Expression of serglycin in human disc is increased in degenerated discs and up-regulated in vitro by exposure to IL-1ß or TNF-α

References

• Gruber HE, Fisher EC Jr, Desai B, Stasky AA, Hoelscher G, Hanley EN (1997) Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-b1. Exp. Cell. Res. 235: 13–21.
   PubMed Web of Science ®Google Scholar
• Gruber HE, Johnson T, Norton HJ, Hanley EN Jr (2002a) The sand rat model for disc degeneration: radiologic characterization of age-related changes. Cross-sectional and prospective analyses. Spine 27: 230–234.
   PubMed Web of Science ®Google Scholar
• Gruber HE, Johnson TL, Leslie K, Ingram JA, Martin D, Hoelscher G, Banks D, Phieffer L, Coldham G, Hanley EN Jr (2002b) Autologous intervertebral disc cell implantation: a model using Psammomys obesus, the sand rat. Spine 27: 1626–1633.
   PubMed Web of Science ®Google Scholar
• Gruber HE, Hoelscher GL, Leslie K, Ingram JA, Hanley EN Jr (2006) Three-dimensional culture of human disc cells within agarose or a collagen sponge: assessment of proteoglycan production. Biomaterials 27: 371–376.
   PubMed Web of Science ®Google Scholar
• Gruber HE, Ingram J, Hoelscher GL, Norton HJ, Hanley EN Jr (2007) Cell polarity in the annulus of the human intervertebral disc. Morphologic, immunocytochemical, and molecular evidence. Spine 32: 1287–1294.
   PubMed Web of Science ®Google Scholar
• Gruber HE, Hoelscher GL, Ingram JA, Morton DS, Hanley EN Jr (2013) Human annulus cells regulate PAPP-A and IGFBP-4 expression, and thereby insulin-like growth factor bioavailability, in response to proinflammatory cytokine exposure in vitro. Connec. Tissue Res. 54: 432–438.
   PubMed Web of Science ®Google Scholar
• Bachmeier BE, Nerlich A, Mittermaier N, Weiler C, Lumenta C, Wuertz K, Boos N (2009) Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration. Eur. Spine J. 18: 1573–1586.
   PubMed Web of Science ®Google Scholar
• Hoshi H, Shimawaki K, Takegawa Y, Phyanagi T, Amano M, Hinou H, Nishimura S-I (2012) Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes. Biochim. Biophys. Acta 1820: 1391–1398.
   PubMed Web of Science ®Google Scholar
• Hoyland JA, Le Maitre C, Freemont AJ (2008) Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology 47: 809–814.
   PubMed Web of Science ®Google Scholar
• Imoto-Tsubakimoto H, Takahashi T, Ueyama T, Ogata T, Adachi A, Nakanishi N, Mitushima K, Naito Y, Matsubara H (2013) Serglycin is a novel adipocytokine highly expressed in epicardial adipose tissue. Biochim. Biophys. Acta 432: 105–110.
   Google Scholar
• Kolset SO, Tveit H (2008) Serglycin−structure and biology. Cell. Molec. Life Sci. 65: 1073–1085.
   PubMed Web of Science ®Google Scholar
• Korpetinou A, Skandalis SS, Labropoulou VT, Smirlaki G, Noulas A, Karamanos NK, Theocharis AD (2014) Serglycin: at the crossroad of inflammation and malignancy. Front. Oncol. 3. article 327.
   PubMedGoogle Scholar
• LeMaitre CL, Hoyland JA, Freemont AJ (2007) Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1ß and TNFa expression profile. Arthr. Res. Ther. 9/4: R77.
   Web of Science ®Google Scholar
• Lemire JM, Chan CK, Bressler S, Miller J, LeBaron RG, Wight TN (2007) Interleukin-1beta selectively decreases the synthesis of versican by arterial smooth muscle cells. J. Cell. Biochem. 101: 753–766.
   PubMed Web of Science ®Google Scholar
• Li X, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo DQL, Bao Y, Zheng FJ, Chia CS, Iyer NG, Kang TB, Zeng YX, Soo KC, Trent JM, Teh BT, Qian CN (2011) Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res. 71: 3162–3172.
   PubMed Web of Science ®Google Scholar
• Lundequist A, Abrink M, Pejler G (2006) Mast cell-dependent activation of pro-matrix metalloprotease 2: a role for serglycin proteoglycan-dependent mast cell proteases. Biol. Chem. 387: 1513–1519.
   PubMed Web of Science ®Google Scholar
• Mall N, Berg E, Theocharis AD, Svineng G, Uhlin-Hansen L, Winberg J-O (2013) In vitro reconstruction of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican. FEBS J. 280: 2870–2887.
   PubMed Web of Science ®Google Scholar
• Meen AL, Oynebraten I, Reine TM, Duelli A, Svennevig K, Pejler G, Jenssen T, Kolset SO (2011) Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROa/CXCL1. J. Biol. Chem. 286: 2636–2647.
   PubMed Web of Science ®Google Scholar
• Melo FR, Grujic M, Spirkoski J, Calounova G, Pejler (2012) Serglycin proteoglycan promotes apoptotic versus necrotic cell death in mast cell. J. Biol. Chem. 287: 18142–18152.
   PubMed Web of Science ®Google Scholar
• Merline R, Schaefer RM, Schaefer L (2009) The matricellular function of small leucine-rich proteoglycans (SLRPs). J. Cell. Commun. 3: 323–335.
   PubMed Web of Science ®Google Scholar
• Omtvedt LA, Kolset SO, Thoen J, Forre Y, Gill M (2001) Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases. Scand. J. Rheumatol. 30: 164–166.
   PubMed Web of Science ®Google Scholar
• Rein TM, Vuong TT, Rutkovskly A, Meen AJ, Vaage J, Jenssen TG, Kolset SO (2015) Serglycin in quiescent and proliferating primary endothelial cells. PLoS ONE 10(12): e0145584.
   PubMed Web of Science ®Google Scholar
• Reine TM, Vuong TT, Jenssen TG, Kolset SO (2014) Serglycin secretion is part of the inflammatory response in activated primary human endothelial cells in vitro. Biochim. Biophys. Acta 1840: 2498–2505.
   PubMed Web of Science ®Google Scholar
• Schick BP, Ho H-CK, Brodbeck KC, Wrigle CW, Klimas J (2003) Serglycin proteoglycan expression and synthesis in embryonic stem cells. Biochim. Biophys. Acta 1593: 259–267.
   PubMed Web of Science ®Google Scholar
• Scully OJ, Chua P-J, Harve KS, Bay B-H, Yip GW (2012) Serglycin in health and diseases. Anat. Rec. 295: 1415–1420.
   Google Scholar
• Skliris A, Labropoulou VT, Papachristou DJ, Aletras A, Karamanos NK, Theocharis AD (2013) Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases. Febs J. 280: 2342–2352.
   PubMed Web of Science ®Google Scholar
• Thompson JP, Pearce RH, Schechter MT, Adams M, Tsang IKY, Bishop PB (1990) Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 15: 411–415.
   PubMed Web of Science ®Google Scholar
• Zhang L, Yang M, Yan D, Cavey G, Davidson P, Gibson G (2010) Molecular interactions of MMP-13 C-terminal domain with chondrocyte proteins. Connec. Tissue Res. 51: 230–239.
   PubMed Web of Science ®Google Scholar