145
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Acute and 28-Day Repeated Dose Oral Toxicity of Bauhinia variegata (Caesalpiniaceae) Stem Bark Extract

, &
Pages 161-172 | Received 01 Feb 2014, Published online: 20 Aug 2014

REFERENCES

  • Ali, M. S., L Azhar, and Z. Amtul. 1999. Antimicrobial screening of Caesalpiniaceae. Fitoterapia. 70:299–
  • Balamurugan, G., and P. Muralidharan. 2010. Antiobesity effect of Bauhinia variegata bark extract on female rats fed on hypercaloric diet. Bangladesh J Pharmacol. 5:8–12.
  • Bodakhe, S. H., and R. Alpana. 2007. Hepatoprotective properties of Bauhinia variegata bark extract. Yakugaku Zasshi. 127:1503–1507.
  • Bodakhe, S. H., A. Ram, K. S. Bodakhe, and D. P. Pandey. 2010. New polyphenolic aromatic glycoside from Bauhinia variegata L. stem bark. Asian. J. Chem. 22:3549–3553.
  • Burger, C., D. R. Fischer, D. A. Cordenunzzi, A. P. Batschauer, V. CechinelFilho, and A. R. Soares. 2005. Acute and subacute toxicity of the hydroalcoholic extract from Wedelia paludosa (Acmelabrasiliensis) (Asteraceae) in mice. J. Pharm. Pharmaceut. Sci. 8:370–373.
  • Cajuday, A. L. and L. G. Poscidio. 2010. Effects of Moringa oleifera Lam. (Moringaceae) on the reproduction of male mice (Mus musculus). J. Med. Plants. Res. 4:1115–1121.
  • Council for Scientific and Industrial Research (CSIR). 1998. The Wealth of India, Vol 2B, Publication and Information Directorate. Council for Scientific and Industrial Research, New Delhi, India. 56–57.
  • Evan, G. O. 2008. Animal Hematotoxicology: A Practical Guide for Toxicologists and Biomedical Researchers. CRC Press, Boca Raton, FL. 9–18.
  • Ghaisas, M. M., S. A. Shaikh, and A. D. Deshpande. 2009. Evaluation of immunomodulatory activity of ethanolic extract of the stem bark of Bauhinia variegata Linn. Int. J. Green Pharm. 3(1):70–74.
  • Hassan, S. W., M. J. Ladan, R. A. Dogondaji, R. A. Umar, L. S. Bilbis, L. G. Hassan, A. A. Ebbo, and I. K. Matazu. 2007. Phytochemical and toxicological studies of aqueous leaves extracts of Erythrophleum africanum. Pak. J. Biol. Sci. 10:3815–3821.
  • Hilaly, J. E., Z. H. Israili, and B. Lyouss. 2004. Acute and chronic toxicological studies of Ajuva iva in experimental animals. J. Ethnopharmacol. 91:43–50.
  • Kaplan, A., R. Jack, K. E. Opheim, B. Toivola, and A. W. Lyon, 1995. Clinical Chemistry Interpretation and Techniques. Williams & Wilkins, Webster, NY. 155–333.
  • Koti, B. C., S. M. Biradar, R. V. Karadi, A. D. Taranalli, and V. S. Benade. 2009. Effect of Bauhinia variegata bark extract on blood glucose level in normal and alloxanised diabetic rats. J. Nat. Remedies. 9(1):27–34.
  • Kulkarni, Y. A., and V. Addepalli. 2010. Toxicological studies on aqueous extract of Gmelina arborea in rodents. Pharm. Biol. 48:1413–1420.
  • Kulkarni, Y. A., and V. Addepalli. 2012. Toxicological evaluation of methanol extract of Gmelina arborea Roxb. bark in mice and rats. Toxicol. Int. 19(2):125–131.
  • Mail, R. G., and A. S. Dhake. 2011. Evaluation of effects of Bauhinia variegata stem bark extract against milk-induced eosinophilia in mice. J. Adv. Pharm. Technol. Res. 2:132–134.
  • Mali, R. G., and A. S. Dhake. 2011. Mast cell stabilizing activity of Bauhinia variegata. J. Herbs Spices Med. Plants. 17(3):268–274.
  • Mukinda, J. T., and J. A. Syce. 2007. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. J. Ethnopharmacol. 112:138–144.
  • Nadkarni, K. M. 2000. Indian Materia Medica. Popular Prakashan, Bombay, India. 184–185.
  • OECD. 2001. The OECD Guidelines for Testing of Chemicals, 407. Repeated Dose Toxicity Test. Organization of Economic Co-operation Development, Paris.
  • OECD. 2001. The OECD Guidelines for Testing of Chemicals, 423. Acute Oral Toxicity Test. Organization of Economic Co-operation Development, Paris.
  • Olson, H., G. Betton, D. Robinson, K. Thomas, A. Monro, G. Kolaja, P. Lilly, et al. 2000. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32:56–67.
  • Pandey, S., and R. C. Agrawal. 2009. Effect of Bauhinia variegata bark extract on DMBA-induced mouse skin carcinogenesis: A preliminary study. Global J. Pharmacol. 3(3):158–162
  • Parasuraman, S. 2011. Toxicological screening. J. Pharmacol. Pharmacother. 2:74–79.
  • Parekh, J., N. Karathia, and S. Chanda. 2006. Evaluation of antibacterial activity and phytochemical analysis of Bauhinia variegata L. bark. Afr. J. Biomed. Res. 9(1):53–56.
  • Rajani, G. P., and P. Ashok. 2009. In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn. Indian J. Pharmacol. 41(5):227–232.
  • Rajkapoor, B., B. Jayakar, R. C. Anandan, and S. Kavimani. 2003. Anti-ulcer effect of Bauhinia variegata Linn. in rats. J. Nat. Remedies. 3:215–217.
  • Rajkapoor, B., B. Jayakar, and N. Murugesh. 2003. Antitumour activity of Bauhinia variegata on Dalton’s ascetic lymphoma. J. Ethnopharmacol. 89:107–109.
  • Rasekh, H. R., P. Nazari, M. Kamli-Nejad, and L. Hosseinzadeh. 2008. Acute and subchronicoral toxicity of Galega officinalis in rats. J. Ethnopharmacol. 116:21–26.
  • Rebecca, M. A., E. L. Ishii-Iwamoto, R. Grespan, R. K. Cuman, S. M. Caparroz-Assef, J. C. Mello, and C. A. Bersani-Amado. 2002. Toxicological studies on Stryphnodendron adstringens. J. Ethnopharmacol. 83:101–104.
  • Rhiouani, H., J. Elhilaly, Z. Israili, and B. Lyoussi. 2008. Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J. Ethnopharmacol. 118:378–386.
  • Teo, S., D. Stirling, S. Thomas, A. Hoberman, A. Kiorpes, and V. Khetani. 2002. A 90–day oral gavage toxicity study of d-methylphenidate and d,l-methylphenidatein Sprague-Dawley rats. Toxicology. 179:183–196.
  • Witthawaskul, P., A. Panthong, D. Kanjanapothi, T. Taesothikul, and N. Lertprasertsuke. 2003. Acute and subacute toxicities of the saponin mixture isolated from Scheffleraleucantha viguier. J. Ethnopharmacol. 89:115–121.
  • Yadava, R. N., and V. M. S. Reddy. 2003. Anti-Inflammatory activity of a novel flavonol glycoside from the Bauhinia variegata Linn. Nat. Prod. Res. 17:165–169.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.