Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex

References

• Akinc A, Thomas M, Klibanov AM, Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005; 7: 657–663
   PubMed Web of Science ®Google Scholar
• Behr JP, Demeneix B, Loeffler JP, Perez-Mutul J. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc Natl Acad Sci USA 1989; 86(18 September)6982–6986
   PubMed Web of Science ®Google Scholar
• Blessing T, Kursa M, Holzhauser R, Kircheis R, Wagner E. Different strategies for formation of pegylated EGF-conjugated PEI/DNA complexes for targeted gene delivery. Bioconjug Chem 2001; 12: 529–537
   PubMed Web of Science ®Google Scholar
• Boeckle S, von Gersdorff K, van der Piepen S, Culmsee C, Wagner E, Ogris M. Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. J Gene Med 2004; 6(10 October)1102–1111
   PubMed Web of Science ®Google Scholar
• Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeneix B, Behr JP. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297–7301
   PubMed Web of Science ®Google Scholar
• Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2 and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther 2004; 10: 302–317
   PubMed Web of Science ®Google Scholar
• Chandler LA, Doukas J, Gonzalez AM, Hoganson DK, Gu DL, Ma C, Nesbit M, Crombleholme TM, Herlyn M, Sosnowski BA, Pierce GF. FGF2-targeted adenovirus encoding platelet-derived growth factor-B enhances de novo tissue formation. Mol Ther 2000; 2: 153–160
   PubMed Web of Science ®Google Scholar
• Chollet P, Favrot MC, Hurbin A, Coll JL. Side-effects of a systemic injection of linear polyethylenimine–DNA complexes. J Gene Med 2002; 4: 84–91
   PubMed Web of Science ®Google Scholar
• Crabb JW, West KA, Dodson WS, Hulmes JD. Amino acid analysis. Current protocols in protein science. John Wiley and Sons, New York 1997
   Google Scholar
• De Smedt SC, Demeester J, Hennink WE. Cationic polymer based gene delivery systems. Pharm Res 2000; 17: 113–126
   PubMed Web of Science ®Google Scholar
• Demeneix B, Behr J, Boussif O, Zanta MA, Abdallah B, Remy J. Gene transfer with lipospermines and polyethylenimines. Adv Drug Deliv Rev 1998; 30: 85–95
   PubMed Web of Science ®Google Scholar
• Eichman JD, Bielinska AU, Kukowska-Latallo JF, Baker JR, Jr. The use of PAMAM dendrimers in the efficient transfer of genetic material into cells. Pharm Sci Technol Today 2000; 3: 232–245
   PubMedGoogle Scholar
• Erbacher P, Bettinger T, Belguise-Valladier P, Zou S, Coll JL, Behr JP, Remy JS. Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI). J Gene Med 1999; 1: 210–222
   PubMed Web of Science ®Google Scholar
• Erbacher P, Bettinger T, Brion E, Coll JL, Plank C, Behr JP, Remy JS. Genuine DNA/polyethylenimine (PEI) complexes improve transfection properties and cell survival. J Drug Target 2004; 12: 223–236
   PubMed Web of Science ®Google Scholar
• Erbacher P, Zou S, Bettinger T, Steffan AM, Remy JS. Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability. Pharm Res 1998; 15: 1332–1339
   PubMed Web of Science ®Google Scholar
• Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM, Danielsen M. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987; 84(21 November)7413–7417
   PubMed Web of Science ®Google Scholar
• Fisher KD, Stallwood Y, Green NK, Ulbrich K, Mautner V, Seymour LW. Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther 2001; 8: 341–348
   PubMed Web of Science ®Google Scholar
• Goula D, Benoist C, Mantero S, Merlo G, Levi G, Demeneix BA. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther 1998; 5: 1291–1295
   PubMed Web of Science ®Google Scholar
• Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2003; 2: 214–221
   PubMed Web of Science ®Google Scholar
• Hermanson G. Bioconjugate techniques. Academic Press, New York 1996
   Google Scholar
• Hughes JA, Rao GA. Targeted polymers for gene delivery. Expert Opin Drug Deliv 2005; 2(1 January)145–157
   PubMedGoogle Scholar
• Kichler A. Gene transfer with modified polyethylenimines. J Gene Med 2004; 6(1)S3–S10
   PubMedGoogle Scholar
• Kircheis R, Kichler A, Wallner G, Kursa M, Ogris M, Felzmann T, Buchberger M, Wagner E. Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery. Gene Ther 1997; 4(5)409–418
   PubMed Web of Science ®Google Scholar
• Kircheis R, Ostermann E, Wolschek MF, Lichtenberger C, Magin-Lachmann C, Wightman L, Kursa M, Wagner E. Tumor-targeted gene delivery of tumor necrosis factor-alpha induces tumor necrosis and tumor regression without systemic toxicity. Cancer Gene Ther 2002; 9: 673–680
   PubMed Web of Science ®Google Scholar
• Klein H., Gong H., Wang H., et al. Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain. Experimental neurology 2002; 1: 66–74
   Google Scholar
• Kopatz I, Remy JS, Behr JP. A model for non-viral gene delivery: Through syndecan adhesion molecules and powered by actin. J Gene Med 2004; 6: 769–776
   PubMed Web of Science ®Google Scholar
• Kunath K, Merdan T, Hegener O, Häberlein H, Kissel T. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. Gene Med 2003; 5(7 July)588–599
   Google Scholar
• Kunath K, von Harpe A, Petersen H, Fischer D, Voigt K, Bickel U. The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice. Pharm Res 2002; 19: 810–817
   PubMed Web of Science ®Google Scholar
• Labat-Moleur F, Steffan AM, Brisson C, Perron H, Feugeas O, Furstenberger P, Oberling F, Brambilla E, Behr JP. An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther 1996; 3: 1010–1017
   PubMed Web of Science ®Google Scholar
• Lanciotti J, Song A, Doukas J, Sosnowski B, Pierce G, Gregory R, Wadsworth S, O'Riordan C. Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates. Mol Ther 2003; 8: 99–107
   PubMed Web of Science ®Google Scholar
• Li D, Yu H, Huang H, Shen F, Wu X, Li J, Wang J, Cao X, Wang Q, Tang G. FGF receptor-mediated gene delivery using ligands coupled to polyethylenimine. J Biomater Appl 2007; 22(2)163–180
   PubMed Web of Science ®Google Scholar
• Maruta F, Parker AL, Fisher KD, Hallissey MT, Ismail T, Rowlands DC, Chandler LA, Kerr DJ, Seymour LW. Identification of FGF receptor-binding peptides for cancer gene therapy. Cancer Gene Ther 2002; 9: 543–552
   PubMed Web of Science ®Google Scholar
• Mishra S, Webster P, Davis ME. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 2004; 83: 97–111
   PubMed Web of Science ®Google Scholar
• Mislick KA, Baldeschwieler JD. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc Natl Acad Sci USA 1996; 93: 12,349–12,354
   Google Scholar
• Ogris M, Wagner E. Tumor-targeted gene transfer with DNA polyplexes. Somat Cell Mol Genet 2002; 27(1–6)85–95
   PubMedGoogle Scholar
• Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E. PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 1999; 6(4)595–605
   PubMed Web of Science ®Google Scholar
• Ogris M, Walker G, Blessing T, Kircheis R, Wolschek M, Wagner E. Tumor-targeted gene therapy: Strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. Control Release 2003; 91(1–2)173–181
   PubMed Web of Science ®Google Scholar
• Ogris M, Steinlein P, Carotta S, Brunner S, Wagner E. DNA/polyethylenimine transfection particles: Influence of ligands, polymer size and PEGylation on internalization and gene expression. AAPS PharmSci 2001; 3: E21
   PubMed Web of Science ®Google Scholar
• Ogris M, Steinlein P, Kursa M, Mechtler K, Kircheis R, Wagner E. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther 1998; 5: 1425–1433
   PubMed Web of Science ®Google Scholar
• Petersen H, Fechner PM, Martin AL, Kunath K, Stolnik S, Roberts CJ, Fischer D, Davies MC, Kissel T. Polyethylenimine-graft-poly(ethylene glycol) copolymers: Influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. Bioconjug Chem 2002; 13: 845–854
   PubMed Web of Science ®Google Scholar
• Ruponen M, Yla-Herttuala S, Urtti A. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: Physicochemical and transfection studies. Biochim Biophys Acta 1999; 1415: 331–341
   PubMed Web of Science ®Google Scholar
• Shi L, Tang GP, Gao SJ, Ma YX, Liu BH, Li Y, Zeng JM, Ng YK, Leong KW, Wang S. Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord. Gene Ther 2003; 10: 1179–1188
   PubMed Web of Science ®Google Scholar
• Snyder SL, Sobocinski PZ. An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines. Anal Biochem 1975; 64(1 March)284–288
   PubMed Web of Science ®Google Scholar
• Sosnowski BA, Gonzalez AM, Chandler LA, Buechler YJ, Pierce GF, Baird A. Targeting DNA to cells with basic fibroblast growth factor (FGF2). J Biol Chem 1996; 271: 33,647–33,653
   Google Scholar
• Tang MX, Redemann CT, Szoka FC, Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996; 7: 703–714
   PubMed Web of Science ®Google Scholar
• Tang MX, Szoka FC. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes. Gene Ther 1997; 4: 823–832
   PubMed Web of Science ®Google Scholar
• Ungaro, De Rosa, Miro, Quaglia. Spectrophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations. Journal of pharmaceutical and biomedical analysis 2003; 31(1)143–149
   PubMed Web of Science ®Google Scholar
• Wagner E. Strategies to improve DNA polyplexes for in vivo gene transfer: Will “artificial viruses” be the answer?. Pharm Res 2004; 21: 8–14
   PubMed Web of Science ®Google Scholar
• Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC, Reynolds BA. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 1996; 16: 7599–7609
   PubMed Web of Science ®Google Scholar
• Zheng W, Nowakowski RS, Vaccarino FM. Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Dev Neurosci 2004; 26: 181–196
   PubMed Web of Science ®Google Scholar