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Journal of Herbs, Spices & Medicinal Plants Volume 21, 2015 - Issue 2
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Original Articles

The Effects of Combretum zeyheri Leaf Extract on Ergosterol Synthesis in Candida albicans

Tichaona MutasaSchool of Pharmacy, College of Health Sciences, University of Zimbabwe, Mt. Pleasant, Harare, ZimbabweView further author information
,
Rumbidzai MangoyiDepartment of Biochemistry, University of Zimbabwe, Mt. Pleasant, Harare, ZimbabweView further author information
&
Stanley MukanganyamaDepartment of Biochemistry, University of Zimbabwe, Mt. Pleasant, Harare, ZimbabweCorrespondence[email protected]
View further author information
Pages 211-217 | Received 18 Mar 2014, Published online: 20 Aug 2014

REFERENCES

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  • Mangoyi, R., W. Mafukidze, K. Marobela, and S. Mukanganyama. 2012. Antifungal activities and preliminary phytochemical investigation of Combretum species from Zimbabwe. J. Microb. Biochem. Tech. 4:037–044.
  • Navarro-Martinez, D. M., G. F. Cánovas, and J. N. R. Guez-López. 2006. Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans. JAC. 57:1083–1092.
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  • Rajput, S. B., and S. M. Karuppayil. 2013. Small molecules inhibit growth, viability and ergosterol biosynthesis in Candida albicans. SpringerPlus. 2:26.
  • Rates, S. M. K. 2001. Plants as source of drugs. Toxicon. 39:603–613.
  • Sanglard, D., F. Ischer, T. Parkinson, D. Falconer, and J. Bille. 2003. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob. Agents Chemother. 47:2404–2412.
  • Subha T. S., and A. Gnanamani. 2008. Effect of active fraction of methanolic extract of Acorus calamus on sterol metabolism of Candida albicans. J. Appl. Biosci. 8:243–250.

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