Nutritional significance and health benefits of omega-3, -6 and -9 fatty acids in animals

References

• Shiels MI. Fatty acids and early human development. Early Hum Dev. 2007;83:761–766.
   PubMed Web of Science ®Google Scholar
• Alagawany M, Attia AI, Ibrahim ZA, Mahmoud RA, El-Sayed SA. The effectiveness of dietary sunflower meal and exogenous enzyme on growth, digestive enzymes, carcass traits and blood chemistry of broilers. Environ Sci Pollut Res. 2017;24(13):12319–12327.
   PubMed Web of Science ®Google Scholar
• Alagawany M, Attia A, Ibrahim ZA, Abd El-Hack ME, Arif M, Emam M. The influences of feeding broilers on graded inclusion of sunflower meal with or without avizyme on growth, protein and energy efficiency, carcass traits and nutrient digestibility. Tur J Vet Anim Sci. 2018;42:168–176.
   Web of Science ®Google Scholar
• Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry. 2006;18(2):155–172.
   PubMed Web of Science ®Google Scholar
• Ortega RM, Rodríguez-Rodríguez E, López-Sobaler AM. Effects of omega-3 fatty acids supplementation in behavior and non-neurodegenerative neuropsychiatric disorders. Br J Nutr. 2012;107:5261–5270.
   Web of Science ®Google Scholar
• Simopoulos AP. Human requirement for n-3 polyunsaturated fatty acids. Symposium: role of poultry products in enriching the human diet with n-3 PUFA. Poult Sci. 2000;79(7):961–970.
   PubMed Web of Science ®Google Scholar
• El-Yamany AT, El-Allawy HMH, Abd El-Samee LD, ElGhamry AA. Evaluation of using different levels and sources of oil in growing Japanese quail diets. J Agric Environ Sci. 2008;3:577–582.
   Google Scholar
• He X, Yang X, Guo Y. Effects of different dietary oil sources on immune function in cyclophosphamide immunosuppressed chickens. Anim Feed Sci Tech. 2007;139(3–4):186–200.
   Web of Science ®Google Scholar
• Cherian G. Essential fatty acids and early life programming in meat type birds. Worlds Poult Sci J. 2011;67(4):599–614.
   Web of Science ®Google Scholar
• Liu G, An S, Yuan J, et al. Dietary fish oil and zinc reduced plasma prostaglandin E2 content by inhibiting phospholipase A2 production in broilers. J Poult Sci. 2014;51(1):66–70.
   Web of Science ®Google Scholar
• Ajuyah AO, Cherian G, Wang Y, Sunwood H, Sim JS. Maternal dietary FA modulate the long-chain n-3 PUFA status of chick cardiac tissue. Lipids. 2003;38(12):1257–1261.
   PubMed Web of Science ®Google Scholar
• Bautista-Ortega J, Goeger DE, Cherian G. Egg yolk omega-6 and omega-3 fatty acids modify tissue lipid components, antioxidant status, and ex vivo eicosanoid production in chick cardiac tissue. Poult Sci. 2009;88(6):1167–1175.
   PubMed Web of Science ®Google Scholar
• Saki AA, Matin HR. Does nutrition help to alleviate sudden death syndrome in broiler chicken? An Overview. Global Vet. 2011;6:262–268.
   Google Scholar
• Al-Zuhairy MA, Jameel YJ. Effect of ND vaccine, multivitamins AD3E, and omega-3 on performance and immune response of broilers. Mirror Res Vet Sci Anim. 2014;3:42–50.
   Google Scholar
• Farag MR, Alagawany M, Dhama K. Flaxseed oil alleviates toxic effects of subacute exposure to acephate on liver and kidney of broiler chicks. Asian J Animal Vet Adv. 2017;12(2):61–70.
   Google Scholar
• Mousa SA, Abdel-Raheem SM, Abdel-Raheem HA, Sadeek AS. Effect of dietary fat sources and antioxidant types on growth performance and carcass quality of Japanese quails. Int J Poultry Sci. 2017;16(11):443–450.
   Google Scholar
• Alagawany M, Abd El-Hack ME, Farag MR. Nutritional strategies to produce organic and healthy poultry products. In The Handbook of Environmental Chemistry. Berlin, Germany: Springer; 2018.
   Google Scholar
• Cohen AE, Johnston CS. Almond ingestion at mealtime reduces postprandial glycemia and chronic ingestion reduces hemoglobin A(1c) in individuals with well-controlled type 2 diabetes mellitus. Metabolism. 2011;60(9):1312–1317.
   PubMed Web of Science ®Google Scholar
• Innis SM. Dietary omega 3 fatty acids and the developing brain. Brain Res. 2008;1237:35–43.
   PubMed Web of Science ®Google Scholar
• Stark AH, Crawford MA, Reifen R. Update on alpha-linolenic acid. Nutr Rev. 2008;66(6):326–332.
   PubMed Web of Science ®Google Scholar
• Scorletti E, Byrne CD. Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease. Annu Rev Nutr. 2013;33(1):231–248.
   PubMedGoogle Scholar
• Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 Fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308(10):1024–1033.
   PubMed Web of Science ®Google Scholar
• Stulnig TM. Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. Int Arch Allergy Immunol. 2003;132(4):310–321.
   PubMed Web of Science ®Google Scholar
• Rymer C, Gibbs RA, Givens DI. Comparison of algal and fish sources on the oxidative stability of poultry meat and its enrichment with omega-3 polyunsaturated fatty acids. Poult Sci. 2010;89(1):150–159.
   PubMed Web of Science ®Google Scholar
• Grey A, Mark B. Clinical trial evidence and use of fish oil supplements. JAMA Intern Med. 2014;174(3):460–462.
   PubMed Web of Science ®Google Scholar
• Freemantle E, Vandal M, Tremblay-Mercier J, et al. Omega-3 fatty acids, energy substrates, and brain function during aging. Prostaglandins Leukot Essent Fatty Acids. 2006;75(3):213–220.
   PubMed Web of Science ®Google Scholar
• Gao F, Taha AY, Ma K, Chang L, Kiesewetter D, Rapoport SI. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. Age. 2013;35(3):597–608.
   PubMedGoogle Scholar
• Chaiyasit W, Elias RJ, Mcclements DJ, Decker EA. Role of physical structures in bulk oils on lipid oxidation. Crit Rev Food Sci Nutr. 2007;47(3):299–317.
   PubMed Web of Science ®Google Scholar
• Dasilva WA, Naiverti Elias AH, Aparecida AJ, et al. Quail egg yolk (Coturnix coturnix japonica) enriched with omega-3 fatty acids. LWT Food Sci Tech. 2009;42:660–663.
   Web of Science ®Google Scholar
• Lunn J, Theobald H. The health effects of dietary unsaturated fatty acids. Nutr Bull. 2006;31(3):178–224.
   Google Scholar
• Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999;70:560–569.
   PubMed Web of Science ®Google Scholar
• Ibrahim D, El-Sayed R, Khater SI, Said EN, El-Mandrawy SAM. (2017) Changing dietary n-6:n-3 ratio using different oil sources affects performance, behavior, cytokines mRNA expression and meat fatty acid profile of broiler chickens. Anim Nutr. 2018;4(1):44–51.
   PubMedGoogle Scholar
• Zengin H, Vural N, Çelik VK. Comparison of changes in fatty acid composition of starved and fed rainbow trout, (Oncorhynchus mykiss) Larvae. Turkish J Fish Aquat Sci. 2013;13:397–405.
   Web of Science ®Google Scholar
• Herawati VE, Hutabarat J, Pinandoyo  , Radjasa OK. Growth and survival rate of tilapia (Oreochromis niloticus) larvae fed by Daphnia magna cultured with organic fertilizer resulted from probiotic bacteria fermentation. HAYATI J Biosci. 2015;22:169–173.
   Google Scholar
• Cherian G, Sim JS. Changes in the breast milk fatty acids and plasma lipids of nursing mothers following consumption of n − 3 polyunsaturated fatty acid enriched eggs. Nutrition. 1996;12(1):8–12.
   PubMed Web of Science ®Google Scholar
• Balevi T, Coskun B. Effects of some dietary oils on performance and fatty acid composition of eggs in layers. Rev Med Vet. 2000;151:847–854.
   Google Scholar
• Wijendran V, Hayes KC. Dietary n-6 and n-3 fatty acid balance and cardiovascular health. Annu Rev Nutr. 2004;24:597–615.
   PubMed Web of Science ®Google Scholar
• El-Badry AM, Graf R, Clavien PA. Omega 3-omega 6: what is right for the liver? J Hepatol. 2007;47(5):718–725.
   PubMed Web of Science ®Google Scholar
• Garg A1. High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis. Am J Clin Nutr. 1998;67(3):577S–582S.
   PubMed Web of Science ®Google Scholar
• Finucane OM, Lyons CL, Murphy AM, et al. Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity. Diabetes. 2015;64(6):2116–2128.
   PubMed Web of Science ®Google Scholar
• Lock AL, Bauman DE. Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids. 2004;39(12):1197–1206.
   PubMed Web of Science ®Google Scholar
• Alagawany M, Farag MR, Dhama K, Patra A. A review on nutritional significance and health benefits of designer eggs. World Poult Sci J. 2018;74(2):317–330.
   Web of Science ®Google Scholar
• Kassis NM, Gigliotti JC, Beamer SK, Tou JC, Jaczynski J. Characterization of lipids and antioxidant capacity of novel nutraceutical egg products developed with omega‐3‐rich oils. J Sci Food Agric. 2012;92(1):66–73.
   PubMed Web of Science ®Google Scholar
• Weggemans RM, Zock PL, Katan MB. Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis. American J Clin Nutr. 2001;73(5):885–891.
   PubMed Web of Science ®Google Scholar
• Koning AJ, Mol TH. Lipid determination in fish meal: an investigation of three standard methods applied to stabilized and non-stabilized anchovy meals at increasing stages of maturity. J Sci Food Agri. 1989;46:259–266.
   Web of Science ®Google Scholar
• Galobart J, Barroeta AC, Baucells MD, Guardiola F. Lipid oxidation in fresh and spray-dried eggs enriched with omega3 and omega6 polyunsaturated fatty acids during storage as affected by dietary vitamin E and canthaxanthin supplementation. Poult Sci. 2001;80(3):327–337.
   PubMed Web of Science ®Google Scholar
• Ayerza R, Coates W. Omega-3 enriched eggs: the influence of dietary alpha-linolenic fatty acid source on egg production and composition. Can J Anim Sci. 2001;81:355–362.
   Web of Science ®Google Scholar
• Fredriksson S, Elwinger K, Pickova J. Fatty acid and carotenoids composition of egg yolk as an effect of microalgae addition to feed formula for laying hens. Food Chem. 2006;99(3):530–537.
   Web of Science ®Google Scholar
• Ehr IJ, Persia ME, Bobeck EA. Comparative omega-3 fatty acid enrichment of egg yolks from first-cycle laying hens fed flaxseed oil or ground flaxseed. Poult Sci. 2017;96(6):1791–1799.
   PubMed Web of Science ®Google Scholar
• Kamely MMA, Karimi T, Khosravinia H. Omega-3 enrichment of quail eggs: age, fish oil, and savory essential oil. J Agr Sci Tech. 2016;18:347–359.
   Web of Science ®Google Scholar
• Eid Y, Zewehil H, Ahmed M, Basyony M, Farok M. Effect of plant source of omega-3 fatty acids and green tea powder on the performance and meat quality of growing rabbits. Egypt J Rabbit Sci. 2010;20:115–134.
   Google Scholar
• Radwan NL, Abd El-Samad MH, Sherin A. Effects of different dietary rations of linoleic acid to a linolenic acid on productive performance, immunity of laying hens and egg yolk fatty acid composition. Egypt Poult Sci. 2012;32:163–188.
   Google Scholar
• Zhang ZF, Zhou TX, Kim IH. Effects of dietary olive oil on growth performance, carcass parameters, serum characteristics, and fatty acid composition of breast and drumstick meat in broilers. Asian Australas J Anim Sci. 2013;26(3):416–422.
   PubMed Web of Science ®Google Scholar
• El Shanti H, Ghazalah A, Abdel-Khalek A, Abu-Nada F. XIII the European Poultry Conference, Tours, France. Worlds Poultry Science Association; 2011.
   Google Scholar
• Park YK, Albright J, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids. 1997;32(8):853–858.
   PubMed Web of Science ®Google Scholar
• Sanz M, Lopez-Bote CJ, Menoyo D, Bautista JM. Abdominal fat deposition and fatty acid synthesis are lower and β-oxidation is higher in broiler chickens fed diets containing unsaturated rather than saturated fat. J Nutr. 2000;130(12):3034–3037.
   PubMed Web of Science ®Google Scholar
• Crespo N, Esteve-Garcia E. Nutrient and fatty acid deposition in broilers fed different dietary fatty acid profiles. Poult Sci. 2002;81(10):1533–1542.
   PubMed Web of Science ®Google Scholar
• Keegan JD, Currie D, Knox A, Moran CA. Redressing the balance: including DHA-rich Aurantiochytrium limacinum in broiler diets increases tissue omega-3 fatty acid content and lowers the n-6:n-3 ratio. Brit Poult Sci. 2019;60 (4):414–422.
   PubMed Web of Science ®Google Scholar
• Keegan JD, Currie D, Knox A, Moran CA. Heterotrophic Aurantiochytrium sp. supplementation to layer diets sustainably increases the omega-3 concentration of eggs. Brit Poult Sci. 2019b;60(5):570–578.
   PubMed Web of Science ®Google Scholar
• Dal Bosco A, Castellini C, Bianchi L, Mugnai C. Effect of dietary α-linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat. Meat Sci. 2004;66(2):407–413.
   PubMed Web of Science ®Google Scholar
• Habeeb AAM, Basuony HA, Michael MI, Gad AE. Role of Omega-3 in the improvement of productive and reproductive performance of New Zealand White female rabbits. Biolo Rhy Res. 2019;1–12. doi:10.1080/09291016.2019.1586100
   Web of Science ®Google Scholar
• Menchetti L, Canali C, Castellini C, Boiti C, Brecchia G. The different effects of linseed and fish oil supplemented diets on insulin sensitivity of rabbit does during pregnancy. Res Vet Sci. 2018;118:126–133.
   PubMed Web of Science ®Google Scholar
• Mattioli S, Dal Bosco A, Maranesi M, Petrucci L, Rebollar P, Castellini C. Dietary fish oil and flaxseed for rabbit does: fatty acids distribution and Δ6-desaturase enzyme expression of different tissues. Animal. 2019;13(9):1934–1942.
   PubMed Web of Science ®Google Scholar
• Rodríguez M, Carro MD, Valiente V, Formoso-Rafferty N, Rebollar PG. Effects of dietary fish oil supplementation on performance, meat quality, and cecal fermentation of growing rabbits. J Anim Sci. 2017;95(8):3620–3630.
   PubMed Web of Science ®Google Scholar
• McAfee JM, Kattesh HG, Lindemann MD, et al. Effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation to lactating sows on growth and indicators of stress in the postweaned pig1,2. J Anim Sci. 2019;97(11):4453–4463.
   PubMed Web of Science ®Google Scholar
• Szostak A, Ogłuszka M, Te Pas MF, et al. Effect of a diet enriched with omega-6 and omega-3 fatty acids on the pig liver transcriptome. Genes Nutr. 2016;11:9.
   PubMed Web of Science ®Google Scholar
• Ekmekcioglu C, Wallner P, Kundi M, Weisz U, Haas W, Hutter HP. Red meat, diseases and healthy alternatives: a critical review. Crit Rev Food Sci Nutr. 2018;58(2):247–261.
   PubMed Web of Science ®Google Scholar
• Nguyen DV, Le VH, Nguyen QV, Malau-Aduli BS, Nichols PD, Malau-Aduli AEO. Omega–3 long-chain fatty acids in the heart, kidney, liver and plasma metabolite profiles of Australian Prime Lambs supplemented with pelleted canola and flaxseed oils. Nutrients. 2017;9(8):893.
   PubMed Web of Science ®Google Scholar
• Moran CA, Morlacchini M, Keegan JD, Fusconi G. The effect of dietary supplementation with Aurantiochytrium limacinum on lactating dairy cows in terms of animal health, productivity and milk composition. J Anim Physiol Anim Nutr. 2018;102(2):576–590.
   PubMed Web of Science ®Google Scholar
• Ataei A, Nazri M, Bahnamiri AZ. Effects of Omega fatty acid supplement and feeding frequency on insulin sensitivity and carcass characteristics in Mahabadi goat kids. Small Rumin Res. 2019;172:1–7.
   Web of Science ®Google Scholar
• Bianchi AE, Silva ASDA, Biazus AH, et al. Adding palm oil to the diet of sheep alters fatty acids profile on yogurt: benefits to consumers. An Acad Bras Ciênc. 2017;89(3):2471–2478.
   PubMed Web of Science ®Google Scholar
• Teama FEI, El-Tarabany AA. Physiological and biochemical response to Omega-3 plus as a dietary supplement to growing goats under hot summer conditions. R Bras Zootec. 2016;45(4):174–180.
   Web of Science ®Google Scholar
• Thesing CS, Bot M, Milaneschi Y, Giltay EJ, Penninx BW. Omega-3 and omega-6 fatty acid levels in depressive and anxiety disorders. Psychoneuroendocrinology. 2018;87:53–62.
   PubMed Web of Science ®Google Scholar
• Alagawany M, Elnesr SS, Farag MR, et al. Omega-3 and omega-6 fatty acids in poultry nutrition: effect on production performance and health. Animals. 2019;9(8):573.
   Web of Science ®Google Scholar
• Moallem U. Invited review: roles of dietary n-3 fatty acids in performance, milk fat composition, and reproductive and immune systems in dairy cattle. J Dairy Sci. 2018;101(10):8641–8661.
   PubMed Web of Science ®Google Scholar
• Zárate R, Jaber-Vazdekis N, Tejera N, Pérez JA, Rodríguez C. Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Sci. 2017;6(1):25.
   Google Scholar
• Marsiñach MS, Cuenca AP. The impact of sea buckthorn oil fatty acids on human health. Lipids Health Dis. 2019;18(1):145.
   PubMedGoogle Scholar
• Bassett CM, McCullough RS, Edel AL, Patenaude A, LaVallee RK, Pierce GN. The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat. Am J Physiol-Heart C. 2011;301(6):H2220–H2226.
   PubMed Web of Science ®Google Scholar
• Johnson M, Bradford C. Omega-3, omega-6 and omega-9 fatty acids: implications for cardiovascular and other diseases. J Glycomics Lipidomics. 2014;4(123):2153–0637.
   Google Scholar
• Darmawan A, Wiryawan KG, Sumiati S. Egg production and quality of magelang duck fed diets containing different ratio of omega 3: omega 6 and organic Zn. Med Pet. 2013;36(3):197–202.
   Google Scholar
• Karsten HD, Patterson PH, Stout R, Crews G. Vitamins A, E and fatty acid composition of the eggs of caged hens and pastured hens. Renew Agric Food Syst. 2010;25(1):45–54.
   Web of Science ®Google Scholar
• Molinari C, Risé P, Guerra C, et al. Eight-week consumption of milk enriched with omega 3 fatty acids raises their blood concentrations yet does not affect lipids and cardiovascular disease risk factors in adult healthy volunteers. Pharma Nutr. 2014;2(4):141–148.
   Google Scholar
• Cardozo L, Cecim M, Soares E, et al. Oxidative stability and fatty acid profile content of milk from cows fed linseed oil diet with or without injectable sodium selenite. Arq Bras Med Vet Zootec. 2013;65(3):826–832.
   Google Scholar
• Qi KK, Chen JL, Zhao GP, Zheng MQ, Wen J. Effect of dietary ω6/ω3 on growth performance, carcass traits, meat quality and fatty acid profiles of Beijing‐you chicken. J Anim Physiol Anim Nutr. 2010;94(4):474–485.
   PubMed Web of Science ®Google Scholar
• Watson H, Mitra S, Croden FC, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018;67(11):1974–1983.
   PubMed Web of Science ®Google Scholar
• Alshatwi AA, Subash-Babu P. Effects of increasing ratios of dietary omega-6/omega-3 fatty acids on human monocyte immunomodulation linked with atherosclerosis. J Funct Foods. 2018;41:258–267.
   Web of Science ®Google Scholar
• Lu Y, Chen RG, Wei SZ, Hu HG, Sun F, Yu CH. Effect of omega 3 fatty acids on C-reactive protein and interleukin-6 in patients with advanced nonsmall cell lung cancer. Medicine. 2018;97(37):e11971.
   PubMed Web of Science ®Google Scholar
• O’Callaghan TF, Mannion D, Apopei D, et al. Influence of supplemental feed choice for pasture-based cows on the fatty acid and volatile profile of milk. Foods. 2019;8(4):137.
   PubMed Web of Science ®Google Scholar
• Kumar F, Tyagi PK, Mir NA, et al. 2020. Dietary flaxseed and turmeric is a novel strategy to enrich chicken meat with long chain ω-3 polyunsaturated fatty acids with better oxidative stability and functional properties. Food Chem. 305:125458.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhuang P, Mao L, et al. Current level of fish and omega-3 fatty acid intakes and risk of type 2 diabetes in China. J Nutr Biochem. 2019;74:108249.
   PubMed Web of Science ®Google Scholar
• Haug A, Vhile SG, Berg J, Hove K, Egelandsdal B. Feeding potentially health promoting nutrients to finishing bulls changes meat composition and allow for product health claims. Meat Sci. 2018;145:461–468.
   PubMed Web of Science ®Google Scholar
• Melo RB, de Barros Silva PG, Oriá RB, et al. Anti-inflammatory effect of a fatty acid mixture with high ω-9: ω-6 ratio and low ω-6: ω-3 ratio on rats submitted to dental extraction. Arch Oral Biol. 2017;74:63–68.
   PubMed Web of Science ®Google Scholar