Vitamin B5 supplementation enhances intestinal development and alters microbes in weaned piglets

References

• Pluske JR, Turpin DL, Kim J-C. Gastrointestinal tract (gut) health in the young pig. Anim Nutr. 2018;4(2):1–14.
   PubMedGoogle Scholar
• Bischoff SC. ‘Gut health’: a new objective in medicine? BMC Med. 2011;9(1):24.
   PubMedGoogle Scholar
• Dong GZ, Pluske JR. The low feed intake in newly-weaned pigs: problems and possible solutions. Asian Australas J Anim Sci. 2007;20(3):440–452.
   Web of Science ®Google Scholar
• Goldstein R, Hebiguchi T, Luk G, et al. The effects of total parenteral nutrition on gastrointestinal growth and development. J Pediatr Surg. 1985;20(6):785–791.
   PubMed Web of Science ®Google Scholar
• Shulman R, Fiorotto M, Sheng H, Garza C. Effect of different total parenteral nutrition fuel mixes on the body composition of infant miniature pigs. Pediatr Res. 1984;18(3):261–265.
   PubMed Web of Science ®Google Scholar
• Jayaraman B, Nyachoti CM. Husbandry practices and gut health outcomes in weaned piglets: a review. Anim Nutr. 2017;3(3):205–211.
   PubMedGoogle Scholar
• Moeser A, Pohl CS, Rajput M. Weaning stress and gastrointestinal barrier development: Implications for lifelong gut health in pigs. Anim Nutr. 2017;3(4):313–321.
   PubMedGoogle Scholar
• Chen C, Wang Z, Li J, et al. Dietary vitamin E affects small intestinal histomorphology, digestive enzyme activity, and the expression of nutrient transporters by inhibiting proliferation of intestinal epithelial cells within jejunum in weaned piglets. J Anim Sci. 2019;97(3):1212–1221.
   PubMed Web of Science ®Google Scholar
• Wang L, Zou L, Li J, Yang H, Yin Y. Effect of dietary folate level on organ weight, digesta pH, short-chain fatty acid concentration, and intestinal microbiota of weaned piglets. J Anim Sci. 2021;99(1):skab015.
   PubMed Web of Science ®Google Scholar
• Wang Z, Li J, Wang Y, et al. Dietary vitamin A affects growth performance, intestinal development, and functions in weaned piglets by affecting intestinal stem cells. J Anim Sci. 2020;98(2):skaa020.
   PubMed Web of Science ®Google Scholar
• Wang Z, Yi Z, Wang Q, et al. Effect of different levels of niacin on serum biochemical parameters, antioxidant status, cytokine levels, inflammatory gene expression and colonic microbial composition in weaned piglets. Animals (Basel). 2022;12(21):3018.
   PubMedGoogle Scholar
• Ragaller V, Lebzien P, Südekum K, Hüther L, Flachowsky G. Pantothenic acid in ruminant nutrition: a review. J Anim Physiol Anim Nutr (Berl). 2011;95(1):6–16.
   PubMed Web of Science ®Google Scholar
• Nitto T, Onodera K. Linkage between coenzyme a metabolism and inflammation: roles of pantetheinase. J Pharmacol Sci. 2013;123(1):1–8.
   PubMed Web of Science ®Google Scholar
• Slyshenkov V, Dymkowska D, Wojtczak L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004;569(1–3):169–172.
   PubMed Web of Science ®Google Scholar
• Wojtczak L, Slyshenkov V. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals—the role of glutathione. Biofactors. 2003;17(1–4):61–73.
   PubMed Web of Science ®Google Scholar
• He W, Hu S, Du X, et al. Vitamin B5 reduces bacterial growth via regulating innate immunity and adaptive immunity in mice infected with mycobacterium tuberculosis. Front Immunol. 2018;9:365.
   PubMedGoogle Scholar
• Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 2004;5(10):987–995.
   PubMed Web of Science ®Google Scholar
• Lerner T, Borel S, Gutierrez M. The innate immune response in human tuberculosis. Cell Microbiol. 2015;17(9):1277–1285.
   PubMed Web of Science ®Google Scholar
• Abiko Y. Metabolism of coenzyme A. In: Metabolism of Sulfur Compounds. New York: Academic Press; 1975:1–25.
   Google Scholar
• Lin Y-H, Lin H-Y, Shiau S-Y. Estimation of dietary pantothenic acid requirement of grouper, Epinephelus malabaricus according to physiological and biochemical parameters. Aquaculture. 2012;324–325:92–96.
   Web of Science ®Google Scholar
• Kobayashi D, Kusama M, Onda M, Nakahata N. The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts. J Pharmacol Sci. 2011;115(2):230–234.
   Web of Science ®Google Scholar
• NRC. Nutrient Requirements of Swine. 11th rev. ed. Washington, DC: The National Academies Press; 2012.
   Google Scholar
• Böhmer B, Roth-Maier D. Effects of high-level dietary B-vitamins on performance, body composition and tissue vitamin contents of growing/finishing pigs. J Anim Physiol Anim Nutr (Berl). 2007;91(1–2):6–10.
   PubMed Web of Science ®Google Scholar
• Groesbeck C, Goodband R, Tokach M, Dritz S, Nelssen J, DeRouchey J. Effects of pantothenic acid on growth performance and carcass characteristics of growing-finishing pigs fed diets with or without ractopamine hydrochloride. J Anim Sci. 2007;85(10):2492–2497.
   PubMed Web of Science ®Google Scholar
• Lorenzett M, Armién A, Henker L, et al. Motor and somatosensory degenerative myelopathy responsive to pantothenic acid in piglets. Vet Pathol. 2023;60(1):101–114.
   PubMed Web of Science ®Google Scholar
• Tang J, Zhang B, Liang S, et al. Effects of pantothenic acid on growth performance and antioxidant status of growing male white Pekin ducks. Poult Sci. 2020;99(9):4436–4441.
   PubMed Web of Science ®Google Scholar
• Wang B, Zhang X, Yue B, et al. Effects of pantothenic acid on growth performance, slaughter performance, lipid metabolism, and antioxidant function of Wulong geese aged one to four weeks. Anim Nutr. 2016;2(4):312–317.
   PubMedGoogle Scholar
• Deng Q, Wang Y, Wang X, et al. Effects of dietary iron level on growth performance, hematological status, and intestinal function in growing-finishing pigs. J Anim Sci. 2021;99(1):skab002.
   PubMed Web of Science ®Google Scholar
• Zhou J, Qin Y, Xiong X, et al. Effects of iron, vitamin A, and the interaction between the two nutrients on intestinal development and cell differentiation in piglets. J Anim Sci. 2021;99(10):skab258.
   PubMed Web of Science ®Google Scholar
• Deng Q, Shao Y, Wang Q, et al. Effects and interaction of dietary electrolyte balance and citric acid on the intestinal function of weaned piglets. J Anim Sci. 2020;98(5):skaa106.
   PubMed Web of Science ®Google Scholar
• Wang L, Yan S, Li J, et al. Rapid communication: The relationship of enterocyte proliferation with intestinal morphology and nutrient digestibility in weaning piglets. J Anim Sci. 2019;97(1):353–358.
   PubMed Web of Science ®Google Scholar
• Yang C, Wang M, Tang X, et al. Effect of dietary amylose/amylopectin ratio on intestinal health and cecal microbes’ profiles of weaned pigs undergoing feed transition or challenged with lipopolysaccharide. Front Microbiol. 2021;12:693839.
   PubMed Web of Science ®Google Scholar
• Krehl WA. Pantothenic acid in swine nutrition. Nutr. Rev. 1957;15(9):275–277.
   PubMed Web of Science ®Google Scholar
• Yang H, Xiong X, Yin Y. Development and renewal of intestinal villi in pigs. In: Nutritional and Physiological Functions of Amino Acids in Pigs. Vienna; New York: Springer; 2013: 29–47.
   Google Scholar
• Montagne L, Pluske J, Hampson D. A review of interactions between dietary fibre and the intestinal mucosa, and their consequences on digestive health in young non-ruminant animals. Anim Feed Sci Technol. 2003;108(1–4):95–117.
   Web of Science ®Google Scholar
• Wang M, Huang H, Hu Y, et al. Effects of dietary microencapsulated tannic acid supplementation on the growth performance, intestinal morphology, and intestinal microbiota in weaning piglets. J Anim Sci. 2020;98(5):skaa112.
   PubMed Web of Science ®Google Scholar
• Wang M, Wang L, Tan X, et al. The developmental changes in intestinal epithelial cell proliferation, differentiation, and shedding in weaning piglets. Anim Nutr. 2022;9:214–222.
   PubMedGoogle Scholar
• Mansbach C, Gorelick F. Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons. Am J Physiol Gastrointest Liver Physiol. 2007;293(4):G645–650.
   PubMed Web of Science ®Google Scholar
• Yang H, Wang X, Xiong X, Yin Y. Energy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis. Sci Rep. 2016;6(1):31917.
   PubMedGoogle Scholar
• Gehart H, Clevers HJ. Tales from the crypt: new insights into intestinal stem cells. Nat Rev Gastroenterol Hepatol. 2019;16(1):19–34.
   PubMed Web of Science ®Google Scholar
• Yang H, Xiong X, Wang X, Yin Y. Mammalian target of rapamycin signaling pathway changes with intestinal epithelial cells renewal along crypt-villus axis. Cell Physiol Biochem. 2016;39(2):751–759.
   PubMedGoogle Scholar
• Yang H, Li F, Kong X, et al. Chemerin regulates proliferation and differentiation of myoblast cells via ERK1/2 and mTOR signaling pathways. Cytokine. 2012;60(3):646–652.
   PubMed Web of Science ®Google Scholar
• Pluske JR, Hampson DJ, Williams IH. Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livest Prod Sci. 1997;51(1–3):215–236.
   Google Scholar
• Yoshii K, Hosomi K, Sawane K, Kunisawa J. Metabolism of dietary and microbial vitamin B family in the regulation of host immunity. Front Nutr. 2019;6:48.
   PubMed Web of Science ®Google Scholar
• McCauley HA, Guasch G. Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia. Trends Mol Med. 2015;21(8):492–503.
   PubMed Web of Science ®Google Scholar
• Lanska DJ. The discovery of niacin, biotin, and pantothenic acid. Ann Nutr Metab. 2012;61(3):246–253.
   PubMed Web of Science ®Google Scholar
• Moiseenok A, Kanunnikova N. Brain CoA and acetyl CoA metabolism in mechanisms of neurodegeneration. Biochemistry (Mosc). 2023;88(4):466–480.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang H, Geerts C, et al. The multiple facets of acetyl-CoA metabolism: Energetics, biosynthesis, regulation, acylation and inborn errors. Mol Genet Metab. 2023;138(1):106966.
   PubMed Web of Science ®Google Scholar
• Birchenough GM, Johansson ME, Gustafsson JK, Bergström JH, Hansson GC. New developments in goblet cell mucus secretion and function. Mucosal Immunol. 2015;8(4):712–719.
   PubMed Web of Science ®Google Scholar
• Gribble F, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol. 2019;15(4):226–237.
   PubMed Web of Science ®Google Scholar
• Liu B, Wang W, Zhu X, et al. Response of gut microbiota to dietary fiber and metabolic interaction with SCFAs in piglets. Front Microbiol. 2018;9:2344.
   PubMed Web of Science ®Google Scholar
• Wang M, Yang C, Wang Q, et al. Effects of dietary amylose-amylopectin ratio on growth performance and intestinal digestive and absorptive function in weaned piglet response to lipopolysaccharide. Animals (Basel). 2022;12(14):1833.
   PubMedGoogle Scholar
• Williams B, Verstegen M, Tamminga S. Fermentation in the large intestine of single-stomached animals and its relationship to animal health. Nutr Res Rev. 2001;14(2):207–228.
   PubMed Web of Science ®Google Scholar
• Zhao L, Lou H, Peng Y, Chen S, Fan L, Li XJ. Elevated levels of circulating short-chain fatty acids and bile acids in type 2 diabetes are linked to gut barrier disruption and disordered gut microbiota. Diabetes Res Clin Pract. 2020;169:108418.
   PubMed Web of Science ®Google Scholar
• Tang S, Zhang S, Zhong R, et al. Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine. Appl Microbiol Biotechnol. 2021;105(21-22):8441–8456.
   PubMed Web of Science ®Google Scholar
• Chen Y, Xie Y, Zhong R, et al. Effects of xylo-oligosaccharides on growth and gut microbiota as potential replacements for antibiotic in weaning piglets. Front Microbiol. 2021;12:641172.
   PubMed Web of Science ®Google Scholar
• Wang X, Tsai T, Deng F, et al. Longitudinal investigation of the swine gut microbiome from birth to market reveals stage and growth performance associated bacteria. Microbiome. 2019;7(1):109.
   PubMed Web of Science ®Google Scholar
• Wang Y, Xu L, Liu J, Zhu W, Mao S. A high grain diet dynamically shifted the composition of mucosa-associated microbiota and induced mucosal injuries in the colon of sheep. Front Microbiol. 2017;8:2080.
   PubMed Web of Science ®Google Scholar
• Kyoung H, Lee J, Cho J, et al. Dietary glutamic acid modulates immune responses and gut health of weaned pigs. Animals (Basel). 2021;11(2):504.
   PubMedGoogle Scholar
• Nomoto R, Ishida-Kuroki K, Nakagawa I, Sekizaki T. Complete genome sequences of four Streptococcus parasuis strains obtained from saliva of domestic pigs in Japan. Microbiol Resour Announc. 2022;11(2):e0124521.
   PubMed Web of Science ®Google Scholar
• Ding S, Azad M, Fang J, et al. Impact of sulfur-containing amino acids on the plasma metabolomics and intestinal microflora of the sow in late pregnancy. Food Funct. 2019;10(9):5910–5921.
   PubMed Web of Science ®Google Scholar
• Mou Q, Yang H, Yin Y, Huang P. Amino acids influencing intestinal development and health of the piglets. Animals (Basel). 2019;9(6):302.
   PubMedGoogle Scholar