QSAR Analyses of the Toxicity of Aliphatic Carboxylic Acids and Salts to Tetrahymena Pyriformis

References

• Zhao , Y. H. , Yuan , X. , Yang , L. H. and Wang , L. S. 1996 . Quantitative structure-activity relationships of organic acids and bases. . Bull. Environ. Contam. Toxicol. , 57 : 242 – 249 .
   PubMedGoogle Scholar
• Zhao , Y. H. , Ji , G. D. , Cronin , M. T. D. and Dearden , J. C. 1998 . QSAR study of the toxicity of benzoic acids to Vibrio fischeri, Daphnia magna, and carp. . Sci. Total Environ. , 216 : 205 – 215 .
   PubMed Web of Science ®Google Scholar
• Blum , D. J. W. and Speece , R. E. 1991 . Quantitative structure-activity relationships for chemical toxicity to environmental bacteria. . Ecotoxicol. Environ. Saf. , 22 : 198 – 224 .
   PubMed Web of Science ®Google Scholar
• Schultz , T. W. 1997 . TETRATOX: Tetrahymena pyriformis population growth impairment endpoint-A surrogate for fish lethality. . Toxicol. Methods , 7 : 289 – 309 .
   Google Scholar
• 1989 . SAS/STAT User's Guide , fourth edition Vol. 2 , 846 Cary, , North Carolina : SAS Institute Inc. . version 6
   Google Scholar
• Dean , J. A. 1992 . Lange's Handbook of Chemistry , 14th edn. 8.19 – 8.79 . New York : McGraw-Hill Publishing .
   Google Scholar
• Hunter , R. S. 1988 . “ Computer calculation of pK a ” . In QSAR 88 Proceedings 3rd International Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Toxicology , Edited by: Turner , J. E. , England , M. W. , Schultz , T. W. and Kwaak , N. J. 33 – 42 . Springfield, VA : NTIS .
   Google Scholar
• Stewart , J. J. P. 1990 . MOPAC manual , 6th edition. 189 USA : Frank J. Seiler Research Laboratory, Colorado Springs, CO, U.S. Air Force Academy .
   Google Scholar
• Wakita , K. , Yoshimoto , M. , Shuichi , M. and Watanabe , H. 1986 . A method for calculation of the aqueous solubility of organic compounds by using new fragment solubility constants. . Chem. Pharmacol. Bull. , 34 : 4663 – 4681 .
   Web of Science ®Google Scholar
• Yalkowsky , S. H. and Valvani , S. C. 1980 . Solubility and partitioning I: Solubility of nonelectrolytes in water. . J. Pharmaceut. Sci. , 69 : 912 – 922 .
   PubMed Web of Science ®Google Scholar
• Cronin , M. T. D. and Schultz , T. W. 1996 . Structure-toxicity relationships for phenols to . Tetrahymena pyriformis. Chemosphere , 32 : 1453 – 1468 .
   PubMed Web of Science ®Google Scholar
• Jaworska , J. S. , Hunter , R. S. and Schultz , T. W. 1995 . Quantitative structure-activity relationships and volume fraction analyses for selected esters. . Arch. Environ. Contam. Toxicol. , 29 : 86 – 93 .
   PubMed Web of Science ®Google Scholar
• Kidder , G. W. and Dewey , V. C. 1951 . “ The biochemistry of ciliates in pure culture. ” . In Biochemistry and Physiology of Protozoa , Edited by: Lwoff , A. Vol. 1 , 323 – 400 . New York : Academic Press .
   Google Scholar
• Mucinni , M. , Layton , A. C. , Sayler , G. S. and Schultz , T. W. 1999 . Aquatic toxicities of halogenated benzoic acids to . Tetrahymena pyriformis. Bull. Environ. Contam. Toxicol. , 62 : 616 – 622 .
   Google Scholar
• Russom , C. L. , Bradbury , S. P. , Broderius , S. J. , Hammermeister , D. E. and Drummond , R. A. 1997 . Predicting modes of toxic action from chemical structure: Acute toxicity in the fathead minnow (Pinephales promelas). . Environ. Toxicol. Chem. , 16 : 948 – 967 .
   Web of Science ®Google Scholar
• Könemann , H. and Musch , A. 1981 . Quantitative structure activity relationships in fish toxicity studies: 2. The influence of pH on the quantitative structure-activity relationship of chlorophcnols. . Toxicology , 19 : 223 – 228 .
   PubMed Web of Science ®Google Scholar
• Saarikoski , J. and Viluksela , M. 1981 . Influence of pH on the toxicity of substituted phenols to fish. . Arch Environ. Contum. Toxicol. , 10 : 749 – 753 .
   Google Scholar
• van Gestel , C. A. M. , Ma , W. and Smit , C. E. 1991 . Development of QSARs in terrestrial ecoloxicology: earthworm toxicity and soil sorption of chlorophenols, chlorobenzenes, and dichloroaniline. . Sci. Total Environ. , 109/110 : 589 – 604 .
   Google Scholar
• Schultz , T. W. , Bearden , A. P. and Jaworska , J. S. 1996 . A novel QSAR approach for estimating the toxicity of phenols. . SAR QSAR Environ. Res. , 5 : 99 – 112 .
   PubMedGoogle Scholar
• Saarikoski , J. and Viluksela , M. 1982 . Relation between physicochemical properties of phenols and their toxicity and accumulation in fish. . Ecotoxicol. Environ. Saf. , 6 : 501 – 512 .
   PubMed Web of Science ®Google Scholar
• Schwarzenbach , R. P. , Stierli , R. , Folsom , B. R. and Zeyer , J. 1988 . Compound properties relevant for assessing the environmental partitioning of nitrophenols. . Environ. Sci. Technol. , 22 : 83 – 92 .
   PubMed Web of Science ®Google Scholar
• Jafvert , C. T. , Westall , J. C. , Grieder , E. and Schwarzenbach , R. P. 1990 . Distribution of hydrophobic ionogenic organic compounds between octanol and water: Organic acids. . Environ. Sci. Technol. , 24 : 1795 – 1803 .
   Web of Science ®Google Scholar
• Austin , R. P. , Davis , A. M. and Manners , C. N. 1995 . Partitioning of ionizing molecules between aqueous buffers and phospholipid vesicles. . J. Pharm. Sci. , 84 : 1180 – 1183 .
   PubMed Web of Science ®Google Scholar
• Escher , B. I. , Snozzi , M. and Schwarzenbach , R. P. 1996 . Uptake, speciation, and uncoupling activity of substituted phenols in energy transducing membranes. . Environ. Sci. Technol. , 30 : 3071 – 3079 .
   Web of Science ®Google Scholar
• Schultz , T. W. , Lin , D. T. and Wesley , S. K. 1992 . QSARs for monosubstituted phenols and the polar narcosis mechanism of toxicity. . Qual. Assur. Good Pract., Regul. Law , 2 : 132 – 143 .
   Google Scholar
• Schüürmann , G. 1990 . QSAR analysis of the acute fish toxicity of organic phosphorothionates using theoretically derived molecular descriptors. . Environ. Toxicol. Chem. , 9 : 417 – 428 .
   Web of Science ®Google Scholar
• Zhao , Y. H. , Wand , L. S. , Gao , H. and Zhang , Z. 1993 . Quantitative structure-activity relationships- relationships between toxicity of organic chemicals to fish and to . Photobacterium phosphoreum. Chemosphere , 26 : 1971 – 1979 .
   Web of Science ®Google Scholar
• Schultz , T. W. , Sinks , G. D. and Bearden , A. P. 1998 . “ QSARs in aquatic toxicology: A mechanism of action approach comparing toxic potency to Pimephales promelas, Tetrahymena pyriformis, and Vibrio fischeri. ” . In Comparative QSAR , Edited by: Devillers , J. 51 – 109 . Taylor and Francis .
   Google Scholar