Progress in tumour-targeted drug delivery based on cell-penetrating peptides

References

• Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell. 1988;55(6):1179–1188.
   PubMed Web of Science ®Google Scholar
• Frankel AD, Pabo CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell. 1988;55(6):1189–1193.
   PubMed Web of Science ®Google Scholar
• Xu J, Khan AR, Fu M, et al. Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs. J Control Release. 2019;309:106–124.
   PubMed Web of Science ®Google Scholar
• Lang J, Zhao X, Qi Y, et al. Reshaping prostate tumor microenvironment to suppress metastasis via cancer-associated fibroblast inactivation with peptide-assembly-based nanosystem. ACS Nano. 2019;13(11):12357–12371.
   PubMed Web of Science ®Google Scholar
• McErlean EM, Ziminska M, McCrudden CM, et al. Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery. J Control Release. 2021;330:1288–1299.
   PubMed Web of Science ®Google Scholar
• Nam SH, Jang J, Cheon DH, et al. pH-Activatable cell penetrating peptide dimers for potent delivery of anticancer drug to triple-negative breast cancer. J Control Release. 2021;330:898–906.
   PubMed Web of Science ®Google Scholar
• Shi XG, Song HJ, Wang CR, et al. Co-assembled and self-delivered epitope/CpG nanocomplex vaccine augments peptide immunogenicity for cancer immunotherapy. Chemical Engineering Journal. 2020;399:125854.
   Web of Science ®Google Scholar
• Vale N, Duarte D, Silva S, et al. Cell-penetrating peptides in oncologic pharmacotherapy: a review. Pharmacol Res. 2020;162:105231.
   PubMed Web of Science ®Google Scholar
• Liu D, Angelova A, Liu J, et al. Self-assembly of mitochondria-specific peptide amphiphiles amplifying lung cancer cell death through targeting the VDAC1-hexokinase-II complex. J Mater Chem B. 2019;7(30):4706–4716.
   PubMed Web of Science ®Google Scholar
• Zhang L, Zhang Y, Tai L, et al. Functionalized cell nucleus-penetrating peptide combined with doxorubicin for synergistic treatment of glioma. Acta Biomater. 2016;42:90–101.
   PubMed Web of Science ®Google Scholar
• Shi NQ, Li Y, Zhang Y, et al. Intelligent "peptide-gathering mechanical arm" tames wild "trojan-horse" peptides for the controlled delivery of cancer nanotherapeutics. ACS Appl Mater Interfaces. 2017;9(48):41767–41781.
   PubMed Web of Science ®Google Scholar
• He X, Chen X, Liu L, et al. Sequentially triggered nanoparticles with tumor penetration and intelligent drug release for pancreatic cancer therapy. Adv Sci. 2018;5(5):1701070.
   Web of Science ®Google Scholar
• Shi K, Wang Y, Zhou X, et al. Tumor microenvironment targeting with dual stimuli-responsive nanoparticles based on small heat shock proteins for antitumor drug delivery. Acta Biomater. 2020;114:369–383.
   PubMed Web of Science ®Google Scholar
• Gessner I, Neundorf I. Nanoparticles modified with cell-penetrating peptides: conjugation mechanisms, physicochemical properties, and application in cancer diagnosis and therapy. Int J Mol Sci. 2020;21(7):2536.
   PubMed Web of Science ®Google Scholar
• Cerrato CP, Kunnapuu K, Langel U. Cell-penetrating peptides with intracellular organelle targeting. Expert Opin Drug Deliv. 2017;14(2):245–255.
   PubMed Web of Science ®Google Scholar
• Kardani K, Milani A, S HS, et al. Cell penetrating peptides: the potent multi-cargo intracellular carriers. Expert Opin Drug Deliv. 2019;16(11):1227–1258.
   PubMed Web of Science ®Google Scholar
• Wei Y, Zhang M, Jiao P, et al. Intracellular paclitaxel delivery facilitated by a dual-functional CPP with a hydrophobic hairpin tail. ACS Appl Mater Interfaces. 2021;13(4):4853–4860.
   PubMed Web of Science ®Google Scholar
• Kim GC, Ahn JH, Oh JH, et al. Photoswitching of cell penetration of amphipathic peptides by control of alpha-helical conformation. Biomacromolecules. 2018;19(7):2863–2869.
   PubMed Web of Science ®Google Scholar
• Chiarpotti MV, Longo GS, Del Pópolo MG. Nanoparticles modified with cell penetrating peptides: assessing adsorption on membranes containing acidic lipids. Colloids Surf B Biointerfaces. 2021;197:111373.
   PubMed Web of Science ®Google Scholar
• Ramírez PG, Del Pópolo MG, Vila JA, et al. Thermodynamics of cell penetrating peptides on lipid membranes: sequence and membrane acidity regulate surface binding. Phys Chem Chem Phys. 2020;22(40):23399–23410.
   PubMed Web of Science ®Google Scholar
• Xie J, Bi Y, Zhang H, et al. Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application. Front Pharmacol. 2020;11:697.
   PubMed Web of Science ®Google Scholar
• Yi A, Sim D, Lee YJ, et al. Development of elastin-like polypeptide for targeted specific gene delivery in vivo. J Nanobiotechnol. 2020;18(1):15.
   PubMed Web of Science ®Google Scholar
• Nadal-Bufí F, Henriques ST. How to overcome endosomal entrapment of cell‐penetrating peptides to release the therapeutic potential of peptides? Pept Sci. 2020;112(6):24168.
   Web of Science ®Google Scholar
• Ha M, Nam SH, Sim K, et al. Highly efficient photothermal therapy with cell-penetrating peptide-modified bumpy Au triangular nanoprisms using low laser power and low probe dose. Nano Lett. 2021;21(1):731–739.
   PubMed Web of Science ®Google Scholar
• Kim AS, Melemenidis S, Gustavsson AK, et al. Increased local tumor control through nanoparticle-mediated, radiation-triggered release of nitrite, an important precursor for reactive nitrogen species. Phys Med Biol. 2020;65(19):195003.
   PubMed Web of Science ®Google Scholar
• Deng X, Mai R, Zhang C, et al. Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment. Eur J Med Chem. 2021; 2021-Mar-05213:113050–113050.
   PubMed Web of Science ®Google Scholar
• Yan X, Li S, Qu Y, et al. Redox-responsive multifunctional polypeptides conjugated with au nanoparticles for tumor-targeting gene therapy and their 1 + 1 > 2 synergistic effects. ACS Biomater Sci Eng. 2020;6(1):463–473.
   PubMed Web of Science ®Google Scholar
• Hua Q, Qiang Z, Chu M, et al. Polymeric drug delivery system with actively targeted cell penetration and nuclear targeting for cancer therapy. ACS Appl Bio Mater. 2019;2(4):1724–1731.
   PubMedGoogle Scholar
• Xiang Y, Shan W, Huang Y. Improved anticancer efficacy of doxorubicin mediated by human-derived cell-penetrating peptide dNP2. Int J Pharm. 2018;551(1–2):14–22.
   PubMedGoogle Scholar
• Liu X, Liu J, Liu D, et al. A cell-penetrating peptide-assisted nanovaccine promotes antigen cross-presentation and anti-tumor immune response. Biomater Sci. 2019;7(12):5516–5527.
   PubMed Web of Science ®Google Scholar
• Yoo J, Rejinold NS, Lee D, et al. CD44-mediated methotrexate delivery by hyaluronan-coated nanoparticles composed of a branched cell-penetrating peptide. ACS Biomater Sci Eng. 2020;6(1):494–504.
   PubMed Web of Science ®Google Scholar
• Iwasaki T, Murakami N, Kawano T. A polylysine-polyhistidine fusion peptide for lysosome-targeted protein delivery. Biochem Biophys Res Commun. 2020;533(4):905–912.
   PubMed Web of Science ®Google Scholar
• Al-Husaini K, Elkamel E, Han XX, et al. Therapeutic potential of a cell penetrating peptide (CPP, NP1) mediated siRNA delivery: evidence in 3D spheroids of colon cancer cells. Can J Chem Eng. 2020;98(6):1240–1254.
   Web of Science ®Google Scholar
• Tu ZX, Donskyi EG, Qiao HS, et al. Graphene oxide-cyclic R10 peptide nuclear translocation nanoplatforms for the surmounting of multiple-drug resistance. Adv Funct Mater. 2020;30(35):2000933. Jun 26.
   Web of Science ®Google Scholar
• Weng H, Bejjanki NK, Zhang J, et al. TAT peptide-modified cisplatin-loaded iron oxide nanoparticles for reversing cisplatin-resistant nasopharyngeal carcinoma. Biochem Biophys Res Commun. 2019;511(3):597–603.
   PubMed Web of Science ®Google Scholar
• Carnevale KJF, Muroski ME, Vakil PN, et al. Selective uptake into drug resistant mammalian cancer by cell penetrating peptide-mediated delivery. Bioconjugate Chem. 2018;29(10):3273–3284.
   PubMed Web of Science ®Google Scholar
• Zhao H, Wu M, Zhu L, et al. Cell-penetrating peptide-modified targeted drug-loaded phase-transformation lipid nanoparticles combined with low-intensity focused ultrasound for precision theranostics against hepatocellular carcinoma. Theranostics. 2018;8(7):1892–1910.
   PubMed Web of Science ®Google Scholar
• Caravan P, Ellison JJ, McMurry TJ, et al. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev. 1999;99(9):2293–2352.
   PubMed Web of Science ®Google Scholar
• Chen YX, Fu Y, Li XD, et al. Peptide-functionalized NaGdF4 nanoparticles for tumor-targeted magnetic resonance imaging and effective therapy. RSC Adv. 2019;9(30):17093–17100.
   Web of Science ®Google Scholar
• Yuan Y, Zhang J, Qi X, et al. Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy. Nat Mater. 2019;18(12):1376–1383.
   PubMed Web of Science ®Google Scholar
• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhao Y, Dong S, et al. Cell-penetrating peptide and transferrin co-modified liposomes for targeted therapy of glioma. Molecules. 2019;24(19):3540.
   PubMed Web of Science ®Google Scholar
• Griffith JI, Rathi S, Zhang W, et al. Addressing BBB heterogeneity: a new paradigm for drug delivery to brain tumors. Pharmaceutics. 2020;12(12):1205.
   PubMed Web of Science ®Google Scholar
• Banks WA. From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov. 2016;15(4):275–292.
   PubMed Web of Science ®Google Scholar
• Tian Y, Mi G, Chen Q, et al. Acid-induced activated cell-penetrating peptide-modified cholesterol-conjugated polyoxyethylene sorbitol oleate mixed micelles for pH-triggered drug release and efficient brain tumor targeting based on a charge reversal mechanism. ACS Appl Mater Interfaces. 2018;10(50):43411–43428.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Duan XH, Feng LB, et al. tLyp-1-conjugated GSH-sensitive biodegradable micelles mediate enhanced pUNO1-hTRAILa/curcumin co-delivery to gliomas. Chem Eng J. 2019;374:392–404.
   Web of Science ®Google Scholar
• Jana A, Narula P, Chugh A, et al. Efficient delivery of anti-miR-210 using Tachyplesin, a cell penetrating peptide, for glioblastoma treatment. Int J Pharm. 2019;572:118789.
   PubMedGoogle Scholar
• Zhang Z, Yu P, Gou Y, et al. Novel brain-tumor-inhibiting copper(II) compound based on a human serum albumin (HSA)-cell penetrating peptide conjugate. J Med Chem. 2019;62(23):10630–10644.
   PubMed Web of Science ®Google Scholar
• Hsu SPC, Dhawan U, Tseng YY, et al. Glioma-sensitive delivery of angiopep-2 conjugated iron gold alloy nanoparticles ensuring simultaneous tumor imaging and hyperthermia mediated cancer theranostics. Appl Mater Today. 2020;18:100510.
   Web of Science ®Google Scholar
• Thorne RG, Pronk GJ, Padmanabhan V, et al. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004; 2004127(2):481–496.
   PubMed Web of Science ®Google Scholar
• Taki H, Kanazawa T, Akiyama F, et al. Intranasal delivery of camptothecin-loaded tat-modified nanomicells for treatment of intracranial brain tumors. Pharmaceuticals. 2012;5(10):1092–1102.
   Google Scholar
• Kanazawa T, Taki H, Okada H. Nose-to-brain drug delivery system with ligand/cell-penetrating peptide-modified polymeric nano-micelles for intracerebral gliomas. Eur J Pharm Biopharm. 2020;152:85–94.
   PubMed Web of Science ®Google Scholar
• Kanazawa T, Akiyama F, Kakizaki S, et al. Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles. Biomaterials. 2013;34(36):9220–9226.
   PubMed Web of Science ®Google Scholar
• Mehta AM, Sonabend AM, Bruce JN. Convection-enhanced delivery. Neurotherapeutics. 2017;14(2):358–371.
   PubMed Web of Science ®Google Scholar
• Zhou Z, Singh R, Souweidane MM. Convection-enhanced delivery for diffuse intrinsic pontine glioma treatment. CN. 2016;15(1):116–128.
   Google Scholar
• Pang HH, Chen PY, Wei KC, et al. Convection-enhanced delivery of a virus-like nanotherapeutic agent with dual-modal imaging for besiegement and eradication of brain tumors. Theranostics. 2019;9(6):1752–1763.
   PubMed Web of Science ®Google Scholar
• Miller AJ, Mihm MC, Jr., Melanoma N. Melanoma. N Engl J Med. 2006;355(1):51–65.
   PubMed Web of Science ®Google Scholar
• Wang MZ, Niu J, Ma HJ, et al. Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression. J Control Release. 2020;322:95–107.
   PubMed Web of Science ®Google Scholar
• Huang S, Zhang Y, Wang L, et al. Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier. J Control Release. 2020;325:10–24.
   PubMed Web of Science ®Google Scholar
• Li N, Peng LH, Chen X, et al. Transcutaneous vaccines: novel advances in technology and delivery for overcoming the barriers. Vaccine. 2011;29(37):6179–6190.
   PubMed Web of Science ®Google Scholar
• Jiang T, Wang T, Li T, et al. Enhanced transdermal drug delivery by transfersome-embedded oligopeptide hydrogel for topical chemotherapy of melanoma. ACS Nano. 2018;12(10):9693–9701.
   PubMed Web of Science ®Google Scholar
• Ruan W, Zhai Y, Yu K, et al. Coated microneedles mediated intradermal delivery of octaarginine/BRAF siRNA nanocomplexes for anti-melanoma treatment. Int J Pharm. 2018;553(1-2):298–309.
   PubMedGoogle Scholar
• Shen Y, Qiu L. Effective oral delivery of gp100 plasmid vaccine against metastatic melanoma through multi-faceted blending-by-blending nanogels. Nanomedicine. 2019;22:102114.
   PubMed Web of Science ®Google Scholar
• Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 2009;61(2):158–171.
   PubMed Web of Science ®Google Scholar
• Tanaka HY, Kano MR. Stromal barriers to nanomedicine penetration in the pancreatic tumor microenvironment. Cancer Sci. 2018;109(7):2085–2092.
   PubMed Web of Science ®Google Scholar
• Elechalawar CK, Hossen MN, Shankarappa P, et al. Targeting pancreatic cancer cells and stellate cells using designer nanotherapeutics in vitro. IJN. 2020;15:991–1003.
   Google Scholar
• Apte MV, Wilson JS, Lugea A, et al. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology. 2013;144(6):1210–1219.
   PubMed Web of Science ®Google Scholar
• Schnittert J, Kuninty PR, Bystry TF, et al. Anti-microRNA targeting using peptide-based nanocomplexes to inhibit differentiation of human pancreatic stellate cells. Nanomedicine. 2017;12(12):1369–1384.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Li E, Zhao J, et al. Highly penetrating nanobubble polymer enhances LINC00511-siRNA delivery for improving the chemosensitivity of triple-negative breast cancer. Anticancer Drugs. 2021;32(2):178–188.
   PubMed Web of Science ®Google Scholar
• Huang HL, Lin WJ. Dual peptide-modified nanoparticles improve combination chemotherapy of etoposide and siPIK3CA against drug-resistant small cell lung carcinoma. Pharmaceutics. 2020;12(3):254.
   PubMed Web of Science ®Google Scholar
• Zhao H, Chen M, Zhao Z, et al. A multicomponent-based microemulsion for boosting ovarian cancer therapy through dual modification with transferrin and SA-R6H4. Drug Deliv Transl Res. 2020.DOI:https://doi.org/10.1007/s13346-020-00859-5
   Google Scholar
• Dufourc EJ, Buchoux S, Toupe J, et al. Membrane interacting peptides: from killers to helpers. CPPS. 2012;13(7):620–631.
   Google Scholar
• Cai L, Yang C, Jia W, et al. Endo/lysosome-escapable delivery depot for improving BBB transcytosis and neuron targeted therapy of Alzheimer's disease. Adv Funct Mater. 2020;30(27):1909999.
   Web of Science ®Google Scholar
• Chen X, Xu K, Yu J, et al. Peptide modified polycations with pH triggered lytic activity for efficient gene delivery. Biomater Sci. 2020;8(22):6301–6308.
   PubMed Web of Science ®Google Scholar
• Nadal-Bufi F, Henriques ST. How to overcome endosomal entrapment of cell-penetrating peptides to release the therapeutic potential of peptides? Pept Sci. 2020;112(6):e24168.
   Web of Science ®Google Scholar
• Sonawane ND, Szoka FC, Jr., Verkman AS. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003;278(45):44826–44831.
   PubMed Web of Science ®Google Scholar
• Li C, Cao XW, Zhao J, et al. Effective therapeutic drug delivery by GALA3, an endosomal escape peptide with reduced hydrophobicity. J Membrane Biol. 2020;253(2):139–152.
   PubMed Web of Science ®Google Scholar
• Poillot C, Dridi K, Bichraoui H, et al. D-maurocalcine, a pharmacologically inert efficient cell-penetrating peptide analogue. J Biol Chem. 2010;285(44):34168–34180.
   PubMed Web of Science ®Google Scholar
• Li P, Zheng Y, Ran H, et al. Ultrasound triggered drug release from 10-hydroxycamptothecin-loaded phospholipid microbubbles for targeted tumor therapy in mice. J Control Release. 2012;162(2):349–354.
   PubMed Web of Science ®Google Scholar
• Lim S, Kim WJ, Kim YH, et al. Identification of a novel cell-penetrating peptide from human phosphatidate phosphatase LPIN3. Mol Cells. 2012;34(6):577–582.
   PubMed Web of Science ®Google Scholar
• Aguilera TA, Olson ES, Timmers MM, et al. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr Biol. 2009;1(5-6):371–381.
   Google Scholar
• Lee SH, Castagner B, Leroux JC. Is there a future for cell-penetrating peptides in oligonucleotide delivery?. Eur J Pharm Biopharm. 2013;85(1):5–11.
   PubMed Web of Science ®Google Scholar
• Guo X, Wei X, Chen Z, et al. Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy. Prog Mater Sci. 2020;107:100599.
   Web of Science ®Google Scholar
• Kim YH, Han ME, Oh SO. The molecular mechanism for nuclear transport and its application. Anat Cell Biol. 2017;50(2):77–85.
   PubMed Web of Science ®Google Scholar
• Peng H, Tang J, Zheng R, et al. Nuclear-targeted multifunctional magnetic nanoparticles for photothermal therapy. Adv Healthc Mater. 2017;6(7):1601289.
   Web of Science ®Google Scholar
• Nischan N, Herce HD, Natale F, et al. Covalent attachment of cyclic TAT peptides to GFP results in protein delivery into live cells with immediate bioavailability. Angew Chem Int Ed Engl. 2015;54(6):1950–1953.
   PubMed Web of Science ®Google Scholar
• Nodling AR, Mills EM, Li X, et al. Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes. Chem Commun. 2020;56(34):4672–4675.
   PubMed Web of Science ®Google Scholar
• Klimpel A, Neundorf I. Bifunctional peptide hybrids targeting the matrix of mitochondria. J Control Release. 2018;291:147–156.
   PubMed Web of Science ®Google Scholar
• Yamada Y, Harashima H. Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases. Adv Drug Deliv Rev. 2008;60(13–14):1439–1462. Oct-
   PubMed Web of Science ®Google Scholar
• Li Q, Yang J, Chen C, et al. A novel mitochondrial targeted hybrid peptide modified HPMA copolymers for breast cancer metastasis suppression. J Control Release. 2020;325:38–51.
   PubMed Web of Science ®Google Scholar
• Zhang J, Sun A, Xu R, et al. Cell-penetrating and endoplasmic reticulum-locating TAT-IL-24-KDEL fusion protein induces tumor apoptosis. J Cell Physiol. 2016;231(1):84–93.
   PubMed Web of Science ®Google Scholar
• Serulla M, Ichim G, Stojceski F, et al. TAT-RasGAP317-326 kills cells by targeting inner-leaflet-enriched phospholipids. Proc Natl Acad Sci USA. 2020;117(50):31871–31881.
   PubMed Web of Science ®Google Scholar
• Perche F. Stimuli-sensitive cell penetrating peptide-modified nanocarriers. Processes. 2019;7(10):727.
   Web of Science ®Google Scholar
• Shi NQ, Qi XR, Xiang B, et al. A survey on "Trojan Horse" peptides: opportunities, issues and controlled entry to "Troy”. J Control Release. 2014;194:53–70.
   PubMed Web of Science ®Google Scholar
• Fernandes C, Suares D, Yergeri MC. Tumor microenvironment targeted nanotherapy. Front Pharmacol. 2018;9:1230.
   PubMed Web of Science ®Google Scholar
• Matsumura S, Aoki I, Saga T, et al. A tumor-environment-responsive nanocarrier that evolves its surface properties upon sensing matrix metalloproteinase-2 and initiates agglomeration to enhance T(2) relaxivity for magnetic resonance imaging. Mol Pharmaceutics. 2011;8(5):1970–1974.
   PubMed Web of Science ®Google Scholar
• Bremmer SC, McNeil AJ, Soellner MB. Enzyme-triggered gelation: targeting proteases with internal cleavage sites. Chem Commun. 2014;50(14):1691–1693.
   PubMed Web of Science ®Google Scholar
• Isaacson KJ, Martin Jensen M, Subrahmanyam NB, et al. Matrix-metalloproteinases as targets for controlled delivery in cancer: an analysis of upregulation and expression. J Control Release. 2017;259:62–75.
   PubMed Web of Science ®Google Scholar
• Guo F, Fu Q, Zhou K, et al. Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy. J Nanobiotechnol. 2020;18(1):48.
   PubMed Web of Science ®Google Scholar
• Tang B, Zaro JL, Shen Y, et al. Acid-sensitive hybrid polymeric micelles containing a reversibly activatable cell-penetrating peptide for tumor-specific cytoplasm targeting. J Control Release. 2018;279:147–156.
   PubMed Web of Science ®Google Scholar
• Yang Y, Yang Y, Xie X, et al. Preparation and characterization of photo-responsive cell-penetrating peptide-mediated nanostructured lipid carrier. J Drug Target. 2014;22(10):891–900.
   PubMed Web of Science ®Google Scholar
• Hambley TW, Hait WN. Is anticancer drug development heading in the right direction? Cancer Res. 2009;69(4):1259–1262.
   PubMed Web of Science ®Google Scholar
• Yang Y, Yang Y, Xie X, et al. Dual-modified liposomes with a two-photon-sensitive cell penetrating peptide and NGR ligand for siRNA targeting delivery. Biomaterials. 2015;48:84–96.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li X, Zhou Y, et al. Preparation of nanobubbles for ultrasound imaging and intracelluar drug delivery. Int J Pharm. 2010;384(1-2):148–153.
   PubMedGoogle Scholar
• Xie X, Lin W, Liu H, et al. Ultrasound-responsive nanobubbles contained with peptide-camptothecin conjugates for targeted drug delivery. Drug Deliv. 2016;23(8):2756–2764.
   PubMed Web of Science ®Google Scholar
• Jing H, Cheng W, Li S, et al. Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy. Colloids Surf B Biointerfaces. 2016;146:387–395.
   PubMed Web of Science ®Google Scholar
• Raucher D, Chilkoti A. Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition. Cancer Res. 2001;61(19):7163–7170.
   PubMed Web of Science ®Google Scholar
• Li NK, Garcia Quiroz F, Hall CK, et al. Molecular description of the LCST behavior of an elastin-like polypeptide. Biomacromolecules. 2014;15(10):3522–3530.
   PubMed Web of Science ®Google Scholar
• Walker LR, Ryu JS, Perkins E, et al. Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer. Drug Des Devel Ther. 2014;8:1649–1658.
   PubMed Web of Science ®Google Scholar
• van Oppen L, Pille J, Stuut C, et al. Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models. Eur J Pharm Biopharm. 2019;137:175–184.
   PubMed Web of Science ®Google Scholar
• Fu H, Shi K, Hu G, et al. Tumor-targeted paclitaxel delivery and enhanced penetration using TAT-decorated liposomes comprising redox-responsive poly(ethylene glycol). J Pharm Sci. 2015;104(3):1160–1173.
   PubMed Web of Science ®Google Scholar
• Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell. 1997;88(2):223–233.
   PubMed Web of Science ®Google Scholar
• Yu Y, Zu C, He D, et al. pH-dependent reversibly activatable cell-penetrating peptides improve the antitumor effect of artemisinin-loaded liposomes. J Colloid Interface Sci. 2021;586:391–403.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li J, Chen JJ, et al. Multifunctional nanoparticles loading with docetaxel and gdc0941 for reversing multidrug resistance mediated by PI3K/Akt signal pathway. Mol Pharmaceutics. 2017;14(4):1120–1132.
   PubMed Web of Science ®Google Scholar
• Laxman K, Reddy BPK, Robinson A, et al. Cell-penetrating peptide-conjugated BF2 -oxasmaragdyrins as NIRF imaging and photothermal agents. ChemMedChem. 2020;15(19):1783–1787.
   PubMed Web of Science ®Google Scholar
• Yu SL, Koo H, Lee HY, et al. Recombinant cell-permeable HOXA9 protein inhibits NSCLC cell migration and invasion. Cell Oncol. 2019;42(3):275–285.
   Web of Science ®Google Scholar
• Ding C, Wu K, Wang W, et al. Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer. Oncotarget. 2017;8(3):4718–4729.
   PubMedGoogle Scholar
• Derossi D, Joliot AH, Chassaing G, et al. The 3rd helix of the antennapedia homeodomain translocates through biological-membranes. J Biol Chem. 1994;269(14):10444–10450.
   PubMed Web of Science ®Google Scholar
• Oehlke J, Scheller A, Wiesner B, et al. Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically. Biochimica Et Biophysica Acta-Biomembranes. 1998;1414(1–2):127–139.
   PubMed Web of Science ®Google Scholar
• Pooga M, Hallbrink M, Zorko M, et al. Cell penetration by transportan. FASEB J. 1998;12(1):67–77.
   PubMed Web of Science ®Google Scholar
• Oh JH, Chong SE, Nam S, et al. Multimeric amphipathic alpha-helical sequences for rapid and efficient intracellular protein transport at nanomolar concentrations. Adv Sci. 2018;5(8):1800240.
   Web of Science ®Google Scholar
• Watkins CL, Brennan P, Fegan C, et al. Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. J Control Release. 2009;140(3):237–244.
   PubMed Web of Science ®Google Scholar
• Nakayama F, Yasuda T, Umeda S, et al. Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12. J Biol Chem. 2011;286(29):25823–25834.
   PubMed Web of Science ®Google Scholar
• Wei Y, Ma L, Zhang L, et al. Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy. IJN. 2017;12:7039–7051.
   Google Scholar
• Kunnapuu K, Veiman KL, Porosk L, et al. Tumor gene therapy by systemic delivery of plasmid DNA with cell-penetrating peptides. FASEB Bioadv. 2019;1(2):105–114.
   PubMedGoogle Scholar
• Taha AAA, Jawad SMH, Al-Barram LFA. Improvement of cancer therapy by TAT peptide conjugated gold nanoparticles. J Clust Sci. 2019;30(2):403–414.
   Web of Science ®Google Scholar
• Niu S, Williams GR, Wu J, et al. A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy. J Nanobiotechnol. 2019;17(1):95.
   PubMed Web of Science ®Google Scholar
• Wen J, Liu F, Tao B, et al. GSH-responsive anti-mitotic cell penetrating peptide-linked podophyllotoxin conjugate for improving water solubility and targeted synergistic drug delivery. Bioorg Med Chem Lett. 2019;29(8):1019–1022.
   PubMed Web of Science ®Google Scholar
• Gregory JV, Kadiyala P, Doherty R, et al. Systemic brain tumor delivery of synthetic protein nanoparticles for glioblastoma therapy. Nat Commun. 2020;11(1):5687.
   PubMed Web of Science ®Google Scholar
• Chen X, Niu S, Bremner DH, et al. Co-delivery of doxorubicin and oleanolic acid by triple-sensitive nanocomposite based on chitosan for effective promoting tumor apoptosis. Carbohydr Polym. 2020;247:116672.
   PubMed Web of Science ®Google Scholar
• Dos Santos Rodrigues B, Kanekiyo T, Singh J. In vitro and in vivo characterization of CPP and transferrin modified liposomes encapsulating pDNA. Nanomedicine. 2020;28:102225.
   PubMed Web of Science ®Google Scholar
• Kong L, Zhang SM, Chu JH, et al. Tumor microenvironmental responsive liposomes simultaneously encapsulating biological and chemotherapeutic drugs for enhancing antitumor efficacy of NSCLC. IJN. 2020;15:6451–6468.
   Google Scholar
• Yoon HY, Yang HM, Kim CH, et al. Enhanced intracellular delivery of BCG cell wall skeleton into bladder cancer cells using liposomes functionalized with folic acid and Pep-1 peptide. Pharmaceutics. 2019;11(12):652.
   PubMed Web of Science ®Google Scholar
• Guo H, Li F, Qiu H, et al. Synergistically enhanced mucoadhesive and penetrable polypeptide nanogel for efficient drug delivery to orthotopic bladder cancer. Research. 2020;2020:1–14.
   Google Scholar
• Saito A, Yamamoto S, Ochi R, et al. An azide-tethered cremophor (R) ELP surfactant allowing facile post-surface functionalization of nanoemulsions. BCSJ. 2020;93(4):568–575.
   Google Scholar
• Gao G, Jiang YW, Jia HR, et al. From perinuclear to intranuclear localization: a cell-penetrating peptide modification strategy to modulate cancer cell migration under mild laser irradiation and improve photothermal therapeutic performance. Biomaterials. 2019;223:119443.
   PubMed Web of Science ®Google Scholar
• You Y, Wang N, He L, et al. Designing dual-functionalized carbon nanotubes with high blood-brain-barrier permeability for precise orthotopic glioma therapy. Dalton Trans. 2019;48(5):1569–1573.
   PubMed Web of Science ®Google Scholar