A complete analysis of winter flounder (Pleuronectes americanus) egg contaminants with respect to early reproduction, with a review of their toxicity and other environmental concentrations

References

• Ahlborg , U. G. , Becking , G. C. , Birnbaum , L. S. , Brouwer , A. , Derks , H. J. G. M. , Feeley , M. , Golor , G. , Hanberg , A. , Larsen , J. C. , Liem , A. K. D. , Safe , S. H. , Schlatter , C. , Wærn , F. , Younes , M. and Yrjänheikki , E. 1994 . Toxic equivalency factors for dioxin‐like PCBs. Report on a WHO‐ECEH and IPCS consultation, December 1993 . Chemosphere , 28 : 1049 – 1067 .
   Web of Science ®Google Scholar
• Ankley , G. T. , Tillett , D. E. , Giesy , J. P. , Jones , P. D. and Verbrugge , D. A. 1991 . Bioassay‐derived 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin equivalents in PCB‐containing extracts from the flesh and eggs of Lake Michigan chinook salmon (Oncorhynchus tshawytscha) and possible implications for reproduction . Can. J. Fish. Aquat. Sci. , 48 : 1685 – 1690 .
   Web of Science ®Google Scholar
• Ax , R. L. and Hansen , L. G. 1975 . Effects of purified polychlorinated biphenyl analogs on chicken reproduction . Poult. Sci. , 54 : 895 – 900 .
   PubMed Web of Science ®Google Scholar
• Ballschmitter , K. and Zell , M. 1980 . Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography, composition of technical Arochlor‐ and Clophen‐PCB mixtures . Fresenius’ Z. Anal. Chem. , 302 : 20 – 31 .
   Google Scholar
• Balon , E. K. 1975 . Terminology of intervals in fish development . J Fish. Res. Board Can. , 32 : 1663 – 1670 .
   Web of Science ®Google Scholar
• Bannister , R. , Davis , D. , Zackarewski , T. , Tizard , I. and Safe , S. 1987 . Arochlor 1254 as a 2,3,7,8‐tetrachloro‐dibenzo‐p‐dioxin antagonist: effects on enzyme induction and immunotoxicity . Toxicology , 46 : 29 – 42 .
   PubMed Web of Science ®Google Scholar
• Biegel , L. , Howie , L. and Safe , S. 1989 . Polychlorinated biphenyl (PCB) congeners as 2,3,7,8‐TCDD antagonists: teratogenicity studies . Chemosphere , 19 : 955 – 958 .
   Web of Science ®Google Scholar
• Binder , R. L. and Lech , J. J. 1984 . Xenobiotics in gametes of Lake Michigan lake trout (Salvelinus namaycush) induce hepatic monooxygenase activity in their offspring . Fundam. Appl. Toxicol. , 4 : 1042 – 1054 .
   PubMedGoogle Scholar
• Binder , R. L. and Stegeman , J. J. 1984 . Microsomal electron transport and xenobiotic monooxygenase activities during the embryonic period of development in the killifish, Fundulus heteroclitus . Toxicol. Appl. Pharmacol. , 73 : 432 – 442 .
   PubMed Web of Science ®Google Scholar
• Birnbaum , L. S. , Weber , H. , Harris , M. W. , Lamb , J. C. IV and McKinney , J. D. 1985 . Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin: increased evidence of cleft palate in mice . Toxicol. Appl. Pharmacol. , 77 : 292 – 302 .
   PubMed Web of Science ®Google Scholar
• Black , D. E. , Phelps , D. K. and Lapan , R. L. 1988 . The effect of inherited contamination on egg and larval winter flounder, Pseudopleuronects americanus . Mar. Environ. Res. , 25 : 45 – 62 .
   Web of Science ®Google Scholar
• Broyles , R. H. and Novek , M. I. 1979 . Uptake and distribution of 2,4,5,2’,4’,5'‐hexachlorobiphenyl in fry of lake trout and chinook salmon and its effect of viability . Toxicol. Appl. Pharmacol. , 50 : 299 – 308 .
   PubMed Web of Science ®Google Scholar
• Burdick , G. E. , Dean , H. J. , Harris , E. J. , Skea , J. , Karcher , R. and Frisa , C. 1972 . Effect of rate and duration of feeding DDT on the reproduction of salmonid fishes reared and held under controlled conditions . N.Y. Fish. Game J. , 19 : 97 – 115 .
   Google Scholar
• Calabrese , A. , Longwell , A. C. and Thurberg , F. P. 1986 . Work/Quality Assurance Project Plan for Reproductive Success of Winter Flounder (Long Island Sound) for EPA, Regions I and II, Long Island Sound Project , Contract rep. Milford , CT : NOAA, NMFS, NEFSC, Milford Laboratory .
   Google Scholar
• Calabrese , A. , Longwell , A. C. and Thurberg , F. P. 1989 . Final Report on Early Reproductive Success of Winter Flounder from Boston Harbor with Comparisons Made to Long Island Sound for EPA, Regions I and II, Long Island Sound Project , Contract rep., NOAA Milford , CT : NMFS, NEFSC, Milford Laboratory .
   Google Scholar
• Cameron , P. , Berg , J. , Dethlefsen , V. and von Westernhagen , H. 1992 . Developmental defects in pelagic embryos of several flatfish species in the southern North Sea . Neth. J. Sea Res. , 29 : 239 – 256 .
   Web of Science ®Google Scholar
• Carr , R. S. and Neff , J. M. 1988 . Influence of prior exposure to xenobiotics on the metabolism and distribution of polychlorinated biphenyls and phenanthrene in winter flounder, Pseudopleuronectes americanus . Mar. Environ. Res. , 24 : 73 – 77 .
   Web of Science ®Google Scholar
• Chang , S. and Longwell , A. C. 1984 . Examining Statistical Associations of Malformation, Cytopathology and Cytogenetic Abnormality of 1977 and 1978 Atlantic Mackerel Embryos with Indicator Levels of Environmental Contaminants , Copenhagen : Intern. C. Explor. Sea, Marine Environmental Quality Committee, Reference Statistics Committee . C. M. 1984/E:11
   Google Scholar
• Clarke , J. U. , McFarland , V. A. and Pierce , B. D. 1989 . Preliminary Recommendations for a Congener‐Specific PCB Analysis in Regulatory Evaluation of Dredged Material , Misc. Pap. D‐89–2 Vicksburg , MA : U.S. Army Engineer Waterways Experiment Station .
   Google Scholar
• Colborn , T. and Clement , C. 1992 . “ Chemically‐Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection ” . In Advances in Modern Environmental Toxicology , Vol. 21 , Princeton , NJ : Princeton Scientific .
   Google Scholar
• Collier , T. K. , Gruger , E. H. Jr. and Varanasi , U. 1985 . Effect of Arochlor 1254 on the biological fate of 2,6‐dimethyl‐naphthalene in coho salmon (Oncorhynchus kisutch) . Bull. Environ. Contam. Toxicol. , 34 : 114 – 120 .
   PubMedGoogle Scholar
• Cooley , W. W. and Lohner , P. R. 1971 . Multivariate Data Analysis , New York : John Wiley & Sons .
   Google Scholar
• Cooper , K. R. 1971 . Effects of polychlorinated dibenzo‐p‐dioxins and polychlorinated dibenzofurans on aquatic organisms . Rev. Aquat. Sci. , 1 : 227 – 242 .
   Google Scholar
• Craik , J. C. A. and Harvey , S. M. 1988 . A preliminary account of metal levels in eggs of farmed and wild Atlantic salmon and their relation to egg viability . Aquaculture , 73 : 309 – 321 .
   Web of Science ®Google Scholar
• Cross , J. N. and Hose , J. E. 1988 . Evidence for impaired reproduction in white croaker (Genyonemus lineatus) from contaminated areas off southern California . Mar. Environ. Res. , 24 : 185 – 188 .
   Web of Science ®Google Scholar
• Dethlefsen , V. 1977 . The influence of DDT and DDE on the embryogenesis and the mortality of larvae of cod (Gadus morhua L) . Ber. Dtsch. Wiss. Komm. Meeresforsch. , 25 : 115 – 148 .
   Google Scholar
• Dillon , T. M. , Benson , W. H. , Stackhouse , R. A. and Crider , A. M. 1990 . Effects of selected PCB congeners on survival, growth, and reproduction in Daphnia magna . Environ. Toxicol. Chem. , 9 : 1317 – 1326 .
   Web of Science ®Google Scholar
• Dipple , A. 1984 . “ Polynuclear aromatic hydrocarbons ” . In Chemical Carcinogens , Edited by: Searle , C. E. Vol. 2 , 245 – 314 . Washington, D.C. : American Chemical Society .
   Google Scholar
• Duane , M. 1974 . “ Interactions of metal ions with nucleic acids ” . In Metal Ions in Biological Systems , Edited by: Sigel , H. Vol. 3 , 1 – 43 . New York : Marcel Dekker .
   Google Scholar
• Duinker , J. C. and Hillebrand , M. T. J. 1983 . Composition of PCB mixture in biotic and abiotic marine compartments (Dutch Wadden Sea) . Bull. Environ. Contam. Toxicol. , 31 : 25 – 32 .
   PubMed Web of Science ®Google Scholar
• EC (Environment Canada) . 1991 . Toxic Chemicals in the Great Lakes and Associated Effects, Vol. 2, Effects , Vol. 2 , Ottawa , , Canada : Department of Fisheries and Oceans and Health and Welfare Canada .
   Google Scholar
• Eisler , R. 1985a . Mirex Hazards to Fish, Wildlife, and Invertebrates: a Synoptic Review. Contaminant Hazard Reviews , Rep. No. 1 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• Eisler , R. 1985b . Selenium Hazards to Fish, Wildlife, and Invertebrates: a Synoptic Review. Contaminant Hazard Reviews , Rep. No. 5 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• Eisler , R. 1987a . Polycyclic Aromatic Hydrocarbon Hazards to Fish, Wildlife, and Invertebrates: a Synoptic Review. Contaminant Hazard Reviews , Rep. No. 11 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• Eisler , R. 1987b . Mercury Hazards to Fish, Wildlife, and Invertebrates: a Synoptic Review. Contaminant Hazard Reviews , Rep. No. 10 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• Eisler , R. 1988 . Arsenic Hazards to Fish, Wildlife, and Invertebrates: a Synoptic Review. Contaminant Hazard Reviews , Rep. No. 12 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• Eisler , R. 1990 . Chlordane Hazards to Fish, Wildlife, and Invertebrates: a Synoptic Review: Contaminant Hazard Reviews , Rep. No. 21 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• Eisler , R. 1993 . Zinc Hazards to Fish, Wildlife, and Invertebrates; a Synoptic Review. Contaminant Hazard Reviews , Rep. No. 26 Washington, D.C. : U.S. Fish and Wildlife Service .
   Google Scholar
• EPA (Environmental Protection Agency) . 1992a . National Study of Chemical Residues in Fish , Vol. 1 , Washington, D.C. : Office of Science and Technology, Standards and Applied Science Division .
   Google Scholar
• EPA (Environmental Protection Agency) . 1992b . National Study of Chemical Residues in Fish , Vol. 2 , Washington, D.C. : Office of Science and Technology, Standards and Applied Science Division .
   Google Scholar
• Flessel , C. P. , Furst , A. and Radding , S. B. 1980 . “ A comparison of carcinogenic metals ” . In Metal Ions in Biological Systems , Edited by: Sigel , H. Vol. 10 , 23 – 54 . New York : Marcel Dekker .
   Google Scholar
• Furness , R. W. and Rainbow , P. S. 1990 . Heavy Metals in the Marine Environment , Boca Raton , FL : CRC Press .
   Google Scholar
• Gardner , G. R. and Pruell , R. J. 1989 . A comparison of both neoplastic and non‐neoplastic disorders in winter flounder (Pseudopleuronectes americanus) from eight areas in New England . Mar. Environ. Res. , 28 : 393 – 397 .
   Web of Science ®Google Scholar
• Giesy , J. P. , Newsted , J. and Gerking , D. L. 1986 . Relationships between chlorinated hydrocarbon concentrations and rearing mortality of chinook salmon (Oncorhynchus tshawytscha) eggs from Lake Michigan. J . Great Lakes Res. , 12 : 82 – 98 .
   Web of Science ®Google Scholar
• Gruger , E. H. Jr. , Karrick , N. L. , Davidson , A. I. and Hruby , T. 1975 . Accumulation of 3,4,3’,4'‐tetrachlorobiphenyl and 2,4,5,2’,4’,5'‐ and 2,4,6,2’,4’,6'‐hexachloro‐biphenyl in juvenile coho salmon . Environ. Sci. Technol. , 9 : 121 – 127 .
   Web of Science ®Google Scholar
• Guiney , P. D. , Melancon , M. J. Jr. , Lech , J. J. and Peterson , R. E. 1979 . Effects of egg and sperm maturation and spawning on the distribution and elimination of a polychlorinated biphenyl in rainbow trout (Salmo gairdneri) . Toxicol. Appl. Pharmacol. , 47 : 261 – 272 .
   PubMed Web of Science ®Google Scholar
• Haake , J. M. , Safe , S. , Mayura , K. and Phillips , T. D. 1987 . Arochlor 1254 as an antagonist of the teratogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin . Toxicol. Lett. , 38 : 299 – 306 .
   PubMed Web of Science ®Google Scholar
• Hansen , P. D. , von Westemhagen , H. and Rosenthal , H. 1985 . Chlorinated hydrocarbons and hatching success in Baltic herring spring spawners . Mar. Environ. Res. , 15 : 59 – 76 .
   Web of Science ®Google Scholar
• Haugen , D. A. and Peak , M. J. 1983 . Mixture of polycyclic aromatic compounds inhibit mutagenesis in the Salmonella/microsome assay by inhibition of metabolic activation . Mutat. Res. , 116 : 257 – 269 .
   PubMed Web of Science ®Google Scholar
• Helder , T. 1981 . Effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin TCDD on early life stages of rainbow trout (Salmo gairdneri, Richardson) . Toxicology , 19 : 101 – 112 .
   PubMed Web of Science ®Google Scholar
• Hesse , S. and Wolff , T. 1977 . In vitro interactions of di‐, tetra‐ and hexa‐chlorobiphenyl with rabbit liver monooxygenase . Biochem. Pharmacol. , 26 : 2043 – 2047 .
   PubMed Web of Science ®Google Scholar
• Hoffman , D. J. and Gay , M. L. 1981 . Embryotoxic effects of benzo(a)pyrene, chrysene, and 7,12‐dimethylbenzo[a]anthracene in petroleum hydrocarbon mixtures in mallard ducks . J Toxicol. Environ. Health , 7 : 775 – 787 .
   PubMed Web of Science ®Google Scholar
• Hogan , J. W. and Brauhn , J. T. 1975 . Abnormal rainbow trout fry from eggs containing high residues of a PCB (Aroclor 1242) . Prog. Fish Cult. , 37 : 229 – 230 .
   Web of Science ®Google Scholar
• IJC (International Joint Commission) . 1989 . Fourth Biennial Report Under the Great Lakes Water Quality Agreement of 1978 to the Governments of the United States and Canada and the State and Provincial Governments of the Great Lakes Basin Ottawa , Ontario
   Google Scholar
• Johnson , W. W. and Finley , M. T. 1980 . Handbook of Acute Toxicity of Chemicals to Fish and Aquatic Invertebrates , Publ. 137 Washington, D.C. : U.S. Department of the Interior, Fish and Wildlife Service . Summaries of Toxicity Tests Conducted at Columbia National Fisheries Research Laboratory, 1965–1978, Resour.
   Google Scholar
• Kihlström , J. E. , Johansson , A. , Ahlbom , J. , Olsson , M. , Jensen , S. and Bergman , Ä. 1992 . Effects of PCB and different fractions of PCB on the reproduction of mink (Mustela vison) . Ambio , 21 : 564 – 569 .
   Web of Science ®Google Scholar
• Long , E. R. , Buchman , J. F. , Bay , S. M. , Breteler , R. J. , Carr , R. S. , Chapman , P. M. , Hose , J.E. , Lissner , A. L. , Scott , J. and Wolfe , D. A. 1990 . Comparative evaluation of five toxicity tests with sediments from San Francisco Bay and Tomales Bay, California . Environ. Toxicol. Chem. , 9 : 1193 – 1214 .
   Web of Science ®Google Scholar
• Longwell , A. C. 1981 . “ Cytologic‐cytogenetic perspectives on petroleum effects in the marine environment — chromosome aberrations. Background paper prepared, submitted, peer reviewed, and used for the National Research Council's ” . In Oil in the Sea — Inputs, Fates and Effects , Milford , CT : NOAA, NMFS, NEFSC, Milford Laboratory .
   Google Scholar
• Longwell , A. C. 1988 . Fish embryos: practical indicators of environmental quality of significance to fisheries . Water Res. Bull. , 24 : 999 – 1005 .
   Google Scholar
• Longwell , A. C. , Chang , S. , Hebert , A. , Hughes , J. B. and Perry , D. 1992 . Pollution and developmental abnormalities of Atlantic fishes . Environ. Biol. Fishes , 35 : 1 – 21 .
   Web of Science ®Google Scholar
• Mac , M. J. , Schwartz , T. R. , Edsall , C. C. and Frank , A. M. 1993 . Polychlorinated biphenyls in Great Lakes lake trout and their eggs: relations to survival and congener composition 1979–1988 . J Great Lakes Res. , 19 : 752 – 765 .
   Web of Science ®Google Scholar
• Macek , K. J. 1968 . Reproduction in brook trout (Salvelinus fontinalis) fed sublethal concentrations of DDT . J Fish. Res. Board Can. , 25 : 1787 – 1796 .
   Web of Science ®Google Scholar
• Maki , A. W. and Johnson , H. E. 1975 . Effects of PCB (Aroclor 1254) and p,p’ DDT on production and survival of Daphnia magna Strauss . Bull. Environ. Contam. Toxicol. , 13 : 412 – 416 .
   PubMed Web of Science ®Google Scholar
• MacLeod , W. D. Jr. , Ramos , L. S. , Friedman , A. J. , Burrows , D. G. , Prohaska , P. G. , Fisher , D. L. and Brown , D. W. 1981 . Analysis of Residual Chlorinated Hydrocarbons, Aromatic Hydrocarbons and Related Compounds in Selected Sources, Sinks and Biota of the New York Bight , Tech. memo. OMPA‐6‐NOAA Boulder , CO : National Oceanic Atmospheric Administration, U.S. Department of Commerce .
   Google Scholar
• Marks , T. A. , Kimmel , G. L. and Staples , R. E. 1981 . Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. Teratogenicity of 3,3’,4,4’,5,5'‐hexachlorobiphenyl . Toxicol. Appl. Pharmacol. , 6l : 269 – 276 .
   Google Scholar
• McFarland , V. A. and Clarke , J. U. 1989 . Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: consideration for a congener‐specific analysis . Environ. Health Perspect. , 81 : 225 – 239 .
   PubMed Web of Science ®Google Scholar
• Mearns , A. J. , Matta , M. , Shigenaka , G. , MacDonald , D. , Buchman , M. , Harris , H. , Golas , J. and Lauenstein , G. 1991 . Contaminant Trends in the Southern California Bight: Inventory and Assessment , Tech. memo. NOS ORCA 62 Seattle , WA : National Oceanic Atmospheric Administration, U.S. Department of Commerce .
   Google Scholar
• Mehendale , H. M. , Chen , P. R. , Fishbein , L. and Matthews , H. B. 1973 . Effect of mirex on the activities of various rat hepatic mixed‐function oxidases . Arch. Environ. Contam. Toxicol. , 1 : 245 – 254 .
   PubMedGoogle Scholar
• Mommsen , T. P. and Walsh , P. J. 1988 . “ Vitellogenesis and oocyte assembly ” . In Fish Physiology, The Physiology of Developing Fish , Edited by: Hoar , W. S. and Randall , D. J. Vol. 11A , 347 – 406 . San Diego : Academic Press .
   Google Scholar
• Monosson , E. and Stegeman , J. J. 1991 . Cytochrome P450E (P4501A) induction and inhibition in winter flounder by 3,3’,4,4'‐tetrachlorobiphenyl — comparison of response in fish from Georges Bank and Narragansett Bay . Environ. Toxicol. Chem. , 10 : 765 – 774 .
   Web of Science ®Google Scholar
• Murchelano , R. A. and Wolke , R. E. 1985 . Epizootic carcinoma in winter flounder Pseudopleuronectes americanus . Science , 228 : 587 – 589 .
   PubMed Web of Science ®Google Scholar
• Murty , A. S. 1986 . Toxicity of Pesticides to Fish , Vol. 2 , Boca Raton , FL : CRC Press .
   Google Scholar
• Nebert , D. W. and Gonzalez , F. J. 1987 . P450 genes: structure, evolution, and regulation . Annu. Rev. Biochem. , 56 : 945 – 993 .
   PubMed Web of Science ®Google Scholar
• NEFSC (Northeast Fisheries Science Center) . 1993 . Status of Fishery Resources off the Northeastern United States for 1993 , Tech. memo. NMFS‐F/NEC‐101 Woods Hole , MA : National Oceanic Atmospheric Administration, U.S. Department of Commerce .
   Google Scholar
• Nelson , D. A. , Miller , J. E. , Rusanowsky , D. , Greig , R. A. , Sennefelder , G. R. , Mercaldo‐Allen , R. , Kuropat , C. , Gould , E. , Thurberg , F. P. and Calabrese , A. 1991 . Comparative reproductive success of winter flounder in Long Island Sound: a three‐year study (biology, biochemistry, and chemistry) . Estuaries , 14 : 318 – 331 .
   Google Scholar
• Nosho , T. and Freeman , K. , eds. Marine Fish Culture and Enhancement, Conference Proceedings . Seattle . Washington Sea Grant Program, University of Washington .
   Google Scholar
• NRC (National Research Council) . 1985 . Oil in the Sea — Inputs, Fates and Effects , Washington, D.C. : National Academy Press .
   Google Scholar
• NSTP (National Status and Trends Program for Marine Environmental Quality) . 1993 . “ Sampling and Analytical Methods of the National Status and Trends Program, National Benthic Surveillance and Mussel Watch Projects, 1984–1992 ” . In Comprehensive Descriptions of Trace Organic Analytical Methods , Vol. 4 , Silver Spring , MD : National Oceanic Atmospheric Administration, U.S. Department of Commerce .
   Google Scholar
• O'Brien , O. R. 1967 . Insecticides, Action and Metabolism , New York : Academic Press .
   Google Scholar
• Perry , D. , Hughes , J. B. and Hebert , A. T. 1991 . Sublethal abnormalities in embryos of winter flounder, Pseudopleuronectes americanus, from Long Island Sound . Estuaries , 14 : 306 – 317 .
   Google Scholar
• Peterson , R. E. , Theobald , H. M. and Kimmel , G. J. 1993 . Development and reproductive toxicity of dioxins and related compounds: cross species comparisons . Crit. Rev. Toxicol. , 23 : 283 – 335 .
   PubMed Web of Science ®Google Scholar
• Prager , M. H. and MacCall , A. D. 1993 . Detection of contaminant and climate effects on spawning success of three pelagic fish stocks off southern California: northern anchovy Engraulis mordax, Pacific sardine Sardinops sagax, and chub mackerel Scomber japonicus . Fish. Bull. , 91 : 310 – 327 .
   Google Scholar
• Safe , S. 1980 . “ Metabolism, uptake, storage and bioaccumulation ” . In Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products , Edited by: Kimbrough , R. D. 81 – 104 . North‐Holland, Amsterdam : Elsevier .
   Google Scholar
• Safe , S. 1987 . Determination of 2,3,7,8‐TCDD toxic equivalent factors (TEFs): support for the use of the in vitro AHH induction assay . Chemosphere , 16 : 791 – 802 .
   Web of Science ®Google Scholar
• Safe , S. 1989 . Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity . Mutat. Res. , 220 : 31 – 47 .
   PubMed Web of Science ®Google Scholar
• Safe , S. 1990 . Polychlorinated biphenyls (PCBs), dibenzo‐p‐dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEF's) . Crit. Rev. Toxicol. , 21 : 51 – 88 .
   PubMed Web of Science ®Google Scholar
• Safe , S. 1994 . Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment . Crit. Rev. Toxicol. , 24 : 87 – 149 .
   PubMed Web of Science ®Google Scholar
• Safe , S. , Bannister , R. , Davis , D. , Hoake , J. M. , Zaharewski , T. , Mayura , T. and Phillips , T. D. Arochlor 1254 as a 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin antagonist in mice (Abstr.) . Seventh Int. Symp. Chlorinated Dioxins and Related Compounds Program . Vol. 2 , Washington, D.C. : U.S. Environmental Protection Agency .
   Google Scholar
• Sargent , L. M. , Sattler , G. L. , Roloff , B. , Xu , Y.‐H. , Sattler , C. A. , Meisner , L. and Pitot , H. C. 1992 . Ploidy and specific karyotypic changes during promotion with phenobarbitol, 2,5,2’,5'‐tetrachlorobiphenyl, and/or 3,4,3’,4'‐tetrachlorobiphenyl in rat liver . Cancer Res. , 52 : 955 – 962 .
   PubMed Web of Science ®Google Scholar
• Shigenaka , G. 1990 . Chlordane in the Marine Environment of the United States: Review and Results from the National Status and Trends Program , Tech. memo. NOS OMA 55 Seattle , WA : National Oceanic Atmospheric Administration, U.S. Department of Commerce .
   Google Scholar
• Smith , R. K. and Cole , C. T. 1973 . Effects of egg concentrations of DDT and dieldrin on development in winter flounder (Pseudopleuronectes americanus) . J. Fish. Res. Board Can. , 30 : 1894 – 1898 .
   Web of Science ®Google Scholar
• Smith , A. G. , Francis , J. E. and Carthew , P. 1990 . Iron as a synergist for hepatocellular carcinoma induced by polychlorinated biphenyls in Ah‐responsive C57BL/10ScSn mice . Carcinogenesis , 11 : 437 – 444 .
   PubMed Web of Science ®Google Scholar
• Smith , V. E. , Spurr , J. M. , Filkins , J. C. and Jones , J. J. 1985 . Organochlorine contaminants of wintering ducks foraging on Detroit River sediments . J Great Lakes Res. , 11 : 231 – 246 .
   Web of Science ®Google Scholar
• Sorensen , E. M. B. 1991 . Metal Poisoning in Fish , Boca Raton , FL : CRC Press .
   Google Scholar
• Speranza , A. W. , Seeley , R. J. , Seeley , V. A. and Perlmutter , A. 1977 . The effect of sublethal concentrations of zinc on reproduction in the zebrafish, Brachydanio rerio Hamilton‐Buchanan . Environ. Pollut. , 12 : 217 – 222 .
   Web of Science ®Google Scholar
• Spies , R. B. and Rice , D. W. Jr. 1988 . Effects of organic contaminants on reproduction of the starry flounder Platichythys stellatus in San Francisco Bay. II. Reproductive success of fish captured in San Francisco Bay and Spawned in the Laboratory . Mar. Biol. , 98 : 191 – 200 .
   Web of Science ®Google Scholar
• Spitsbergen , J. M. , Walker , M. K. , Olson , J. R. and Peterson , R. E. 1991 . Pathologic alterations in early life stages of lake trout, Salvelinus namaycush, exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin as fertilized eggs. Aquat . Toxicol. , 19 : 41 – 72 .
   Web of Science ®Google Scholar
• Stadnicki , S. , Lin , F. S. D. and Allen , J. R. 1979 . DNA single strand breaks caused by 2,2’,5,5'‐tetrachlorobiphenyl and its metabolites . Res. Commun. Chem. Pathol Pharmacol. , 24 : 313 – 327 .
   PubMedGoogle Scholar
• Stegeman , J. J. , Teng , F. Y. and Snowberger , E. A. 1987 . Induced cytochrome P450 in winter flounder Pseudo‐pleuronectes americanus from coastal Massachusetts evaluated by catalytic assay and monoclonal antibody probes . Can. J. Fish. Aquat. Sci. , 44 : 1270 – 1277 .
   Web of Science ®Google Scholar
• Stiles‐Jewell , S. 1994 . Cytogenetic and Viability Effects of Petroleum Aromatic and PCB Hydrocarbons, Temperature and Salinity, on Early Development of the American Oyster, Crassostrea virginica Gmelin , Amherst : University of Massachusetts . Ph.D. dissertation
   Google Scholar
• Stow , C. A. and Carpenter , S. R. 1994 . PCB accumulation in Lake Michigan coho salmon: individual based models using allometric relationships . Environ. Sci. Technol. , 28 : 1543 – 1549 .
   PubMed Web of Science ®Google Scholar
• Underwood , E. J. 1979 . “ Interactions of trace metals ” . In Toxicity of Heavy Metals in the Environment, Part 2 , Edited by: Oehme , F. W. 641 – 668 . New York : Marcel Dekker .
   Google Scholar
• Varanasi , U. , ed. 1989 . Metabolism of Polycyclic Aromatic Hydrocarbons in the Aquative Environment , Boca Raton , FL : CRC Press .
   Google Scholar
• Vitaliano , J. S. and Zdanowicz , V. S. 1992 . Trace metals in eggs of winter flounder from Boston Harbor, a contaminated American estuary . Mar. Pollut. Bull. , 24 : 364 – 367 .
   Web of Science ®Google Scholar
• Waid , J. S. , ed. 1986a . PCBs and the Environment , Vol. 1 , Boca Raton , FL : CRC Press .
   Google Scholar
• Waid , J. S. , ed. 1986b . PCBs and the Environment , Vol. 2 , Boca Raton , FL : CRC Press .
   Google Scholar
• Waid , J. S. , ed. 1986c . PCBs and the Environment , Vol. 3 , Boca Raton , FL : CRC Press .
   Google Scholar
• Walker , M. K. and Peterson , R. E. 1991 . Potencies of polychlorinated dibenzo‐p‐dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8‐tetrachloro‐dibenzo‐p‐dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss) . Aquat. Toxicol. , 21 : 219 – 238 .
   Web of Science ®Google Scholar
• Walker , M. K. , Spitsbergen , J. M. , Olson , J. R. and Peterson , R. E. 1991 . 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) toxicity during early life stage development of lake trout (Salvelinus namaycush) . Can. J. Fish. Aquat. Sci. , 48 : 875 – 883 .
   Web of Science ®Google Scholar
• Wardell , R. E. , Seegmiller , R. E. and Bradshaw , W. S. 1982 . Induction of prenatal toxicity in the rat by diethyl‐stilbestrol, zeranol, 3,4,3’,4'‐tetrachlorobiphenyl, cadmium, and lead . Teratology , 26 : 229 – 237 .
   PubMedGoogle Scholar
• Ware , D. M. 1975 . Relation between egg size, growth and natural mortality of larval fishes . J Fish. Res. Board Can. , 32 : 2503 – 2512 .
   Web of Science ®Google Scholar
• Weis , J. S. and Weis , P. 1989 . Effects of environmental pollutants on early fish development . Rev. Aquat. Sci. , 1 : 45 – 73 .
   Google Scholar
• von Westernhagen , H. , Cameron , P. , Dethlefsen , V. and Janssen , D. 1989 . Chlorinated hydrocarbons in North Sea whiting (Merlangius merlangus L.), and effects on reproduction. I. Tissue burden and hatching success . Helgol. Meeresunters. , 43 : 45 – 60 .
   Google Scholar
• von Westernhagen , H. , Rosenthal , H. , Dethlefsen , V. , Ernst , W. , Harms , U. and Hansen , P.‐D. 1981 . Bioaccumulating substances and reproductive success in Baltic flounder Platichthys flesus . Aquat. Toxicol. , 1 : 85 – 99 .
   Web of Science ®Google Scholar
• Williams , L. L. and Giesy , J. P. 1992 . Relationships among concentrations of individual polychlorinated biphenyl (PCB) congeners, 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin equivalents (TCDD‐. EQ), and rearing mortality of chinook salmon (Oncorhynchus tshawytscha) eggs from Lake Michigan . J Great Lakes Res. , 18 : 108 – 124 .
   Web of Science ®Google Scholar
• Wisk , J. D. and Cooper , K. R. 1990 . The stage specific toxicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in embryos of the Japanese medaka (Oryzias latipes) . Environ. Toxicol. Chem. , 9 : 1159 – 1169 .
   Web of Science ®Google Scholar
• Zdanowicz , V. S. and Gadbois , D. 1990 . Contaminants in Sediment and Fish Tissue from Estuarine and Coastal Sites of the Northeastern United States: Data Summary for the Baseline Phase of the National Status and Trends Program, Benthic Surveillance Project, 1984–1986 , Tech. memo. NMFS‐F/NEC‐79 Woods Hole , MA : NOAA, NMFS, NEFSC .
   Google Scholar