Exploring the Antidiabetic Mechanism of Brachylaena Ilicifolia Using Target Directed in Vitro Screening

References

• Akinrinde, A. S.; Koekemoer, T.; Van der Venter, M.; Bradley, G. In Vitro Investigation of Potential Anti-diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker, Acta. Pharm. 2018, 68, 389–407. DOI: https://doi.org/10.2478/acph-2018-0023.
   Google Scholar
• International Diabetes Federation (IDF). Diabetes Atlas, 9th edn; International Diabetes Federation: Brussels, Belgium, 2019. assessed date February/18/2021 www.idf.org/diabetesatlas
   Google Scholar
• Khan, A. K.; Najmi, M.; Akhtar, M.; Aqil, M.; Mujeeb, M.; Pillai, K. K. A Pharmacological Appraisal of Medicinal Plants with Antidiabetic Potential. J. Pharm. Bioallied Sci. 2012, 4(1), 27–42. DOI: https://doi.org/10.4103/0975-7406.92727.
   PubMedGoogle Scholar
• He, C. N.; Wang, C. L.; Guo, S. X. Study on Chemical Constituents in Herbs of Anoectochilus Roxburghii II, China. J. Chin. Mat. Med. 2005, 30, 761–776.
   Google Scholar
• Jung, M.; Park, M.; Lee, H. C.; Kang, Y.; Kang, E. S.; Kim, S. K. Antidiabetic Agents from Medicinal Plants. Curr. Med. Chem. 2006, 13(10), 1203–1218. https://doi.org/10.2174/092986706776360860
   PubMed Web of Science ®Google Scholar
• Abesundara, K. J. M.; Mastui, T.; Matsumoto, K. α-Glucosidase Inhibitory Activity of Some Sri Lanka Plant Extracts, One of Which, Cassia Auriculata, Exerts a Strong Antihyperglycemic Effect in Rats Comparable to the Therapeutic Drug Acarbose. J. Agri. Food Chem. 2004, 52(9), 2541–2545. DOI: https://doi.org/10.1021/jf035330s.
   PubMed Web of Science ®Google Scholar
• Malviya, N.;.; Jain, S; Malviya, S. Antidiabetic Potential of Medicinal Plants. Acta Pol. Pharm. Drug Res. 2010, 67, 113–118.
   PubMed Web of Science ®Google Scholar
• Odeyemi, S. A Comparative Study of the in Vitro Antidiabetic Properties, Mechanism of Action and Cytotoxicity of Albuca Setosa and Albuca Bracteata Bulb Extracts. Dep. Biochem. Microbiol. Univ. Fort Hare. PhD Thesis. 2015.
   Google Scholar
• Jayaprasad, B.; Sharavanan, P. S.; Rivaraj, R. Antidiabetic Effect of Chloroxylon Swietenia Bark Extracts on Streptozotocin Induced Diabetic Rats. J. Basic Appl. Sci. 2016, 5, 61–69.
   Google Scholar
• Mukesh, D.; Prabhakar, P. Mechanism of Action of Medicinal Plants Towards Diabetes Mellitus - A Review. Phyto. Theura. Val. 2008, 22, 182–204.
   Google Scholar
• Sujatha, S.; Jamimo, J. S. Complimentary Therapeutic Potential: a Focus on Polyherbal Products for Hyperglycaemia. Asia J. Sci. Res. 2012, 5(1), 1–13.
   Google Scholar
• Coates, P.;. Trees of Southern Africa. Struik; Cape Town: South Africa, 1984.
   Google Scholar
• Sagbo, I. J. Phytochemical Analysis and Antibacterial Properties of Aqueous and Ethanolic Extracts of Brachylaena Elliptica and Brachylaena Ilicifolia. MSc Disser. Univ. Fort Hare. 2015.
   Google Scholar
• Sagbo, I. J.; Afolayan, A. J.; Bradley, G. Antioxidant, Antibacterial and Phytochemical Properties of Two Medicinal Plants against the Wound Infecting Bacteria. Asian Pacific J. Trop. Biomed. 2017, 7(9), 817–825. DOI: https://doi.org/10.1016/j.apjtb.2017.08.009.
   Web of Science ®Google Scholar
• Mosmann, T. Rapid Colorimetric Assay for Cellular Growth and Survival: application to Proliferation and Cytotoxicity Assays. J. Immunol. Meth. 1984, 65(1–2), 55–63. DOI: https://doi.org/10.1016/0022-1759(83)90303-4.
   Web of Science ®Google Scholar
• Akinrinde, A.; Koekemoer, T.; Van der Venter, M.; Bradley, G. Anti-Proliferative Activities of the Aqueous Root Extract of Dianthus Thunbergii Ss Hooper (Caryophyllacea). Afr. J. Tradit. Complement Altern. Med. 2018, 15(4), 32–44. https://doi.org/https://doi.org/10.21010/ajtcam.v15i4.5.
   Google Scholar
• Sagbo, I. J.; Van De Venter, M.; Koekemoer, T.; Bradley, G. In Vitro Antidiabetic Activity and Mechanism of Action of Brachylaena Elliptica (Thunb.) DC. Evid-Based Complement. Altern. Med. 2018, 4170372, 13. https://doi.org/https://doi.org/10.1155/2018/4170372
   Google Scholar
• Odeyemi, S.; Dewar, J. In Vitro Antidiabetic Activity Affecting Glucose Uptake in HepG2 Cells following Their Exposure to Extracts of Lauridia Tetragona (L.f.) R.H. Archer. Pro. 2020, 8, 33. DOI: https://doi.org/10.3390/pr8010033.
   Google Scholar
• Kazeem, M. I.; Adamson, J. O.; Ogunwande, I. A. Modes of Inhibition of α-Amylase and α-Glucosidase by Aqueous Extract of Morinda Lucida Benth Leaf. BioMed Res. Inter. 2013, 527570, 6 pages, https://doi.org/https://doi.org/10.1155/2013/527570
   Google Scholar
• Unuofin, J. O.; Otunola, G. A.; Afolayan, A. J. Inhibition of Key Enzymes Linked to Obesity and Cytotoxic Activities of Whole Plant Extracts of Vernonia Mespilifolia Less. Pro. 2019, 7, 841.
   Google Scholar
• Al-Masri, M.; Mohammad, M. K.; Tahaa, M. O. Inhibition of Dipeptidyl Peptidase IV (DPP IV) Is One of the Mechanisms Explaining the Hypoglycemic Effect of Berberine. J. Enzyme Inhib. Med. Chem. 2009, 24(5), 1061–1066. DOI: https://doi.org/10.1080/14756360802610761.
   PubMed Web of Science ®Google Scholar
• Majak, W. Review of Toxic Glycosides in Rangeland and Pasture Forages. J. Range Manag. 2001, 54(4), 494–498. DOI: https://doi.org/10.2307/4003121.
   Google Scholar
• Orech, F. O.; Akenga, T.; Ochora, J.; Friis, H. J.; Aagaard-Hansen, J. Potential Toxicity of Some Traditional Leafy Vegetables Consumed in Nyang’oma Division, Western Kenya. African J. Food Nutr. Sci. 2005, 1, 1–13.
   Google Scholar
• Gahr, S.; Merger, M.; Bollheimer, L. C.; Hammerschmied, C. G.; Sch¨olmerich, J.; H¨ugl, S. R. Hepatocyte Growth Factor Stimulates Proliferation of Pancreatic -cells Particularly in the Presence of Subphysiological Glucose Concentrations. Mol. Endocrinol. 2002, 28(2), 99–110. DOI: https://doi.org/10.1677/jme.0.0280099.
   Google Scholar
• Van de Venter, M.; Roux, S.; Bungu, L. C.; Louw, J.; Crouch, N. R.; Grace, O. M.; Maharaj, V.; Pillay, P.; Sewnarian, P.; Bhagwandin, N., et al. Antidiabetic Screening and Scoring of 11 Plants Traditionally Used in South Africa. J. Ethnopharmacol. 2008, 119(1), 81–86.
   PubMed Web of Science ®Google Scholar
• Anila, L.; Vijayalakshmi, N.; Tian, C. Beneficial Effect of Flavonoids from Sesamum Indicum, Emblica Officinalis and Momordica Charantia. Phytother. Res. 2002, 14, 592–595.
   Web of Science ®Google Scholar
• Gupta, R. N.; Pareek, A.; Suthar, M. G. S.; Rathore, G. S.; Basniwal, P. K. D.; Jain, D. Study of Glucose Uptake Activity of Helicteres Isora Linn. Fruits in L6 Cell Lines. Int. J. Diab. Dev. Ctries. 2010, 29, 170–173.
   Web of Science ®Google Scholar
• Dachani, S. R.; Avanapu, S. R.; Ananth, P. H. In Vitro Antioxidant and Glucose Uptake Effect of Trichodesma Indicum in L 6 Cell Lines. J. Pharm. Bio. Sci. 2012, 3, 810–819.
   Google Scholar
• Erion, D. M.; Park, H. J.; Lee, H. Y. The Role of Lipids in the Pathogenesis and Treatment of Type 2 Diabetes and Associated Co-morbidities. BMB Rep. 2016, 49(3), 139–148. DOI: https://doi.org/10.5483/BMBRep.2016.49.3.268.
   PubMed Web of Science ®Google Scholar
• Manaharan, T.; Appleton, D.; Cheng, H. M.; Palanisamy, U. Flavonoids Isolated from Syzygium Aqueum Leaf Extract as Potential Antihyperglycemic Agents. Food Chem. 2012, 132(4), 1802–1807. DOI: https://doi.org/10.1016/j.foodchem.2011.11.147.
   Web of Science ®Google Scholar
• Deutschländer, M. S.; van de Venter, M.; Roux, S.; Louw, J.; Lall, N. Hypoglycaemic Activity of Four Plant Extracts Traditionally Used in South Africa for Diabetes. J Ethnopharmacol. 2009, 124(3), 619–624. DOI: https://doi.org/10.1016/j.jep.2009.04.052.
   PubMed Web of Science ®Google Scholar
• Bischoff, H. Pharmacology of Alpha-glucosidase Inhibition. Eur. J. Clin. 1994, 24, 3–10.
   Google Scholar
• Kwon, Y. I.; Vattem, D. V.; Shetty, K. Evaluation of Clonal Herbs of Lamiaceae Species for Management of Diabetes and Hypertension. Asia Pac. J. Clin. Nutr. 2006, 15(1), 107–118.
   PubMed Web of Science ®Google Scholar
• Shanak, S.; Saad, B.; Zaid, H. Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants. Evid-Based Complement. Altern. Med. 2018, 3583067, 18. https://doi.org/https://doi.org/10.1155/2019/3583067
   Google Scholar
• McIntosh, C. H. S.; Demuth, H. U.; Pospisilik, J. A.; Pederson, R. Dipeptidyl peptidase-IV Inhibitors: how Do They Work as New Anti-Diabetic Agents? Regul Pept. 2005, 128(2), 159–165. DOI: https://doi.org/10.1016/j.regpep.2004.06.001.
   PubMedGoogle Scholar