disequilibrium in the human genome. Nat Rev Genet. 2002;3(4):299–309.
  • Smith RD. The nonlinear structure of linkage disequilibrium. Theor Popul Biol. 2020;S0040–5809(20)30027-7.
  • Li J, Erdenee S, Zhang S, et al. Genetic effects of PRNP gene insertion/deletion (indel) on phenotypic traits in sheep. Prion. 2018;12(1):42–53.
  • Lin S, Li C, Li C, Zhang X. Growth hormone receptor mutations related to individual dwarfism. IJMS. 2018;19(5):1433.
  • Kang Z, Zhang S, He L, et al. A 14-bp functional deletion within the CMTM2 gene is significantly associated with litter size in goat. Theriogenology. 2019;139:49–57.
  • Ferlaino M, Rogers MF, Shihab HA, et al. An integrative approach to predicting the functional effects of small indels in non-coding regions of the human genome. BMC Bioinformatics. 2017;18(1):442.
  • Montgomery SB, Goode DL, Kvikstad E, 1000 Genomes Project Consortium, et al. The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes. Genome Res. 2013;23(5):749–761.
  • Armstrong E, Ciappesoni G, Iriarte W, et al. Novel genetic polymorphisms associated with carcass traits in grazing Texel sheep. Meat Sci. 2018;145:202–208.
  • Sahu AR, Jeichitra V, Rajendran R, Raja A. Polymorphism of growth hormone receptor (GHR) gene in Nilagiri sheep. Trop Anim Health Prod. 2017;49(2):281–285.
  • Mao C, Akhatayeva Z, Cheng H, et al. A novel 23 bp indel mutation in PRL gene is associated with growth traits in Luxi Blackhead sheep. Anim Biotechnol. 2020;
  • Li-Juan W, Qiu-Ling L, Chang-Fa W, et al. CRS-PCR polymorphisms of the GHR gene and its relationship with milk production traits in Chinese Holstein cows. Chin J Agric Biotechnol. 2009;6(3):215–219.
  • Wittke-Thompson JK, Pluzhnikov A, Cox NJ. Rational inferences about departures from Hardy–Weinberg equilibrium. Am J Hum Genet. 2005;76(6):967–986.
  • Fedorova L, Fedorov A. Introns in gene evolution. Genetica. 2003;118(2–3):123–131.
  • Sironen A, Thomsen B, Andersson M, Ahola V, Vilkki J. An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig. Proc Natl Acad Sci USA. 2006;103(13):5006–5011.
  • Sjakste T, Paramonova N, Grislis Z, Trapina I, Kairisa D. Analysis of the single-nucleotide polymorphism in the 5′UTR and part of intron I of the sheep MSTN gene. DNA Cell Biol. 2011;30(7):433–444.
  • Rose AB. Introns as gene regulators: A brick on the accelerator. Front Genet. 2018;9:672.
  • Shi T, Xu Y, Yang MJ, Zhou Y, et al. Genetic variation, association analysis, and expression pattern of SMAD3 gene in Chinese cattle. Czech J Anim Sci. 2016;61(No. 5):209–216.
  • Zhang S, Zhao H, Lei C, et al. Effects of genetic variations within goat PITX2 gene on growth traits and mRNA expression. Anim Biotechnol. 2020;31(2):107–114.
  • Brooks AJ, Dai W, O'Mara ML, et al. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science. 2014;344(6185):1249783.
  • Listrat A, Hocquette JF, Picard B, Ménissier F, Djiane J, Jammes H. Growth hormone receptor gene expression in the skeletal muscle of normal and double-muscled bovines during foetal development. Reprod Nutr Dev. 2005;45(4):393–403.
  • Huang Z, Xie Z. Study on the developmental changes of muscular GHR mRNA expression in sheep. Agric Sci Technol. 2009;10(1):93–96. (in Chinese)
  • Huang Z, Xie Z. Developmental changes of GHR mRNA expression level in sheep liver. J Anhui Agri Sci. 2009;37(13):5894–5896,5942. (in Chinese)
  • Ymer SI, Herington AC. Developmental expression of the growth hormone receptor gene in rabbit tissues. Mol Cell Endocrinol. 1992;83(1):39–49.

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