Betatrophin, elabela, asprosin, glucagon and subfatin peptides in breast tissue, blood and milk in gestational diabetes

References

• Abu-Farha M, Al Madhoun A, Abubaker J. 2016. The rise and the fall of betatrophin/ANGPTL8 as an inducer of β-cell proliferation. J Diabetes Res. 2016:4860595. 10.1155/2016/4860595.
   PubMed Web of Science ®Google Scholar
• Ahrén B. 2015. Glucagon: early breakthroughs and recent discoveries. Peptides. 67:74–81. 10.1016/j.peptides.2015.03.011.
   PubMed Web of Science ®Google Scholar
• Aydin S. 2010. The presence of the peptides apelin, ghrelin and nesfatin-1 in the human breast milk, and the lowering of their levels in patients with gestational diabetes mellitus. Peptides. 31:2236–2240. 10.1016/j.peptides.2010.08.021.
   PubMed Web of Science ®Google Scholar
• Aydin S, Kuloglu T, Aydin S. 2013. Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus. Peptides. 47:66–70. 10.1016/j.peptides.2013.07.001.
   PubMed Web of Science ®Google Scholar
• Aydin S. 2015. A short history, principles, and types of ELISA, and our laboratory experience with peptide/protein analyses using ELISA. Peptides. 72:4–15. 10.1016/j.peptides.2015.04.012.
   PubMed Web of Science ®Google Scholar
• Aydin S. 2018. Gestational diabetes and peptides in breast milk. In: Rajendram R, Preedy V, Patel V, Eds., Nutrition and diet in maternal diabetes an evidence-based approach. Humana Press: Cham, Switzerland; p. 367–383.
   Google Scholar
• Aydin S, Aydin S, Ozkan Y, Kumru S. 2006. Ghrelin is present in human colostrum, transitional and mature milk. Peptides. 27:878–882. 10.1016/j.peptides.2005.08.006.
   PubMed Web of Science ®Google Scholar
• Aydin S, Eren MN, Kuloglu T, Aydin S, Yilmaz M, Gul E, Kalayci M, Yel Y, Cakmak T, Bico S. 2015. Alteration of serum and cardiac tissue adropin, copeptin, irisin and TRPM2 expressions in DOX treated male rats. Biotech Histochem. 90:197–205. 10.3109/10520295.2014.977949.
   PubMed Web of Science ®Google Scholar
• Azad MB, Nickel NC, Bode L, Brockway M, Brown A, Chambers C, Goldhammer C, Hinde K, McGuire M, Munblit D, Patel AL, Pérez-Escamilla R, Rasmussen KM, Shenker N, Young BE, Zuccolo L. 2021. Breastfeeding and the origins of health: interdisciplinary perspectives and priorities. Matern Child Nutr. 17:e13109. 10.1111/mcn.13109.
   PubMed Web of Science ®Google Scholar
• Ballard O, Morrow AL. 2013. Human milk composition: nutrients and bioactive factors. Pediatr Clin No Am. 60:49–74. 10.1016/j.pcl.2012.10.002.
   PubMed Web of Science ®Google Scholar
• Baykus Y, Yavuzkir S, Ustebay S, Ugur K, Deniz R, Aydin S. 2019. Asprosin in umbilical cord of newborns and maternal blood of gestational diabetes, preeclampsia, severe preeclampsia, intrauterine growth retardation and macrosemic fetus. Peptides. 120:170132. 10.1016/j.peptides.2019.170132.
   PubMed Web of Science ®Google Scholar
• Beis C, Grigorakis SI, Philippou G, Alevizaki M, Anastasiou E. 2005. Lack of suppression of plasma glucagon levels in late pregnancy persists postpartum only in women with previous gestational diabetes mellitus. Acta Diabetol. 42:31–35. 10.1007/s00592-005-0171-5.
   PubMed Web of Science ®Google Scholar
• Boquien CY. 2018. Human milk: an ideal food for nutrition of preterm newborn. Front Pediatr. 6:295–301. 10.3389/fped.2018.00295.
   PubMed Web of Science ®Google Scholar
• Çatlı G, Olgaç Dündar N, Dündar BN. 2014. Adipokines in breast milk: an update. J Clin Res Pediatr Endocrinol. 6:192–201. 10.4274/jcrpe.1531.
   PubMed Web of Science ®Google Scholar
• Chen Z, Wu C, Liu Y, Li H, Zhu Y, Huang C, Lin H, Qiao Q, Huang M, Zhu Q, Wang L. 2020. Elabela attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway. Cell Death Dis. 11:698. 10.1038/s41419-020-02912-0.
   PubMed Web of Science ®Google Scholar
• Chng SC, Ho L, Tian J, Reversade B. 2013. Elabela: a hormone essential for heart development signals via the apelin receptor. Dev Cell. 27:672–680. 10.1016/j.devcel.2013.11.002.
   PubMed Web of Science ®Google Scholar
• Dadmanesh M, Aghajani H, Fadaei R, Ghorban K. 2018. Lower serum levels of meteorin-like/subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines. PLoS One. 13:e0204180. 10.1371/journal.pone.0204180.
   PubMed Web of Science ®Google Scholar
• D’alessio D. 2011. The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes Metab. 13:126–132. 10.1111/j.1463-1326.2011.01449.x.
   PubMed Web of Science ®Google Scholar
• Dawid M, Mlyczyńska E, Jurek M, Respekta N, Pich K, Kurowska P, Gieras W, Milewicz T, Kotula-Balak M, Rak A. 2021. Apelin, APJ, and elabela: role in placental function, pregnancy, and foetal development-an overview. Cells. 11:99. 10.3390/cells11010099.
   PubMed Web of Science ®Google Scholar
• Donovan SM. 2019. Human milk proteins: composition and physiological significance. Nestle Nutr Inst Workshop Ser. 90:93–101.
   PubMedGoogle Scholar
• Dror DK, Allen LH. 2018. Overview of nutrients in human milk. Adv Nutr. 9:278S–294S. 10.1093/advances/nmy022.
   PubMed Web of Science ®Google Scholar
• Erol O, Ellidag HY, Ayik H, Ozel MK, Derbent AU, Yilmaz N. 2015. Evaluation of circulating betatrophin levels in gestational diabetes mellitus. Gynecol Endocrinol. 31:652–656. 10.3109/09513590.2015.1056142.
   PubMed Web of Science ®Google Scholar
• Espes D, Martinell M, Carlsson PO. 2014. Increased circulating betatrophin concentrations in patients with type 2 diabetes. Int J Endocrinol. 2014:323407. 10.1155/2014/323407.
   PubMed Web of Science ®Google Scholar
• Fadaei R, Dadmanesh M, Moradi N, Ahmadi R, Shokoohi Nahrkhalaji A, Aghajani H, Ghorban K. 2020. Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules. Arch Physiol Biochem. 126:335–340. 10.1080/13813455.2018.1538248.
   PubMed Web of Science ®Google Scholar
• Fallucca F, Russo A, Tinelli FP, Giangrande L, Pedullà C, De Gado F, Pachì A. 1979. Influence of pregnancy on glucagon levels in insulin-dependent diabetic women. Acta Diabetol Lat. 16:359–364. 10.1007/BF02587657.
   PubMedGoogle Scholar
• Fu J, Hou C, Li L, Feng D, Li G, Li M, Li C, Gao S, Li M. 2016. Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome. Cardiovasc Diabetol. 15:142–144. 10.1186/s12933-016-0461-y.
   PubMed Web of Science ®Google Scholar
• Gao T, Jin K, Chen P, Jin H, Yang L, Xie X, Yang M, Hu C, Yu X. 2015. Circulating betatrophin correlates with triglycerides and postprandial glucose among different glucose tolerance statuses–a case-control study. PLoS One. 10:e0133640. 10.1371/journal.pone.0133640.
   PubMed Web of Science ®Google Scholar
• Gerich JE. 1981. Physiology of glucagon. Int Rev Physiol. 24:243–275.
   PubMedGoogle Scholar
• Goldman AS, Chheda S, Keeney SE, Schmalstieg FC. 2020. Immunology of human milk and host immunity. Fetal Neonat Physiol. 2011:1690–1701.
   Google Scholar
• Goyal A, Gupta Y, Singla R, Kalra S, Tandon N. 2020. American diabetes association ‘‘standards of medical care—2020 for gestational diabetes mellitus’’: a critical appraisal. Diabetes Ther. 11:1639–1644. 10.1007/s13300-020-00865-3.
   PubMed Web of Science ®Google Scholar
• Grigorakis SI, Alevizaki M, Beis C, Anastasiou E, Alevizaki CC, Souvatzoglou A. 2000. Hormonal parameters in gestational diabetes mellitus during the third trimester: high glucagon levels. Gynecol Obstet Invest. 49:106–109. 10.1159/000010225.
   PubMed Web of Science ®Google Scholar
• Groener JB, Valkanou A, Kender Z, Pfeiffenberger J, Kihm L, Fleming T, Nawroth PP, Kopf S. 2019. Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes. PLoS One. 14:e0222771. 10.1371/journal.pone.0222771.
   PubMed Web of Science ®Google Scholar
• Guo YY, Li T, Liu H, Tang L, Li YC, Hu HT, Su YF, Lin Y, Wang YY, Li C, Huang HF, Jin L, Liu XM. 2020. Circulating levels of elabela and apelin in the second and third trimesters of pregnancies with gestational diabetes mellitus. Gynecol Endocrinol. 36:890–894. 10.1080/09513590.2020.1739264.
   PubMed Web of Science ®Google Scholar
• He Y, Hu W, Yang G, Guo H, Liu H, Li L. 2020. Adipose insulin resistance and circulating betatrophin levels in women with PCOS. Biomed Res Int. 2020:1253164. 10.1155/2020/1253164.
   PubMed Web of Science ®Google Scholar
• Horie I, Haraguchi A, Ito A, Nozaki A, Natsuda S, Akazawa S, Mori Y, Ando T, Higashijima A, Hasegawa Y, Yoshida A, Miura K, Masuzaki H, Kawakami A, Abiru N. 2020. Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes. J Diabetes Invest. 11:232–240. 10.1111/jdi.13096.
   PubMed Web of Science ®Google Scholar
• Hsu SM. 1990. Immunohistochemistry. Methods Enzymol. 184:357–363.
   PubMed Web of Science ®Google Scholar
• Huang Y, Fang C, Ma Z, Guo H, Wang R, Hu J. 2016. Betatrophin levels were increased in pregnant women with or without gestational diabetes mellitus and associated with beta cell function. Rev Bras Ginecol Obstet. 38:287–292. 10.1055/s-0036-1584566.
   PubMedGoogle Scholar
• Hu H, Sun W, Yu S, Hong X, Qian W, Tang B, Wang D, Yang L, Wang J, Mao C, Zhou L, Yuan G. 2014. Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients. Diabetes Care. 37:2718–2722. 10.2337/dc14-0602.
   PubMed Web of Science ®Google Scholar
• Hu G, Wang Z, Zhang R, Sun W, Chen X. 2021. The role of apelin/apelin receptor in energy metabolism and water homeostasis: a comprehensive narrative review. Front Physiol. 12:632886. 10.3389/fphys.2021.632886.
   PubMed Web of Science ®Google Scholar
• Janoschek R, Hoffmann T, Morcos YAT, Sengle G, Dötsch J, Hucklenbruch-Rother E. 2020. Asprosin in pregnancy and childhood. Mol Cell Pediatr. 7:18–13. 10.1186/s40348-020-00110-8.
   PubMedGoogle Scholar
• Karagoz ZK, Aydin S, Ugur K, Tigli A, Deniz R, Baykus Y, Sahin I, Yalcin MH, Yavuz A, Aksoy A, Aydin S. 2022. Molecular communication between apelin-13, apelin-36, elabela, and nitric oxide in gestational diabetes mellitus. Eur Rev Med Pharmacol Sci. 26:3289–3300. 10.26355/eurrev_202205_28748.
   PubMed Web of Science ®Google Scholar
• Kong FJ, Ma LL, Li G, Chen YX, Zhou JQ. 2017. Circulating betatrophin levels and gestational diabetes mellitus: a systematic review and meta-analysis. PLoS One. 12:e0169941. 10.1371/journal.pone.0169941.
   PubMed Web of Science ®Google Scholar
• Ko JR, Seo DY, Kim TN, Park SH, Kwak HB, Ko KS, Rhee BD, Han J. 2019. Aerobic exercise training decreases hepatic asprosin in diabetic rats. J Clin Med. 8:666. 10.3390/jcm8050666.
   PubMed Web of Science ®Google Scholar
• Kulina GR, Rayfield EJ. 2016. The role of glucagon in the pathophysiology and management of diabetes. Endocr Pract. 22:612–621. 10.4158/EP15984.RA.
   PubMed Web of Science ®Google Scholar
• Kunz C. 2012. Historical aspects of human milk oligosaccharides. Adv Nutr. 3:430S–439S. 10.3945/an.111.001776.
   PubMed Web of Science ®Google Scholar
• Lamm S, Cole B, Glynn K, Ullmann W. 1973. Lead content of milks fed to infants–1971–1972. N Engl J Med. 289:574–575. 10.1056/NEJM197309132891109.
   PubMed Web of Science ®Google Scholar
• Lee YH, Wang MY, Yu XX, Unger RH. 2016. Glucagon is the key factor in the development of diabetes. Diabetologia. 59:1372–1375. 10.1007/s00125-016-3965-9.
   PubMed Web of Science ®Google Scholar
• Li ZY, Song J, Zheng SL, Fan MB, Guan YF, Qu Y, Xu J, Wang P, Miao CY. 2015. Adipocyte metrnl antagonizes insulin resistance through PPARγ signaling. Diabetes. 64:4011–4022. 10.2337/db15-0274.
   PubMed Web of Science ®Google Scholar
• Liu W, Yan J, Pan W, Tang M. 2020. Apelin/elabela-APJ: a novel therapeutic target in the cardiovascular system. Ann Transl Med. 8:243. 10.21037/atm.2020.02.07.
   PubMed Web of Science ®Google Scholar
• Mennella JA, Beauchamp GK. 1991. The transfer of alcohol to human milk. Effects on flavor and the infant’s behavior. N Engl J Med. 325:981–985. 10.1056/NEJM199110033251401.
   PubMed Web of Science ®Google Scholar
• Muthu ML, Reinhardt DP. 2020. Fibrillin-1 and fibrillin-1-derived asprosin in adipose tissue function and metabolic disorders. J Cell Commun Sign. 14:159–173. 10.1007/s12079-020-00566-3.
   PubMed Web of Science ®Google Scholar
• Naiemian S, Naeemipour M, Zarei M, Najafi ML, Gohari A, Behroozikhah MR, Haydari H, Miri M. 2020. Serum concentration of asprosin in new-onset type 2 diabetes. Diabetol Metab Syndr. 12:65. 10.1186/s13098-020-00564-w.
   PubMed Web of Science ®Google Scholar
• Oruc Y, Celik F, Ozgur G, Beyazyildiz E, Ugur K, Yardim M, Sain I, Akkoc RF, Aydin S. 2020. Altered blood and aqueous humor levels of asprosin, 4-hydroxynonenal, and 8-hydroxy-deoxyguanosine in patients with diabetes mellitus and cataract with and without diabetic retinopathy. Retina. 40:2410–2416. 10.1097/IAE.0000000000002776.
   PubMed Web of Science ®Google Scholar
• Padmanabhan V, Cardoso RC. 2020. Neuroendocrine, autocrine, and paracrine control of follicle-stimulating hormone secretion. Mol Cell Endocrinol. 500:110632. 10.1016/j.mce.2019.110632.
   PubMed Web of Science ®Google Scholar
• Pietrzak-Fiećko R, Kamelska-Sadowska AM. 2020. The comparison of nutritional value of human milk with other mammals’ milk. Nutrients. 12:1404–1422. 10.3390/nu12051404.
   PubMed Web of Science ®Google Scholar
• Reaven GM, Chen YD, Golay A, Swislocki AL, Jaspan JB. 1987. Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 64:106–110. 10.1210/jcem-64-1-106.
   PubMed Web of Science ®Google Scholar
• Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR. 2016. Asprosin, a fasting-induced glucogenic protein hormone. Cell. 165:566–579. 10.1016/j.cell.2016.02.063.
   PubMed Web of Science ®Google Scholar
• Sahin Ersoy G, Altun Ensari T, Subas S, Giray B, Simsek EE, Cevik O. 2016. WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus. J Matern Fetal Neonatal Med. 30:942–946. 10.1080/14767058.2016.1192118.
   PubMed Web of Science ®Google Scholar
• Samuel TM, Zhou Q, Giuffrida F, Munblit D, Verhasselt V, Thakkar SK. 2020. Nutritional and non-nutritional composition of human milk is modulated by maternal, infant, and methodological factors. Front Nutr. 7:576133. 10.3389/fnut.2020.576133.
   PubMed Web of Science ®Google Scholar
• Schäffer L, Brand CL, Hansen BF, Ribel U, Shaw AC, Slaaby R, Sturis J. 2008. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 376:380–383. 10.1016/j.bbrc.2008.08.151.
   PubMed Web of Science ®Google Scholar
• Schmid A, Karrasch T, Schäffler A. 2021. Meteorin-like protein (METRNL) in obesity, during weight loss and in adipocyte differentiation. J Clin Med. 10:4338–4355. 10.3390/jcm10194338.
   PubMed Web of Science ®Google Scholar
• Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M. 1998. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 251:471–476. 10.1006/bbrc.1998.9489.
   PubMed Web of Science ®Google Scholar
• Tengholm A, Gylfe E. 2017. cAMP signalling in insulin and glucagon secretion. Diabetes Obes Metab. 19:42–53. 10.1111/dom.12993.
   PubMed Web of Science ®Google Scholar
• Thai JD, Gregory KE. 2020. Bioactive factors in human breast milk attenuate intestinal inflammation during early life. Nutrients. 12:581–596. 10.3390/nu12020581.
   PubMed Web of Science ®Google Scholar
• Ugur K, Erman F, Turkoglu S, Aydin Y, Aksoy A, Lale A, Karagöz ZK, Ugur I, Akkoc RF, Yalniz M. 2022. Asprosin, visfatin and subfatin as new biomarkers of obesity and metabolic syndrome. Eur Rev Med Pharmacol Sci. 26:2124–2133. 10.26355/eurrev_202203_28360.
   PubMed Web of Science ®Google Scholar
• Unger RH, Aguilar-Parada E, Muller WA, Eisentraut AM. 1970. Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest. 49:837–848. 10.1172/JCI106297.
   PubMed Web of Science ®Google Scholar
• Ustebay S, Baykus Y, Deniz R, Ugur K, Yavuzkir S, Yardim M, Kalayci M, Çaglar M, Aydin S. 2019. Chemerin and dermcidin in human milk and their alteration in gestational diabetes. J Hum Lact. 35:550–558. 10.1177/0890334419837523.
   PubMed Web of Science ®Google Scholar
• Wada Y, Lönnerdal B. 2020. Bioactive peptides derived from human milk proteins: an update. Curr Opin Clin Nutr Metab Care. 23:217–222. 10.1097/MCO.0000000000000642.
   PubMed Web of Science ®Google Scholar
• Wang Ylfy GH. 2016. Changes and clinical significance of betatrophin level in plasma and cord blood in pregnant women with gestational diabetes mellitus. Hainan Med J. 7:1070–1072.
   Google Scholar
• Xu F, Wu M, Lu X, Zhang H, Shi L, Xi Y, Zhou H, Wang J, Miao L, Gong DW, Cui W. 2022. Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: mediation of anti-apoptotic effect via Akt phosphorylation. Peptides. 147:170682. 10.1016/j.peptides.2021.170682.
   PubMed Web of Science ®Google Scholar
• Yamada H, Saito T, Aoki A, Asano T, Yoshida M, Ikoma A, Kusaka I, Toyoshima H, Kakei M, Ishikawa SE. 2015. Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes. Endocr J. 62:417–421. 10.1507/endocrj.EJ14-0525.
   PubMed Web of Science ®Google Scholar
• Yavuzkir S, Ugur K, Deniz R, Ustebay DU, Mirzaoglu M, Yardim M, Sahin I, Baykus Y, Karagoz ZK, Aydin S. 2020. Maternal and umbilical cord blood subfatin and spexin levels in patients with gestational diabetes mellitus. Peptides. 126:170277. 10.1016/j.peptides.2020.170277.
   PubMed Web of Science ®Google Scholar
• Yi P, Park JS, Melton DA. 2013. Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell. 153:747–758. 10.1016/j.cell.2013.04.008.
   PubMed Web of Science ®Google Scholar
• Yuan M, Li W, Zhu Y, Yu B, Wu J. 2020. Asprosin: a novel player in metabolic diseases. Front Endocrinol (Lausanne). 11:64. 10.3389/fendo.2020.00064.
   PubMed Web of Science ®Google Scholar
• Yu P, Ma S, Dai X, Cao F. 2020. Elabela alleviates myocardial ischemia reperfusion-induced apoptosis, fibrosis and mitochondrial dysfunction through PI3K/AKT signaling. Am J Transl Res. 12:4467–4477.
   PubMed Web of Science ®Google Scholar
• Zhang L, Chen C, Zhou N, Fu Y, Cheng X. 2019. Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride. Clin Chim Acta. 489:183–188. 10.1016/j.cca.2017.10.034.
   PubMed Web of Science ®Google Scholar
• Zhang X, Jiang H, Ma X, Wu H. 2020. Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus. J Diabetes Invest. 11:349–355. 10.1111/jdi.13148.
   PubMed Web of Science ®Google Scholar
• Zheng J, Liu J, Hong BS, Ke W, Huang M, Li Y. 2020. Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance, but not those with glucose disorders. BMC Endocr Disord. 20:51. 10.1186/s12902-020-0531-8.
   PubMed Web of Science ®Google Scholar
• Zheng Q, Tian G, Xu F, Ci X, Luan R, Wu L, Lu X. 2021. The role of elabela in kidney disease. Int Urol Nephrol. 53:1851–1857. 10.1007/s11255-021-02790-1.
   PubMed Web of Science ®Google Scholar