Publication Cover
Endothelium
Journal of Endothelial Cell Research
Volume 8, 2001 - Issue 3
12
Views
16
CrossRef citations to date
0
Altmetric
Original

Modulation of Angiogenesis and Progelatinase a by Thrombin Receptor Mimetics and Antagonists

, , , &
Pages 195-206 | Received 25 Jul 2000, Accepted 01 Mar 2001, Published online: 31 Jan 2011

References

  • Tsopanoglou N. E., Pipili-Synetos E., Maragoudakis M. E. Thrombin promotes angiogenesis by a mechanism independent of fibrin formation. Am. J. Physiol. 1993; 264: C1302–1307, Cell Physiol. 33
  • Haralabopoulos G. C., Grant D. S., Kleinman H. K., Maragoudakis M. E. Thrombin promotes endothelial cel alignment in Matrigel in vitro and angiogenesis in vivo. Am. J. Physiol. 1997; 273: C239–C242
  • Tsopanoglou N. E., Pipili-Synetos E., Maragoudakis M. E. On the mechanism of thrombin-induced angiogenesis. Potentiation of VEGF activity on endothelial cells by up-regulation of its receptors. J. Biol. Chem. 1999; 274: 23969–23976
  • Vu T.-K., Hung D., Wheaton V., Coughlin S. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057–1068
  • Nierodzik M. L., Kajumo F., Karpatikin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res. 1992; 52: 3267–3272
  • Even-Ram S., Usiely B., Cohen P., Grisaru-Granovsky S., Maoz M., Ginzburg Y., Reich R., Vlodavsky I., Bar-Shavit R. Thrombin receptor expression in malignant and physiological invation processes. Nat. Med. 1998; 4: 909–914
  • Sorensen H. T., Mellem K. L., Steffensen F. H., Olsen J. H., Nielsen G. L. The risk of diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N. Engl. J. Med. 1998; 338: 1169–1173
  • Sloan B. F., Rozhin J., Johnson K., Taylor H., Crissman J. D., Honn K. V. Cathepsin B: association with plasma membrane in metastatic tumours. Proc. Natl. Acad. Sci. (USA) 1986; 83: 2483–2487
  • Rickles F. R., Edwards R. L. Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 1983; 62(1)14–31
  • Maragoudakis M. E., Pipili-Synetos E., Sakkoula E., Pana-Giotopoulos D., Craniti N., Matsoukas J. Inhibition of TRAP-induced angiogenesis by the tripeptide Phe-Pro-Arg, a thrombin-receptor-derived peptide analogue. LiPS 1996; 3: 227–232
  • Panagiotopoulos D., Matsoukas J., Alexopoulos K., Zebeki A., Mavromoustakos T., Saiffedine M., Hollenberg M. Synthesis and activities of cyclic thrombin-receptor-derived peptide analogues of the Ser42-Phe-Leu-Leu-Arg46 motif sequence containing D-Phe and/or D-Arg. LiPS 1996; 3: 233–240
  • Alexopoulos K., Fatseas P., Melissari E., Vlahakow D., Smith J., Mavromoustakos T., Seifeddine M., Moore G., Hollenberg M., Matsoukas J. Design and synthesis of thrombin-receptor non-peptide mimetics utilizing a piperazine scaffold. Biorg. & Med. Chem. 1998; 7: 1033–1041
  • Jaffe E. A., Nachman R-L., Becker C. G., Minick C. C.R.R. Mimick CR culture of human endothelial cells derived from umbilical veins. Identification and immunological reaction. J. Clin. Invest. 1973; 52: 2745–2756
  • Heussen G., Dowdle E. B. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal. Biochem 1980; 102: 192–202
  • Zucker S., Conner C., Massimo B., Ende H., Drew M., Seiki M., Bahou W. F. Thrombin induces the activation of progelatinase A in vascular endothelial cells. J. Biol. Chem. 1995; 270: 23730–23738
  • Folkman J. Tumor angiogenesis. Adv. Cane. Res. 1985; 43: 172–203
  • Maragoudakis M. E., Panoutsacopoulou M., Sarmonika M. Rate of basement membrane biosynthesis as an index of angiogenesis. Tissue and Cell 1988; 20: 531–539
  • Maragoudakis M. E., Haralabopoulos G. C., Tsopanoglou N. E., Pipili-Synetos E. Validation of collagenous protein synthesis as an index of angiogenesis with the use of morphological methods. Microvascular Res. 1995; 50: 215–222
  • Duhamel-Clerin E., Orvain C., Lanza F., Cazenave J-P., Klein-Soyer C. Thrombin-receptor-mediated increase of two matrix metalloproteinases, MMP-1 and MMP-3 in human endothelial cells. Atheroscl., Thromb. and Vasc. Biology 1997; 17: 1931–1938
  • Tapparelli C., Metternich R., Ehrhardt C., Cook N. S. Synthetic low molecular weight thrombin inhibitors: molecular design and pharmacological profile. TIPS 1993; 14: 366–376
  • Li W. W., Li V. W., Casey R., Tsakayannis D., Kruger E. A., Lee A., Sun Y. L., Bonar C. A., Cornelius S. Clinical trials of angiogenesis based therapies: overview and new quiding principles. In Angiogenesis: Models, Modulators and Clinical Applications, M. E. Maragoudakis. Plenum Press. 1998; 475–492
  • Matsoukas J., Panagiotopoulos D., Keramida M., Mavromoustakos T., Yamdagni R., Qiao W., Moore G., Saiffed-Dine M., Hollenberg M. Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: Importance of the Phe/Arg relative conformation and the primary amino group for activity. J. Med. Chem. 1996; 39: 3585–3591
  • Matsoukas J., Hollenberg M., Mavromoustakos T., Panagiotopoulos D., Alexopoulos K., Yamdagni R., Wu Q., Moore G. Conformational analysis of the thrombin receptor agonist peptides SFLLR and SFLLR-NH2 by NMR: Evidence for cyclic bio-active conformation. J. Prot. Chem. 1997; 16: 113–131

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.