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Original Articles

Di‐n‐Butyl phthalate: Evaluation of risks to health from environmental exposure in Canada

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Pages 257-268 | Published online: 19 Nov 2008

References

  • Abe , S. and Sasaki , M. 1977 . Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals . J. Natl. Cancer Inst. , 58 : 1635 – 1641 .
  • Aitio , A. and Parkki , M. 1978 . Effect of phthalate esters on drug metabolising enzyme activities in rat liver . Arch. Int. Pharmacodyn. , 235 : 187 – 195 .
  • Aldyreva , M.V. , Klimova , T.S. , Izyumova , A.S. and Timofieskaya , L.A. 1975 . Effect of plasticisers on reproductive function . Gig. Tr. Prof. Zabol. , 12 : 25 – 29 . (cited in HSE, 1986)
  • Antonyuk , O.K. and Aldyreva , M.V. 1973 . Substantiation of the maximum allowable concentration of dibutyl phthalate in the air of industrial premises . Gig. trud. Prof. Zabol. , : 26 – 30 . (cited in HSE, 1986)
  • Barber , E.D. , Astill , B.D. , Moran , E.J. , Schneider , B.F. , Gray , T.J.B. , Lake , B.G. and Evans , J.G. 1987 . Peroxisome induction studies on seven phthalate esters . Toxicol. Ind. Health. , 3 : 7 – 24 .
  • Bell , F.P. , Patt , C.S. , Brundage , B. , Gillies , P.J. and Phillips , W.A. 1978 . Studies on lipid biosynthesis and cholesterol content of liver and serum lipoproteins in rats fed various phthalate esters . Lipids , 13 : 66 – 74 .
  • Bornmann , G. and Loeser , A. 1956 . The reaction of the body to the action of various plasticizers . Zeit. Lebensmittel‐Untersuchung Forsch. , 103 : 413 – 434 . (cited in HSE)
  • Cater , B.R. , Cook , M.W. , Gangolli , S.D. and Grasso , P. 1977 . Studies on dibutyl phthalate‐induced testicular atrophy in the rat: Effect on zinc metabolism . Toxicol. Appl. Pharmacol. , 41 : 609 – 618 .
  • CIRC (Cosmetic Ingredient Review Committee) . 1985 . Final report on the safety assessment of dibutyl phthalate, and diethyl phthalate . Journal of the American College of Toxicology , 4 : 267 – 303 .
  • Cummings , A.M. and Gray , L.E. Jr. 1987 . Dibutyl phthalate: maternal effects versus fetotoxicity . Toxicol. Lett. , 39 : 43 – 50 .
  • EHD (Environmental Health Drectorate) . 1992 . Determination of “Toxic”; under Paragraph 11c) of the Canadain Environmental Protection Act , Ottawa, Ontario, , Canada : Bureau of Chemical Hazards, Environmental Health Directorate, Health Protection Branch, Department of National Health and Welfare . Unpublished
  • Florin , I. , Rutberg , L. , Curvall , M. and Enzell , C.R. 1980 . Screening of tobacco smoke constituents for mutagenicity using the Ames’ test . Toxicology. , 18 : 219 – 232 .
  • Fukuoka , M. , Tanmoto , T. , Zhou , Y. , Kawasaki , N. , Tan , A. , Ikekoto , I. and Machida , T. 1989 . Mechanism of testicular atrophy induced by di‐n‐butyl phthalate in rats. Part 1 . J. Appl. Toxicol. , 9 : 277 – 283 .
  • Fukuoka , M. , Zhou , Y. , Tanaka , A. , Ikemoto , I. and Machida , T. 1990 . Mechanism of testicular atrophy induced by di‐n‐butyl phthalate in rats. Part 2. The effects on some testicular enzymes . J. Appl. Toxicol. , 10 : 285 – 293 .
  • Gilloli , R. , Bulgherain , C. , Terrana , T. , Filippini , G. , Massette , N. and Boeri , R. 1978 . Horizontal and longitudinal study of a population employed in the production of phthalates . Med. Lav. , 69 : 620 – 631 .
  • Golder Associates . 1987 . Testing of Specific Organic Compounds in Sods in Background Urban Area, Port Credit and Oakville/Burtington. Ontario. , Shell Canada Limited and Texaco Canada Limited . Working paper to
  • Golder Associates, SENES Consultants Limited and CanTox . 1987 . Summary Interpretation of the Influence of Soil Conditions on the Decommissioning of the Oakville Refinery Site. , Working paper 4 Shell Canada Limited .
  • Gray , L.E. Jr. , Laskey , J.W. , Ostby , J. and Ferrell , J. 1983 . The effects of dibutyl phthlate on the reproductive tract of the male and female rat and hamster . Toxicologist. , 3 : 22 (abstract #87)
  • Gray , T.J.B. and Butterworth , K.R. 1980 . Testicular atrophy produced by phthalate esters . Arch. Toxicol. , : 452 – 455 .
  • Gray , T.J.B. , Rowland , I.R. , Foster , P.M.D. and Gangolli , S.D. 1982 . Species differences in the testicular toxicity of phthalate esters . Toxicol. Lett. , 11 : 141 – 147 .
  • Halina , G.P. 1993 . Alberta Environment , (personal communication, unpublished data)
  • Hamano , Y. , Kuwano , A. , Inoue , K. , Oda , Y. , Yamamoto , H. , Mitsuda , B. and Kunita , N. 1977 . Studies on toxicity of phthalic acid esters, 1st Report ‐ Teratogenic effects in mice administered orally . Osaka‐furitsu Koshu Esei kenkytuho Kenkyxl Hokokm Shokukhim Esei Hen. , 8 : 29 – 33 .
  • Hardin , B.D. , Schuler , R.L. , Burg , J. R. , Booth , G.M. , Hazelden , K.P. , Mackenzie , K.M. , Piccirillo , V.J. and Smith , K.N. 1987 . Evaluation of 60 chemicals in a preliminary developmental toxicity test . Teratogen. Carcinogen. Mutagen. , 7 : 29 – 48 .
  • Hoff , R.M. and Chan , K.W. 1987 . Measurement of polycyclic aromatic hydrocarbons in air along the Niagara river . Environ. Sd. Techno). , 21 : 556 – 561 .
  • HSE (Health and Safety Executive) . 1986 . Review of the Toxicity of the Esters of o‐Phthalic Add (Phthalate Esters). , Toxicity Review 14 183 London : HMSO publications .
  • Ikemoto , I. , Kotera , S. , Katsurai , K. , Inaba , Y. , Machida , T. and Tanaka , A. 1983 . Experimental testicular damage induced by dibutyl phthalate and monobutyl phthalate . Japanese Journal of Fertility and Sterility , 28 : 17 – 23 .
  • Ishidate , M. and Odashima , S. 1977 . Chromosome tests with 134 compounds on Chinese hamster cells in vitro ‐ a screening for chemical carcinogens . Mutat. Res. , 48 : 337 – 354 .
  • Kawano , M. 1980 . Toxicological studies on phthalate esters. 1. Inhalation effects of dibutyl phthalate (DBP) on rats . Jpn. J. Hyg. , 35 : 684 – 692 .
  • Kawashima , Y. , Hanioka , N. , Matsumura , M. and Kozuka , H. 1983 . Induction of microsomal stearoyt‐CoA desaturation by the administration of various peroxisome proliferators . Biochim. Biophys. Acta , 752 : 259 – 264 .
  • Killinger , J. , Basarau , A. , Mezza , L. , Persing , R. , Peters , A and Melnick , R. 1989 . Perinatal dose study of dibutyl phthalate in rats and mice . Toxicologist. , 9 : 273 (abstract no. 1095)
  • Killinger , J. , Melnick , R. , Basarau , A. , Hite , J. , Ryan , M. , Sawhney , A. and Kurtz , P. 1991 . Effect of dibutyl phthalate on the F344 rat with and without in utero exposure . Toxicologist. , 11 : 341 (abstract no. 1338)
  • Kozumbo , W.J. , Kroll , R. and Rubin , R.J. 1982 . Assessment of the mutagenicity of phthalate esters . Environ. Health Perspect. , 45 : 103 – 109 .
  • Krauskopf , L.G. 1973 . Studies of the toxicity of phthalates via ingestion . Environ. Health Perspect. , 3 : 61 – 72 .
  • Lake , B.Q. , Cook , W.M. , Worrell , N.R. , Cunmnghame , M.E. , Evans , J.G. , Price , R.J. , Young , P.J. and Carpanini , F.M.B. 1991 . Dose‐response relationships for induction of hepatic peroxisome proliferation and testicular atrophy by phthalate esters in the rat . Hum. Exp. Toxicol. , 10 : 67 (abstract)
  • Lamb , J.C. , Chapin , R.E. , Teague , J. , Lawton , A.D. and Rell , J.R. 1987 . Reproductive effects of four phthalic acid esters in the mouse . Toxicol. Appl. Pharmacol. , 88 : 255 – 269 .
  • Lehman , A.J. 1955 . Insect repellents . Assoc. Food Drug Off. , 19 : 87 – 99 .
  • Meek , M.E. , Newhook , R. , Liteplo , R.G. and Armstrong , V.C. 1994 . Approach to assessment of risk to human health for Priority Substances under the Canadian Environmental Protection Act . J. Environ. Sci Health , C12 (2) : 105 – 134 .
  • Men'shikova , T.A. 1971 . Hygienic evaluation of dibutyl phthalate in relation to the use of polymer finishes in shipboard living quarters . Hyg. Sanit. , 36 : 349 – 353 . (cited in HSE. 1986)
  • Milkov , L.E. , Aldyrova , M.V. , Popova , T.B. , Lopukhova , K.A. , Makarenko , Y.L. , Malyar , L.M. and Shakhova , T.K. 1973 . Health status of workers exposed to phthalate plasticizers in the manufacture of artificial leather and films based on PVC resins . Environ. Health Perspect. , 3 : 175 – 178 .
  • MOE (Ontario Ministry of the Envronment) . 1984 . Drinking Water Survey of Selected Municipalities in the Niagara Area and Lake Ontario
  • Murakami , K. , Nishiyama , K. and Higuti , T. 1986a . Mitochondrial effect of orally administered dibutyl phthalate in rats . Jap. J. Hyg. , 41 : 769 – 774 .
  • Murakami , K. , Niswyama , K. and Higuti , T. 1986b . Toxicity of dibutyl phthalate and its metabolites in rats . Jap. J. Hyg. , 41 : 775 – 780 .
  • NHW (National Health and Welfare) . 1992 . Market basket survey of foods from Halifax. , Ottawa : Food Research Division. Food Directorate, Health Protection Branch . (unpublished results)
  • Nikonorow , M. , Mazur , H. and Piekacz , H. 1973 . Effect of orally administered plasticizers and polyvinyl chloride stabilizers in the rat . Toxicol. Appl. Pharmacol. , 26 : 253 – 259 .
  • Oishi , S. and Hiraga , K. 1980a . Testicular atrophy induced by phthalic acid esters. Effect on testosterone and zinc concentrations . Toxicol. Appl. Pharmacol. , 53 : 35 – 41 .
  • Obhi , S. and Hiraga , K. 1980b . Effect of phthalic acid esters on mouse testes . Toxicol. Lett. , 5 : 413 – 416 .
  • Ota , H. , Takashima , K. , Takashima , Y. , Onda , H. , Kodama , H. and Yamada , N. 1973 . Biological effects of phthalate esters (I): Histopathological findings from experiments in mice . Nippon Byorigakkai Kaishi , 62 : 119 – 120 .
  • Ota , H. , Onda , H. , Kodama , H. and Yamada , N. 1974 . Biological effects of phthalate esters. Histopathological investigation by experiments on mice . Nippon Eiseigaku Kaishi , 29 : 519 – 524 .
  • Otson , R. and Benoit , F.M. Indoor Air Quality in Cold Climates. An Air Pollution Control Association Speciality Conference . Surveys of selected organics in residential air , Edited by: Walkinshaw , D.S. pp. 224 – 236 .
  • Radeva , M. and Dinoyeva , S. 1966 . The toxicity of the plasticiser dibutyl phthlate with oral administration to white rats . Khig. i. Zdrav. , 9 : 510 – 515 . (cited in HSE. 1986)
  • Reel , J.R. , Lawton , A.D. and Lamb , J.C. 1984 . Di(n‐butyl) Phthalate: Reproduction and Fertility Assessment in CD‐1 Mice when Administered in the Feed , 100 National Toxicology Program . NTIS Publication Number PB85–144798
  • Shahim , M.M. and von Borstel , R.C. 1977 . Mutagenic and lethal effects of α‐benzenehexachloride, dibutyl phthalate and trichloroethylene in Saccharomyces cerevisiae . Mutat. Res. , 48 : 173 – 180 .
  • Shiota , K. , Chou , M.J. and Nishmura , H. 1980 . Embryotoxic effects of di(2‐ethylhexyl)phthalate (DEHP) and di‐n‐butyl phthalate (DBP) in mice . Environ. Res. , 22 : 245 – 253 .
  • Shiota , K. and Nishmura , H. 1982 . Teratogenictty of di(2‐ethylhexYl)phthalate (DEHP) and di‐n‐butyl phthalate (DBP) in mice . Environ. Health Perspect , 45 : 65 – 70 .
  • Singh , A.R. , Lawrence , W.H. and Autian , J. 1972 . Teratogenichy of phthalate esters in rats . J. Pharm. Sci. , 61 : 51 – 55 .
  • Smith , C.C. 1953 . Toxicity of butyl stearate, dibutyl sebacate, dibutyl phthalate and methoxyethyl oleate . Ind. Hyg. Occup. Med. , 7 : 310 – 318 .
  • Spink , D. 1986 . Alberta Environment , (unpublished data)
  • Srivastava , S.P. , Srivastava , S. , Saxena , D.K. , Chandra , S.V. and Seth , P.K. 1990 . Testicular effects of di‐n‐butyl phthalate (DBP): Biochemical and histopathoiogical alterations . Arch. Toxicol. , 64 : 148 – 152 .
  • Tanino , M. , Ikemoto , I. and Tanaka , A. 1987 . Enzyme levels in rat testis damaged experimentally with dibutyl phthalate . Jikeikai Med. J. , 34 : 245 – 252 . (cited in ATSDR. 1990)
  • Thomas , G.H. 1973 . Quantitative determination and confirmation of identity of trace amounts of dialkyl phthalates in environmental samples . Environ. Health Perspect. , 3 : 23 – 28 .
  • White , R.D. , Earnest , D.L. and Carter , D.E. 1983 . The effect of intestinal esterase inhibition on the in vivo absorption and toxicity of di‐n‐butyl phthalate . Fd. Cosmet. Toxicol. , 21 : 99 – 101 .
  • Williams , D.T. 1973 . Dibutyl‐ and di‐(2‐ethylhexy)l phthalate in fish . J. Agr. Food Chem. , 21 : 1128 – 1129 .
  • Woodward , K.N. 1988 . Phthalate esters toxicity and metabolism , Vol I & II , Boca Raton, Florida : CRC Press Inc. .
  • Yamada , A. 1974 . Toxicity of phthalic acid esters and hepatotoxicity of di‐(2‐ethyl hexyl) phthalate . J. Food Hyg. Soc. Japan. , 15 : 147 – 152 .
  • Zeiger , E. , Haworth , S. , Speck , W. and Mortelmans , K. 1982 . Phthalate ester testing in the National Toxicology Program's environmental mutagenesis test development program . Environ. Health Perspect. , 45 : 99 – 101 .
  • Zeiger , E. , Haworth , S. , Mortelmans , K. and Speck , W. 1985 . Mutagenicity testing of di(2‐ethylhexyl)phthalate and related chemicals in Salmonella . Environ. Mutagen. , 7 : 213 – 232 .
  • Author to whom correspondence or requests for the complete Assessment Report and (unpublished) Supporting Documentation should be addressed.

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