189
Views
9
CrossRef citations to date
0
Altmetric
Articles

The hydroalcoholic extract of Zingiber officinale diminishes diazinon-induced hepatotoxicity by suppressing oxidative stress and apoptosis in rats

, , & ORCID Icon

References

  • Abdel-Azeem AS, Hegazy AM, Ibrahim KS, Farrag A-RH, El-Sayed EM. 2013. Hepatoprotective, antioxidant, and ameliorative effects of ginger (Zingiber officinale Roscoe) and vitamin E in acetaminophen treated rats. J Diet Suppl. 10:195–209.
  • Abu-Sheir WA. 2016. The protective role of vitamin C against histological changes and some biochemical indices in liver of rats chronically exposed to diazinon. Egypt J Hosp Med. 64:395–404. doi:10.12816/0029031.
  • Afifi E. 2009. Influence of ginger on some biochemical changes induced by diazinon pesticide or fat in male rats. Isotope Rad Res. 41:1027–1041.
  • Attia AM, Ibrahim FA, Nabil GM, Aziz SW. 2013. Antioxidant effects of ginger (Zingiber officinale Roscoe) against lead acetate-induced hepatotoxicity in rats. Afr J Pharm Pharmacol. 7:1213–1219. doi:10.5897/AJPP2013.3465.
  • Attyah AM, Ismail SH. 2017. Protective effect of ginger extract against cisplatin-induced hepatotoxicity and cardiotoxicity in rats. Iraq J Pharm Sci. 21:27–33.
  • Beydilli H, Yilmaz N, Cetin ES, Topal Y, Celik OI, Sahin C, Topal H, Cigerci IH, Sozen H, Sozen H. 2015. Evaluation of the protective effect of silibinin against diazinon induced hepatotoxicity and free-radical damage in rat liver. Iran Red Cresc Med J. 17:e25310.
  • Boussabbeh M, Salem IB, Hamdi M, Fradj SB, Abid-Essefi S, Bacha H. 2016. Diazinon, an organophosphate pesticide, induces oxidative stress and genotoxicity in cells deriving from large intestine. Env Sci Pollut Res. 23:2882–2889. doi:10.1007/s11356-015-5519-y.
  • Damodar D, D’Souza UJ, Bhat S. 2015. Protective role of vitamin E on diazinon-induced hepatotoxicity by biochemical and histological alterations in Wistar rats. Natl J Physiol Pharm Pharmacol. 5:398–406. doi:10.5455/njppp.2015.5.2306201569.
  • El-Demerdash FM, Nasr HM. 2014. Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol. 28:89–93. doi:10.1016/j.jtemb.2013.10.001.
  • El-Sharaky A, Newairy A, Kamel M, Eweda S. 2009. Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food Chem Toxicol. 47:1584–1590. doi:10.1016/j.fct.2009.04.005.
  • El-Shenawy NS, Al-Eisa RA, El-Salmy F, Omema S. 2009. Prophylactic effect of vitamin E against hepatotoxicity, nephrotoxicity, haematological indices and histopathology induced by diazinon insecticide in mice. Curr Zool. 55:219–226. doi:10.1093/czoolo/55.3.219.
  • El-Shenawy NS, El-Salmy F, Al-Eisa RA, El-Ahmary B. 2010. Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver. Pest Biochem Physiol. 96:101–107. doi:10.1016/j.pestbp.2009.09.008.
  • Gokcimen A, Gulle K, Demirin H, Bayram D, Kocak A, Altuntas I. 2007. Effects of diazinon at different doses on rat liver and pancreas tissues. Pest Biochem Physiol. 87:103–108. doi:10.1016/j.pestbp.2006.06.011.
  • Haleagrahara N, Jackie T, Chakravarthi S, Rao M, Kulur A. 2010. Protective effect of Etlingera elatior (torch ginger) extract on lead acetate-induced hepatotoxicity in rats. J Toxicol Sci. 35:663–671. doi:10.2131/jts.35.663.
  • Hamzeh M, Hosseinimehr SJ, Khalatbary AR, Mohammadi HR, Dashti A, Amiri FT. 2018. Atorvastatin mitigates cyclophosphamide-induced hepatotoxicity via suppression of oxidative stress and apoptosis in rat model. Res Pharm Sci. 13:440–449. doi:10.4103/1735-5362.236837.
  • Jeena K, Liju VB, Kuttan R. 2013. Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Ind J Physiol Pharmacol. 57:51–62.
  • Kalender S, Ogutcu A, Uzunhisarcikli M, Açikgoz F, Durak D, Ulusoy Y, Kalender Y. 2005. Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes. Toxicology. 211:197–206. doi:10.1016/j.tox.2005.03.007.
  • Kim L, Kim J. 2016. Anti-inflammatory properties of ginger extract in an in vitro model of inflamed human intestinal epithelium. FASEB J. 30:lb234–lb234.
  • Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. 2015. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Indus Health. 31:367–376. doi:10.1177/0748233713475519.
  • Mohammadian M, Mianabadi M, Zargari M, Karimpour A, Khalafi M, Amiri FT. 2018. Effects of olive oil supplementation on sodium arsenate-induced hepatotoxicity in mice. Int J Prevent Med. 9:59. doi:10.4103/ijpvm.IJPVM_165_18
  • Naeimi RA, Amiri FT, Khalatbary AR, Ghasemi A, Zargari M, Ghesemi M, Hosseinimehr SJ. 2017. Atorvastatin mitigates testicular injuries induced by ionizing radiation in mice. Reprod Toxicol. 72:115–121. doi:10.1016/j.reprotox.2017.06.052.
  • Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S. 2008. The current state of serum biomarkers of hepatotoxicity. Toxicology. 245:194–205. doi:10.1016/j.tox.2007.11.021.
  • Riane K, Ouled-Haddar H, Alyane M, Sifour M, Espinos C, Esteban MA. 2019. Assessment of Streptococcus salivarius ssp Thermophilus antioxidant efficiency and its role in reducing paracetamol hepatotoxicity. Iran J Biotechnol. 17:e2061. doi:10.229252/ijb.2370.
  • Rush T, Liu X, Hjelmhaug J, Lobner D. 2010. Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. 166:899–906. doi:10.1016/j.neuroscience.2010.01.025.
  • Sabina EP, Pragasam SJ, Kumar S, Rasool M. 2011. 6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice. Zhong Xi Yi Jie He Xue Bao. 9:1264–1269. doi:10.3736/jcim20111116.
  • Sakr SA, Mahran HA, Lamfon HA. 2011. Protective effect of ginger (Zingiber officinale) on adriamycin-induced hepatotoxicity in albino rats. J Med Plants Res. 5:133–140.
  • Shanmugam KR, Mallikarjuna K, Nishanth K, Kuo CH, Reddy KS. 2011. Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues. Food Chem. 124:1436–1442. doi:10.1016/j.foodchem.2010.07.104.
  • Thongchuai B, Narongchai P, Narongchai S, Panthong A, Lertprasertsuk N, Praputpittaya C. 2010. Effects of Zingiber officinale Roscoe on methyl parathion intoxication in rats. Chiang Mai Med J. 49:81–88.
  • Tohma H, Gülçin İ, Bursal E, Gören AC, Alwasel SH, Köksal E. 2017. Antioxidant activity and phenolic compounds of ginger (Zingiber officinale Rosc.) determined by HPLC-MS/MS. J Food Meas Charac. 11:556–566. doi:10.1007/s11694-016-9423-z.
  • Vipin A, Rao R, Kurrey NK, KA AA, Venkateswaran G. 2017. Protective effects of phenolics rich extract of ginger against aflatoxin B 1-induced oxidative stress and hepatotoxicity. Biomed Pharmacother. 91:415–424. doi:10.1016/j.biopha.2017.04.107.
  • Yaghubi Beklar S, Hamzeh M, Karimpour A, Amiri FT. 2019. Zingiber officinale mitigates diazinon-induced testicular toxicity via suppression of oxidative stress and apoptosis in mice model. J Res Pharm. 23:224–234.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.