Delivery of testosterone to the brain by intranasal administration: Comparison to intravenous testosterone

References

• WA Banks, MJ During, and ML Niehoff. (2004). Brain uptake of glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration. J Pharmacol Exp Ther 309:469–475.
   PubMed Web of Science ®Google Scholar
• O Beauchet. (2006). Testosterone and cognitive function: Current clinical evidence of a relationship. Eur J Endocrinol 155:773–781.
   PubMed Web of Science ®Google Scholar
• J Born, T Lange, W Kern, GP McGregor, U Bickel, and HL Fehm. (2002). Sniffing neuropeptides: A transnasal approach to the human brain. Nat Neurosci 5:514–516.
   PubMed Web of Science ®Google Scholar
• EB Brittebo, and JJ Rafter. (1984). Steroid metabolism by rat nasal mucosa: Studies on progesterone and testosterone. J Steroid Biochem 20:1147–1151.
   PubMedGoogle Scholar
• MM Cherrier, AM Matsumoto, JK Amory, S Asthana, W Bremner, ER Peskind, MA Raskind, and S Craft. (2005). Testosterone improves spatial memory in men with Alzheimer's disease and mild cognitive impairment. Neurology 64:2063–2068.
   PubMed Web of Science ®Google Scholar
• EM Cornford, LD Braun, WH Oldendorf, and MA Hill. (1982). Comparison of lipid-mediated blood–brain-barrier penetrability in neonates and adults. Am J Physiol 243:C161–C168.
   PubMed Web of Science ®Google Scholar
• H Davson, and MB Segal. (1996). Physiology of the CSF and Blood–Brain Barriers. Boca Raton: CRC Press.
   Google Scholar
• S Diano, SA Farr, SE Benoit, EC McNay, I da Silva, B Horvath, FS Gaskin, N Nonaka, LB Jaeger, WA Banks, JE Morley, S Pinto, RS Sherwin, L Xu, KA Yamada, MW Sleeman, MH Tschop, and TL Horvath. (2006). Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9:381–388.
   PubMed Web of Science ®Google Scholar
• MJ During, L Cao, DS Zuzga, JS Francis, HL Fitzsimons, X Jiao, RJ Bland, M Klugmann, WA Banks, DJ Drucker, and CN Haile. (2003). Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9:1173–1179.
   PubMed Web of Science ®Google Scholar
• KN Fargo, CL Iwema, MC Clark-Phelps, and DR Sengelaub. (2007). Exogenous testosterone reverses age-related atrophy in a spinal neuromuscular system. Horm Behav 51:20–30.
   PubMed Web of Science ®Google Scholar
• WHII Frey. (2002). Bypassing the blood–brain barrier to deliver therapeutic agents to the brain and spinal cord. Drug Deliv Technol 2:46–49.
   Google Scholar
• J Glowinski, and LL Iversen. (1966). Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem 13:655–669.
   PubMed Web of Science ®Google Scholar
• MT Haren, GA Wittert, IM Chapman, P Coates, and JE Morley. (2005). Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in elderly men with low-normal gonadal status. Maturitas 50:124–133.
   PubMed Web of Science ®Google Scholar
• AA Hussain, AA Al-Bayatti, A Dakkuri, K Okochi, and MA Hussain. (2002). Testosterone 17beta-N,N-dimethylglycinate hydrochloride: A prodrug with a potential for nasal delivery of testosterone. J Pharm Sci 91:785–789.
   PubMed Web of Science ®Google Scholar
• AJ Kastin, and V Akerstrom. (2003). Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Related Metab Disorders: J Int Assoc Study Obes 27:313–318.
   PubMed Web of Science ®Google Scholar
• W Kern, J Born, H Schreiber, and HL Fehm. (1999). Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes 48:557–563.
   PubMed Web of Science ®Google Scholar
• KT Ko, TE Needham, and H Zia. (1998). Emulsion formulations of testosterone for nasal administration. J Microencapsul 15:197–205.
   PubMed Web of Science ®Google Scholar
• TCA Kumar, GFX David, A Sankaranarayanan, V Puri, and KR Sundram. (1982). Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying. Proc Natl Acad Sci USA 79:4185–4189.
   PubMed Web of Science ®Google Scholar
• SP Marynick, WW Haven, MH Ebert, and DL Loriaux. (1976). Studies on the transfer of steroid hormones across the blood–cerebrospinal fluid barrier in Rhesus monkey. Endocrinology 99:400–405.
   PubMed Web of Science ®Google Scholar
• A Matsumoto. (2005). Testosterone prevents synaptic loss in the perineal motoneuron pool in the spinal cord in male rats exposed to chronic stress. Stress 8:133–140.
   PubMed Web of Science ®Google Scholar
• JE Morley, and HM Perry3. (2003). Androgens and women at the menopause and beyond. J Gerontol Biol Sci 58:M409–M416.
   PubMed Web of Science ®Google Scholar
• JE Morley, P Patrick, and HM Perry3. (2002). Evaluation of assays available to measure free testosterone. Metabolism 51:554–559.
   PubMed Web of Science ®Google Scholar
• Y Pan, H Zhang, AB Acharya, PH Patrick, D Oliver, and JE Morley. (2005). Effect of testosterone on functional recovery in a castrate male rat stroke model. Brain Res 1043:195–204.
   PubMed Web of Science ®Google Scholar
• WM Pardridge, LJ Mietus, AM Frumar, BJ Davidson, and HL Judd. (1980). Effects of human serum on transport of testosterone and estradiol into rat brain. Am J Physiol 239:E103–E108.
   PubMed Web of Science ®Google Scholar
• JL Shifren. (2004). The role of androgens in female sexual dysfunction. Mayo Clin Proc 79:S19–S24.
   PubMed Web of Science ®Google Scholar
• MC Tavares, B Topic, C Abreu, I Waga, U Gomes, C Tomaz, and C Mattern. (2007). Effects of intra-nasally administered testosterone on sexual proceptive behavior in female capuchin monkeys (Cebus apella). Behav Brain Res 179:33–42.
   PubMed Web of Science ®Google Scholar
• RG Thorne, GJ Pronk, V Padmanabhan, and WHII Frey. (2004). Delivery of insulin-like growth factor-1 to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127:481–496.
   PubMed Web of Science ®Google Scholar
• B Topic, MC Tavares, C Tomaz, and C Mattern. (2007). Prolonged effects of intra-nasally administered testosterone on proceptive behavior in female capuchin monkeys (Cebus apella). Behav Brain Res 179:60–68.
   PubMed Web of Science ®Google Scholar
• SJ Weber, DL Greene, VJ Hruby, HI Yamamura, F Porreca, and TP Davis. (1992). Whole body and brain distribution of [3H]cyclic[d-Pen2,d-Pen5] enkephalin after intraperitoneal, intravenous, oral and subcutaneous administration. J Pharmacol Exp Ther 263:1308–1316.
   PubMed Web of Science ®Google Scholar