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Research Article

Chitosan-mediated orally delivered nucleic acids: A gutful of gene therapy

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Pages 257-261 | Received 17 Sep 2007, Accepted 05 Jan 2008, Published online: 08 Oct 2008

References

  • Bhavsar MD, Amiji MM. Polymeric nano- and microparticle technologies for oral gene delivery. Expert Opin Drug Deliv 2007; 4(3)197–213
  • Candy T, Sharma CP. Chitosan as a biomaterial. Biomater Artif Cells Artif Organs 1990; 18: 1–24
  • Chen J, Yang WL, Li G, Qian J, Xue JL, Fu SK, Lu DR. Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan–DNA nanoparticles. World J Gastroenterol 2004; 10(1)112–116
  • Dass CR. Lipoplex-mediated delivery of nucleic acids: Factors affecting in vivo transfection. J Mol Med 2004; 82: 579–591
  • Dass CR, Burton MA. Modified microplex vector enhances transfection of cells in culture while maintaining tumour-selective gene delivery in vivo. J Pharm Pharmacol 2003; 55(1)19–25
  • Dass CR, Ek ET, Contreras KG, Choong PF. A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma. Clin Exp Metastasis 2006; 23: 367–380
  • Dass CR, Contreras KG, Dunstan DE, Choong PF. Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma. Biomaterials 2007; 28(19)3026–3033
  • Deng Z, Tian Y, Lee SH, Ribbe AE, Mao C. DNA-encoded self-assembly of gold nanoparticles into one-dimensional arrays. Angew Chem Int Ed Engl 2005; 44: 3582–3585
  • Guliyeva U, Oner F, Ozsoy S, Haziroğlu R. Chitosan microparticles containing plasmid DNA as potential oral gene delivery system. Eur J Pharm Biopharm 2006; 62(1)17–25
  • Henriksen I, Våagen SR, Sande SA, Smistad G, Karlsen J. Interactions between liposomes and chitosan II: Effect of selected parameters on aggregation and leakage. Int J Pharm 1997; 146: 193–203
  • Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm Res 1998; 15(9)1326–1331
  • Kai E, Ochiya T. A method for oral DNA delivery with N-acetylated chitosan. Pharm Res 2004; 21(5)838–843
  • Kaiser J. Clinical research. Death prompts a review of gene therapy vector. Science 2007; 317(5838)580
  • Lehr C-M, Bouwstra JA, Schacht E, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm 1992; 78: 43–48
  • Loretz B, Foger F, Werle M, Bernkop-Schnurch A. Oral gene delivery: Strategies to improve stability of pDNA towards intestinal digestion. J Drug Target 2006; 14(5)311–319
  • Martien R, Loretz B, Schnurch AB. Oral gene delivery: Design of polymeric carrier systems shielding toward intestinal enzymatic attack. Biopolymers 2006; 83(4)327–336
  • Mathiowitz E, Jacob JS, Jong YS, Carino GP, Chickering DE, Chaturvedi P, Santos CA, Vijayaraghavan K, Montgomery S, Bassett M, Morrell C. Biologically erodable microspheres as potential oral drug delivery systems. Nature 1997; 386: 410–414
  • Picard FJ, Bergeron MG. Rapid molecular theranostics in infectious diseases. Drug Discov Today 2002; 7(21)1092–1101
  • Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5(4)387–391
  • Schipper NG, Varum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm Res 1996; 13(11)1686–1692
  • Sharma J, Chhabra R, Liu Y, Ke Y, Yan H. DNA-templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew Chem Int Ed Engl 2006; 45: 730–735
  • Takeshita F, Minakuchi Y, Nagahara S, Honma K, Sasaki H, Hirai K, et al. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc Natl Acad Sci USA 2005; 102: 12177–12182
  • Yan H, Park SH, Finkelstein G, Reif JH, LaBean TH. DNA-templated self-assembly of protein arrays and highly conductive nanowires. Science 2003; 301: 1882–1884
  • Zhao W, Gao Y, Kandadai SA, Brook MA, Li Y. DNA polymerization on gold nanoparticles through rolling circle amplification: Towards novel scaffolds for three-dimensional periodic nanoassemblies. Angew Chem Int Ed Engl 2006; 45: 2409–2413
  • Zheng F, Shi XW, Yang GF, Gong LL, Yuan HY, Cui YJ, Wang Y, Du YM, Li Y. Chitosan nanoparticle as gene therapy vector via GI mucosa administration: Results of an in vitro and in vivo study. Life Sci Jan 2007; 80(4)388–396

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