Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway

References

• Toral PG, Monahan FJ, Hervás G, Frutos P, Moloney AP. Review: modulating ruminal lipid metabolism to improve the fatty acid composition of meat and milk. Challenges and opportunities. Animal. 2018;12(s2):S272–S81.
   PubMedGoogle Scholar
• Hocquette JF, Gondret F, Baéza E, Médale F, Jurie C, Pethick DW. Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers. Animal. 2010;4(2):303–319.
   PubMed Web of Science ®Google Scholar
• Wood JD, Enser M, Fisher AV, et al. Fat deposition, fatty acid composition and meat quality: a review. Meat Sci. 2008;78(4):343–358.
   PubMed Web of Science ®Google Scholar
• Gondret F, Louveau I, Mourot J, et al. Dietary energy sources affect the partition of body lipids and the hierarchy of energy metabolic pathways in growing pigs differing in feed efficiency. J Anim Sci. 2014;92(11):4865–4877.
   PubMed Web of Science ®Google Scholar
• Essén-Gustavsson B, Karlsson A, Lundström K, Enfält AC. Intramuscular fat and muscle fibre lipid contents in halothane-gene-free pigs fed high or low protein diets and its relation to meat quality. Meat Sci. 1994;38(2):269–277.
   PubMed Web of Science ®Google Scholar
• Katsumata M. Promotion of intramuscular fat accumulation in porcine muscle by nutritional regulation. Anim Sci J. 2011;82(1):17–25.
   PubMed Web of Science ®Google Scholar
• Zhao SM, Ren LJ, Chen L, et al. Differential expression of lipid metabolism related genes in porcine muscle tissue leading to different intramuscular fat deposition. Lipids. 2009;44(11):1029–1037.
   PubMed Web of Science ®Google Scholar
• Liu HW, Wei CC, Chen YJ, Chen YA, Chang SJ. Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle. Mol Nutr Food Res. 2016;60(10):2288–2296.
   PubMed Web of Science ®Google Scholar
• Qiao X, Li Y, Mai J, Ji X, Li Q. Effect of dibutyltindilaurate on triglyceride metabolism through the inhibition of the mTOR pathway in human HL7702 liver cells. Molecules. 2018;23(7):1654.
   Web of Science ®Google Scholar
• Li N, Zhao F, Wei C, et al. Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells. Int J Mol Sci. 2014;15(9):16998–17013.
   PubMed Web of Science ®Google Scholar
• Křížová L, Dadáková K, Kašparovská J, Kašparovský T. Isoflavones. Molecules. 2019;24(6):1076.
   Web of Science ®Google Scholar
• Hussain H, Green IR. A patent review of the therapeutic potential of isoflavones (2012–2016). Expert Opin Ther Pat. 2017;27(10):1135–1146.
   PubMed Web of Science ®Google Scholar
• Hu C, Wong WT, Wu R, Lai WF. Biochemistry and use of soybean isoflavones in functional food development. Crit Rev Food Sci Nutr. 2019;5:1–15.
   Google Scholar
• Setchell KDR. The history and basic science development of soy isoflavones. Menopause. 2017;24(12):1338–1350.
   PubMed Web of Science ®Google Scholar
• Rietjens IM, Sotoca AM, Vervoort J, Louisse J. Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks. Mol Nutr Food Res. 2013;57(1):100–113.
   PubMed Web of Science ®Google Scholar
• Ørgaard A, Jensen L. The effects of soy isoflavones on obesity. Exp Biol Med. 2008;233(9):1066–1080.
   Web of Science ®Google Scholar
• Kim S, Shin HJ, Kim SY, et al. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol Cell Endocrinol. 2004;220(1–2):51–58.
   PubMed Web of Science ®Google Scholar
• Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Löwik CW. Peroxisome proliferator-activated receptor gamma (PPARgamma) as a molecular target for the soy phytoestrogen genistein. J Biol Chem. 2003;278(2):962–967.
   PubMed Web of Science ®Google Scholar
• Luo J, Liu D. Does GPER really function as a G protein-coupled estrogen receptor in vivo? Front Endocrinol. 2020;11:148.
   PubMed Web of Science ®Google Scholar
• Molina L, Bustamante FA, Bhoola KD, Figueroa CD, Ehrenfeld P. Possible role of phytoestrogens in breast cancer via GPER-1/GPR30 signaling. Clin Sci. 2018;132(24):2583–2598.
   Web of Science ®Google Scholar
• Otto C, Rohde-Schulz B, Schwarz G, et al. G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Endocrinology. 2008;149(10):4846–4856.
   PubMed Web of Science ®Google Scholar
• Sandén C, Broselid S, Cornmark L, et al. G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. Mol Pharmacol. 2011;79(3):400–410.
   PubMed Web of Science ®Google Scholar
• Li Z, Lu Q, Ding B, Xu J, Shen Y. Bisphenol A promotes the proliferation of leiomyoma cells by GPR30-EGFR signaling pathway. J Obstet Gynaecol Res. 2019;45(7):1277–1285.
   PubMed Web of Science ®Google Scholar
• Zhao B, Xiong Y, Zhang Y, Jia L, Zhang W, Xu X. Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway. Exp Biol Med. 2020;245(6):552–561.
   PubMed Web of Science ®Google Scholar
• Liu EYL, Xu ML, Jin Y, Wu Q, Dong TTX, Tsim KWK. Genistein, a phytoestrogen in soybean, induces the expression of acetylcholinesterase via G protein-coupled receptor 30 in PC12 cells. Front Mol Neurosci. 2018;11:59.
   PubMed Web of Science ®Google Scholar
• Huang X, Zang Y, Zhang M, Yuan X, Li M, Gao X. Nuclear factor of κB1 is a key regulator for the transcriptional activation of milk synthesis in bovine mammary epithelial cells. DNA Cell Biol. 2017;36(4):295–302.
   PubMed Web of Science ®Google Scholar
• Li P, Zhou C, Li X, Yu M, Li M, Gao X. CRTC2 is a key mediator of amino acid-induced milk fat synthesis in mammary epithelial cells. J Agric Food Chem. 2019;67(37):10513–10520.
   PubMed Web of Science ®Google Scholar
• Li X, Li P, Wang L, Zhang M, Gao X. Lysine enhances the stimulation of fatty acids on milk fat synthesis via the GPRC6A-PI3K-FABP5 signaling in bovine mammary epithelial cells. J Agric Food Chem. 2019;67(25):7005–7015.
   PubMed Web of Science ®Google Scholar
• Yu M, Qi H, Gao X. Daidzein promotes milk synthesis and proliferation of mammary epithelial cells via the estrogen receptor α-dependent NFκB1 activation. Anim Biotechnol. 2020;13:1–10.
   Google Scholar
• Romana-Souza B, Saguie BO, Pereira de Almeida Nogueira N, et al. Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-κB and NRF2 pathways. Food Res Int. 2020;131:108984.
   PubMed Web of Science ®Google Scholar
• Leroy JL, Vanholder T, Mateusen B, et al. Non-esterified fatty acids in follicular fluid of dairy cows and their effect on developmental capacity of bovine oocytes in vitro. Reproduction. 2005;130(4):485–495.
   PubMed Web of Science ®Google Scholar
• Xie P, Zhang AT, Wang C, Azzam MM, Zou XT. Molecular cloning, characterization, and expression analysis of fatty acid translocase (FAT/CD36) in the pigeon (Columba livia domestica). Poult Sci. 2012;91(7):1670–1679.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xia G, Zhang Y, et al. Palmitate induces VSMC apoptosis via toll like receptor (TLR)4/ROS/p53 pathway. Atherosclerosis. 2017;263:74–81.
   PubMed Web of Science ®Google Scholar
• Li P, Yu M, Zhou C, et al. FABP5 is a critical regulator of methionine- and estrogen-induced SREBP-1c gene expression in bovine mammary epithelial cells. J Cell Physiol. 2018;234(1):537–549.
   PubMed Web of Science ®Google Scholar
• Moon YA. The SCAP/SREBP pathway: a mediator of hepatic steatosis. Endocrinol Metab. 2017;32(1):6–10.
   Google Scholar
• Zheng W, Rogoschin J, Niehoff A, et al. Combinatory effects of phytoestrogens and exercise on body fat mass and lipid metabolism in ovariectomized female rats. J Steroid Biochem Mol Biol. 2018;178:73–81.
   PubMed Web of Science ®Google Scholar
• Duan X, Meng Q, Wang C, et al. Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor. Phytomedicine. 2017;25:83–92.
   PubMed Web of Science ®Google Scholar
• Veiga FMS, Graus-Nunes F, Rachid TL, Barreto AB, Mandarim-de-Lacerda CA, Souza-Mello V. Anti-obesogenic effects of WY14643 (PPAR-alpha agonist): hepatic mitochondrial enhancement and suppressed lipogenic pathway in diet-induced obese mice. Biochimie. 2017;140:106–116.
   PubMed Web of Science ®Google Scholar
• Ivanova EA, Myasoedova VA, Melnichenko AA, Orekhov AN. Peroxisome proliferator-activated receptor (PPAR) gamma agonists as therapeutic agents for cardiovascular disorders: focus on atherosclerosis. Curr Pharm Des. 2017;23(7):1119–1124.
   PubMed Web of Science ®Google Scholar
• Takaoka O, Mori T, Ito F, et al. Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis. J Steroid Biochem Mol Biol. 2018;181:125–132.
   PubMed Web of Science ®Google Scholar
• Du ZR, Feng XQ, Li N, et al. G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia. Phytomedicine. 2018;43:11–20.
   PubMed Web of Science ®Google Scholar
• Khan K, Pal S, Yadav M, et al. Prunetin signals via G-protein-coupled receptor, GPR30(GPER1): Stimulation of adenylyl cyclase and cAMP-mediated activation of MAPK signaling induces Runx2 expression in osteoblasts to promote bone regeneration. J Nutr Biochem. 2015;26(12):1491–1501.
   PubMed Web of Science ®Google Scholar
• Cimmino I, Oriente F, D’Esposito V, et al. Low dose bisphenol-A regulates inflammatory cytokines through GPR30 in mammary adipose cells. J Mol Endocrinol. 2019;63(4):273–283.
   PubMed Web of Science ®Google Scholar
• Ogawa M, Kitano T, Kawata N, et al. Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice. J Nutr Biochem. 2017;49:63–70.
   PubMed Web of Science ®Google Scholar
• Robb EL, Stuart JA. Multiple phytoestrogens inhibit cell growth and confer cytoprotection by inducing manganese superoxide dismutase expression. Phytother Res. 2014;28(1):120–131.
   PubMed Web of Science ®Google Scholar
• Broselid S, Berg KA, Chavera TA, et al. G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production. J Biol Chem. 2014;289(32):22117–22127.
   PubMed Web of Science ®Google Scholar
• Gurevich EV, Tesmer JJ, Mushegian A, Gurevich VV. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther. 2012;133(1):40–69.
   PubMed Web of Science ®Google Scholar
• Tutzauer J, Sjöström M, Bendahl PO, et al. Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer. PLoS One. 2020;15(4):e0231786.
   PubMed Web of Science ®Google Scholar
• Gonzalez de Valdivia E, Sandén C, Kahn R, Olde B, Leeb-Lundberg LMF. Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity. Biosci Rep. 2019;39.
   PubMed Web of Science ®Google Scholar
• Chakrabarti S, Davidge ST. G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation. PLoS One. 2012;7(12):e52357.
   PubMed Web of Science ®Google Scholar