Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model

References

• Richeldi L, Collard HR, Jones MG. Idiopathic pulmonary fibrosis. Lancet. 2017;389(10082):1941–1952.
   PubMed Web of Science ®Google Scholar
• Selman M, King TE, Pardo A, et al. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 2001;134(2):136–151.
   PubMed Web of Science ®Google Scholar
• Gifford AH, Matsuoka M, Ghoda LY, et al. Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes. Mucosal Immunol. 2012;5(5):480–484.
   PubMed Web of Science ®Google Scholar
• Taskar VS, Coultas DB. Is idiopathic pulmonary fibrosis an environmental disease? Proc Am Thorac Soc. 2006;3(4):293–298.
   PubMedGoogle Scholar
• Ley B, Collard HR. Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol. 2013;5:483–492.
   PubMedGoogle Scholar
• Bolourani S, Brenner M, Wang P. The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis. J Mol Med (Berl). 2021;99(10):1373–1384.
   PubMedGoogle Scholar
• Poletti V, Capozzolo A. Respiratory rehabilitation in the COVID-19 era. Respiration. 2020;99(6):461–462.
   PubMedGoogle Scholar
• Betensley A, Sharif R, Karamichos D. A systematic review of the role of dysfunctional wound healing in the pathogenesis and treatment of idiopathic pulmonary fibrosis. J Clin Med. 2016;6(1):2.
   PubMed Web of Science ®Google Scholar
• Bringardner BD, Baran CP, Eubank TD, et al. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal. 2008;10(2):287–301.
   PubMed Web of Science ®Google Scholar
• Wight TN, Potter-Perigo S. The extracellular matrix: an active or passive player in fibrosis? Am J Physiol Gastrointest Liver Physiol. 2011;301(6):G950–5.
   PubMed Web of Science ®Google Scholar
• Luzina IG, Todd NW, Iacono AT, et al. Roles of T lymphocytes in pulmonary fibrosis. J Leukoc Biol. 2008;83(2):237–244.
   PubMed Web of Science ®Google Scholar
• Raghu G, Johnson WC, Lockhart D, et al. Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: results of a prospective, open-label phase II study. Am J Respir Crit Care Med. 1999;159(4 Pt 1):1061–1069.
   PubMed Web of Science ®Google Scholar
• Rafii R, Juarez MM, Albertson TE, et al. A review of current and novel therapies for idiopathic pulmonary fibrosis. J Thorac Dis. 2013;5(1):48–73.
   PubMedGoogle Scholar
• Fujimoto H, Kobayashi T, Azuma A. Idiopathic pulmonary fibrosis: treatment and prognosis. Clin Med Insights Circ Respir Pulm Med. 2015;9(1):179–185.
   PubMedGoogle Scholar
• Smargiassi A, Pasciuto G, Conte EG, et al. Pharmacological treatement of IPF. In Meyer KC, Nathan SD, editors. Idiopathic pulmonary fibrosis. Berlin, Germany: Springer; 2019. p. 325–364.
   Google Scholar
• Ballester B, Milara J, Cortijo J. Pirfenidone anti-fibrotic effects are partially mediated by the inhibition of MUC1 bioactivation. Oncotarget. 2020;11(15):1306–1320.
   PubMedGoogle Scholar
• Misra HP, Rabideau C. Pirfenidone inhibits NADPH-dependent microsomal lipid peroxidation and scavenges hydroxyl radicals. Mol Cell Biochem. 2000;204(1–2):119–126.
   PubMed Web of Science ®Google Scholar
• Ito Y, Tazaki G, Kondo Y, et al. Therapeutic effect of nintedanib on acute exacerbation of interstitial lung diseases. Respir Med Case Rep. 2019;26:317–320.
   PubMedGoogle Scholar
• Griffiths MJ, McAuley DF. RAGE: a biomarker for acute lung injury. Thorax. 2008;63(12):1034–1036.
   PubMed Web of Science ®Google Scholar
• He M, Kubo H, Ishizawa K, et al. The role of the receptor for advanced glycation end-products in lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2007;293(6):L1427–36.
   PubMed Web of Science ®Google Scholar
• Englert JM, Kliment CR, Ramsgaard L, et al. Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis. Int J Clin Exp Pathol. 2011;4(3):241–254.
   PubMedGoogle Scholar
• Teissier T, Boulanger E. The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging. Biogerontology. 2019;20(3):279–301.
   PubMed Web of Science ®Google Scholar
• Hudson BI, Lippman ME. Targeting RAGE signaling in inflammatory disease. Annu Rev Med. 2018;69:349–364.
   PubMed Web of Science ®Google Scholar
• Sun Y, Liu WZ, Liu T, et al. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res. 2015;35(6):600–604.
   PubMed Web of Science ®Google Scholar
• Kierdorf K, Fritz G. RAGE regulation and signaling in inflammation and beyond. J Leukoc Biol. 2013;94(1):55–68.
   PubMed Web of Science ®Google Scholar
• Bopp C, Bierhaus A, Hofer S, et al. Bench-to-bedside review: the inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Crit Care. 2008;12(1):201.
   PubMed Web of Science ®Google Scholar
• Aghasafari P, George U, Pidaparti R. A review of inflammatory mechanism in airway diseases. Inflamm Res. 2018;68:59–74.
   PubMedGoogle Scholar
• Oh J, Lee J, Piao C, et al. A self-assembled DNA-nanoparticle with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke. Biomater Sci. 2019;7(5):2174–2190.
   PubMedGoogle Scholar
• Ha J, Kim M, Lee Y, et al. Intranasal delivery of self-assembled nanoparticles of therapeutic peptides and antagomirs elicits anti-tumor effects in an intracranial glioblastoma model. Nanoscale. 2021;13(35):14745–14759.
   PubMedGoogle Scholar
• Kim M, Lee Y, Lee M. Hypoxia-specific anti-RAGE exosomes for nose-to-brain delivery of anti-miR-181a oligonucleotide in an ischemic stroke model. Nanoscale. 2021;13(33):14166–14178.
   PubMed Web of Science ®Google Scholar
• Kim G, Lee Y, Ha J, et al. Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation. J Control Release. 2021;330:684–695.
   PubMed Web of Science ®Google Scholar
• Kim G, Kim M, Lee Y, et al. Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes. J Control Release. 2020;317:273–281.
   PubMed Web of Science ®Google Scholar
• Piao C, Zhuang C, Choi M, et al. A RAGE-antagonist peptide potentiates polymeric micelle-mediated intracellular delivery of plasmid DNA for acute lung injury gene therapy. Nanoscale. 2020;12(25):13606–13617.
   PubMed Web of Science ®Google Scholar
• Lee S, Piao C, Kim G, et al. Production and application of HMGB1 derived recombinant RAGE-antagonist peptide for anti-inflammatory therapy in acute lung injury. Eur J Pharm Sci. 2018;114:275–284.
   PubMed Web of Science ®Google Scholar
• Liu MH, Lin AH, Ko HK, et al. Prevention of Bleomycin-Induced pulmonary inflammation and fibrosis in mice by paeonol. Front Physiol. 2017;8(193):193.
   PubMedGoogle Scholar
• Fernandez IE, Eickelberg O. The impact of TGF-β on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc. 2012;9(3):111–116.
   PubMedGoogle Scholar
• Eickelberg O, Kohler E, Reichenberger F, et al. Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-beta1 and TGF-beta3. Am J Physiol. 1999;276(5):L814–24.
   PubMedGoogle Scholar
• Upagupta C, Shimbori C, Alsilmi R, et al. Matrix abnormalities in pulmonary fibrosis. Eur Respir Rev. 2018;27(148):180033.
   PubMed Web of Science ®Google Scholar
• Hinz B, Pittet P, Smith-Clerc J, et al. Myofibroblast development is characterized by specific cell-cell adherens junctions. Mol Biol Cell. 2004;15(9):4310–4320.
   PubMedGoogle Scholar
• Bargagli E, Penza F, Bianchi N, et al. Controversial role of RAGE in the pathogenesis of idiopathic pulmonary fibrosis. Respir Physiol Neurobiol. 2009;165(2–3):119–120.
   PubMedGoogle Scholar
• Oczypok EA, Perkins TN, Oury TD. All the "RAGE" in lung disease: the receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr Respir Rev. 2017;23:40–49.
   PubMed Web of Science ®Google Scholar