Publication Cover
Journal of Environmental Science and Health, Part C
Environmental Carcinogenesis and Ecotoxicology Reviews
Volume 14, 1996 - Issue 1
51
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

Carcinogenicity of organophosphorus pesticides/compounds: An analysis of their structure‐activity relationshipsFootnote1

, , &
Pages 1-42 | Published online: 19 Nov 2008

References

  • Woo , Y.‐t. , Lai , D.Y. , Argus , M.F. and Arcos , J.C. 1985 . Toxicol. Lett. , 79 : 219
  • Ecobichon , D.J. 1996 . Casarett and Doull's Toxicology, , 5th edn. , Edited by: Klaassen , C.D. 643 New York : McGraw‐Hill .
  • Arcos , J.C. , Woo , Y.‐t. , Argus , M.F. and Lai , D.Y. 1982 . Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Vol. IIIA, Aliphatic Carcinogens , 415 New York : Academic Press .
  • IARC . 1979 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 20, Some Halogenated Hydrocarbons , Lyon, , France : International Agency for Research on Cancer .
  • IARC . 1981 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 26, Some Antineoplastic and Immunosuppressive Agents , Lyon, , France : International Agency for Research on Cancer .
  • IARC . 1983 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 30, Miscellaneous Pesticides , Lyon, , France : International Agency for Research on Cancer .
  • IARC . 1990 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 48, Some Flame Retardants and Textile Chemicals, and Exposures in the Textile Manufacturing Industries , Lyon, , France : International Agency for Research on Cancer .
  • IARC . 1990 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 50, Pharmaceutical Drugs , Lyon, , France : International Agency for Research on Cancer .
  • IARC . 1991 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 53, Occupational Exposures in Insecticide Application, and Some Pesticides , Lyon, , France : International Agency for Research on Cancer .
  • Williams , D.I. , Nestmann , E.R. , LeBel , G.L. , Benoit , F.M. and Otson , R. 1982 . Chemosphere , 11 : 263
  • Fest , C. and Schmidt , K.J. 1973 . The Chemistry of Organophosphorus Pesticides — Reactivity, Synthesis, Mode of Action, Toxicology , Berlin : Springer‐Verlag .
  • Eto , M. 1974 . Organophosphorus Pesticides. Organic and Biological Chemistry , Cleveland, Ohio : CRC Press .
  • Bedford , C.T. and Robinson , J. 1972 . Xenobiotica , 2 : 307
  • Wright , A.S. , Hutson , D.H. and Wooder , M.F. 1979 . Arch. Toxicol. , 42 : 1
  • Bull , D.L. 1972 . Residue Rev. , 43 : 1
  • O'Brien , R.D. 1967 . Insecticides: Action and Mechanism , New York : Academic Press .
  • Murphy , S.D. 1986 . Casarett and Doull's Toxicology, , 3rd edn. , Edited by: Klaassen , C.D. , Amdur , M.O. and Doull , J. 534 New York : Macmillan .
  • Miller , E.C. and Miller , J.A. 1976 . Chemical Carcinogens , ACS Monograph No. 173 Edited by: Searle , C.E. 737 Washington, DC : American Chemical Society .
  • Woo , Y.‐t. , Arcos , J.C. and Lai , D.Y. 1988 . Chemical Carcinogens: Activation Mechanisms, Structural and Electronic Factors, and Reactivity , Edited by: Politzer , P. and Martin , F.J. Jr. 1 Amsterdam, Holland : Elsevier .
  • Preussmann , R. , Schneider , H. and Epple , F. 1969 . Arzneim‐Forsch. , 19 : 1059
  • Fischer , G.W. and Lohs , K. 1973 . Arch. Geschwalstforsch. , 42 : 34
  • Sidell , F.R. 1992 . Chemical Warfare Agents , Edited by: Somani , S.M. 155 New York : Academic Press .
  • Somani , S.M. , Solana , R.P. and Dube , S.N. 1992 . Chemical Warfare Agents , Edited by: Somani , S.M. 67 New York : Academic Press .
  • Wild , D. 1975 . Mutat. Res. , 32 : 133
  • NTP . 1986 . Toxicology and Carcinogenesis Studies of Chlorinated Trisodium Phosphate in B6C3F, Mice (Gavage Studies) , NTP Tech Report No. 294 Research Triangle Park, NC : National Toxicology Program .
  • NTP . 1985 . Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 287 Research Triangle Park, NC : National Toxicology Program .
  • NTP . 1987 . Toxicology and Carcinogenesis Studies of Dimethyl Hethylphosphonate in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 323 Research Triangle Park, NC : National Toxicology Program .
  • NTP . 1986 . Toxicology and Carcinogenesis Studies of Dimethyl Morpholinophosphoramidate in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 298 Research Triangle Park, NC : National Toxicology Program .
  • Calvin , G. , Long , P.H. , Stitzel , K.A. , Anderson , R.L. , Balmbra , R.R. and Bruce , R.D. 1988 . Fd. Chem. Toxicol. , 26 : 601
  • NTP . 1987 . Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethy1)phosphonium Sulfate (TUPS) and Tetrakis(hydroxymethyl)‐phosphonium (THPC) in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 296 Research Triangle Park, NC : National Toxicology Program .
  • Microbiological Associates . 1985 . KRONITEX TBP (Tributyl Phosphate) Mutagenicity Screening Test Salmonella Microsomal Assay (AMES Test) , Washington, DC : U.S. Environmental Protection Agency . EPA/OTS; Doc #40–7821020,
  • NTP . 1994 . Toxicology and Carcinogenesis Studies of Tricresyl Phosphate in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies) , NTP Tech Report No. 433 Research Triangle Park, NC : National Toxicology Program .
  • NTP . 1991 . Toxicology and Carcinogenesis Studies of Tris(2‐chloroethyl)phosphate in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 391 Research Triangle Park, NC : National Toxicology Program .
  • NTP . 1984 . Toxicology and Carcinogenesis Studies of Tris(2‐ethylhexyl)phosphate in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 274 Research Triangle Park, NC : National Toxicology Program .
  • OPP . 1985 . Carcinogenicity Peer Review of Acephate , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1993 . Carcinogenicity Peer Review of Fosetyl‐Al (Aliette) , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • ATSDR . 1994 . Toxicological Profile for Diazinon (Draft for Public Comment) , Atlanta, GA. : Agency for Toxic Substances and Disease Registry .
  • ATSDR . 1995 . Toxicological Profile for Dichlorvos (Draft for Public Comment) , Atlanta, GA. : Agency for Toxic Substances and Disease Registry .
  • OPP . 1991 . Carcinogenicity Peer Review of Dimethoate , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • ATSDR . 1993 . Toxicological Profile for Disulfoton (Draft for Public Comment) , Atlanta, GA. : Agency for Toxic Substances and Disease Registry .
  • OPP . 1991 . Carcinogenicity Peer Review of Glyphosate , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1990 . Carcinogenicity Peer Review of Malathion , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • NCI . 1979 . Bioassay of Methyl Parathion for Possible Carcinogenicity , NCI Tech Report No. 157 Bethesda, MD. : National Cancer Institute .
  • OPP . 1991 . Carcinogenicity Peer Review of Parathion , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1994 . Carcinogenicity Peer Review of Phosmet , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1989 . Carcinogenicity Peer Review of Phosphamidon , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1994 . Carcinogenicity Peer Review of Gardona (Tetrachlorvinphos) , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1990 . Carcinogenicity Peer Review of Tribufos , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1995 . Carcinogenicity Peer Review of Trichlorfon , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • Bedford , C.T. 1975 . Mutat. Res. , 29 : 195
  • Ishidate , M. , Sofuni , T. , Yoshikawa , K. , Hayashi , M. , Nohmi , T. , Sawada , M. and Matsuoka , A. 1984 . Fd. Chem. Toxicol. , 22 : 623
  • Woo , Y.‐t. , Lai , D.Y. , Arcos , J.C. and Argus , M.F. 1988 . Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Vol. IIIC, Natural, Metal, Fiber, and Macromolecular Carcinogens , 505 San Diego : Academic Press .
  • Biodynamics . 1990 . A Twenty‐four month chronic gavage study in rats with RTEMPA (Dequest) , Washington, DC : U.S. Environmental Protection Agency . EPA/OPTS Public Files 8EHQ‐0490–0937,
  • Glow , P.H. 1968 . Nature (London) , 221 : 1265
  • Food and Drug Research Laboratory . 1985 . Chronic intubation study in rats with EDITEMPA (final report) , Washington, DC : U.S. Environmental Protection Agency . EPA/OPTS Public Files 8EHQ‐1185–0483,
  • American Biogenics . 1986 . Twenty‐four month chronic oral (gavage) toxicity study in rats utilizing EDITEMPA , Washington, DC : U.S. Environmental Protection Agency . EPA/OPTS Public Files 8EHQ‐0486–0483,
  • Biodynamics . 1986 . A Twenty‐four month chronic gavage study in mice with 35631 (EDITEMPA) , Washington, DC : U.S. Environmental Protection Agency . EPA/OPTS Public Files 8EHQ‐0486–0483,
  • Treon , J.E. , Dutra , F.M. and Cleveland , F.P. 1953 . AMR Arch. Ind. Hyg. Occup. Med. , 8 : 170
  • Kimbrough , R.D. and Gaines , I.B. 1973 . Bull. Environ. Contam. Toxicol. , 10 : 225
  • Zapp , J.A. Jr. 1975 . Science , 190 : 422
  • Lee , K.P. , Trochimowicz , H.J. and Sarver , J.W. 1977 . Lab. Invest. , 36 : 344
  • Laham , S. , Long , G. and Broxup , B. 1985 . Arch. Environ. Hlth. , 40 : 301
  • Pharmaco LSR . 1994 . An Oncogenicity Study of Tributyl Phosphate in the Rat via Dietary Administration , Washington, DC : U.S. Environmental Protection Agency . submitted to
  • Pharmaco LSR . 1994 . An Oncogenicity Study of Tributyl Phosphate in the Mouse via Dietary Administration , Washington, DC : U.S. Environmental Protection Agency . submitted to
  • NCI . 1978 . Bioassay of Trimethylphosphate for Possible Carcinogenicity , NCI Tech Report No. 81 Bethesda, MD. : National Cancer Institute .
  • NCI . 1978 . Bioassay of Tris(2,3‐dibromopropyl)phosphate for Possible Carcinogenicity , NCI Tech Report No. 76 Bethesda, MD. : National Cancer Institute .
  • Woo , Y.‐t. , Arcos , J.C. and Lai , D.Y. 1985 . Handbook of Carcinogen Testing , Edited by: Milman , H.A. and Weisburger , E.K. 1 Park Ridge, NJ : Noyes Publications .
  • Albert , R.E. , Sellakumar , A.R. , Laskin , S. , Kuschner , M. , Nelson , N. and Snyder , C.A. 1982 . J. Natl. Cancer Inst. , 68 : 597
  • Ashby , J. , Styles , J.A. and Paton , D. 1978 . Br. J. Cancer , 38 : 418
  • Yamauchi , K. and Kinoshita , M. 1973 . J. Chen. Soc. Perkin Trans , 1 (4) : 391
  • NCI . 1978 . Bioassay of Azinphosmethyl for Possible Carcinogenicity , NCI Tech Report No. 69 Bethesda, MD. : National Cancer Institute .
  • OPP . 1993 . Rfd Peer Review of Chlorpyrifos , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • NCI . 1979 . Bioassay of Coumaphos for Possible Carcinogenicity , NCI Tech Report No. 96 Bethesda, MD. : National Cancer Institute .
  • NCI . 1979 . Bioassay of Diazinon for Possible Carcinogenicity , NCI Tech Report No. 137 Bethesda, MD. : National Cancer Institute .
  • NCI . 1977 . Bioassay of Dichlorvos for Possible Carcinogenicity , NCI Tech Report No. 10 Bethesda, MD. : National Cancer Institute .
  • NIP . 1989 . Toxicology and Carcinogenesis Studies of Dichlorvos in F344/N Rats and B6C3F1 Mice (Gavage Studies) , NTP Tech Report No. 342 Research Triangle Park, NC : National Toxicology Program .
  • NCI . 1977 . Bioassay of Dimethoate for Possible Carcinogenicity , NCI Tech Report No. 4 Bethesda, MD. : National Cancer Institute .
  • NCI . 1978 . Bioassay of Dioxathion for Possible Carcinogenicity , NCI Tech Report No. 125 Bethesda, MD. : National Cancer Institute .
  • OPP . 1992 . Rfd Peer Review of Ebuphos , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • OPP . 1993 . Rfd Peer Review of Fenamiphos , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • NCI . 1979 . Bioassay of Fenthion for Possible Carcinogenicity , NCI Tech Report No. 103 Bethesda, MD. : National Cancer Institute .
  • OPP . 1992 . Rfd Peer Review of Fonofos , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • NCI . 1979 . Bioassay of Halaoxon for Possible Carcinogenicity , NCI Tech Report No. 135 Bethesda, MD. : National Cancer Institute .
  • NCI . 1978 . Bioassay of Malathion for Possible Carcinogenicity , NCI Tech Report No. 24 Bethesda, MD. : National Cancer Institute .
  • NCI . 1979 . Bioassay of Malathion for Possible Carcinogenicity , NCI Tech Report No. 192 Bethesda, MD. : National Cancer Institute .
  • OPP . 1994 . Rfd Peer Review of Naled , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • NCI . 1979 . Bioassay of Parathion for Possible Carcinogenicity , NCI Tech Report No. 70 Bethesda, MD. : National Cancer Institute .
  • NCI . 1979 . Bioassay of Phosphamidon for Possible Carcinogenicity , NCI Tech Report No. 16 Bethesda, MD. : National Cancer Institute .
  • OPP . 1994 . Rfd Peer Review of Terbufos , Washington, DC : Office of Pesticide Programs, U.S. Environmental Protection Agency .
  • NCI . 1978 . Bioassay of Tetrachlorvinphos for Possible Carcinogenicity , NCI Tech Report No. 33 Bethesda, MD. : National Cancer Institute .
  • U.S. EPA . 1987 . The Risk Assessment Guidelines of 1986 , Washington, DC : U.S. Environmental Protection Agency . EPA/600/8–87/045,
  • Gibel , W. , Lohs , K. , Wildner , G.P. , Ziebarth , D. and Stieglitz , R. 1973 . Arch. Geschwulstforsch. , 41 : 311
  • Woo , Y.‐t. and Arcos , J.C. 1989 . Carcinogenicity and Pesticides: Principles Issues and Relationships , ACS Symposium Series No. 414 Edited by: Ragsdale , N.N. and Menzer , R.E. 175 Washington, DC : American Chemical Society .
  • This review has been written as a part of support documents to develop a knowledge rule‐based artificial intelligence/expert system for predicting and/or assessing the carcinogenic potential of chemical compounds (see ref. 1). The contents of this paper have been reviewed and approved by the U.S. Environmental Protection Agency's Office of Pollution Prevention and Toxics. Approval does not signify that the contents necessarily reflect the views or policies of the Agency.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.