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Research Article

Optimal designs for phase II clinical trials with heterogeneous patient populations

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Pages 1-14 | Received 28 Apr 2021, Accepted 03 Apr 2022, Published online: 06 Jul 2022

References

  • Jung, S. H., M. N. Chang, and S. J. Kang. 2012. Phase II cancer clinical trials with heterogeneous patient populations. Journal of Biopharmaceutical Statistics 22 (2):312–328. doi:10.1080/10543406.2010.536873.
  • London, W. B., and C. M.N. 2005. One- and two-stage designs for stratified phase II clinical trials. Statistics in Medicine 24 (17):2597–2611. doi:10.1002/sim.2139.
  • Simon, R. 1989. Optimal two-stage designs for phase II clinical trials. Controlled Clinical Trials 10 (1):1–10. doi:10.1016/0197-2456(89)90015-9.
  • Sposto, R., and G. P.s. 2009. An adjustment for patient heterogeneity in the design of two-stage phase II trials. Statistics in Medicine 28 (20):2566–2579. doi:10.1002/sim.3624.

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