Epigenetic modulation: Research progress on histone acetylation levels in major depressive disorders

References

• Moussavi S, Chatterji S, Verdes E, et al. Depression, chronic diseases, and decrements in health: results from the world health surveys. Lancet. 2007;370(9590):851–858.
   PubMed Web of Science ®Google Scholar
• Eckshtain D, Kuppens S, Ugueto A, et al. Meta-analysis: 13-year follow-up of psychotherapy effects on youth depression. J Am Acad Child Adolesc Psychiatry. 2020;59(1):45–63.
   PubMed Web of Science ®Google Scholar
• Smith K. Mental health: a world of depression. Nature. 2014;515(7526):181.
   PubMedGoogle Scholar
• Huang Y, Wang Y, Wang H, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study. Lancet Psychiatry. 2019;6(3):211–224.
   PubMed Web of Science ®Google Scholar
• Tsankova N, Renthal W, Kumar A, et al. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci. 2007;8(5):355–367.
   PubMed Web of Science ®Google Scholar
• Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci. 2006;7(2):137–151.
   PubMed Web of Science ®Google Scholar
• Wang J, Hodes GE, Zhang H, et al. Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nat Commun. 2018;9(1):477.
   PubMedGoogle Scholar
• Nestler EJ, Barrot M, DiLeone RJ, et al. Neurobiology of depression. Neuron. 2002;34(1):13–25.
   PubMed Web of Science ®Google Scholar
• Berger SL, Kouzarides T, Shiekhattar R, et al. An operational definition of epigenetics. Genes Dev. 2009;23(7):781–783.
   PubMed Web of Science ®Google Scholar
• Nestler EJ. Epigenetic mechanisms of depression. JAMA Psychiatry. 2014;71(4):454–456.
   PubMed Web of Science ®Google Scholar
• Gold PW. The organization of the stress system and its dysregulation in depressive illness. Mol Psychiatry. 2015;20(1):32–47.
   PubMed Web of Science ®Google Scholar
• Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet. 2009;10(1):32–42.
   PubMed Web of Science ®Google Scholar
• Suo H, Wang P, Tong J, et al. NRSF is an essential mediator for the neuroprotection of trichostatin a in the MPTP mouse model of parkinson's disease. Neuropharmacology. 2015;99:67–78.
   PubMed Web of Science ®Google Scholar
• Sabari BR, Zhang D, Allis CD, et al. Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol. 2017;18(2):90–101.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Tan M, Xie Z, et al. Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol. 2011;7(1):58–63.
   PubMed Web of Science ®Google Scholar
• Morgan M, Shilatifard A. Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation. Nat Genet. 2020;52(12):1271–1281.
   PubMed Web of Science ®Google Scholar
• Yoon S, Eom GH. HDAC and HDAC inhibitor: from cancer to cardiovascular diseases. Chonnam Med J. 2016;52(1):1–11.
   PubMedGoogle Scholar
• Holbert MA, Marmorstein R. Structure and activity of enzymes that remove histone modifications. Curr Opin Struct Biol. 2005;15(6):673–680.
   PubMed Web of Science ®Google Scholar
• Han SH. Potential role of sirtuin as a therapeutic target for neurodegenerative diseases. J Clin Neurol. 2009;5(3):120–125.
   PubMed Web of Science ®Google Scholar
• Michishita E, Park JY, Burneskis JM, et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16(10):4623–4635.
   PubMed Web of Science ®Google Scholar
• Jin S, Scotto KW. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol Cell Biol. 1998;18(7):4377–4384.
   PubMed Web of Science ®Google Scholar
• Boyes J, Byfield P, Nakatani Y, et al. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature. 1998;396(6711):594–598.
   PubMed Web of Science ®Google Scholar
• Eom GH, Kook H. Posttranslational modifications of histone deacetylases: implications for cardiovascular diseases. Pharmacol Ther. 2014;143(2):168–180.
   PubMed Web of Science ®Google Scholar
• Luger K, Mäder AW, Richmond RK, et al. Crystal structure of the nucleosome core particle at 2.8 a resolution. Nature. 1997;389(6648):251–260.
   PubMed Web of Science ®Google Scholar
• Kramer AF, Cepeda NJ, Cepeda ML. Methylphenidate effects on task-switching performance in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2001;40(11):1277–1284.
   PubMed Web of Science ®Google Scholar
• Strahl BD, Allis CD. The language of covalent histone modifications. Nature. 2000;403(6765):41–45.
   PubMed Web of Science ®Google Scholar
• Brewin CR, Furnham A. Attributional versus preattributional variables in self-esteem and depression: a comparison and test of learned helplessness theory. J Pers Soc Psychol. 1986;50(5):1013–1020.
   PubMed Web of Science ®Google Scholar
• Papp M, Willner P, Muscat R. An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology (Berl). 1991;104(2):255–259.
   PubMed Web of Science ®Google Scholar
• Tsankova NM, Kumar A, Nestler EJ. Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci. 2004;24(24):5603–5610.
   PubMed Web of Science ®Google Scholar
• Tsankova NM, Berton O, Renthal W, et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9(4):519–525.
   PubMed Web of Science ®Google Scholar
• Fuchikami M, Morinobu S, Kurata A, et al. Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor (BDNF) gene and histone acetylation at its promoters in the rat hippocampus. Int J Neuropsychopharmacol. 2009;12(1):73–82.
   PubMed Web of Science ®Google Scholar
• Kendler KS. Twin studies of psychiatric illness: an update. Arch Gen Psychiatry. 2001;58(11):1005–1014.
   PubMed Web of Science ®Google Scholar
• Gräff J, Tsai LH. Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci. 2013;14(2):97–111.
   PubMed Web of Science ®Google Scholar
• Willner P. Dopamine and depression: a review of recent evidence. I. Empirical studies. Brain Res. 1983;287(3):211–224.
   PubMedGoogle Scholar
• Zacharko RM, Anisman H. Stressor-induced anhedonia in the mesocorticolimbic system. Neurosci Biobehav Rev. 1991;15(3):391–405.
   PubMed Web of Science ®Google Scholar
• Willner P, Muscat R, Papp M. Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev. 1992;16(4):525–534.
   PubMed Web of Science ®Google Scholar
• Hasler G, Drevets WC, Manji HK, et al. Discovering endophenotypes for major depression. Neuropsychopharmacology. 2004;29(10):1765–1781.
   PubMed Web of Science ®Google Scholar
• Nestler EJ, Carlezon WA.Jr. The mesolimbic dopamine reward circuit in depression. Biol Psychiatry. 2006;59(12):1151–1159.
   PubMed Web of Science ®Google Scholar
• Berton O, McClung CA, Dileone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006;311(5762):864–868.
   PubMed Web of Science ®Google Scholar
• Krishnan V, Han MH, Graham DL, et al. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007;131(2):391–404.
   PubMed Web of Science ®Google Scholar
• Covington HE, Maze I, LaPlant QC, et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci. 2009;29(37):11451–11460.
   PubMed Web of Science ®Google Scholar
• Hinwood M, Tynan RJ, Day TA, et al. Repeated social defeat selectively increases δFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex. Cereb Cortex. 2011;21(2):262–271.
   PubMed Web of Science ®Google Scholar
• Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science. 2012;338(6103):68–72.
   PubMed Web of Science ®Google Scholar
• Miguel-Hidalgo JJ, Rajkowska G. Morphological brain changes in depression: can antidepressants reverse them. CNS Drugs. 2002;16(6):361–372.
   PubMed Web of Science ®Google Scholar
• Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry. 2004;161(11):1957–1966.
   PubMed Web of Science ®Google Scholar
• Snyder JS, Soumier A, Brewer M, et al. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 2011;476(7361):458–461.
   PubMed Web of Science ®Google Scholar
• Eliwa H, Belzung C, Surget A. Adult hippocampal neurogenesis: is it the alpha and omega of antidepressant action. Biochem Pharmacol. 2017;141:86–99.
   PubMed Web of Science ®Google Scholar
• van Praag H, Schinder AF, Christie BR, et al. Functional neurogenesis in the adult hippocampus. Nature. 2002;415(6875):1030–1034.
   PubMed Web of Science ®Google Scholar
• Licznerski P, Duman RS. Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression. Neuroscience. 2013;251:33–50.
   PubMed Web of Science ®Google Scholar
• Pittenger C, Duman RS. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology. 2008;33(1):88–109.
   PubMed Web of Science ®Google Scholar
• Covington HE, Vialou VF, LaPlant Q, et al. Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition. Neurosci Lett. 2011;493(3):122–126.
   PubMed Web of Science ®Google Scholar
• Covington HE, Maze I, Vialou V, et al. Antidepressant action of HDAC inhibition in the prefrontal cortex. Neuroscience. 2015;298:329–335.
   PubMed Web of Science ®Google Scholar
• Lv Z, Weng X, Du C, et al. Downregulation of HDAC6 promotes angiogenesis in hepatocellular carcinoma cells and predicts poor prognosis in liver transplantation patients. Mol Carcinog. 2016;55(5):1024–1033.
   PubMed Web of Science ®Google Scholar
• Mostofa A, Distler A, Meads MB, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6(24):e151713.
   PubMed Web of Science ®Google Scholar
• Hahnen E, Hauke J, Tränkle C, et al. Histone deacetylase inhibitors: possible implications for neurodegenerative disorders. Expert Opin Investig Drugs. 2008;17(2):169–184.
   PubMed Web of Science ®Google Scholar
• Kazantsev AG, Thompson LM. Therapeutic application of histone deacetylase inhibitors for Central nervous system disorders. Nat Rev Drug Discov. 2008;7(10):854–868.
   PubMed Web of Science ®Google Scholar
• Hockly E, Richon VM, Woodman B, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington’s disease. Proc Natl Acad Sci U S A. 2003;100(4):2041–2046.
   PubMed Web of Science ®Google Scholar
• Dowling CM, Hollinshead K, Grande D, et al. Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Sci Adv. 2021;7(3):eabc4897.
   PubMed Web of Science ®Google Scholar
• Guerriero JL, Sotayo A, Ponichtera HE, et al. Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages. Nature. 2017;543(7645):428–432.
   PubMed Web of Science ®Google Scholar
• Shukla S, Tekwani BL. Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation. Front Pharmacol. 2020;11:537.
   PubMed Web of Science ®Google Scholar
• Choi M, Lee SH, Wang SE, et al. Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats. Proc Natl Acad Sci U S A. 2015;112(51):15755–15760.
   PubMed Web of Science ®Google Scholar
• Martínez-Pacheco H, Picazo O, López-Torres A, et al. Biochemical and behavioral characterization of IN14, a new inhibitor of HDACs with antidepressant-like properties. Biomolecules. 2020;10(2):299.
   PubMed Web of Science ®Google Scholar
• Fuchikami M, Yamamoto S, Morinobu S, et al. The potential use of histone deacetylase inhibitors in the treatment of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2016;64:320–324.
   PubMed Web of Science ®Google Scholar
• Haddad PM, Das A, Ashfaq M, et al. A review of valproate in psychiatric practice. Expert Opin Drug Metab Toxicol. 2009;5(5):539–551.
   PubMed Web of Science ®Google Scholar
• Kelly DL, Conley RR, Feldman S, et al. Adjunct divalproex or lithium to clozapine in treatment-resistant schizophrenia. Psychiatr Q. 2006;77(1):81–95.
   PubMed Web of Science ®Google Scholar
• Citraro R, Leo A, De Caro C, et al. Effects of histone deacetylase inhibitors on the development of epilepsy and psychiatric comorbidity in WAG/rij rats. Mol Neurobiol. 2020;57(1):408–421.
   PubMed Web of Science ®Google Scholar
• Fischer A, Sananbenesi F, Mungenast A, et al. Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci. 2010;31(12):605–617.
   PubMed Web of Science ®Google Scholar
• Erburu M, Muñoz-Cobo I, Domínguez-Andrés J, et al. Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity. Eur Neuropsychopharmacol. 2015;25(11):2036–2048.
   PubMed Web of Science ®Google Scholar
• Somoza JR, Skene RJ, Katz BA, et al. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. Structure. 2004;12(7):1325–1334.
   PubMed Web of Science ®Google Scholar
• Marchion DC, Bicaku E, Turner JG, et al. HDAC2 regulates chromatin plasticity and enhances DNA vulnerability. Mol Cancer Ther. 2009;8(4):794–801.
   PubMed Web of Science ®Google Scholar
• Schroeder FA, Lin CL, Crusio WE, et al. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry. 2007;62(1):55–64.
   PubMed Web of Science ®Google Scholar
• Mann Brukner A, Ben-Hur T, Honig A, et al. Effects of valproic acid on cerebral nutrient carriers’ expression in the rat. Front Pharmacol. 2018;9:1054.
   PubMed Web of Science ®Google Scholar
• Yamawaki Y, Fuchikami M, Morinobu S, et al. Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus. World J Biol Psychiatry. 2012;13(6):458–467.
   PubMed Web of Science ®Google Scholar
• Schmauss C. An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine. Sci Rep. 2015;5:8171.
   PubMed Web of Science ®Google Scholar
• Khan N, Jeffers M, Kumar S, et al. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J. 2008;409(2):581–589.
   PubMed Web of Science ®Google Scholar
• Grayson DR, Kundakovic M, Sharma RP. Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders. Mol Pharmacol. 2010;77(2):126–135.
   PubMed Web of Science ®Google Scholar
• Sone M, Itoh H, Yamahara K, et al. Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration. Arterioscler Thromb Vasc Biol. 2007;27(10):2127–2134.
   PubMed Web of Science ®Google Scholar
• Uchida S, Hara K, Kobayashi A, et al. Epigenetic status of GDNF in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron. 2011;69(2):359–372.
   PubMed Web of Science ®Google Scholar
• Bode KA, Schroder K, Hume DA, et al. Histone deacetylase inhibitors decrease toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology. 2007;122(4):596–606.
   PubMed Web of Science ®Google Scholar
• Leighton SP, Nerurkar L, Krishnadas R, et al. Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Mol Psychiatry. 2018;23(1):48–58.
   PubMed Web of Science ®Google Scholar
• Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006;27(1):24–31.
   PubMed Web of Science ®Google Scholar
• Meylan EM, Halfon O, Magistretti PJ, et al. The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: possible relevance for treatment-resistant depression. Neuropharmacology. 2016;107:111–121.
   PubMed Web of Science ®Google Scholar
• Ghosh B, Zhao WN, Reis SA, et al. Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. Bioorg Med Chem Lett. 2016;26(4):1265–1271.
   PubMed Web of Science ®Google Scholar