Exposure to Formaldehyde and Its Potential Human Health Hazards

REFERENCES

• Agency for Toxic Substances and Disease Registry . 1999 . Toxicological Profile for Formaldehyde , Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services .
   Google Scholar
• Bolt , H M , Degen , G H and Hengstler , J G . 2010 . The carcinogenicity debate on formaldehyde: How to derive safe exposure limits? . Arch Toxicol , 84 ( 6 ) : 421 – 422 .
   PubMedGoogle Scholar
• Bracamonte , B G , Ortiz , F J and Diez , L I . 1995 . Occupational allergic contact dermatitis due to formaldehyde and textile finish resins . Contact Dermatitis , 33 : 139 – 140 .
   PubMedGoogle Scholar
• California Air Resources Board . 1996 . Determination of Formaldehyde and Toluene Diisocyanate Emissions from Indoor Residential Sources , Sacramento, CA : Research Division, California Air Resources Board .
   Google Scholar
• Cai , Y , Lin , S , Jin , Y , Chen , H , Zheng , J and Chen , B . 2000 . Investigation of formaldehyde level in marketed marine products . Strait J Prevent Med , 6 ( 5 ) : 32 – 39 .
   Google Scholar
• Naya , M and Nakanish , J . 2005 . Risk assessment of formaldehyde for the general population in Japan . Regul Toxicol Pharmacol , 43 ( 3 ) : 232 – 248 .
   PubMedGoogle Scholar
• Dales , R and Raizenne , M . 2004 . Residential exposure to volatile organic compounds and asthma . J Asthma , 41 : 259 – 270 .
   PubMed Web of Science ®Google Scholar
• Arts , J HE , Rennen , M AJ and de-Heer , C . 2006 . Inhaled formaldehyde: Evaluation of sensory irritation in relation to carcinogenicity . Regul Toxicol Pharm , 44 : 144 – 160 .
   PubMed Web of Science ®Google Scholar
• Casset , A , Marchand , C , Purohit , A , le-Calve , S , Uring-Lambert , B and Donnay , C . 2006 . Inhaled formaldehyde exposure: Effect on bronchial response to mite allergen in sensitized asthma patients . Allergy , 61 : 1344 – 1350 .
   PubMed Web of Science ®Google Scholar
• American Conference of Government Industrial Hygienists ®Worldwide . Documentation of the TLVs® and BEIs® with Other Worldwide Occupational Exposure Values—2003. CD-ROM . Cincinnati, OH : American Conference of Government Industrial Hygienists; .
   Google Scholar
• Jurvelin , J A , Edwards , R D , Vartiainen , M , Pasanen , P and Jantunen , M J . 2003 . Residential indoor, outdoor, and workplace concentrations of carbonyl compounds: Relationships with personal exposure concentrations and correlation with sources . J Air Waste Manag Assoc , 53 : 560 – 573 .
   PubMedGoogle Scholar
• Baumann , M GD , Lorenz , L F , Batterman , S A and Zhang , G Z . 2000 . Aldehyde emissions from particleboard and medium density fiberboard products . Forest Product J. , 50 : 75 – 82 .
   Web of Science ®Google Scholar
• Atkinson , R and Arey , J . 2003 . Gas-phase troposheric chemistry of biogenic volatile organic compounds: a review . Atmos Environ. , 37 : 197 – 219 .
   Web of Science ®Google Scholar
• Pratt , G C , Dymond , M and Ellickson , K . Validation of a novel air toxic risk model with air monitoring . J Risk Anal , DOI: 10.1111/j.1539-6924.2011.01640.x
   Google Scholar
• Leovic , K W , Sheldon , L S , Whitaker , D A , Hetes , R G , Calcagni , J A and Baskir , J N . 1996 . Measurement of indoor air emissions from dry-process photocopy machines . J Air Waste Manag Assoc. , 46 : 821 – 829 .
   PubMedGoogle Scholar
• Que , Z , Furuno , T , Katoh , S and Nishino , Y . 2007 . The mathematical model for the formaldehyde emission from wood-based board in room . Build Environ , 42 ( 6 ) : 2321 – 2324 .
   Google Scholar
• Myers , GE. 1986 . Formaldehyde Release from Wood Products , 87 – 106 . American Chemical Society (ACS) Symposium Series, Washington DC, USA .
   Google Scholar
• Agency for Toxic Substances and Disease Registry . 2007 . Toxicological Profile for Formaldehyde , 512 – 521 . Atlanta : Public Health Service, US Department of Health and Human Services .
   Google Scholar
• International Agency for Research on Cancer (IARC) . 1995 . Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Wood Dust and Formaldehyde , Lyon, , France : International Association for Research on Cancer .
   Google Scholar
• July 1999 . “ Agency for Toxic Substance & Disease Registry/Environmental Protection Agency ” . In Toxicological Profile for Formaldehyde , 468 – 476 . Dept. of Health and Human Services .
   Google Scholar
• Turrio-Baldassarri , L , Battistelli , C L , Conti , L , Crebelli , R , Berardis , B D Iamiceli , A L . 2004 . Emission comparison of urban bus engine fueled with diesel oil and “biodiesel” blend . Sci Total Environ. , 327 : 147 – 162 .
   PubMed Web of Science ®Google Scholar
• Baker , R R . 2006 . The generation of formaldehyde in cigarettes—overview and recent experiments . Food Chem Toxicol. , 44 : 1799 – 1822 .
   PubMed Web of Science ®Google Scholar
• Reuss , G , Disteldorf , W , Gamer , A O and Hilt , A . 2003 . “ Formaldehyde ” . In Ullmann's Encyclopedia of Industrial Chemistry , 6th rev. ed , Vol. 15 , 1 – 34 . Weinheim : Wiley-VCH Verlag GmbH .
   Google Scholar
• Groah , W J , Bradfield , J , Gramp , G , Rudzinski , R and Heroux , G . 1991 . Comparative response of reconstituted wood products to European and North American test methods for determining formaldehyde emissions . Environ Sci Technol , 25 : 117 – 122 .
   Google Scholar
• World Health Organization . 1989 . Formaldehyde (Environmental Health Criteria 89) , Geneva : International Programme on Chemical Safety .
   Google Scholar
• Gerberich , H R and Seaman , G C . 2004 . “ Formaldehyde ” . In Kirk–Othmer Encyclopedia of Chemical Technology , 5th ed. , Edited by: Kroschwitz , J I and Howe-Grant , M . Vol. 11 , 929 – 951 . New York : John Wiley and Sons .
   Google Scholar
• Bizzari , S. 2007 . CEH Marketing Research Report: Formaldehyde , 106 658.5000 A. SRI International .
   Google Scholar
• Bizzari , S and Formaldehyde . 2010 . Available at: http://www.sriconsulting.com/CEH/Public/Reports/658.5000/
   Google Scholar
• Chemical Information Services . 2004 . “ Directory of World Chemical Producers ” . Dallas, TX Available at: www.chemicalinfo.com
   Google Scholar
• Park , B-D , Kang , E-C and Park , J-Y . 2008 . Thermal curing behavior of modified urea-formaldehyde resin adhesives with two formaldehyde scavengers and their influence on adhesion performance . J App Poly Sci , 110 : 1573 – 1580 .
   Web of Science ®Google Scholar
• ChemSources . 2009 . “ Formaldehyde. Chemical Sources International ” . Available at: http://www.chemsources.com/ (accessed April 30, 2009)
   Google Scholar
• 2009 . “ ChemSources. Paraformaldehyde. Chemical Sources International ” . Available at: http://www.chemsources.com/ (accessed April 30, 2009)
   Google Scholar
• ChemSources . 2009 . “ Trioxane ” . Chemical Sources International . Available at: http://www.chemsources.com/ (accessed April 30, 2009)
   Google Scholar
• 2001 . Documentation of the Threshold Limit Values and Biological Exposure Indices , 7th ed. , 26 Cincinnati : American Conference of Government Industrial Hygienists . Author
   Google Scholar
• World Health Organization . 2003 . Formaldehyde , A CICAD (Concise International Chemical Assessment Document) No. 40. International Programme on Chemical Safety (IPSC) .
   Google Scholar
• Franks , S J . 2005 . A mathematical model for the absorption and metabolism of formaldehyde vapour by humans . Toxicol Appl Pharmacol. , 206 : 309 – 320 .
   PubMed Web of Science ®Google Scholar
• Kulle , T J . 1993 . Acute odor and irritation response in healthy nonsmokers with formaldehyde exposure . Inhal Toxicol. , 5 : 323 – 332 .
   Web of Science ®Google Scholar
• Paustenbach , D , Alarie , Y , Kulle , T , Schachter , N , Smith , R Swenberg , J . 1997 . A recommended occupational exposure limit for formaldehyde based on irritation . J Toxicol Environ Heal. , 50 : 217 – 263 .
   PubMed Web of Science ®Google Scholar
• Neuss , S , Holzmann , K and Speit , G . 2010 . Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro . Toxicol Lett , 198 ( 2 ) : 289 – 295 .
   PubMedGoogle Scholar
• Wolkoff , P and Nielsen , G D . 2010 . Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline . Environ Int , 36 ( 7 ) : 788 – 799 .
   PubMed Web of Science ®Google Scholar
• Speit , G , Schutz , P , Weber , I , Ma-Hock , L , Kaufmann , W , Gelbke , H P and Durrer , S . 2011 . Analysis of micronuclei, histopathological changes and cell proliferation in nasal epithelium cells of rats after exposure to formaldehyde by inhalation . Mutat Res , 721 : 127 – 135 .
   PubMed Web of Science ®Google Scholar
• Zhang , D Z , Zhang , F L , Jin , S Y and Liu , Y H . 1999 . Investigation on the health of workers occupationally exposed to low level of formaldehyde . Chinese J Ind Hyg Occup Dis. , 17 ( 5 ) : 13 – 14 .
   Google Scholar
• Salonen , H , Pasanen , A L , Lappalainen , S , Riuttala , H , Tuomi , T and Pasanen , P . 2009 . Volatile organic compounds and formaldehyde as explaining factors for sensory irritation in office environments . J Occup Environ Hyg , 6 ( 4 ) : 239 – 247 .
   PubMedGoogle Scholar
• 1989 . “ International Programme on Chemical Safety ” . In Formaldehyde , Environmental Health Criteria 89 Geneva : World Health Organization .
   Google Scholar
• National Poisons Information Service . 2002 . Formaldehyde , TOXBASE® .
   Google Scholar
• Hao , G , Liu , L and Wu , J . 1998 . Clinical analysis on 17 cases of acute poisoning caused by the inhalation of formaldehyde . Hebei Med , 4 ( 6 ) : 58 – 69 .
   Google Scholar
• Liu , W J and Song , J L . 2001 . Analysis on a case of formaldehyde poisoning . J Chinese People's Pub Secur Uni , 24 : 22 – 23 .
   Google Scholar
• Li , S and Song , Z . 2006 . An incident of food poisoning in students caused by formaldehyde . Chinese J Sch Heal. , 27 : 341 – 348 .
   Google Scholar
• Zhang , L , Li , J , Xu , C , Xu , J and Liu , H F . 2006 . A research on the formaldehyde residua in preserved sleeve fish and its influencing factors . Shanghai J Preven Med. , 18 ( 4 ) : 179 – 183 .
   Google Scholar
• Cronin , E . 1991 . Formaldehyde is a significant allergen in women with hand eczema . Contact Dermatitis , 25 ( 5 ) : 276 – 282 .
   PubMedGoogle Scholar
• Meding , B and Swanbeck , G . 1990 . Occupational hazard in an industrial city . Contact Dermatitis , 22 ( 1 ) : 13 – 23 .
   PubMedGoogle Scholar
• Flyvholm , M A and Menne , T . 1992 . Allergic contact dermatitis from formaldehyde: A case study focusing on sources of formaldehyde exposure . Contact Dermatitis , 27 ( 1 ) : 27 – 36 .
   PubMedGoogle Scholar
• Sanchez , I , Rodriguez , F , Quinones , D , Garcia-Abujeta , J L , Fernandez , L and Martin-Gil , D . 1997 . Occupational dermatitis due to formaldehyde in newspaper . Contact Dermatitis , 37 ( 3 ) : 131 – 132 .
   PubMedGoogle Scholar
• Scheman , A J , Carroll , P A , Brown , K H and Osburn , A H . 1998 . Formaldehyde-related textile allergy: An update . Contact Dermatitis , 38 ( 6 ) : 332 – 336 .
   PubMedGoogle Scholar
• Rudzki , E , Rebandel , P and Grzywa , Z . 1989 . Patch tests with occupational contactants in nurses, doctors and dentists . Contact Dermatitis , 20 ( 4 ) : 247 – 259 .
   PubMedGoogle Scholar
• Rastogi , S C . 1992 . A survey of formaldehyde in shampoos and skin creams on the Danish market . Contact Dermatitis , 27 ( 4 ) : 235 – 240 .
   PubMedGoogle Scholar
• Su , H and Zheng , R . 1995 . Four contact dermatitis cases exposed to phenolic aldehyde resin . J Preven Med , 1 : 1 – 8 .
   Google Scholar
• Wu , D F and Wu , Y H . 2001 . Investigation of dermatitis caused by occupational formaldehyde exposure . J Labour Med , 18 ( 4 ) : 226 – 227 .
   Google Scholar
• Brooks , S M , Hammad , Y , Richards , I , Giovonco-Barbas , J and Jenkins , K . 1998 . The spectrum of irritant-induced asthma: sudden and not-so sudden onset and the role of allergy . Chest , 113 : 42 – 49 .
   PubMed Web of Science ®Google Scholar
• Vandenplas , O , Fievez , P , Delwiche , J P , Boulanger , J and Thimpont , J . 2004 . Persistent asthma following accidental exposure to formaldehyde . Allergy , 59 : 115 – 116 .
   PubMedGoogle Scholar
• Yue , W , Jin , X B , Pan , X C and Ding , J . 2004 . Relationship between indoor air formaldehyde exposure and allergic asthma in adults. Chinese J Pub Heal . 20 ( 8 ) : 904 – 906 .
   Google Scholar
• Rumchev , K B , Spickett , J T , Bulsara , M K , Phillips , M R and Stick , S M . 2002 . Domestic exposure to formaldehyde significantly increases the risk of asthma in young children . Eur Resp J. , 20 ( 2 ) : 403 – 408 .
   PubMed Web of Science ®Google Scholar
• McGwin , G , Lienert , J and Kennedy , J I . 2010 . Formaldehyde exposure and asthma in children: A systematic review . Environ Health Perspect , 118 ( 3 ) : 313 – 317 .
   PubMed Web of Science ®Google Scholar
• Krakowiak , A , Gorski , P , Pazdrak , K and Ruta , U . 1998 . Airway response to formaldehyde inhalation in asthmatic subjects with suspected respiratory formaldehyde sensitization . Am J Indus Med. , 33 : 274 – 281 .
   PubMed Web of Science ®Google Scholar
• Kim , C W , Song , J S , Ahn , Y S , Park , S H , Noh , J H and Hong , C S . 2001 . Occupational asthma due to formaldehyde . Yonsei Med J , 42 : 440 – 445 .
   PubMed Web of Science ®Google Scholar
• Dai , D and Bao , Z . 1999 . Investigative report on formaldehyde occupational workers . Ind Heal Occup Dis. , 1 : 43 – 51 .
   Google Scholar
• Li , Z G and Chen , B C . 2002 . Effect of low concentration formaldehyde on the health of workers . Chinese J Ind Med. , 15 ( 5 ) : 302 – 303 .
   Google Scholar
• Costa , S , Pina , C , Coelho , P , Costa , C , Silva , S Porto , B . 2011 . Occupational exposure to formaldehyde: Genotoxic risk evaluation by comet assay and micronucleus test using human peripheral lymphocytes . J Toxicol Environ Health A , 74 : 1040 – 1051 .
   PubMed Web of Science ®Google Scholar
• Geng , Y , Meng , X , Li , X and Lu , G . 2004 . Occupational damage in densified wood board producing field and its effect on workers’ health . Occup Heal. , 20 ( 8 ) : 21 – 22 .
   Google Scholar
• Fan , W , Zhou , Y , Jin , F , Du , L and Jin , X . 2006 . The health effects of pathologists exposed to formaldehyde . J Occup Environ Med. , 23 ( 6 ) : 466 – 468 .
   Google Scholar
• Rager , J E , Smeester , L , Jaspers , I , Sexton , K G and Fry , R C . 2011 . Epigenetic changes induced by air toxics: Formaldehyde exposure alters miRNA expression profiles in human lung cells . Environ Health Perspect , 119 ( 4 ) : 494 – 500 .
   PubMed Web of Science ®Google Scholar
• Bono , R , Romanazzi , V , Munnia , A , Piro , S , Allione , A Ricceri , F . 2010 . Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: The role of air formaldehyde exposure . Chem Res Toxicol , 23 ( 8 ) : 1342 – 1348 .
   PubMedGoogle Scholar
• Feng , Y , Wang , W , Jiang , Z , Hu , G , Zhong , S and Zhang , H . 1996 . Health status of wood workers exposed to formaldehyde . Anhui J Preven Med. , 2 ( 2 ) : 99 – 100 .
   Google Scholar
• Tang , L X and Zhang , Y S . 2003 . Health investigation on workers exposed to formaldehyde . Occup Heal. , 19 ( 7 ) : 34 – 35 .
   Google Scholar
• Lu , Y , Chen , X J , Yang , X Y and Xue , Z Q . 2007 . A survey of the effection to teachers’ health from formaldehyde contact . J Xinjiang Med Uni. , 30 ( 3 ) : 234 – 237 .
   Google Scholar
• Songur , A , Ozen , O A and Sarsilmaz , M . 2010 . The toxic effects of formaldehyde on the nervous system . Rev Environ Contam Toxicol , 203 : 105 – 118 .
   PubMed Web of Science ®Google Scholar
• Armon , C. 2009 . Smoking may be considered an established risk factor for sporadic ALS . Neurology , 73 : 1693 – 1698 .
   PubMed Web of Science ®Google Scholar
• Wang , H , O’Reilly , E J , Weisskopf , M G , Logroscino , G , McCullough , M L Thun , M J . 2011 . Smoking and risk of amyotrophic lateral sclerosis: A pooled analysis of 5 prospective cohorts. . Arch Neurol. , 68 ( 2 ) : 207 – 215 .
   PubMedGoogle Scholar
• Weisskopf , M G , Morozova , N , O’Reilly , E J , McCullough , M L , Calle , E E , Thun , M J and Ascherio , A . 2009 . Prospective study of chemical exposures and amyotrophic lateral sclerosis . J Neurol Neurosurg Psychiatry. , 80 : 558 – 561 .
   PubMed Web of Science ®Google Scholar
• Cassee , F R , Arts , J H , Groten , J P and Feron , V J . 1996 . Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats . Arch Toxicol , 70 : 329 – 337 .
   PubMed Web of Science ®Google Scholar
• Hester , S D , Benavides , G B , Yoon , L , Morgan , K T , Zou , F , Barry , W and Wolf , D C . 2003 . Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium . Toxicology , 187 ( 1 ) : 13 – 24 .
   PubMedGoogle Scholar
• Appelman , L M , Woutersen , R A , Zwart , A , Falke , H E and Feron , V J . 1988 . One-year inhalation toxicity study of formaldehyde in male rats with a damaged or undamaged nasal mucosa . J Appl Toxicol , 8 ( 2 ) : 85 – 90 .
   PubMed Web of Science ®Google Scholar
• Rusch , G M , John , J , Clary , J J , Rinehart , W E and Bolte , H F . 1983 . A 26-week inhalation toxicity study with formaldehyde in the monkey, rat, and hamster . Toxicol App Pharmacol , 68 ( 3 ) : 329 – 343 .
   PubMed Web of Science ®Google Scholar
• Lacroix , J S , Kurt , A M , Pochon , N , Bretton , C , Lunberg , J M and Deshusses , J . 1995 . Neutral endopeptidase activity and concentration of sensory neuropeptide in the human nasal mucosa . Eur Arch Otorhinolaryngol , 252 : 465 – 468 .
   PubMed Web of Science ®Google Scholar
• Boysen , M , Zadig , E , Digernes , V , Abeler , V and Reith , A . 1990 . Nasal mucosa in workers exposed to formaldehyde: A pilot study . Br J Ind Med , 47 ( 2 ) : 116 – 121 .
   PubMedGoogle Scholar
• Hong , Z , Tong , Z and Shi , J . 2007 . Effects of formaldehyde on respiratory system and pulmonary function of workers . Chinese J Pub Heal. , 23 ( 7 ) : 849 – 850 .
   Google Scholar
• Wang , W , Wang , Q and Zhou , Y . 2000 . Effects of low concentration of formaldehyde on respiratory system and pulmonary function of workers . Chinese J Ind Med. , 13 ( 2 ) : 115 – 116 .
   Google Scholar
• Kriebel , D , Sama , S R and Cocanour , B . 1993 . Reversible pulmonary responses to formaldehyde. A study of clinical anatomy students . Am Rev Respirat Dis , 148 : 1509 – 1515 .
   PubMed Web of Science ®Google Scholar
• Akbar-Khanzadeh , F and Mlynek , J S . 1997 . Changes in respiratory function after one and three hours of exposure to formaldehyde in non-smoking subjects . Occup Environ Med , 54 : 296 – 300 .
   PubMedGoogle Scholar
• Tong , Z M , Zhu , S X and Shi , J . 2007 . Effect of formaldehyde on blood component and blood biochemistry of exposed workers . Chinese J Ind Med. , 20 ( 6 ) : 409 – 410 .
   Google Scholar
• Yang , W H . 2007 . Hemogram of workers exposed to low concentration of formaldehyde . Prac Preven Med. , 14 ( 3 ) : 792 – 799 .
   Google Scholar
• Huang , Y , Zou , Z and Deng , H . 2007 . An analysis report about peripheral blood anemia induced by excessive formaldehyde in abiding place. . Jiangsu Environ Sci Technol , 20 : 16 – 17 .
   Google Scholar
• Huang , W , Lu , Y , Chang , X , Bai , L , Zhao , H and Liu , W . 2007 . Indoor air pollution in newly redecorated rooms . J Environ Heal , 24 ( 2 ) : 101 – 103 .
   Google Scholar
• Kuo , H , Jian , G , Chen , C , Liu , C and Lai , J. 1997 . White blood cell count as an indicator of formaldehyde exposure . Bull Environ Cont Toxicol , 59 ( 2 ) : 261 – 267 .
   PubMedGoogle Scholar
• Zhou , D , Zhang , J and Wang , H . 2011 . Assessment of the potential reproductive toxicity of long-term exposure of adult male rats to low-dose formaldehyde . Toxicol Ind Health , 27 ( 7 ) : 591 – 598 .
   PubMed Web of Science ®Google Scholar
• Zhang , R , Lee , I K , Kang , K A , Piao , M J , Kim , K C Kim , B J . 2010 . Cytoprotective effects of triphlorethol-A against formaldehyde-induced oxidative damage and apoptosis: Role of mitochondria-mediated caspase-dependent pathway . J Toxicol Environ Health A , 73 ( 21–22 ) : 1477 – 1489 .
   PubMed Web of Science ®Google Scholar
• Xu , S Y , Yi , G L and Li , S H . 2007 . Hygienic investigation of the effect of formaldehyde on the workers’ health . Occup Heal. , 23 ( 7 ) : 491 – 492 .
   Google Scholar
• Taskinen , H K , Kyyronen , P , Hemminki , K , Hoikkala , M , Lajunen , K and Lindbohm , M L . 1994 . Laboratory work and pregnancy outcome . J Occup Med. , 36 ( 3 ) : 311 – 319 .
   PubMedGoogle Scholar
• Taskinen , H K , Kyyronen , P , Sallmen , M , Virtanen , S V , Liukkonen , T A and Huida , O . 1999 . Reduced fertility among female wood workers exposed to formaldehyde . Am J Ind Med. , 36 ( 1 ) : 206 – 212 .
   PubMedGoogle Scholar
• Zhang , L , Steinmaus , C , Eastmond , D A , Xin , X K and Smith , M T . 2009 . Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms . Muta Res , 681 : 150 – 168 .
   PubMed Web of Science ®Google Scholar
• Ladeira , C , Viegas , S , Carolino , E , Prista , J , Gomes , M C and Brito , M . 2011 . Genotoxicity biomarkers in occupational exposure to formaldehyde—The case of histopathology laboratories . Mutat Res , 721 : 15 – 20 .
   PubMed Web of Science ®Google Scholar
• Lu , K , Moeller , B , Doyle-Eisele , M , McDonald , J and Swenberg , J A . 2011 . Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde . Chem Res Toxicol , 24 : 159 – 161 .
   PubMed Web of Science ®Google Scholar
• Washam , C . 2011 . Epigenetics of formaldehyde: Altered microRNAs may be key to adverse effects . Environ Health Perspect , 119 : 176 – 182 .
   PubMedGoogle Scholar
• IARC . 2006 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 88 Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxypropan-2-ol Available at: http://monographs.iarc.fr/ENG/Monographs/vol88/index.php
   Google Scholar
• Yang , Y , Allen , B C , Tan , Y M , Liao , K H and Clewell , H J . 2010 . Bayesian analysis of a rat formaldehyde DNA-protein cross-link model . J Toxicol Environ Health A , 73 ( 12 ) : 787 – 806 .
   PubMed Web of Science ®Google Scholar
• Jiang , L . 2006 . Mensuration of indoor formaldehyde pollution of Pingdingshan municipal office building . J Pingdingshan Ins Technol. , 15 ( 3 ) : 38 – 39 .
   Google Scholar
• Tong , Z M , Shi , J , Zhao , J S , Yang , H , Jiang , R M and Kong , L . 2006 . Analysis on genetic toxicity of formaldehyde on occupational exposure population . Chinese J Pub Heal. , 22 ( 7 ) : 783 – 784 .
   Google Scholar
• Cheng , Y , Ying , C , Yan , W , Zhang , J and Zhang , M . 1995 . Nasal mucosa epithelial cell and lymphoblast micronuclei of formaldehyde exposed population . Sanit Antiepid Stat Jingsha City. , 14 ( 5 ) : 293 – 295 .
   Google Scholar
• Knasmueller , S , Holland , N , Wultsch , G , Jandl , B , Burgaz , S and Nersesyan , A . 2011 . Use of nasal cells in micronucleus assays and other genotoxicity studies . Mutagenesis , 26 ( 1 ) : 231 – 238 .
   PubMedGoogle Scholar
• Ye , X , Yan , W , Xie , H , Zhao , M and Ying , C . 2005 . Cytogenetic analysis of nasal mucosa cells and lymphocytes from high-level long-term formaldehyde exposed workers and low-level short-term exposed waiters . Muta Res. , 588 ( 1 ) : 22 – 27 .
   PubMedGoogle Scholar
• Yu , L Q , Jiang , S F , Leng , S G , Zhang , C Z , Yan , Y J and Niu , Y . 2005 . Early genetic effects on workers occupationally exposed to formaldehyde . Chinese J Preven Med. , 39 ( 6 ) : 392 – 395 .
   Google Scholar
• Costa , S , Coelho , P , Costa , C , Silva , S , Mayan , O and Santos , L S . 2008 . Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde . Toxicology , 252 : 40 – 48 .
   PubMed Web of Science ®Google Scholar
• Neri , M , Bonassi , S , Knudsen , L E , Sram , R J , Holland , N and Ugolini , D . 2006 . Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Overview and critical issues . Mutat Res. , 612 ( 1 ) : 1 – 13 .
   PubMedGoogle Scholar
• Environment Canada/Health Canada. Canadian Environmental Protection Act . 1999 . “ Priority substances list assessment report. Formaldehyde ” . Government of Canada, Environment Canada, Health Canada . 2001
   Google Scholar
• World Health Organization . 2002 . Concise International Chemical Assessment Document 40. Formaldehyde , Geneva : Author .
   Google Scholar
• McGregor , D , Bolt , H , Cogliano , V and Richter-Reichhelm , H B . 2006 . Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS Human Framework for the Analysis of a cancer mode of action for humans . Crit Rev Toxicol , 36 ( 10 ) : 821 – 835 .
   PubMed Web of Science ®Google Scholar
• Jakab , M G , Klupp , T , Besenyei , K , Biro , A , Major , J and Tompa , A . 2010 . Formaldehyde-induced chromosomal aberrations and apoptosis in peripheral blood lymphocytes of personnel working in pathology departments . Mutat Res , 698 ( 1–2 ) : 11 – 17 .
   PubMedGoogle Scholar
• Korobitsyn , B A . 2011 . Multiplicative model for assessment of chemical-induced cancer risk . Int J Environ Health Res , 21 : 1 – 21 .
   PubMed Web of Science ®Google Scholar
• 2011 . “ National Toxicology Program (NTP) ” . In Report on Carcinogens , 12th ed , Department of Health and Human Services, Public Health Service, National Toxicology Program . Available at: http://ntp.niehs.nih.gov/go/roc12
   Google Scholar
• Integrated Risk Information System . 2010 . Formaldehyde , Washington, DC : US Environmental Protection Agency . Available at: http://cfpub.epa.gov/ncea/iris_drafts/recordisplay.cfm?deid=223614
   Google Scholar
• Meng , F , Bermudez , E , McKinzie , P B , Andersen , M E , Clewell , H J and Parsons , B L . 2010 . Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde . Regul Toxicol Pharmacol , 57 ( 2–3 ) : 274 – 283 .
   PubMed Web of Science ®Google Scholar
• Thompson , C M and Grafstrom , R C . 2011 . Considerations for the implausibility of leukemia induction by formaldehyde . Toxicol Sci , 120 : 230 – 232 .
   PubMedGoogle Scholar
• Schwilk , E , Zhang , L , Smith , M T , Smith , A H and Steinmaus , C . 2010 . Formaldehyde and leukemia: An updated meta-analysis and evaluation of bias . J Occup Environ Med , 52 : 878 – 886 .
   PubMed Web of Science ®Google Scholar
• Pinkerton , L , Hein , M and Stayner , L . 2004 . Mortality among a cohort of garment workers exposed to formaldehyde: An update . Occup Environ Med , 61 ( 3 ) : 193 – 200 .
   PubMed Web of Science ®Google Scholar
• Hauptmann , M , Stewart , P A and Lubin , J H . 2009 . Morality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde . J Nat Cancer Ins. , 101 : 1696 – 1708 .
   PubMed Web of Science ®Google Scholar
• Dreyfuss , J H . 2010 . Occupational formaldehyde exposure linked to increased risk of myeloid leukemia and death . CA Cancer J Clin , 60 ( 3 ) : 135 – 136 .
   PubMedGoogle Scholar
• Hauptmann , M , Lubin , J H , Stewart , P A , Hayes , R B and Blair , A . 2003 . Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries . J Nat Cancer Ins. , 95 ( 21 ) : 1915 – 1923 .
   Google Scholar
• Coggon , D , Harris , E C and Poole , J . 2003 . Extended follow-up of a cohort of British chemical workers exposed to formaldehyde . J Nat Cancer Ins. , 95 ( 21 ) : 1608 – 1615 .
   PubMedGoogle Scholar
• Marsh , G M and Youk , A O . 2004 . Reevaluation of mortality risks from leukemia in the formaldehyde cohort study of the National Cancer Institute . Regulatory Toxicology and Pharmacology , 40 ( 2 ) : 113 – 124 .
   PubMedGoogle Scholar
• Gardner , M J , Pannett , B , Winter , P D and Cruddas , A M . 1993 . A cohort study of workers exposed to formaldehyde in the British chemical industry: An update . Br J Indus Med , 50 : 827 – 834 .
   PubMedGoogle Scholar
• Andjelkovich , D A , Shy , C M , Brown , M H , Jansen , D B and Richardson , R B . 1994 . Mortality of iron foundry workers. III. Lung cancer case-control study . J Occup Med. , 36 : 1301 – 1309 .
   PubMedGoogle Scholar
• Hansen , J and Olsen , J H . 1995 . Formaldehyde and cancer morbidity among male employees in Denmark . Cancer Causes Control , 6 : 354 – 360 .
   PubMed Web of Science ®Google Scholar
• Lu , K , Collins , L B , Ru , H , Bermudez , E and Swenberg , J A . 2010 . Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia . Toxicol Sci , 116 ( 2 ) : 441 – 451 .
   PubMed Web of Science ®Google Scholar
• Blair , A , Saracci , R and Stewart , P A . 1990 . Epidemiologic evidence on the relationship between formaldehyde exposure and cancer . Scand J Work Environ Hea. , 16 : 381 – 393 .
   PubMed Web of Science ®Google Scholar
• Partanen , T . 1993 . Formaldehyde exposure and respiratory cancer- a meta-analysis of the epidemiologic evidence . Scand J Work Environ Heal , 19 : 8 – 15 .
   PubMed Web of Science ®Google Scholar
• Andersen , M E , Clewell , H J , Bermudez , E , Dodd , D E , Willson , G A , Campbell , J L and Thomas , R S . 2010 . Formaldehyde: Integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound . Toxicol Sci , 118 ( 2 ) : 716 – 731 .
   PubMed Web of Science ®Google Scholar
• European Union . 2008 . “ Commission of the European Communities No 2008/0025. Regulation of the European Parliament and of the Council: On cosmetic products ” . Available at: http://ec.europa.eu/enterprise/cosmetics/doc/com_2008_49/com_2008_49_en.pdf
   Google Scholar
• Regulation Concerning Occupational Health and Safety . Government of Quebec. Regulations on health and safety. Gazette officielle du Québec, Part 2 . Laws and Regulations , 133 5020 – 33 . Quebec; 2001
   Google Scholar
• NTP . 2010 . “ Final report on carcinogens background document for formaldehyde ” . Research Triangle Park, NC : US Department of Health and Human Services, Public Health Service, National Toxicology Program . Available at: http://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/November/Formaldehyde_BD_Final.pdf
   Google Scholar
• IARC . 2009 . “ A review of human carcinogens—Part F: Chemical agents and related occupations ” . International Agency for Research on Cancer . Available at: http://monographs.iarc.fr/pdfnews/WG-100F.pdf
   Google Scholar
• Occupational Safety and Health Administration . Toxic and hazardous substances. Formaldehyde. Occupational Safety and Health Administration. Code of Federal Regulations. 29 CFR 1910.1048. 2007 .
   Google Scholar
• Environmental Protection Agency . “ Designation of hazardous substances ” . US Environmental Protection Agency. Code of Federal Regulations. 40 CFR 302.4. 2008 . Available at: http://www.epa.gov/lawsregs/search/40cfr.html
   Google Scholar
• Food and Drug Administration . 2008 . “ EAFUS: A food additive database ” . US Food and Drug Administration . Available at: http://vm.cfsan.fda.gov/~dms/eafus.html
   Google Scholar
• Carraro , E , Gasparini , S and Gilli , G . 1999 . Identification of a chemical marker of environmental exposure to formaldehyde . Environ Res. , 80 : 132 – 137 .
   PubMed Web of Science ®Google Scholar
• Vinzents , P and Laursen , B . 1993 . A national cross-sectional study of the working environment in the Danish wood and furniture industry—Air pollution and noise . Ann Occup Hyg , 37 : 25 – 34 .
   PubMedGoogle Scholar
• Malaka , T and Kodama , A M . 1990 . Respiratory health of plywood workers occupationally exposed to formaldehyde . Arch Environ Heal , 45 ( 5 ) : 288 – 294 .
   PubMed Web of Science ®Google Scholar
• Wu , P-C , Li , Y-Y , Lee , C-C , Chiang , C-M and Su , H-JJ . 2003 . Risk assessment of formaldehyde in typical office buildings in Taiwan . Indoor Air , 13 : 359 – 363 .
   PubMed Web of Science ®Google Scholar
• Burgaz , S , Cakmak , G , Erdem , O , Yilmaz , M and Karakaya , A E . 2001 . Micronuclei frequencies in exfoliated nasal mucosa cells from pathology and anatomy laboratory workers exposed to formaldehyde . Neoplasma , 48 : 144 – 147 .
   PubMed Web of Science ®Google Scholar
• Milton , D K , Walters , M D , Hammond , K and Evans , J S . 1996 . Worker exposure to endotoxin, phenolic compounds, and formaldehyde in a fiberglass insulation manufacturing plant . Am Ind Hygiene Assoc J , 57 : 889 – 896 .
   PubMed Web of Science ®Google Scholar
• Anderson , L G , Lanning , J A , Barrell , R , Miyagishima , J , Jones , R H and Wolfe , P . 1996 . Sources and sinks of formaldehyde and acetaldehyde: An analysis of Denver's ambient concentration data . Atmos Environ. , 30 : 2113 – 2123 .
   Web of Science ®Google Scholar
• Bolstad-Johnson , D M , Burgess , J L , Crutchfield , C D , Storment , S , Gerkin , R and Wilson , J R . 2000 . Characterization of firefighter exposures during fire overhaul . Am Ind Hyg Assoc J , 61 : 636 – 641 .
   Web of Science ®Google Scholar
• Suruda , A , Schulte , P , Boeniger , M , Hayes , R B , Livingston , G K Steenland , K . 1993 . Cytogenetic effects of formaldehyde exposure in students of mortuary science . Cancer Epidemiol Biomark Preven. , 2 : 453 – 460 .
   PubMed Web of Science ®Google Scholar
• Wiglusz , R , Nikel , G , Igielska , B and Sitko , E . 2002 . Volatile organic compound emissions from particleboard veneered with decorative paper foil . Holzforschung , 56 : 108 – 110 .
   Google Scholar
• Kim , S and Kim , H-J . 2005 . Comparison of formaldehyde emission from building finishing materials at various temperatures in under heating system . Indoor Air , 15 : 317 – 325 .
   PubMed Web of Science ®Google Scholar
• Kelly , T J , Smith , D L and Satola , J . 1999 . Emission rates of formaldehyde from materials and consumer products found in California homes . Environ Sci Technol , 33 : 81 – 88 .
   Web of Science ®Google Scholar
• Arbejdstilsynet [Danish Working Environment Authority] . 2002 . “ Limit Values for Substances and Material ” . Copenhagen : WEA-Guide .
   Google Scholar
• Institut national de Recherche et de Securite . Threshold Limit Values for Occupational Exposure to Chemicals in France; 2005 .
   Google Scholar
• Health & Safety Executive . 2002 . Occupational Exposure Limits 2002 , (EH40/2002) Norwich : Her Majesty’ Stationery Office; .
   Google Scholar
• Suva , G and Luzern , A . 2003 . Swiss Accident Insurance (Swiss OELs) .
   Google Scholar
• American Conference of Government Industrial Hygienists . 2007 . “ Formaldehyde. Threshold limit values for chemical substances and physical agents and biological exposure indices ” . 31 Cincinnati : Author .
   Google Scholar
• Formaldehyde , NIOSH. 2005 . NIOSH Pocket Guide to Chemical Hazards , Atlanta, GA : National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention . Available at: http://www.cdc.gov/niosh/npg/
   Google Scholar
• Environmental Protection Agency . 2007 . “ Acute exposure guideline levels (AEGLs) ” . Washington, DC : Office of Pollution Prevention and Toxics, US Environmental Protection Agency . Available at: http://www.epa.gov/oppt/aegl/pubs/compiled.pdf
   Google Scholar