150
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Hepatoprotective Effects of Terminalia chebula Fruit Extract against 2-AAF–Induced Hepatic Damage in Albino Mice: Role of MDR1 and COX-2

, , , &
Pages 402-420 | Received 23 Apr 2013, Published online: 02 May 2014

REFERENCES

  • Achari C, G. V. Reddy, T. C. Reddy, and P. Reddanna. 2011. Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependant modulation of MDR-1. Med. Chem. 7:432–442.
  • Agarwal, S., G. V. Reddy, and P. Reddanna. 2009. Eicosanoids in inflammation and cancer: the role of COX-2. Expert Rev. Clin. Immunol. 5:145–165.
  • Beaucham, C., and I. Fridovich. 1971. Superoxide dismutase: improved assays and an assay applicable to acylamide gels. Anal Biochem. 44:276–287.
  • Borbath I, I. A. Leclercq, J. Abarca-Quinones, C. Desaeger, V. Lebrun, P. Moulin, C. Sempoux, and Y. Horsmans. 2007. Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide. Cancer Sci. 98:1831–1839.
  • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–54.
  • Burt, R. K., and S. S. Thorgeirsson. 1988. Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics. J. Natl. Cancer Inst. 80:1383–1386.
  • Clare, D. A., M. N. Duong, D. Darr, F. Archibald, and I. Fridovich. 1984. Effects of molecular oxygen on detection of superoxide radical with nitroblue tetrazolium and on activity stains for catalase. Anal. Biochem. 140:532–537.
  • Espada, J., P. Valverde, and J. C. Stockert. 1993. Selective fluorescence of eosinophilic structures in grasshopper and mammalian testis stained with haematoxylin–eosin. Histochemistry 99:385–390.
  • Fairchild, C. R., S. P. Ivy, and T. Rushmore. 1987. Carcinogen induced MDR overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc. Natl. Acad. Sci. USA. 84:7701–7705.
  • Fardel, O., L. Payen, A. Courtois, V. Lecureur, and A. Guillouzo. 1998. Induction of multidrug resistance gene expression in rat liver cells in response to acute treatment by the DNA-damaging agent methyl methanesulfonate. Biochem. Biophys. Res. Commun. 245:85–89.
  • Grover, I. S., and S. Bala. Antimutagenic activity of Terminalia chebula (myroblan) in Salmonella typhimurium. Indian J. Exp. Biol. 30:339–341.
  • Guan, J., X. P. Chen, H. Zhu, S. F. Luo, and B. Cao. 2004. Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multi drug resistance induced by HBx in hepatoma cell line. World J. Gastroenterol. 10:3522–3527.
  • Hartwell, J. L. 1982. Plants Used against Cancer. Quarterman Publications, Inc., Lawrence, MA.
  • Hissin, P. J., and H. Russell. 1976. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74: 214–226.
  • Hsu, T. C., M. R. Young, J. Cmarik, and N. H. Colburn. 2000. Activator protein 1 (AP-1)-and nuclear factor kappaB (NFkappaB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28:1338–1348.
  • Huang, W. C., and M. C. Hung. 2009. Induction of Akt activity by chemotherapy confers acquired resistance. J. Formosa Med. Assoc. 108:180–194.
  • Kaur, S., S. Arora, K. Kaur, and S. Kumar. 2002. The in vitro antimutagenic activity of Triphala–An Indian herbal drug. Food Chem. Toxicol. 40:527–534.
  • Koga, H., S. Sakisaka, M. Ohishi, T. Kawaguchi, E. Taniguchi, K. Sasatomi, M. Harada, et al. 1999. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 29:688–696.
  • Koga, H. 2003. Hepatocellular carcinoma: Is there a potential for chemoprevention using cyclooxygenase-2 inhibitors? Cancer 98:661–667.
  • Kuo M. T., Z. Liu, Y. Wei, Y. C. Lin-Lee, S. Tatebe, G. B. Mills, and H. Unate. 2002. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene 13:1945–1954.
  • Lee, S. H., S. Y. Ryu, S. U. Choi, C. O. Lee, Z. S. No, S. K. Kim, and J. W. Ahn. 1995. Hydrolyzable tannins and related compounds having cytotoxic activity from the fruits of Terminalia chebula. Arch. Pharm. Res. 18:118–120.
  • Montoliu, C., S. Valles, J. Renau-Piqueras, and C. Guerri, C. 1994. Ethanol induced oxygen radical formation and lipid peroxidation in rat brain: Effect of chronic alcohol consumption. J Neurochem. 63:1855–62.
  • Naik, G. H., K. I. Priyadarsini, D. B. Naik, R. Gangabhagirathi, and H. Mohan. 2004. Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine 11:530–538.
  • Nishanth, R. P., B. S. Ramakrishna, R. G. Jyotsna, K. R. Roy, G. V. Reddy, P. K. Reddy, and P. Reddanna. 2011. C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line. Eur. J. Pharmacol. 649:74–83.
  • Paglia, D. E., and W. N. Valentine. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70:158–169.
  • Patel, V. A., M. J. Dunn, and A. Sorokin. 2002. Regulation of MDR-1 by cyclooxygenase-2. J. Biol. Chem. 277:38915–38920.
  • Reddy, B. M., N. K. Rao, M. Ramesh, A. V. N. Appa Rao, L. J. Lin, L. Z. Lin, and G. A. Cordell. 1994. Chemical investigation of the fruits of Terminalia chebula. Pharm. Biol. 32:352–356.
  • Reddy, D. B., and P. Reddanna. 2009. Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 27:112–117.
  • Reddy, D. B., T. C. Reddy, G. Jyotsna, S. Sharan, N. Priya, V. Lakshmipathi, and P. Reddanna. 2009. Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line. J. Ethnopharmacol. 124(3):506–512.
  • Reitman, S., and S. Frankel. 1957. Standard methods in clinical chemistry. Am. J. Clin. Chem. 28:56–59.
  • Roy, K. R., K. M. Arunasree, A. Dooth, R. Aparna, G. V. Reddy, S. Vali, and P. Reddanna. 2007. C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and in silico analysis. Arch. Biochem. Biophys. 459:169–177.
  • Roy, K. R., R. P. Nishanth, D. Sreekanth, G. V. Reddy, and P. Reddanna. 2008. C-Phycocyanin ameliorates 2-acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino mice. Hepatol. Res. 5:511–520.
  • Roy, K. R., G. V. Reddy, L. Maitreyi, S. Agarwal, C. Achari, S. Vali, and P. Reddanna. 2010. Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line. Cancer Chemother. Pharmacol. 65:903–911.
  • Saleem, A., M. Husheem, P. Harkonen, and K. Pihlaja. 2002. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. J. Ethnopharmacol. 81:327–336.
  • Sherawat, A., and S. Sultana. 2006. Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats. Life Sci. 79:1456–1465.
  • Shuchita, D., S. D. Kamat, and D. V. Kamat. 2010. Effect of aqueous extract of terminalia chebula on metallobetalactamase. Int. J. Pharm. Pharm. Sci. 2:172–175.
  • Sohni, Y. R., and R. M. Bhatt. 1996. Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. J. Ethnopharmacol. 54:119–124.
  • Tiwawech, D., R. Hasegawa, Y. Kurata, M. Tatematsu, M. A. Shibata, W. Thamavit, and N. Ito. 1991. Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats. Carcinogenesis 12:985–990.
  • Wartenberg, M., F. C. Ling, M. Schallenberg, A. T. Baumer, K. Petrat, J. Hescheler, and H. Sauer. 2001. Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J. Biol. Chem. 276: 17420–17428.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.