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Articles

Comparison of myotoxic effects of levobupivacaine, bupivacaine and ropivacaine: apoptotic activity and acute effect on pro-inflammatory cytokines

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References

  • Amaniti E, Drampa F, Kouzi-Koliakos K, Kapoukranidou D, Pourzitaki C, Tsalie E, Vasilakos D. 2006. Ropivacaine myotoxicity after single intramuscular injection in rats. Eur J Anesth. 23:130–135. doi: 10.1017/S0265021505002036.
  • Bahadır A, Ceyhan A, Oz Gergin O, Yalçın B, Ülger M, Özyazgan TM, Yay A. 2018. Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: an experimental rat model. Anatol J Cardiol. 19:213–221.
  • Borazan M, Karalezli A, Oto S. 2009. Induction of apoptosis of rabbit corneal endothelial cells by preservative-free lidocaine hydrochloride 2%, ropivacaine 1%, or levobupivacaine 0.75%. J Cataract Refract Surg. 35:753–758. doi: 10.1016/j.jcrs.2008.12.016.
  • Boselli E, Duflo F, Debon R, Allaouchiche B, Chassard D, Thomas L, Portoukalian J. 2003. The induction of apoptosis by local anesthetics: a comparison between lidocaine and ropivacaine. Anesth Analg. 96:755–756. doi: 10.1213/01.ANE.0000047201.85815.9D.
  • Casati A, Putzu M. 2005. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different? Best Pract Res Clin Anaesthesiol. 15:247–268. doi: 10.1016/j.bpa.2004.12.003.
  • Cohen JJ. 1993. Apoptosis: the physiological pathway of cell death. Hosp Pract. 28:35–43. doi: 10.1080/21548331.1993.11442887.
  • Dinarello CA. 1998. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol. 16:457–499. doi: 10.3109/08830189809043005.
  • Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. 2009. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci USA. 106:7125–7130. doi: 10.1073/pnas.0900598106.
  • Foster AH, Carlson BM. 1980. Myotoxicity of local anesthetics and regeneration of the damaged muscle fibers. Anesth Analg. 59:727–773.
  • Grishko V, Xu M, Wilson G, Pearsall AW. 2010. Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, andropivacaine. J Bone Joint Surg Am 92:609–618. doi: 10.2106/JBJS.J.00272.
  • Gungor I, Yilmaz A, Ozturk AM, Ergun MA, Menevse S, Kaya K. 2014. Bupivacaine and levobupivacaine induce apoptosis in rat chondrocyte cell cultures at ultra-low doses. Eur J Orthop Surg Traumatol. 24:291–295. doi: 10.1007/s00590-013-1202-5.
  • Hall-Craggs EC. 1980. Early ultrastructural changes in skeletal muscle exposed to the local anesthetic bupivacaine (Marcaine). Br J Exp Pathol. 61:139–149.
  • Hasturk A, Atalay B, Calisaneller T, Ozdemir O, Oruckaptan H, Altinors N. 2009. Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia/reperfusion injury and correlation with tissue damage. Turk Neurosurg. 19:353–359.
  • Hogan Q, Dotson R, Erickson S, Kettler R, Hogan K. 1994. Local anesthetic myotoxicity: a case and review. Anesthesiology. 80:942–947. doi: 10.1097/00000542-199404000-00029.
  • Horiguchi T, Shibata MA, Ito Y, Eid NA, Abe M, Otsuki Y. 2002. Macrophage apoptosis in rat skeletal muscle treated with bupivacaine hydrochloride: possible role of MCP-1. Muscle Nerve. 26:79–86. doi: 10.1002/mus.10168.
  • Kim M, Lee YS, Mathews HL, Wurster RD. 1997. Induction of apoptotic cell death in a neuroblastoma cell line by dibucaine. Exp Cell Res. 231:235–241. doi: 10.1006/excr.1997.3480.
  • Komai H, Lokuta AJ. 1999. Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles. Anesthesiology. 90:835–843. doi: 10.1097/00000542-199903000-00027.
  • Lee HT, Xu H, Siegel CD, Krichevsky IE. 2003. Local anesthetics induce human renal cell apoptosis. Am J Nephrol. 23:129–139. doi: 10.1159/000069304.
  • Lee WY, Park CJ, Shin TJ, Yum KW, Yoon TG, Seo KS, Kim HJ. 2009. Only tetracaine and not other local anesthetics induce apoptosis in rat cortical astrocytes. Br J Anaesth. 103:719–725. doi: 10.1093/bja/aep237.
  • Leone S, Di Cianni S, Casati A, Fanelli G. 2008. Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed. 79:92–105.
  • Loddick SA, Rothwell NJ. 1996. Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab. 16:932–940. doi: 10.1097/00004647-199609000-00017.
  • Natori S, Selzner M, Valentino KL, Fritz LC, Srinivasan A, Clavien PA, Gores GJ. 1999. Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism. Transplantation. 68:89–96.
  • Nouette-Gaulain K, Sirvent P, Canal-Raffin M, Morau D, Malgat M, Molimard M, Mercier J, Lacampagne A, Sztark F, Capdevila X. 2007. Effects of intermittent femoral nerve injections of bupivacaine, levobupivacaine and ropivacaine on mitochondrial energy metabolism and intracellular calcium homeostasis in rat psoas muscle. Anesthesiology. 106:1026–1034.
  • Okland S, Komorowski TE, Carlson BM. 1989. Ultrastructure of mepivacaine-induced damage and regeneration in rat extraocular muscle. Invest Ophthalmol Vis Sci. 30:1643–1651.
  • Oz GO, Yıldız K, Bayram A, Sencar L, Coşkun G, Yay A, Biçer C, Ozdamar S, Polat S. 2015. Comparison of the myotoxic effects of levobupivacaine, bupivacaine, and ropivacaine: an electron microscopic study. Ultrastruct Pathol. 39:169–176. doi: 10.3109/01913123.2015.1014610.
  • Park CJ, Park SA, Yoon TG, Lee SJ, Yum KW, Kim HJ. 2005. Bupivacaine induces apoptosis via ROS in the Schwann cell line. J Dent Res. 84:852–857. doi: 10.1177/154405910508400914.
  • Pizzolato P, Renegar OJ. 1959. Histopathologic effects of long exposure to local anesthetics on peripheral nerves. Anesth Analg. 38:138–141. doi: 10.1213/00000539-195903000-00011.
  • Politi PK, Havaki S, Manta P, Lyritis G. 2006. Bupivacaine-induced regeneration of rat soleus muscle: ultrastructural and immunohistochemical aspects. Ultrastruct Pathol. 30:461–469. doi: 10.1080/01913120600854434.
  • Schling P, Rudolph C, Heimerl S, Fruth S, Schmitz G. 2006. Expression of tumor necrosis factor alpha and its receptors during cellular differentiation. Cytokine. 33:239–245. doi: 10.1016/j.cyto.2006.02.007.
  • Unami A, Shinohara Y, Ichikawa T, Baba Y. 2003. Biochemical and microarray analyses of bupivacaine-induced apoptosis. J Toxicol Sci. 28:77–94. doi: 10.2131/jts.28.77.
  • Yay A, Goktepe O, Bahadir A, Ozdamar S, Oktem IS, Coruh A, Baran M 2018. Assessment of markers expressed in human hair follicles according to different skin regions. Adv Clin Exp Med. 27(7). doi: 10.17219/acem/74429.
  • Yildiz K, Efesoy SN, Ozdamar S, Yay A, Bicer C, Aksu R, Kilic E. 2011. Myotoxic effects of levobupivacaine, bupivacaine and ropivacaine in a rat model. Clin Invest Med. 34:E273. doi: 10.25011/cim.v34i5.15670.
  • Zink W, Bohl JR, Hacke N, Sinner B, Martin E, Graf BM. 2005. The long term myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blocks. Anesth Analg. 101:548–554. doi: 10.1213/01.ANE.0000155956.59842.0A.
  • Zink W, Graf BM. 2004. Local anesthetic myotoxicity. Reg Anesth Pain Med. 29:333–340. doi: 10.1097/00115550-200407000-00007.
  • Zink W, Graf BM, Sinner B, Martin E, Fink RH, Kunst G. 2002a. Differential effects of bupivacaine on intracellular Ca2+ regulation: potential mechanisms of its myotoxicity. Anesthesiology. 97:710–716. doi: 10.1097/00000542-200209000-00026.
  • Zink W, Seif C, Bohl JR, Hacke N, Braun PM, Sinner B, Martin E, Fink RH, Graf BM. 2003. The acute myotoxic effects of bupivacaine and ropivacaine after continuous peripheral nerve blockades. Anesth Analg. 97:1173–1179.
  • Zink W, Seif C, Bohl JR, Martin E, Graf BM. 2002b. Bupivacaine, but not ropivacaine induces apoptosis in mammalian skeletal muscle fibers. Anesthesiology. 96:A971. doi: 10.1097/00000542-200209002-00971.

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