Regulatory impacts of PPARGC1A gene expression on milk production and cellular metabolism in buffalo mammary epithelial cells

References

• Goldammer T, Weikard R, Miziara MN, et al. A radiation hybrid map of river buffalo (Bubalus bubalis) chromosome 7 and comparative mapping to the cattle and human genomes. Cytogenet Genome Res. 2007;119(3-4):235–241.
   PubMed Web of Science ®Google Scholar
• Liang H, Ward WF. PGC-1α: a key regulator of energy metabolism. Adv Physiol Educ. 2006;30(4):145–151.
   PubMed Web of Science ®Google Scholar
• Yoon JC, Puigserver P, Chen G, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001;413(6852):131–138.
   PubMed Web of Science ®Google Scholar
• Pasandideh M, Mohammadabadi MR, Esmailizadeh AK, Tarang A. Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle. Czech J Anim Sci. 2015;60(3):97–104.
   Web of Science ®Google Scholar
• Weikard R, Kühn C, Goldammer T, Freyer G, Schwerin M. The bovine PPARGC1A gene: molecular characterization and association of an SNP with a variation of milk fat synthesis. Physiol Genomics. 2005;21(1):1–13.
   PubMed Web of Science ®Google Scholar
• Ramayo-Caldas Y, Fortes MRS, Hudson NJ, et al. A marker-derived gene network reveals the regulatory role of PPARGC1A, HNF4G, and FOXP3 in the intramuscular fat deposition of beef cattle. J Anim Sci. 2014;92(7):2832–2845.
   PubMed Web of Science ®Google Scholar
• Hosseini, Seyed Mahdi, Tingzhu, Ye, Pasandideh, Majid, Liang, Aixin, Hua, Guohua, Schreurs, Nicola M, Raza, Sayed Haidar Abbas, (2021). Genetic Association of PPARGC1A gene single nucleotide polymorphism with milk production traits in Italian Mediterranean Buffalo. Biomed Res Int, 2021:3653157.
   PubMed Web of Science ®Google Scholar
• Burgoyne RD, Duncan JS. Secretion of milk proteins. J Mammary Gland Biol Neoplasia. 1998;3(3):275–286.
   PubMed Web of Science ®Google Scholar
• Wang Z, Hou X, Qu B, Wang J, Gao X, Li Q. Pten Regulates Development and Lactation in the Mammary Glands of Dairy Cows. PLoS One. 2014;9(7):e102118.
   PubMed Web of Science ®Google Scholar
• Qiu L, Fan X, Zhang Y, Teng X, Miao Y. Molecular characterization, tissue expression, and polymorphisms of buffalo PPARGC1A gene. Arch Anim Breed. 2020;63(2):249–259.
   PubMed Web of Science ®Google Scholar
• Gouilleux F, Wakao H, Mundt V, Groner B. Prolactin induces phosphorylation of Tyr694 of STAT5 (MGF), a prerequisite for DNA binding and induction of transcription. Embo J. 1994;13(18):4361–4369.
   PubMed Web of Science ®Google Scholar
• Sher T, Yi HF, McBride OW, Gonzalez FJ. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator-activated receptor. Biochemistry. 1993;32(21):5598–5604.
   PubMed Web of Science ®Google Scholar
• Knutti D, Kaul A, Kralli A. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell Biol. 2000;20(7):2411–2422.
   PubMed Web of Science ®Google Scholar
• Zhou F, Ouyang Y, Miao Y. Peroxisome proliferator-activated receptor gamma regulates genes involved in milk fat synthesis in mammary epithelial cells of water buffalo. Anim Sci J. 2021;92(1):e13537.
   PubMed Web of Science ®Google Scholar
• Xu W, Chen Q, Jia Y, et al. Isolation, characterization, and SREBP1 functional analysis of mammary epithelial cells in buffalo. J. Food Biochem. 2019;43:e12997.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Chen C, Hu X, Ahmad MJ, et al. Novel Insight into the Role of Squalene Epoxidase (SQLE) Gene in Determining Milk Production Traits in Buffalo. Int J Mol Sci. 2023;24(3):2436.
   PubMed Web of Science ®Google Scholar
• Tian H, Luo J, Shi H, et al. Role of peroxisome proliferator-activated receptor-α on the synthesis of monounsaturated fatty acids in goat mammary epithelial cells. J Anim Sci. 2020;98(3):skaa062.
   PubMed Web of Science ®Google Scholar
• Summerton JE. Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity. Curr Top Med Chem. 2007;7(7):651–660.
   PubMed Web of Science ®Google Scholar
• Fu XF, Yao K, Du X, et al. PGC-1α regulates the cell cycle through ATP and ROS in CH1 cells. J Zhejiang Univ Sci B. 2016;17(2):136–146.
   PubMed Web of Science ®Google Scholar
• Piccinin E, Morgano A, Peres C, et al. PGC-1α induced browning promotes involution and inhibits lactation in mammary glands. Cell Mol Life Sci. 2019;76(24):5011–5025.
   PubMed Web of Science ®Google Scholar
• Wang M, Moisá S, Khan MJ, Wang J, Bu D, Loor JJ. MicroRNA expression patterns in the bovine mammary gland are affected by the stage of lactation. J Dairy Sci. 2012;95(11):6529–6535.
   PubMed Web of Science ®Google Scholar
• Ivanova E, Le Guillou S, Hue-Beauvais C, Le Provost F. Epigenetics: new insights into mammary gland biology. Genes. 2021;12(2):231.
   PubMed Web of Science ®Google Scholar
• Schorr K, Li M, Krajewski S, Reed JC, Furth PA. Bcl-2 gene family and related proteins in mammary gland involution and breast cancer. J Mammary Gland Biol Neoplasia. 1999;4(2):153–164.
   PubMed Web of Science ®Google Scholar
• Aquilano K, Baldelli S, Pagliei B, Cannata SM, Rotilio G, Ciriolo MR. p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance. Antioxid Redox Signal. 2013;18(4):386–399.
   PubMed Web of Science ®Google Scholar
• Kusano T, Nishino T, Okamoto K, Hille R, Nishino T. The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells. Redox Biol. 2023;59:102573.
   PubMed Web of Science ®Google Scholar
• Huang J, Li J, Ning Y, et al. Enhancement of PPARα-inhibited leucine metabolism-stimulated β-casein synthesis and fatty acid synthesis in primary bovine mammary epithelial cells. J Agric Food Chem. 2023;71(43):16184–16193.
   PubMed Web of Science ®Google Scholar
• Farrell HM, Jimenez-Flores R, Bleck GT, et al. Nomenclature of the Proteins of Cows. J Dairy Sci. 2004;87(6):1641–1674.
   PubMed Web of Science ®Google Scholar
• Schennink A, Bovenhuis H, Léon-Kloosterziel KM, Van Arendonk JA, Visker MH. Effect of polymorphisms in the FASN, OLR1, PPARGC1A, PRL, and STAT5A genes on bovine milk-fat composition. Anim Genet. 2009;40(6):909–916.
   PubMed Web of Science ®Google Scholar
• Sharma A, Shandilya UK, Sodhi M, et al. Milk-derived mammary epithelial cells as a non-invasive source to define stage-specific abundance of milk protein and fat synthesis transcripts in native Sahiwal cows and Murrah buffaloes. 3 Biotech. 2019;9(3):106.
   PubMedGoogle Scholar
• Tian Z, Zhang Y, Zhang H, et al. Transcriptional regulation of milk fat synthesis in dairy cattle. J Funct Foods. 2022;96:105208.
   Web of Science ®Google Scholar
• Hadsell DL, Olea W, Wei J, et al. Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiol Genomics. 2011;43(6):271–285.
   PubMed Web of Science ®Google Scholar
• Liu L, Lin Y, Liu L, et al. Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells. Vitro Cell Dev Biol Animal. 2016;52(10):1044–1059.
   PubMed Web of Science ®Google Scholar
• Li N, Zhao F, Wei C, et al. Function of SREBP1 in the milk fat synthesis of dairy cow mammary epithelial cells. Int J Mol Sci. 2014;15(9):16998–17013.
   PubMed Web of Science ®Google Scholar
• Zhou F, Xue J, Shan X, Qiu L, Miao Y. Functional roles for AGPAT6 in milk fat synthesis of buffalo mammary epithelial cells. Anim Biotechnol. 2023;34(7):2120–2131.
   PubMed Web of Science ®Google Scholar
• Bionaz M, Loor JJ. Gene networks driving bovine milk fat synthesis during the lactation cycle. BMC Genomics. 2008;9(1):366.
   PubMed Web of Science ®Google Scholar