Methadone Maintenance Dosing Guideline for Opioid Dependence, a Literature Review

REFERENCES

• Dole , V P and Nyswander , M . 1965 . A medical treatment for diacetylmorphine (heroin) addiction: a clinical trial with methadone hydrochloride . JAMA , 193 : 80 – 4 .
   Web of Science ®Google Scholar
• Dole , V P and Nyswander , M E . 1966 . Rehabilitation of heroin addicts after blockade with methadone . N Y State J Med , 66 : 2011 – 7 .
   PubMedGoogle Scholar
• Ball , J C and Ross , A . 1991 . The effectiveness of methadone maintenance treatment: patients, programs, services and outcome , New York : Springer-Verlag .
   Google Scholar
• Eissenberg , T , Bigelow , G E , Strain , E C , Walsh , S L , Brooner , R K , Stitzer , M L and Johnson , R E . 1997 . Dose-related efficacy of levomethadyl acetate for treatment of opioid dependence: a randomized clinical trial . JAMA , 277 : 1945 – 51 .
   PubMed Web of Science ®Google Scholar
• Ling , W , Charuvastra , V C , Kaim , S C and Klett , C J . 1976 . Methadyl acetate and methadone as maintenance treatments for heroin addicts: a Veterans Administration cooperative study . Arch Gen Psychiatry , 33 : 709 – 20 .
   PubMed Web of Science ®Google Scholar
• Marsch , L A . 1998 . The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behavior, and criminality: a meta-analysis . Addiction , 93 : 515 – 32 .
   PubMed Web of Science ®Google Scholar
• Maddux , J F , Esquivel , M , Vogtsberger , K N and Desmond , D P . 1991 . Methadone dose and urine morphine . J Subst Abuse Treat. , 8 : 195 – 201 .
   PubMed Web of Science ®Google Scholar
• Brugal , M T , Domingo-Salvany , A , Puig , R , Barrio , G , van der de Olalla , G and de la Fuente , L . 2005 . Evaluating the impact of methadone maintenance programmes on mortality due to overdose and aids in a cohort of heroin users in Spain . Addiction , 100 : 981 – 9 .
   PubMed Web of Science ®Google Scholar
• Rathod , N H , Addenbrooke , W M and Rosenbach , A F . 2005 . Heroin dependence in an English town: 33-year follow-up . Br J Psychiatry , 187 : 421 – 5 .
   PubMed Web of Science ®Google Scholar
• Sorensen , H J , Jepsen , P W , Haastrup , S and Juel , K . 2005 . Drug-use pattern, comorbid psychosis and mortality in people with a history of opioid addiction . Acta Psychiatr Scand , 111 : 244 – 9 .
   PubMed Web of Science ®Google Scholar
• Termorshuizen , F , Krol , A , Prins , M , Geskus , R , van den Brink , W and van Ameijden , E J . 2005 . Long-term outcome of chronic drug use: the Amsterdam Cohort Study among drug users . Am J Epidemiol , 161 : 271 – 9 .
   PubMed Web of Science ®Google Scholar
• De Angelis , D , Hickman , M and Yang , S Y . 2004 . Estimating long-term trends in the incidence and prevalence of opiate use/injecting drug use and the number of former users: back-calculation methods and opiate overdose deaths . Am J Epidemiol , 160 : 994 – 1004 .
   PubMed Web of Science ®Google Scholar
• Vlahov , D , Wang , C L , Galai , N , Bareta , J , Mehta , S H , Strathdee , S A and Nelson , K E . 2004 . Mortality risk among new onset injection drug users . Addiction , 99 : 946 – 54 .
   PubMed Web of Science ®Google Scholar
• Oppenheimer , E , Tobutt , C , Taylor , C and Andrew , T . 1994 . Death and survival in a cohort of heroin addicts from London clinics: a 22-year follow-up study . Addiction , 89 : 1299 – 308 .
   PubMed Web of Science ®Google Scholar
• Barr , H L , Antes , D , Ottenberg , D J and Rosen , A . 1984 . Mortality of treated alcoholics and drug addicts: the benefits of abstinence . J Stud Alcohol , 45 : 440 – 52 .
   PubMed Web of Science ®Google Scholar
• Haastrup , S and Jepsen , P W . 1988 . Seven year follow-up of 300 young opioid addicts . Acta Psychiatr Scand , 77 : 503 – 9 .
   Web of Science ®Google Scholar
• Joe , G W , Lehman , W and Simpson , D D . 1982 . Addict death rates during a four-year posttreatment follow-up . Am J Publ Health , 72 : 703 – 9 .
   PubMed Web of Science ®Google Scholar
• Joe , G W and Simpson , D D . 1987 . Mortality rates among opioid addicts in a longitudinal study . Am J Publ Health , 77 : 347 – 8 .
   PubMed Web of Science ®Google Scholar
• Smyth , B , Hoffman , V , Fan , J and Hser , Y-I . 2007 . Years of potential life lost among heroin addicts 33 years after treatment . Prev Med , 44 : 369 – 74 .
   PubMed Web of Science ®Google Scholar
• Alterman , A L , Rutherford , M J , Cacciola , J S , McKaym , J R and Boardman , C R . 1998 . Prediction of 7 months methadone maintenance treatment response by four measures of antisociality . Drug Alcohol Depend , 49 : 217 – 23 .
   PubMed Web of Science ®Google Scholar
• McLellan , A T . 1983 . Patient characteristics associated with outcome , Edited by: Cooper , J R , Altman , F , Brown , B S and Czechowicz , D . Washington, DC : U.S. Government Printing Office . Research on the treatment of drug addiction: state of the art (NIDA Research Monograph Series Publication No. ADM 83–1281)
   Google Scholar
• McLellan , A T , Luborsky , L , Woody , G E , O'Brien , C P and Druley , K A . 1983 . Predicting response to drug and alcohol treatment: role of psychiatric severity . Arch Gen Psychiatry , 40 : 620 – 5 .
   PubMed Web of Science ®Google Scholar
• Broers , B , Morabia , A and Hirschel , B . 1994 . A cohort study of drug users' compliance with zidovudine treatment . Arch Intern Med , 154 : 1121 – 7 .
   PubMed Web of Science ®Google Scholar
• Wedam , E F , Bigelow , G E , Johnson , R E , Nuzzo , P A and Haigney , M C . 2007 . QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial . Arch Intern Med , 167 : 2469 – 75 .
   PubMed Web of Science ®Google Scholar
• Johnson , R E , Chutuape , M A , Strain , E C , Walsh , S L , Stitzer , M L and Bigelow , G E . 2000 . A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence . N Engl J Med , 343 : 1290 – 7 .
   PubMed Web of Science ®Google Scholar
• Rhoades , H M , Creson , D , Elk , R , Schmitz , J and Grabowski , J . 1998 . Retention, HIV risk, and illicit drug use during treatment: methadone dose and visit frequency . Am J Public Health , 88 : 34 – 9 .
   PubMed Web of Science ®Google Scholar
• Preston , K L , Umbricht , A and Epstein , D H . 2000 . Methadone dose increase and abstinence reinforcement for treatment of continued heroin use during methadone maintenance . Arch Gen Psychiatry , 57 : 395 – 404 .
   PubMed Web of Science ®Google Scholar
• Strain , E C , Bigelow , G E , Liebson , I A and Stitzer , M L . 1999 . Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial . JAMA , 281 : 1000 – 5 .
   PubMed Web of Science ®Google Scholar
• Ling , W , Wesson , D R , Charuvastra , C and Klett , C J . 1996 . A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence . Arch Gen Psychiatry , 53 : 401 – 7 .
   PubMed Web of Science ®Google Scholar
• Schottenfeld , R S , Pakes , J R , Oliveto , A , Ziedonis , D and Kosten , T R . 1997 . Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse . Arch Gen Psychiatry , 54 : 713 – 20 .
   PubMed Web of Science ®Google Scholar
• Donny , E C , Walsh , S L , Bigelow , G E , Eissenberg , T and Stitzer , M L . 2002 . High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioiddependent humans . Psychopharmacology (Berl) , 161 : 202 – 12 .
   PubMed Web of Science ®Google Scholar
• Faggiano , F , Vigna-Taglianti , F , Versino , E and Lemma , P . 2003 . Methadone maintenance at different dosages for opioid dependence . Cochrane Database Syst Rev , 3, July CD002208
   PubMedGoogle Scholar
• Effective medical treatment of opiate addiction . 1998 . National Consensus Development Panel on Effective Medical Treatment of Opiate Addiction . JAMA , 280 : 1936 – 43 .
   PubMed Web of Science ®Google Scholar
• Pollack , H A and D'Aunno , T . 2008 . Dosage patterns in methadone treatment: results from a national survey, 1988–2005 . Health Serv Res , 43 ( 6 ) : 2143 – 63 .
   PubMed Web of Science ®Google Scholar
• Maxwell , S and Shinderman , M . 1999 . Optimizing response to methadone maintenance treatment: use of higher dose methadone . J Psychoactive Drugs , 31 : 95 – 102 .
   PubMed Web of Science ®Google Scholar
• Maxwell , S and Shinderman , M S . 2002 . Optimizing long-term response to methadone maintenance treatment: a 152-week follow-up using higher-dose methadone . J Addict Dis , 21 : 1 – 12 .
   PubMed Web of Science ®Google Scholar
• Donny , E C , Brasser , S M , Bigelow , G E , Stitzer , M L and Walsh , S L . 2005 . Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers . Addiction , 100 : 1496 – 509 .
   PubMed Web of Science ®Google Scholar
• Banys , P , Tusel , D J , Sees , K L , Reilly , P M and Delucchi , K L . 1994 . Low (40 mg) versus high (80 mg) dose methadone in a 180-day heroin detoxification program . J Subst Abuse Treat , 11 : 225 – 32 .
   PubMed Web of Science ®Google Scholar
• Brady , T M , Salvucci , S , Sverdlov , L S , Male , A , Kyeyune , H , Sikali , E , De Sale , S and Yu , P . 2005 . Methadone dosage and retention: an examination of the 60 mg/day threshold . J Addict Dis , 24 : 23 – 47 .
   PubMed Web of Science ®Google Scholar
• Blaney , T and Craig , R J . 1999 . Methadone maintenance Does dose determine differences in outcome? . J Subst Abuse Treat , 16 : 221 – 8 .
   PubMed Web of Science ®Google Scholar
• Trafton , J A , Minkel , J and Humphreys , K . 2006 . Determining effective methadone doses for individual opioid-dependent patients . PLoS Med , 3 : e80
   PubMed Web of Science ®Google Scholar
• Maddux , J F , Prihoda , T J and Vogtsberger , K N . 1997 . The relationship of methadone dose and other variables to outcomes of methadone maintenance . Am J Addict , 6 : 246 – 55 .
   PubMed Web of Science ®Google Scholar
• Farr , M , Mas , A , Torrens , M , Moreno , V and Cam , J . 2002 . Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis . Drug Alcohol Depend , 65 : 283 – 90 .
   PubMed Web of Science ®Google Scholar
• Hartel , D M , Schoenbaum , E E , Selwyn , P A , Kline , J , Davenny , K , Klein , R S and Friedland , G H . 1995 . Heroin use during methadone maintenance treatment: the importance of methadone dose and cocaine use . Am J Public Health , 85 : 83 – 8 .
   PubMed Web of Science ®Google Scholar
• Torrens , M , Castillo , C and Pérez-Sol , V . 1996 . Retention in a low-threshold methadone maintenance program . Drug Alcohol Depend , 41 : 55 – 9 .
   PubMed Web of Science ®Google Scholar
• D'ippoliti , D , Davoli , M , Perucci , C A , Pasqualini , F and Bargagli , A M . 1998 . Retention in treatment of heroin users in Italy: the role of treatment type and of methadone maintenance dosage . Drug Alcohol Depend , 52 : 167 – 71 .
   PubMed Web of Science ®Google Scholar
• Kosten , T R , Schottenfeld , R , Ziedonis , D and Falcioni , J . 1993 . Buprenorphine vs. methadone maintenance for opioid dependence . J Nervous Mental Disease , 181 : 358 – 64 .
   PubMed Web of Science ®Google Scholar
• Johnson , R E , Jaffe , J H and Fudala , P J . 1992 . A controlled trial of buprenorphine treatment for opioid dependence . JAMA , 267 : 2750 – 5 .
   PubMed Web of Science ®Google Scholar
• Strain , E C , Stitzer , M L , Liebson , I A and Bigelow , G E . 1993 . Methadone dose and treatment outcome . Drug Alcohol Depend , 33 : 105 – 17 .
   PubMed Web of Science ®Google Scholar
• Strain , E C , Stitzer , M L , Liebson , I A and Bigelow , G E . 1993 . Dose-response effects of methadone in the treatment of opioid dependence . Ann Intern Med , 119 : 23 – 7 .
   PubMed Web of Science ®Google Scholar
• Roszell , D K and Calsyn , D A . 1986 . Methadone dosage: patient characteristics and clinical correlates . Int J Addict , 21 : 1233 – 46 .
   PubMed Web of Science ®Google Scholar
• Latowsky , M . 2006 . Methadone death, dosage, and torsade de pointes: risk-benefit policy implications . J Psychoactive Drugs , 38 : 513 – 9 .
   PubMed Web of Science ®Google Scholar
• Cruciani , R A . 2008 . Methadone: to ECG or not to ECG…That is still the question . J Pain Symptom Manage , 36 : 545 – 52 .
   PubMed Web of Science ®Google Scholar
• Peles , E , Bodner , G , Kreek , M J , Rados , V and Adelson , M . 2007 . Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: a cross-sectional study . Addiction , 102 : 289 – 300 .
   PubMed Web of Science ®Google Scholar
• Kornick , C A , Kilborn , M J , Santiago-Palma , J , Schulman , G , Thaler , H T , Keefe , D L , Katchman , A N , Pezzullo , J C , Ebert , S N , Woosley , R L , Payne , R and Manfredi , P L . 2003 . QTc interval prolongation associated with intravenous methadone . Pain , 105 : 499 – 506 .
   PubMed Web of Science ®Google Scholar
• Maremmani , I , Pacini , M , Cesaroni , C , Lovrecic , M , Perugi , G and Tagliamonte , A . 2005 . QTc interval prolongation in patients on long-term methadone maintenance therapy . Eur Addict Res , 11 : 44 – 9 .
   PubMed Web of Science ®Google Scholar
• Ehret , G B , Voide , C , Gex-Fabry , M , Chabert , J , Shah , D , Broers , B , Piguet , V , Musset , T , Gaspoz , J M , Perrier , A , Dayer , P and Desmeules , J A . 2006 . Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors . Arch Intern Med , 166 : 1280 – 7 .
   PubMed Web of Science ®Google Scholar
• Fanoe , S , Hvidt , C , Ege , P and Jensen , G B . 2007 . Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen . Heart , 93 : 1051 – 5 .
   PubMed Web of Science ®Google Scholar
• Cruciani , R A , Sekine , R , Homel , P , Lussier , D , Yap , Y , Suzuki , Y , Schweitzer , P , Yancovitz , S R , Lapin , J A , Shaiova , L , Shen , R G and Portenoy , R K . 2005 . Measurement of QTc in patients receiving chronic methadone therapy . J Pain Symptom Manage , 29 : 385 – 91 .
   PubMed Web of Science ®Google Scholar
• Martell , B A , Arnsten , J H , Krantz , M J and Gourevitch , M N . 2005 . Impact of methadone treatment on cardiac repolarization and conduction in opioid users . Am J Cardiol , 95 : 915 – 8 .
   PubMed Web of Science ®Google Scholar
• Krantz , M J , Kutinsky , I B , Robertson , A D and Mehler , P S . 2003 . Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes . Pharmacotherapy , 23 : 802 – 5 .
   PubMed Web of Science ®Google Scholar
• Krantz , M J , Martin , J , Stimmel , B , Mehta , D and Haigney , M CP . 2009 . QTc interval screening in methadone treatment . Ann Intern Med , 150 : 387 – 95 .
   PubMed Web of Science ®Google Scholar
• 2006 . Dolophine Hydrochloride C II (Methadone Hydrochloride Tablets, USP) 5 mg, 10 mg, Rx Only , Columbus, OH : Roxane Laboratories . Accessed at www.fda.gov/cder/foi/label/2006/006134s028lbl.pdf on 12 November 2008
   Google Scholar
• Zanis , D A and Woody , G E . 1998 . One-year mortality rates following methadone treatment discharge . Drug Alcohol Depend , 52 : 257 – 60 .
   PubMed Web of Science ®Google Scholar
• Woody , G E , Kane , V , Lewis , K and Thompson , R . 2007 . Premature deaths after discharge from methadone maintenance: a replication . J Addict Med , 1 : 180 – 5 .
   PubMed Web of Science ®Google Scholar