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Original Articles

SAR—The U.S. Regulatory Perspective

, , &
Pages 29-38 | Received 01 Mar 1993, Accepted 15 Sep 1993, Published online: 24 Sep 2006

References

  • TSCA—Toxic Substances Control Act. 1976 . United States Public Law 94–469, 90 Stat. 2003, October 11, 1976
  • Auer , C. M. and Gould , D. H. 1987 . Carcinogenicity assessment and the role of structure-activity relationships (SAR) analysis under TSCA Section 5 . Environ. Carcinog. Rev. , C5 ( 1 ) : 29 – 71 .
  • Auer , C. M. , Nabholz , J. V. and Baetcke , K. P. 1990 . Mode of action and the assessment of chemical hazards in the presence of limited data: Use of structure-activity-relationships (SAR) under TSCA, Section 5 . Environ. Hlth. Perspect. , 87 : 183 – 197 .
  • Nabholz , J. V. 1991 . Environmental hazard and risk assessment under the United States Toxic Substances Control Act . Sci. Total Environ. , 109/110 : 649 – 665 .
  • Zeeman , M. and Gilford , J. 1993 . “ Ecological hazard evaluation and risk assessment under EPA's Toxic Substances Control Act (T.S.C.A.): An introduction ” . In Environmental Toxicology and Risk Assessment—1st Volume , ASTM STP 1179 Edited by: Landis , W. , Hughes , J. and Lewis , M. 7 – 21 . Philadelphia, PA : American Society for Testing & Materials .
  • National Research Council . 1984 . Toxicity Testing: Strategies to Determine Needs and Priorities , 84 Washington, D.C. : National Academy Press .
  • Van Leeuwen , C. J. and van der Zandt , P. T.J. 1992 . Application of QSARs, extrapolation and equilibrium partitioning in aquatic effects assessment. I. Narcotic industrial pollutants . Environ. Toxicol. Chem. , 11 : 267 – 282 .
  • Zeeman , M. , Nabholz , J. V. and Clements , R. 1993 . “ The development of SAR/QSAR for use under EPA's Toxic Substances Control Act (TSCA): An Introduction ” . In Environmental Toxicology and Risk Assessment—2nd Volume , ASTM STP 1216 Edited by: Gorsuch , J. W. , Dwyer , F. J. , Ingersoll , C. G. and LaPoint , T. W. 523 – 539 . Philadelphia, PA : American Society for Testing and Materials .
  • Visser , R. 1992 . The OECD Existing Chemicals Programme: Sharing the burden . Risk Analysis , 12 ( 2 ) : 169 – 172 .
  • Hart , J. W. QSAR—a Western European regulatory perspective . Presented at the 5th International Workshop on QSAR in Environmental Toxicology . July 19–23 1992 , Duluth, Minnesota, USA.
  • OECD . 1990 . A Survey of New Chemicals Notification Procedures in OECD Member Countries , OECD Environment Monographs No. 35 171 Paris : Organization for Economic Co-operation and Development .
  • Clements , R. G. , ed. 1988 . Estimating Toxicity of Industrial Chemicals to Aquatic Organisms Using Structure Activity Relationships , 286 Washington, D.C. : U.S. Environmental Protection Agency, Office of Pollution Prevention & Toxics . EPA-560–6–88–001
  • Clements , R. G. , Nabholz , J. V. , Johnson , D. and Zeeman , M. 1993 . “ The use and application of QSARs in the Office of Toxic Substances for ecological hazard assessment of new chemicals ” . In Environmental Toxicology and Risk Assessment—1st Volume , ASTM STP 1179 Edited by: Landis , W. , Hughes , J. and Lewis , M. 56 – 74 . Philadelphia, PA : American Society for Testing & Materials .
  • Clements , R. G. , Nabholz , J. V. , Johnson , D. and Zeeman , M. 1993 . “ The use of quantitative structure activity relationships (QSARs) as screening tools in environmental assessment ” . In Environmental Toxicology and Risk Assessment—2nd Volume , ASTM STP 1216 Edited by: Gorsuch , J. W. , Dwyer , F. J. , Ingersoll , C. G. and LaPoint , T. W. 555 – 570 . Philadelphia, PA : American Society for Testing and Materials .
  • Nabholz , J. V. , Miller , P. and Zeeman , M. 1993 . “ Environmental risk assessment of new chemicals under the Toxic Substances Control Act (TSCA) Section 5 ” . In Environmental Toxicology and Risk Assessment—1st Volume , ASTM STP 1179 Edited by: Landis , W. , Hughes , J. and Lewis , M. 40 – 55 . Philadelphia, PA : American Society for Testing & Materials .
  • Nabholz , J. V. , Clements , R. G. , Zeeman , M. , Osborn , K. C. and Wedge , R. 1993 . “ Validation of structure activity relationships used by the Office of Pollution Prevention and Toxics for the environmental hazard assessment of industrial chemicals ” . In Environmental Toxicology and Risk Assessment—2nd Volume , ASTM STP 1216 Edited by: Gorsuch , J. W. , Dwyer , F. J. , Ingersoll , C. G. and LaPoint , T. W. 571 – 590 . Philadelphia, PA : American Society for Testing and Materials .
  • OECD . 1992 . Report of the OECD Workshop on Quantitative Structure Activity Relationships (QSARS) in Aquatic Effects Assessment , OECD Environment Monographs No. 58 95 Paris : Organization for Economic Co-operation and Development .
  • U.S. EPA . 1990 . Hydrofluorocarbons and Hydrochlorofluorocarbons—Interim Report , 71 Washington, D.C. : U.S. Environmental Protection Agency, Office of Pollution Prevention & Toxics .

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