Trichloroethylene: Evaluation of risks to health from environmental exposure in Canada

References

• ATSDR (AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY) . 1989 . Toxicological Profile for Trichloroethylene , 139 Atlanta, Georgia : U.S. Public Health Service . Report No. ATSDR/TP‐88/24.
   Google Scholar
• AME (ALBERTA MINISTRY OF ENVIRONMENT) . 1990 . Data from the Drinking Water Survey Program on Trichloroethylene, 1985–1989
   Google Scholar
• ASTRAND , I. and OVRUM , P. 1976 . Exposure to trichloroethylene. I. Uptake and distribution in man . Scand. J. Work Environ. Health , 4 : 199 – 211 .
   Web of Science ®Google Scholar
• AXLSON , O. , ANDERSSON , C. , SELDEN , A. and HOGSTEDT , C. 15–17 November 1984 . “ Cancer morbidity and exposure to trichloroethylene ” . In ICOST, International Conference on Organic Solvent Toxicity 15–17 November , Stockholm 1984 (Abstract in Arbete och Hatsa 29, 126)
   Google Scholar
• BELILES , R.P. 1980 . Teratogenic‐mutagenic risk of workplace contaminants: trichloroethylene, perch/oroethylene and carbon disulfide , Department of Health, Education and Welfare . (contract no. 210–77–0047). In ATSDR (1989) and CARB 11990)
   Google Scholar
• BELL , R.W. , CHAPMAN , R.E. , KRUSCHEL , B.D. , SPENCER , M.J. , SMITH , K.V. and LUSIS , M.A. 1991 . The 1990 Toronto Personal Exposure Pilot (PEP) Study , Toronto, Ontario : Ontario Ministry of the Environment . Draft.
   Google Scholar
• BELL , Z.G. , OLSON , K.H. and BENYA , T.J. 1978 . Final Report of Audit Findings of the Manufacturing Chemists Association: Administered Trichloroethylene Chronic Inhalation Study , Decatur, Illinois : Industrial Biotest Laboratories, Inc. . Unpublished. In NRC (1989) and Maltoni et al (1986)
   Google Scholar
• BIRNER , G. , VAMVAKAS , S. , DEKANT , W. and HENSCHLER , D. in press . The nephrotoxic and genotoxic N‐acetyl‐S‐dichlorovinyl‐L‐cysteine is a urinary metabolite after occupational 1,1,2‐trichloroethene exposure in humans: implications for the risk of trichloroethene exposure . Environ. Health Perspect. , (in press).
   Web of Science ®Google Scholar
• BRUCKNER , J.V. , DAVIS , B.D. and BLANCATO , J.N. 1989 . Metabolism, toxicity, and carcinogenicity of trichloroethylene . Toxicology , 20 (1) : 31 – 50 .
   Web of Science ®Google Scholar
• BUBEN , J.A. and O'FLAHERTY , E.J. 1985 . Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose‐effect study . Toxicol. Appl. Pharmacol. , 78 : 105 – 122 .
   PubMed Web of Science ®Google Scholar
• BULL , R.J. , SANCHEZ , I.M. , NELSON , M.A. , LARSON , J.L. and LANSING , A.J. 1990 . Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate . Toxicol. , 63 : 341 – 359 .
   PubMed Web of Science ®Google Scholar
• CARB (CALIFORNIA AIR RESOURCES BOARD) . 1990 . Proposed identification of trichloroethylene as a toxic air contaminant , State of California Air Resources Board, Stationary Source Division . Technical Support Document.
   Google Scholar
• CHAN , C.C. , VANIER , L. , MARTIN , J.W. and WILLIAMS , D.T. 1990 . Determination of organic contaminants in residential indoor air using an adsorption‐thermal desorption technique . J. Air Waste Manage. Assoc. , 40 : 62 – 67 .
   PubMed Web of Science ®Google Scholar
• COMMANDEUR , J.N.M. and VERMEULEN , N.P.E. 1990 . Identification of N‐acetyl(2,2‐dichlorovinyl‐L‐cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat . Chem. Res. Toxicol. , 3 : 212 – 218 .
   PubMed Web of Science ®Google Scholar
• COMMANDEUR , J.N.M. , BOOGAARD , P.J. , MULDER , G.J. and VERMEULEN , N.P.E. 1991 . Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S‐conjugates of trichloroethylene . Arch. Toxicol. , 65 (5) : 373 – 380 .
   PubMed Web of Science ®Google Scholar
• DAFT , J.L. 1988 . Rapid determination of fumigant and industrial chemical residues in food . J. Assoc. Off. Anal. Chem. , 71 (4) : 748 – 760 .
   PubMedGoogle Scholar
• DAFT , J.L. 1989 . Determination of fumigants and related chemicals in fatty and nonfatty foods . J. Agric. Food Chem. , 37 : 560 – 564 .
   Web of Science ®Google Scholar
• DALBEY , W. and BINGHAM , E. 1978 . Metabolism of trichloroethylene by isolated perfused lung . Toxicol. Appl. Pharmacol. , 43 : 267 – 277 .
   PubMed Web of Science ®Google Scholar
• DANN , T. 1992 . Unpublished data on concentrations of trichloroethylene at Canadian sites , Ottawa : Environment Canada .
   Google Scholar
• DeANGELO , A.B. and DANIEL , F.B. 1992 . An evaluation of the carcinogenicity of the chloroacetic acids in the male F344 rat . The Toxicologist , 12 : 206 (Abstract)
   Google Scholar
• DeANGELO , A.B. , DANIEL , F.B. , McMILLAN , L. , WERNSING , P. and SAVAGE , R.E. Jr. 1989 . Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids . Toxicol. Appl. Pharmacol. , 101 : 285 – 298 .
   PubMed Web of Science ®Google Scholar
• DeANGELO , A.B. , DANIEL , F.B. , STOBER , J.A. and OLSON , G.R. 1991 . The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse . Fund. Appl. Toxicol. , 16 : 337 – 347 .
   PubMedGoogle Scholar
• DEKANT , W. , KOOB , M. and HENSCHLER , D. 1990a . Metabolism of trichloroethene ‐ in vivo and in vitro evidence for activation by glutathione conjugation . Chem.‐Biol. Interactions , 73 : 89 – 101 .
   PubMed Web of Science ®Google Scholar
• DEKANT , W. , VAMVAKAS , S. , KOOB , M. , KOCHLING , A. , KANHAI , W. , MULLER , D. and HENSCHLER , D. 1990b . A mechanism of haloalkene‐induced renal carcinogenesis . Environ. Health Perspect. , 88 : 107 – 110 .
   PubMed Web of Science ®Google Scholar
• ELCOMBE , C.R. , ROSE , M.S. and PRATT , I.S. 1985 . Biochemical, histological and ultrasctructural changes in rat and mouse liver following the administration of trichloroethylene: possible relevance to species differences in hepatocarcinogenicity . Toxicol, Appl. Pharmacol. , 79 : 401 – 411 . In Klaunig et al. (1989)
   PubMed Web of Science ®Google Scholar
• ENTZ , R.C. and DIACHENKO , G.W. 1988 . Residues of volatile halocarbons in margarines . Food Add. Contain. , 5 (3) : 267 – 276 .
   PubMedGoogle Scholar
• ENTZ , R.C. and HOLLIFIELD , H.C. 1982 . Headspace gas chromatogrsphic analysis of foods for volatile halocarbons . J. Agric. Food Chem. , 30 : 84 – 88 .
   Web of Science ®Google Scholar
• ENVIRO‐TEST LABORATORIES . 1991 . Cayley Background Background Study: Analysis of Food Products for Target Organic and Inorganic Parameters , Edmonton, Alberta : Under contract to Hazardous Waste Section, Environmental Health Directorate, Health and Welfare Canada, Ottawa . Series: 91‐E1208.
   Google Scholar
• ENVIRONMENT CANADA . Moncton 1989a . Atlantic Region Federal‐Provincial Toxic Chemical Survey of Municipal Drinking Water Sources , Data Summary Report Moncton , N.B. : Water Quality Branch . Province of New Brunswick. Pub. No. IWD‐AR‐WQB‐89–155.
   Google Scholar
• ENVIRONMENT CANADA . 1989b . Atlantic Region Federal‐Provincial Toxic Chemical Survey of Municipal Drinking Water Sources , Data Summary Report Moncton, N.B. : Water Quality Branch . Province of Prince Edward Island. Pub. No. IWD‐AR‐WQB‐89–156.
   Google Scholar
• ENVIRONMENT CANADA . 1989c . Atlantic Region Federal‐Provincial Toxic Chemical Survey of Municipal Drinking Water sources , Data Summary Report Moncton, N.B. : Water Quality Branch . Province of Newfoundland. Pub. No. IWD‐AR‐WQB‐89–157.
   Google Scholar
• EHD (ENVIRONMENTAL HEALTH DIRECTORATE) . 1992 . Approach for the determination of “toxic”; under paragraph 11(c) of the Canadian Environmental Protection Act , Ottawa : Bureau of Chemical Hazards, Health Protection Branch, Departmental of National Health and Welfare . (unpublished)
   Google Scholar
• FELDMAN , R.G. , CHIRICO‐POST , J. and PROCTOR , S.P. 1988 . Blink reflex latency after exposure to trichloroethylene in well water . Arch. Environ. Health , 43 (2) : 143 – 148 .
   PubMedGoogle Scholar
• FERRARIO , J.B. , LAWLER , G.C. , DeLEON , I.R. and LASETER , J.L. 1985 . Volatile organic pollutants in biota and sediments of Lake Pontchartrain . Bull. Environ. Contam. Toxicol. , 34 : 246 – 255 .
   PubMed Web of Science ®Google Scholar
• FORKERT , P.G. and BIRCH , D.W. 1989 . Pulmonary toxicity of trichloroethylene in mice. Covalent binding and morphological manifestations . Drug Metabolism and Disposition , 17 (1) : 106 – 113 .
   PubMed Web of Science ®Google Scholar
• FORKERT , P.G. and TROUGHTON , K.M. 1987 . Airway injury by trichloroethylene: ascanning electron microscopic study . J. Pathol. , 152 : 119 – 125 .
   PubMed Web of Science ®Google Scholar
• FORKERT , P.G. , SYLVESTRE , P.L. and POLAND , J.S. 1985 . Lung injury induced by trichloroethylene . Toxicol. , 34 : 143 In Bruckner et al, (1989)
   Google Scholar
• FREDRIKSSON , M. , BENGTSSON , N. O. , HARDELL , L. and AXELSON , O. 1989 . Colon cancer, physical activity, and occupational exposures ‐ a case‐control study . Cancer , 63 : 1838 – 1842 .
   PubMed Web of Science ®Google Scholar
• FUKUDA , K. , TAKEMOTO , K. and TSURUTA , H. 1983 . Inhalation carcinogenicity of trichloroethylene in mice and rats . industrial Health , 21 : 143 – 254 .
   PubMedGoogle Scholar
• GARTRELL , M.J. , CRAIM , J.C. , PODREBARAC , D.S. and GUNDERSON , E.L. 1986a . Pesticides, selected elements, and other chemicals in infant and toddler total diet samples, October 1980‐March 1982 . J. Assoc. Off. Anal. Chem. , 69 (1) : 123 – 145 .
   PubMedGoogle Scholar
• GARTRELL , M.J. , CRAUN , J.C. , PODREBARAC , D.S. and GUNDERSON , E.L. 1986b . Pesticides, selected elements, and other chemicals in adult total diet samples, October 1980‐March 1982 . J. Assoc. Off. Anal. Chem. , 69 (1) : 146 – 161 .
   PubMedGoogle Scholar
• GOSSETT , R.W. , BROWN , D.A. and YOUNG , D.R. 1983 . Predicting the bioaccumulation of organic compounds in marine organisms using octanol/water partition coefficients . Marine Pollut. Bull. , 14 (10) : 387 – 392 .
   Web of Science ®Google Scholar
• HEALY , T.E. , POOLE , T.R. and HOOPER , A. 1982 . Rat fetal development and maternal exposure to trichloroethylene at 100 ppm . Br. J. Anaesth. , 54 : 337 – 341 .
   PubMed Web of Science ®Google Scholar
• HEIKES , D.L. 1987 . Purge and trap method for determination of volatile halocarbons and carbon disulfide in table‐ready foods . J. Assoc. Off. Anal. Chem. , 70 (2) : 215 – 226 .
   PubMedGoogle Scholar
• HEIKES , D.L. and HOPPER , M.L. 1986 . Purge and trap method for determination of fumigants in whole grains, milled grain products, and intermediate grain‐based foods . J. Assoc. Off. Anal. Chem. , 69 (6) : 990 – 998 .
   PubMedGoogle Scholar
• HENSCHLER , D. , ROMEN , W. , ELSASSER , H.M. , REICHERT , D. , EDER , E. and RADWAN , Z. 1980 . Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species . Arch. Toxicol. , 43 : 237 – 248 .
   PubMed Web of Science ®Google Scholar
• HERREN‐FREUND , S.L. , PEREIRA , M.A. , KHOURY , M.D. and OLSON , G. 1987 . The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver . Toxicol. Appl. Pharmacol. , 90 : 183 – 189 .
   PubMed Web of Science ®Google Scholar
• IRIS . 1992 . Integrated Risk Information System. Carcinogenicity Assessment for Lifetime Exposure , U.S. Environmental Protection Agency .
   Google Scholar
• ISAACSON , L.G. and TAYLOR , D.H. 1989 . Maternal exposure to 1,1,2‐trichloroethylene affects myelin in the hippocampal formation of the developing rat . Brain Research , 488 : 403 – 407 .
   PubMed Web of Science ®Google Scholar
• ISAACSON , L.G. , SPOHLER , S.A. and TAYLOR , D.H. 1990 . Trichloroethylene affects learning and decreases myelin in the rat hippocampus . Neurotoxicol. Teratol. , 12 : 375 – 381 .
   PubMed Web of Science ®Google Scholar
• KATZ , R. , TAI , C.N. , DIENER , R.M. , MCCONNELL , R.F. and SEMONICK , D.E. 1981 . Dichloroacetate, sodium: 3‐month oral toxicity studies in rats and dogs . Toxicol. Appl. Pharmacol. , 57 : 273 – 287 .
   PubMed Web of Science ®Google Scholar
• KENDALL , P.R.W. 1990 . The Quality of Drinking Water in Toronto: A Review of Tap Water, Bottled Water and Water Treated by a Point‐Of‐Use Device , Summary Report City of Toronto, Toronto, Ontario
   Google Scholar
• KJELLSTRAND , P. , HOLMQUIST , B. , ALM , P. , KANJE , M. , ROMARE , S. , JONSSON , I. , MANSSON , L. and BJERKEMO , M. 1983a . Trichloroethylene: further studies on the effects on body and organ weights and plasma butyrylcholinesterase activity in mice . Acts Pharmacol. Toxicol. , 53 : 375 – 384 .
   PubMedGoogle Scholar
• KLAUNIG , J.E. , RUCH , R.J. and LIN , E.C. 1989 . Effects of trichloroethylene and its metabolites on rodent hepatocyte intercellular communication . Toxicol. Appl. Pharmacol. , 99 : 454 – 465 .
   PubMed Web of Science ®Google Scholar
• KNUCKLES , M.E. 1990 . The effects of trichloroethylene and its metabolite TCA on peroxisome proliferation and the induction of cytochrome p‐452 . Diss. Abstr. Int. B , 50 (9) : 3897 – 3898 .
   Google Scholar
• KYRKLUND , T. , ALLING , C. , HAGLID , K.G. and KJELLSTRAND , P. 1983 . Chronic exposure to trichloroethylene: lipid and acyl group composition in the gerbil cerebral cortex and hippocampus . Neurotoxicol. , 4 (4) : 35 – 42 .
   PubMed Web of Science ®Google Scholar
• LARSON , J.L. and BULL , R.J. 1992b . Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice . Toxicol. Appl. Pharmacol. , 115 : 268 – 277 .
   PubMed Web of Science ®Google Scholar
• LIU , Y.‐T. , JIN , C. , CHEN , Z. , CAI , S.‐X. , YIN , S.N. , LI , G.‐L. , WATANABE , T. , NAKATSUKA , H. , SEIJI , K. , INOUE , O. , KAWAI , T. , UKAI , H. and IKEDA , M. 1988 . Increased subjective symptom prevalence among workers exposed to trichloroethylene at sub‐OEL levels . Tohoku J. Exp. Med. , 155 : 183 – 195 .
   PubMed Web of Science ®Google Scholar
• MALTONI , C. , LEFEMINE and COTTI , G. 1986 . “ Experimental Research on Trichloroethylene Carcinogenesis ” . In Archives of Research on Industrial Carcinogenesis , Vol. V , 393 Princeton, J.J. : Princeton Scientific Publishing .
   Google Scholar
• MALTONI , C. , LEFEMINE , G. , COTTI , G. and PERINO , G. 1988 . Long‐term carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague‐Dawley rats and Swiss mice and B6C3F1 mice . Ann. New York Acad. Sci. , 534 : 316 – 342 .
   PubMed Web of Science ®Google Scholar
• MEEK , M.E. , NEWHOOK , R. , LITEPLO , R.G. and ARMSTRONG , V.C. 1994 . Approach to assessment of risk to human health for Priority Substances under the Canadian Environmental Protection Act . J. Environ. Sci Health , C12 (2) : 105 – 134 .
   Web of Science ®Google Scholar
• NAGAYA , T. , ISHIKAWA , N. and HATA , H. 1989a . Sister‐chromatid exhanges in lymphocytes of workers exposed to trichloroethylene . Mut. Res. , 222 : 279 – 282 .
   PubMedGoogle Scholar
• NAROTSKY , M.G. , SCHLICHT , M. , BERMAN , E. , ELDER , J.A. , MACPHAIL , R.C. and KAVLOCK , R.J. 1990 . Effects of trichloroethylene in an in vivo developmental toxicity screen . Teratol. Soc. Abstr. , 41 (5) : 580
   Google Scholar
• NCI (NATIONAL CANCER INSTITUTE) . 1976 . Carcinogenesis Bioassay of Trichloroethylene, CAS No. 79–01–6 , 197 Bethesda, Md. : National Cancer Institute . NCI‐CG‐TR‐2. DHEW Publ. No. (NIH)76–802.
   Google Scholar
• NRC (NATIONAL RESEARCH COUNCIL) . 1989 . “ Trichloroethylene ” . In Committee on Toxicology Emergency and Continuous Exposure Guidance Levels for Selected Airborne Contaminants. Vol. 8, Lithium chromate and trichloroethylene 31 – 65 .
   Google Scholar
• NTP (NATIONAL TOXICOLOGY PROGRAM) . 1985 . Trichloroethylene: Reproduction and Fertility Assessment in CD‐1 Mice when Administered in the Feed , Bethesda, Md. : Department of Health and Human Services, National Institutes of Health . NTP‐86–068.
   Google Scholar
• NTP (NATIONAL TOXICOLOGY PROGRAM) . 1988 . Toxicology and carcinogenesis studies of trichloroethylene (CAS no. 79–01–6) in four strains of rats (ACI, August, Marshall, Osborne‐Mendel) (gavage studies) , Department of Health and Human Services, National Institutes of Health . NTP TR 273.
   Google Scholar
• NTP (NATIONALTOXICOLOGYPROGRAM) . 1990 . Carcinogenesis studies of trichloroethylene (without epichlorohydrin) (CAS No. 79–01–6) in F344/N rats and B6C3F, mice (gavage studies) , Department of Health and Human Services, National Institutes of Health . NTP TR 243.
   Google Scholar
• NSMH (NOVA SCOTIA MINISTRY OF HEALTH) . 1991 . VOC Survey of Municipal Water Supplies in Nova Scotia, 1987‐October 1990 , Halifax, Nova Scotia : Public Health Inspection .
   Google Scholar
• NUTRITION CANADA . 1977 . Food Consumption Patterns Report , Ottawa : Health and Welfare Canada . Unpublished Data.
   Google Scholar
• ODUM , J. , FOSTER , J.R. and GREEN , T. 1992 . A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene . Chem.‐Biol. Interact. , 83 : 135 – 153 .
   PubMed Web of Science ®Google Scholar
• OME (ONTARIO MINISTRY OF THE ENVIRONMENT) . 1990 . Data from the Drinking Water Surveillance Program (DWSP) on trichloroethylene up to November 20, 1990
   Google Scholar
• OTSON , R. , FELLIN , P. and WHITMORE , R. A national pilot study on occurrence of airborne VOCs in residences ‐ design and progress . Presented at the 1992 EPA/AWMA Symposium on “Measurement of Toxic and Related Air Pollutants” . May 4–8 1992 , Durham, NC. (unpublished)
   Google Scholar
• OTSON , R. , WILLIAMS , D.T. and BOTHWELL , P.D. 1982 . Volatile organic compounds in water at thirty Canadian potable water treatment facilities . J. Assoc. Off. Anal. Chem. , 65 (6) : 1370 – 74 .
   Google Scholar
• PELLIZZARI , E.D. , MICHAEL , L.C. , PERRITT , K. , SMITH , D.J. , HARTWELL , T.D. and SEBESTIK , J. 1989 . Comparison of Indoor and Outdoor Toxic Air Pollutant Levels in Several Southern California Communities , Final Report fo the California Air Resources Board Contract No. A5–174–33. In CARB (1990)
   Google Scholar
• QME (QUEBEC MINISTRY OF THE ENVIRONMENT) . 1990 . Data collected under the Micro‐pollutant Surveillance Program, 1985–1988
   Google Scholar
• RAABE , O.G. 1988 . “ Retention and metabolism of toxics ” . In Inhalation uptake of xenobiotic vapors by people , California Air Resources Board . Contract report No. A5–155–33 prepared for the
   Google Scholar
• RASMUSSEN , K. , SABROE , S. , WOHLERT , M. , INGERSLEV , H.J. , KAPPEL , B. and NIELSEN , J. 1988 . A genotoxic study of metal workers exposed to trichloroethylene ‐ sperm parameters and chromosome aberrations in lymphocytes . Int. Arch. Occup. Environ. Health , 60 : 419 – 423 .
   PubMed Web of Science ®Google Scholar
• SANDERS , V.M. , TUCKER , A.N. , WHITE , K.L. JR. , KAUFFMANN , B.M. , HALLETT , P. , CARCHMAN , R.A. , BORZELLECA , F. and MUNSON , A.E. 1982 . Humoral and cell‐mediated immune status in mice exposed to trichloroethylene in the drinking water . Toxicol. Appl. Pharmacol. , 62 : 358 – 368 .
   PubMed Web of Science ®Google Scholar
• SEMI , K. , JIN , C. , WATANABE , T. , NAKATSUKA , H. and IKEDA , M. 1990 . Sister chromatid exhanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits . Int. Arch. Occup. Environ. Health , 62 : 171 – 176 .
   PubMed Web of Science ®Google Scholar
• SHAH , J.J. and SINGH , H.B. 1988 . Distribution of volatile organic chemicals in outdoor and indoor air. A national VOCs data base . Environ. Sci. Technol. , 22 (12) : 1381 – 1388 .
   PubMed Web of Science ®Google Scholar
• SHARPE , C.R. , ROCHON , J.E. , ADAM , J.E. and SUISSA , S. 1989 . Case‐control study of hydrocarbon exposures in patients with renal cell carcinoma . C.M.A.J. , 140 : 1309 – 1318 .
   PubMed Web of Science ®Google Scholar
• SPIRTAS , R. , STEWART , P.A. , LEE , J.S. , MARANO , D.E. , FORBES , C.D. , GRAUMAN , D.J. , PETTIGREW , H.M. , BLAIR , A. , HOOVER , R.N. and COHEN , J.L. 1991 . Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results . Br. J. Ind. Med. , 48 : 515 – 530 .
   PubMedGoogle Scholar
• TAYLOR , D.H. , LAGORY , K.E. , ZACCARO , D.J. , PFOHL , R.J. and LAURIE , R.D. 1985 . Effect of trichloroethylene on the exploratory and locomotor activity of rats exposed during development . Sci. Total Environ. , 47 : 415 – 420 .
   PubMed Web of Science ®Google Scholar
• TUCKER , A.N. , SANDERS , V.M. , BARNES , D.W. , BRADSHAW , T.J. , WHITE , K.L. Jr. , SAIN , L.E. , BORZELLACA , J.F. and MUNSON , A.E. 1982 . Toxicology of trichloroethylene in the mouse . Toxicol. Appl. Pharmacol. , 62 : 351 – 357 .
   PubMed Web of Science ®Google Scholar
• US EPA (U.S. ENVIRONMENTAL PROTECTION AGENCY) . 1988 . Health Effects Assessment for Trichloroethylene , Cincinnati, OH : Office of Research and Development . PB90–142498. EPA/600/8–89/097.
   Google Scholar
• US EPA (U.S. ENVIRONMENTAL PROTECTION AGENCY) . 1987 . The Total Exposure Assessment Methodology (TEAM) Study: Summary and Analysis Volume I , EPA 600/6–87/002a. In CARB (1990)
   Google Scholar
• VAMVAKAS , S. , DEKANT , W. and HENSCHLER , D. 1989 . Genotoxicity of haloalkene and haloalkane glutathione S‐conjugates in porcine kidney cells . Toxicol. In Vitro , 3 (2) : 151 – 156 .
   PubMed Web of Science ®Google Scholar
• van DUUREN , B.L. , GOLDSCHMIDT , B.M. , LOEWENGART , G. , SMITH , A.C. , MELCHIONNE , S. , SEIDMAN , I. and ROTH , D. 1979 . Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice . J. Nat. Cancer Inst. , 63 : 1433 – 1439 .
   PubMed Web of Science ®Google Scholar
• WALLACE , L. , NELSON , W. , ZIEGENFUS , R. , PELLIZZARI , E. , MICHAEL , L. , WHITMORE , R. , ZELON , H. , HARTWELL , T. , PERRITT , R. and WESTERDAHL , D. 1991 . The Los Angeles TEAM study: personal exposures, indoor‐outdoor air concentrations, and breath concentrations of 25 volatile organic compounds . J. Exposure Analysis Environ. Epidemiol. , 1 (2) : 157 – 192 .
   PubMedGoogle Scholar
• WITHEY , J.R. , COLLINS , B.T. and COLLINS , P.G. 1983 . Effect of vehicle on the pharmacokinetics and uptake of four halogenated hydrocarbons from the gastrointestinal tract of the rat . J. Appl. Toxicol. , 3 : 249 – 253 .
   PubMed Web of Science ®Google Scholar
• ZENICK , H. , BLACKBURN , K. , HOPE , E. , RICHDALE , N. and SMITH , M.K. 1984 . Effects of trichloroethylene exposure on male reproductive function in rats . Toxicology , 31 : 237 – 250 .
   PubMed Web of Science ®Google Scholar
• Author to whom correspondence or requests for the complete Assessment Report or (unpublished) Supporting Documentation should be addressed.
   Google Scholar