Salmonella enterica Typhimurium engineered for nontoxic systemic colonization of autochthonous tumors

References

• Broadway KM, Scharf BE. Salmonella Typhimurium as an anticancer therapy: recent advances and perspectives. Curr Clin Micro Rpt. 2019;6(4):225–239.
   Web of Science ®Google Scholar
• Pawelek JM, Low KB, Bermudes D. Tumor-targeted Salmonella as a novel anticancer vector [Research Support, Non-U.S. Gov't]. Cancer Res. 1997;57(20):4537–4544.
   PubMed Web of Science ®Google Scholar
• Nemunaitis J, Cunningham C, Senzer N, et al. Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients [Clinical Trial]. Cancer Gene Ther. 2003;10(10):737–744.
   PubMed Web of Science ®Google Scholar
• Toso JF, Gill VJ, Hwu P, et al. Phase I study of the intravenous administration of attenuated Salmonella Typhimurium to patients with metastatic melanoma [Clinical Trial Clinical Trial, Phase I]. J Cin Oncol. 2002;20(1):142–152.
   PubMed Web of Science ®Google Scholar
• Heimann DM, Rosenberg SA. Continuous intravenous administration of live genetically modified Salmonella Typhimurium in patients with metastatic melanoma. J Immunother. 2003;26(2):179–180.
   PubMed Web of Science ®Google Scholar
• Falk P. Differences in vascular pattern between the spontaneous and the transplanted C3H mouse mammary carcinoma. Eur J Cancer Clin Oncol. 1982;18(2):155–165.
   PubMedGoogle Scholar
• Lee JC, Kim DC, Gee MS, et al. Interleukin-12 inhibits angiogenesis and growth of transplanted but not in situ mouse mammary tumor virus-induced mammary carcinomas. Cancer Res. 2002;62(3):747–755.
   PubMed Web of Science ®Google Scholar
• Wang H, Chen T, Wan L, et al. Attenuated Salmonella engineered with an apoptosis-inducing factor (AIF) eukaryotic expressing system enhances its anti-tumor effect in melanoma in vitro and in vivo. Appl Microbiol Biotechnol. 2020;104(8):3517–3528.
   PubMed Web of Science ®Google Scholar
• Chen T, Zhao X, Ren Y, et al. Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I. Appl Microbiol Biotechnol. 2019;103(2):929–939.
   PubMed Web of Science ®Google Scholar
• Igarashi K, Kawaguchi K, Zhao M, et al. Recombinant methioninase combined with tumor-targeting Salmonella Typhimurium A1-R induced regression in a PDOX mouse model of doxorubicin-resistant dedifferentiated liposarcoma. Anticancer Res. 2020;40(5):2515–2523.
   PubMed Web of Science ®Google Scholar
• Igarashi K, Kawaguchi K, Zhao M, et al. Exquisite tumor targeting by salmonella A1-R in combination with caffeine and valproic acid regresses an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft mouse model. Transl Oncol. 2020;13(2):393–400.
   PubMed Web of Science ®Google Scholar
• Mateos-Chavez AA, Munoz-Lopez P, Becerra-Baez EI, et al. Live attenuated salmonella enterica expressing and releasing cell-permeable bax BH3 peptide through the MisL autotransporter system elicits antitumor activity in a murine xenograft model of human B non-hodgkin's lymphoma. Front Immunol. 2019;10:2562.
   PubMed Web of Science ®Google Scholar
• Jin C, Duan X, Liu Y, et al. T cell immunity induced by a bivalent Salmonella-based CEACAM6 and 4-1BBL vaccines in a rat colorectal cancer model. Oncol Lett. 2017;13(5):3753–3759.
   PubMed Web of Science ®Google Scholar
• Sorenson B, Banton K, Frykman N, et al. Attenuated Salmonella Typhimurium with interleukin 2 gene prevents the establishment of pulmonary metastases in a model of osteosarcoma. J Pediatr Surg. 2008;43(6):1153–1158.
   PubMed Web of Science ®Google Scholar
• Sorenson B, Leonard Saltzman, et al. Antioxidant oils and Salmonella enterica Typhimurium reduce tumor in an experimental model of hepatic metastasis. Onco Targets Ther. 2011;4:59–69.
   PubMed Web of Science ®Google Scholar
• Murakami T, Hiroshima Y, Miyake K, et al. Efficacy of tumor-targeting Salmonella Typhimurium A1-R against malignancies in patient-derived orthotopic xenograft (PDOX) murine models. Cells. 2019;8(6):599.
   Web of Science ®Google Scholar
• Drees JJ, Mertensotto MJ, Augustin LB, et al. Vasculature disruption enhances bacterial targeting of autochthonous tumors. J Cancer. 2015;6(9):843–848.
   PubMed Web of Science ®Google Scholar
• Galan JE, Nakayama K, Curtiss R, et al. Cloning and characterization of the asd gene of Salmonella Typhimurium: use in stable maintenance of recombinant plasmids in Salmonella vaccine strains. Gene. 1990;94(1):29–35.
   PubMed Web of Science ®Google Scholar
• Karsi A, Lawrence ML. Broad host range fluorescence and bioluminescence expression vectors for Gram-negative bacteria. Plasmid. 2007;57(3):286–295.
   PubMed Web of Science ®Google Scholar
• Leschner S, Deyneko IV, Lienenklaus S, et al. Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic. Nucleic Acids Res. 2012;40(7):2984–2994.
   PubMed Web of Science ®Google Scholar
• Ryan RM, Green J, Williams PJ, et al. Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors [Evaluation Studies Research Support, Non-U.S. Gov't]. Gene Ther. 2009;16(3):329–339.
   PubMed Web of Science ®Google Scholar
• Datsenko KA, Wanner BL. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA. 2000;97(12):6640–6645.
   PubMed Web of Science ®Google Scholar
• Karsi A, Menanteau-Ledouble S, Lawrence ML. Development of bioluminescent Edwardsiella ictaluri for noninvasive disease monitoring. FEMS Microbiol Lett. 2006;260(2):216–223.
   PubMed Web of Science ®Google Scholar
• Kong Q, Six DA, Liu Q, et al. Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity. Infect Immun. 2012;80(9):3215–3224.
   PubMed Web of Science ®Google Scholar
• Nasvall J. Direct and Inverted Repeat stimulated excision (DIRex): simple, single-step, and scar-free mutagenesis of bacterial genes. PLoS One. 2017;12(8):e0184126.
   PubMed Web of Science ®Google Scholar
• Drees J, Mertensotto M, Liu G, et al. Attenuated Salmonella enterica Typhimurium reduces tumor burden in an autochthonous breast cancer model. Anticancer Res. 2015;35(2):843–849.
   PubMed Web of Science ®Google Scholar
• Chapman K, Sewell F, Allais L, et al. A global pharmaceutical company initiative: an evidence-based approach to define the upper limit of body weight loss in short term toxicity studies. Regul Toxicol Pharmacol. 2013;67(1):27–38.
   PubMed Web of Science ®Google Scholar
• Maude SL, Barrett D, Teachey DT, et al. Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 2014;20(2):119–122.
   PubMed Web of Science ®Google Scholar
• Rolli J, Loukili N, Levrand S, et al. Bacterial flagellin elicits widespread innate immune defense mechanisms, apoptotic signaling, and a sepsis-like systemic inflammatory response in mice. Crit Care. 2010;14(4):R160.
   PubMed Web of Science ®Google Scholar
• Uchiya KI, Kamimura Y, Jusakon A, et al. Salmonella fimbrial protein FimH is involved in expression of proinflammatory cytokines in a toll-like receptor 4-dependent manner. Infect Immun. 2019;87(3):e00881–18.
   PubMed Web of Science ®Google Scholar
• Grossman N, Leive L. Complement activation via the alternative pathway by purified Salmonella lipopolysaccharide is affected by its structure but not its O-antigen length. J Immunol. 1984;132(1):376–385.
   PubMed Web of Science ®Google Scholar
• Kong Q, Yang J, Liu Q, et al. Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar Typhimurium. Infect Immun. 2011;79(10):4227–4239.
   PubMed Web of Science ®Google Scholar
• Hammarlof DL, Kroger C, Owen SV, et al. Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella. Proc Natl Acad Sci USA. 2018;115(11):E2614–E2623.
   PubMed Web of Science ®Google Scholar
• Nakayama K, Kelly SM, Curtiss R. Construction of an Asd + expression vector: stable maintenance and high expression of cloned genes in a Salmonella vaccine strain. Nat Biotechnol. 1988;6(6):693–697.
   Google Scholar
• Galen JE, Buskirk AD, Tennant SM, et al. Live attenuated human salmonella vaccine candidates: tracking the pathogen in natural infection and stimulation of host immunity. EcoSal Plus. 2016;7(1).DOI:10.1128/ecosalplus.ESP-0010-2016
   PubMedGoogle Scholar
• Low KB, Ittensohn M, Le T, et al. Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo. Nat Biotechnol. 1999;17(1):37–41.
   PubMed Web of Science ®Google Scholar
• Kong Q, Six DA, Liu Q, et al. Palmitoylation state impacts induction of innate and acquired immunity by the Salmonella enterica serovar Typhimurium msbB mutant. Infect Immun. 2011;79(12):5027–5038.
   PubMed Web of Science ®Google Scholar
• Mi Z, Feng ZC, Li C, et al. Salmonella-mediated cancer therapy: an innovative therapeutic strategy. J Cancer. 2019;10(20):4765–4776.
   PubMed Web of Science ®Google Scholar
• Forbes NS, Coffin RS, Deng L, et al. White paper on microbial anti-cancer therapy and prevention. J Immunother Cancer. 2018;6;6(1):78.
   Google Scholar
• de Jong HK, Parry CM, van der Poll T, et al. Host-pathogen interaction in invasive Salmonellosis. PLoS Pathog. 2012;8(10):e1002933.
   PubMed Web of Science ®Google Scholar
• Low KB, Ittensohn M, Luo X, et al. Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans [Research Support, Non-U.S. Gov't]. Methods Mol Med. 2004;90:47–60.
   PubMedGoogle Scholar
• Hoiseth SK, Stocker BA. Aromatic-dependent Salmonella Typhimurium are non-virulent and effective as live vaccines. Nature. 1981;291(5812):238–239.
   PubMed Web of Science ®Google Scholar