Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment

References

• Wang S, Wang L, Wu C, et al. E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts. Arthritis Res Ther. 2018;20(1):225.
   PubMedGoogle Scholar
• Abbasi M, Mousavi MJ, Jamalzehi S, et al. Strategies toward rheumatoid arthritis therapy; the old and the new. J Cell Physiol. 2019;234(7):10018–10031.
   PubMed Web of Science ®Google Scholar
• Schellekens GA, de Jong BA, van den Hoogen FH, et al. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.1998. J Immunol. 2015;195(1):8–16.
   PubMed Web of Science ®Google Scholar
• Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038.
   PubMed Web of Science ®Google Scholar
• Xiao C, Zhou J, He Y, et al. Effects of triptolide from radix tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats. Chin Med. 2009;4(4):13.
   PubMedGoogle Scholar
• Burmester GR, Pope JE. Novel treatment strategies in rheumatoid arthritis. Lancet. 2017;389(10086):2338–2348.
   PubMed Web of Science ®Google Scholar
• Ratsimandresy RA, Rappaport J, Zagury JF. Anti-cytokine therapeutics: history and update. Curr Pharm Des. 2009;15(17):1998–2025.
   PubMed Web of Science ®Google Scholar
• Han R, Rostami-Yazdi M, Gerdes S, et al. Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases. Br J Clin Pharmacol. 2012;74(3):424–436.
   PubMed Web of Science ®Google Scholar
• Tasneem S, Liu B, Li B, et al. Molecular pharmacology of inflammation: medicinal plants as anti-inflammatory agents. Pharmacol Res. 2019;139:126–140.
   PubMed Web of Science ®Google Scholar
• Li XJ, Jiang ZZ, Zhang LY. Triptolide: progress on research in pharmacodynamics and toxicology. J Ethnopharmacol. 2014;155(1):67–79.
   PubMed Web of Science ®Google Scholar
• Huang G, Yuan K, Zhu Q, et al. Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis. Mol Immunol. 2018;101:210–220.
   PubMed Web of Science ®Google Scholar
• Tao X, Davis LS, Lipsky PE. Effect of an extract of the Chinese herbal remedy tripterygium wilfordii hook F on human immune responsiveness. Arthritis Rheum. 1991;34(10):1274–1281.
   PubMedGoogle Scholar
• Yuan K, Li X, Lu Q, et al. Application and mechanisms of triptolide in the treatment of inflammatory diseases-a review. Front Pharmacol. 2019;10:1469.
   PubMed Web of Science ®Google Scholar
• Fan D, He X, Bian Y, et al. Triptolide modulates TREM-1 signal pathway to inhibit the inflammatory response in rheumatoid arthritis. Int J Mol Sci. 2016;17(4):498.
   PubMed Web of Science ®Google Scholar
• Xu H, Zhao H, Lu C, et al. Triptolide inhibits osteoclast differentiation and bone resorption in vitro via enhancing the production of IL-10 and TGF-β1 by regulatory T cells. Mediators Inflamm. 2016;2016:8048170.
   PubMed Web of Science ®Google Scholar
• Lu J, Jiang F, Lu A, et al. Linkers having a crucial role in Antibody-Drug conjugates. Int J Mol Sci. 2016;17(4):561.
   PubMed Web of Science ®Google Scholar
• Tai T, Huang X, Su Y, et al. Glycyrrhizin accelerates the metabolism of triptolide through induction of CYP3A in rats. J Ethnopharmacol. 2014;152(2):358–363.
   PubMed Web of Science ®Google Scholar
• Zhang C, Sun PP, Guo HT, et al. Safety profiles of tripterygium wilfordii hook F: a systematic review and Meta-Analysis. Front Pharmacol. 2016;7:402.
   PubMed Web of Science ®Google Scholar
• Li P, Yang X, Yang Y, et al. Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice. J Control Release. 2020;319:87–103.
   PubMed Web of Science ®Google Scholar
• Lee SM, Kim HJ, Ha YJ, et al. Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. ACS Nano. 2013;7(1):50–57.
   PubMed Web of Science ®Google Scholar
• Li R, He Y, Zhu Y, et al. Route to rheumatoid arthritis by macrophage-derived microvesicle-coated nanoparticles. Nano Lett. 2019;19(1):124–134.
   PubMed Web of Science ®Google Scholar
• Yang Y, Guo L, Wang Z, et al. Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and re-polarization. Biomaterials. 2021;264:120390.
   PubMed Web of Science ®Google Scholar
• Wang Q, Jiang H, Li Y, et al. Targeting NF-kB signaling with polymeric hybrid micelles that co-deliver siRNA and dexamethasone for arthritis therapy. Biomaterials. 2017;122:10–22.
   PubMed Web of Science ®Google Scholar
• Zhang L, Chang J, Zhao Y, et al. Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis. Int J Nanomedicine. 2018;13:2051–2064.
   PubMed Web of Science ®Google Scholar
• Wang D, Goldring SR. The bone, the joints and the balm of gilead. Mol Pharm. 2011;8(4):991–993.
   PubMedGoogle Scholar
• Prasad LK, O'Mary H, Cui Z. Nanomedicine delivers promising treatments for rheumatoid arthritis. Nanomedicine (Lond). 2015;10(13):2063–2074.
   PubMed Web of Science ®Google Scholar
• Wang Q, Li Y, Chen X, et al. Optimized in vivo performance of acid-liable micelles for the treatment of rheumatoid arthritis by one single injection, Tsinghua university press. Nano Res. 2019;12(2):421–428.
   Web of Science ®Google Scholar
• Wang Y, Liu Z, Li T, et al. Enhanced therapeutic effect of RGD-modified polymeric micelles loaded with low-dose methotrexate and nimesulide on rheumatoid arthritis. Theranostics. 2019;9(3):708–720.
   PubMed Web of Science ®Google Scholar
• Quan LD, Purdue PE, Liu XM, et al. Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. Arthritis Res Ther. 2010;12(5):R170.
   PubMed Web of Science ®Google Scholar
• Zhang N, Xu C, Li N, et al. Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation. Drug Deliv. 2018;25(1):1182–1191.
   PubMed Web of Science ®Google Scholar
• Chandrupatla D, Molthoff C, Lammertsma AA, et al. The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis. Drug Deliv Trans Res. 2019;9(1):366–378.
   PubMed Web of Science ®Google Scholar
• Verma A, Jain A, Tiwari A, et al. Folate conjugated double liposomes bearing prednisolone and methotrexate for targeting rheumatoid arthritis. Pharm Res. 2019;36(8):123.
   PubMed Web of Science ®Google Scholar
• Alam MM, Han HS, Sung S, et al. Endogenous inspired biomineral-installed hyaluronan nanoparticles as pH-responsive carrier of methotrexate for rheumatoid arthritis. J Control Release. 2017;252:62–72.
   PubMed Web of Science ®Google Scholar
• Seo J, Park SH, Kim MJ, et al. Injectable Click-Crosslinked hyaluronic acid depot to prolong therapeutic activity in articular joints affected by rheumatoid arthritis. ACS Appl Mater Interfaces. 2019;11(28):24984–24998.
   PubMed Web of Science ®Google Scholar
• Trujillo-Nolasco RM, Morales-Avila E, Ocampo-García BE, et al. Preparation and in vitro evaluation of radiolabeled HA-PLGA nanoparticles as novel MTX delivery system for local treatment of rheumatoid arthritis. Mater Sci Eng C Mater Biol Appl. 2019;103:109766.
   PubMed Web of Science ®Google Scholar
• Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. Nature. 2013;498(7454):380–384.
   PubMed Web of Science ®Google Scholar
• Gao P, Ascano M, Wu Y, et al. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 2013;153(5):1094–1107.
   PubMed Web of Science ®Google Scholar
• Sauer JD, Sotelo-Troha K, von Moltke J, et al. The N-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun. 2011;79(2):688–694.
   PubMed Web of Science ®Google Scholar
• Burdette DL, Monroe KM, Sotelo-Troha K, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011;478(7370):515–518.
   PubMed Web of Science ®Google Scholar
• Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med. 2001;344(12):907–916.
   PubMed Web of Science ®Google Scholar
• Shin JM, Kim SH, Thambi T, et al. A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis. Chem Commun (Camb). 2014;50(57):7632–7625.
   PubMed Web of Science ®Google Scholar
• Kim YJ, Chae SY, Jin CH, et al. Ionic complex systems based on hyaluronic acid and PEGylated TNF-related apoptosis-inducing ligand for treatment of rheumatoid arthritis. Biomaterials. 2010;31(34):9057–9064.
   PubMed Web of Science ®Google Scholar
• Yang MD, Ding JX, Zhang Y, et al. Activated macrophage-targeted dextran-methotrexate/folate conjugate prevents deterioration of collagen-induced arthritis in mice. J Mater Chem B. 2016;4(12):2102–2113.
   PubMed Web of Science ®Google Scholar
• Choudhary N, Bhatt LK, Prabhavalkar KS. Experimental animal models for rheumatoid arthritis. Immunopharmacol Immunotoxicol. 2018;40(3):193–200.
   PubMed Web of Science ®Google Scholar
• Zhao J, Zhao M, Yu C, et al. Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis. Int J Nanomedicine. 2017;12:6735–6746.
   PubMed Web of Science ®Google Scholar