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Original Articles

Biotransformation of Terpenic Compounds by Fungi. II - Metabolism of α-(-)-thujone

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Pages 263-266 | Received 06 Apr 1994, Published online: 04 Oct 2006

References

  • Ismaili-Alaoui , M. , Benjilali , B. , Buisson , D. and Azerad , R. 1992 . Biotransformation of Terpenic Compounds by Fungi. I - Metabolism of R-(+)-pulegone . Tetrahedron Letters , 33 : 2349
  • Ishida , T. , Toyota , M. and Asakawa , Y. 1989 . Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (−)-perillaldehyde, (−)-myrtenal, cuminaldehyde, thujone and (±)-carvone in rabbits . Xenobiotica , 19 : 843
  • Ilidrissi , A. , Berrada , M. , Holeman , M. and Maury , G. 1990 . Bioconversions de cétones cycliques monoterpéniques . Fitoterapia , 51 : 23
  • α+β-thujone techn. from natural oil of cedar leaves, purchased from Fluka AG. (ref. n°89230, Buchs, Switzerland). GC analysis on DBwax capillary column (30 m × 0.32 mm); carrier gas: helium; column temperature: 90 to 180°C, 5°C/min
  • This Aspergillus, strain was isolated from a mint leaves infusion and selected as resisting to high concentrations of monoterpenic compounds. For culture and incubation conditions, see ref. 1
  • Dihedral angles in α-thujone 1, (as shown in the figure beside), and in metabolite 3, were measured in energy-minimized conformations obtained by using Alchemy® III program (Tripos Ass. Inc., St.Louis, Missouri)

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