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- PCMODEL for Windows, version 5.13. The input conformations were kept as close to the binding geometry as possible.
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- Selected Spectroscopic Data on 4: FABMS 726 (M+ + Na+ + H+); 1H-NMR (DMSO-d6, 400 MHz) 0.76 (d, 3H), 0.79 (s, 3H), 0.94 (s, 3H), 1.00–2.20 (m, 26H), 3.51 (s, 3H), 4.83 (s, 1H), 5.31 (s, 1H), 7.58 (t, 1H), 7.88 (d, 1H), 8.09–8.14 (5H), 8.39 (s, 1H), 13.15 (br.s, 2H); 13C-NMR (DMSO-d6, 75 MHz) 12.16, 17.24, 22.51, 23.00, 25.49, 25.77, 26.04, 30.18, 31.66, 33.41, 34.05, 35.05, 40.89, 44.91, 47.40, 49.61, 51.07, 74.29, 76.38, 129.126, 129.694, 130.36, 131.12, 132.24, 132.58, 133.63, 135.19, 164.23, 164.39, 166.34, 166.48, 173.52; IR, cm−1, nujol: 1700, 3200–3700 [α]D 24 = +66(c, = 1.4, THF) Found C, 70.00; H, 7.36. Reqd. C41H50O10C, 70.06; H, 7.10.
- The solubility of 4, in CHCl3 is only 1.64 mM at 27°C. However, we were able to solubilise as much as 6 mM of host 4, in the presence of the guest.
- The acid was initially dissolved in THF, required volumes added into the NMR tubes and evaporated to dryness in vacuo for 3 h.
- Lancelot , G. 1977 . J. Am. Chem. Soc. , 88 : 7037 It is well documented in all these examples that these aromatic signals can be followed to obtain the association constant (Ka ) with reliability.