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Original Articles

A Chemoenzymatic Synthesis of The Macrocyclic Lactone (S)-Curvularin

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Pages 65-68 | Received 07 Jun 1995, Published online: 04 Oct 2006

References

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  • Chikashita , H. , Kittaka , E. , Kimura , Y. and Itoh , K. 1989 . Facile construction of optically active 1,3-diols. Synthesis of (2S',4R)-7-octene-2.4-diol and endo-(1S,3S,5R)- and exo-(1R,3S,5S)-1,3-dimethyl-2, 9-dioxabicyclo[3.3.1]nonane . Bulletin of the Chemical Society of Japan , 62 : 833 – 837 .
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  • [α]D 20 = -33.4° (c 0.62, EtOH). Different [α]D values are published for natural 7 in the literature: [α]D 20 = -33.9° (c 2.0, EtOH), 5 [α]D = -28.6° (c 0.4, EtOH), 15 [[α]D = -36.3° (c 3.8, EtOH).16
  • Ghisalberti , E. L. , Hockless , D. C. R. , Rowland , C. Y. and White , A. H. 1993 . Structural study of curvularin, a cell division inhibitor . Australian Journal of Chemistry , 46 : 571 – 575 .
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