106
Views
16
CrossRef citations to date
0
Altmetric
Original

Anti-Hypertensive Drugs Alter Cytokine Production from Preeclamptic Placentas and Peripheral Blood Mononuclear Cells

, , , &
Pages 343-356 | Published online: 07 Jul 2009

REFERENCES

  • Kauma SW, Wang Y, Walsh SW. Preeclampsia is associated with decreased placental interleukin-6 production. J Soc Gynecol Invest 1995; 2: 614–617
  • Wang Y, Walsh SW. TNF alpha concentrations and mRNA expression are increased in preeclamptic placentas. J Reprod Immunol 1996; 32: 157–169
  • Hennessy A, Pilmore HL, Simmons LA, Painter DM. A deficiency of placental IL-10 in preeclampsia. J Immunol 1999; 163: 3491–3495
  • Redman CWG, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response—a review. Placenta 2003; 24(Suppl A)S21–27
  • Orange S, Horvath J, Hennessy A. Preeclampsia is associated with a reduced interleukin-10 production from peripheral blood mononuclear cells. Hypertens Pregnancy 2003; 22: 1–8
  • Conrad KP, Miles TM, Benyo DF. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 1998; 40: 102–111
  • Gavras I, Manolis AJ, Gavras H. The alpha2 -adrenergic receptors in hypertension and heart failure: experimental and clinical studies. J Hypertens 2001; 19: 2115–2124
  • Sarkar S, Tsai SW, Nguyen TT, Plevyak M, Padbury JF, Rubin LP. Inhibition of placental 11beta-hydroxysteroid dehydrogenase type 2 by catecholamines via alpha-adrenergic signaling. Am J Physiol Regul Integr Comp Physiol 2001; 281: R1966–1974
  • Szelenyi J, Kiss JP, Puskas E, Szelenyi M, Vizi ES. Contribution of differently localized alpha 2- and beta-adrenoceptors in the modulation of TNF-alpha and IL-10 production in endotoxemic mice. Ann N Y Acad Sci 2000; 917: 145–153
  • Yankowitz J. Pharmacologic treatment of hypertensive disorders during pregnancy. J Perinat Neonatal Nurs 2004; 18: 230–240
  • Wang Y, Kudo M, Xu M, Ayub A, Ashraf M. Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J Mol Cell Cardiol 2001; 33: 2037–2046
  • Wang X, Wei M, Laurikka J, Kuukasjarvi P, Rinne T, Honkonen EL, Nieminen R, Moilanen E, Tarkka M. The anti-inflammatory effect of diazoxide in coronary artery bypass grafting. Shock 2004; 22: 23–28
  • Knowles HJ, Tian YM, Mole DR, Harris AL. Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ Res 2004; 95: 162–169
  • Prandota J. Furosemide: progress in understanding its diuretic, anti-inflammatory, and bronchodilating mechanism of action, and use in the treatment of respiratory tract diseases. Am J Ther 2002; 9: 317–328
  • Xu B, Makris A, Thornton C, Ogle R, Horvath JS, Hennessy A. Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy. J Hypertens 2006; 24: 915–922
  • Turner MA, Shaikh SA, Greenwood SL. Secretion of interleukin-1beta and interleukin-6 by fragments of term human placental villi: signalling pathways and effects of tumour necrosis factor alpha and mode of delivery. Placenta 2002; 23: 467–474
  • Benyo DF, Miles TM, Conrad KP. Hypoxia stimulates cytokine production by villous explants from the human placenta. J Clin Endocrinol Metab 1997; 82: 1582–1588
  • Thornton C, Makris A, Ogle R, Hennessy A. Generic obstetric database systems are unreliable for reporting the hypertensive disorders of pregnancy. Aust N Z J Obstet Gynaecol 2004; 44: 505–509
  • Sato TA, Keelan JA, Mitchell MD. Critical paracrine interactions between TNF-alpha and IL-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin E2 production. J Immunol 2003; 170: 158–166
  • Rowe J, Campbell S, Gallery ED. Effects of hypoxia on regulation of prostanoid production in decidual endothelial cells in normal and preeclamptic pregnancy. J Soc Gynecol Invest 2000; 7: 118–124
  • Di Santo S, Malek A, Sager R, Andres AC, Schneider H. Trophoblast viability in perfused term placental tissue and explant cultures limited to 7–24 hours. Placenta 2003; 24: 882–894
  • Lonergan M, Aponso D, Marvin KW, Helliwell RJ, Sato TA, Mitchell MD, Chaiwaropongsa T, Romero R, Keelan JA. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptors, and the soluble receptor osteoprotegerin in human gestational membranes and amniotic fluid during pregnancy and labor at term and preterm. J Clin Endocrinol Metab 2003; 88: 3835–3844
  • Nakajima H, Yanase N, Oshima K, Sasame A, Hara T, Fukazawa S, Takata R, Hata K, Mukai K, Yamashina A, Mizuguchi J. Enhanced expression of the apoptosis inducing ligand TRAIL in mononuclear cells after myocardial infarction. Jpn Heart J 2003; 44: 833–844
  • Rein DT, Breidenbach M, Honscheid B, Friebe-Hoffmann U, Engel H, Gohring UJ, Uekermann L, Kurbacher CM, Schondorf T. Preeclamptic women are deficient of interleukin-10 as assessed by cytokine release of trophoblast cells in vitro. Cytokine 2003; 23: 119–125
  • Heikkinen J, Mottonen M, Komi J, Alanen A, Lassila O. Phenotypic characterization of human decidual macrophages. Clin Exp Immunol 2003; 131: 498–505
  • Lidstrom C, Matthiesen L, Berg G, Sharma S, Ernerudh J, Ekerfelt C. Cytokine secretion patterns of NK cells and macrophages in early human pregnancy decidua and blood: implications for suppressor macrophages in decidua. Am J Reprod Immunol 2003; 50: 444–452
  • Roberts CT, White CA, Wiemer NG, Ramsay A, Robertson SA. Altered placental development in interleukin-10 null mutant mice. Placenta 2003; 24(Suppl A)S94–99
  • Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683–765
  • Redman CWG, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999; 180: 499–506
  • Saito S, Sakai M. Th1/Th2 balance in preeclampsia. J Reprod Immunol 2003; 59: 161–173
  • Szelenyi J, Kiss JP, Puskas E, Selmeczy Z, Szelenyi M, Vizi ES. Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice. Neuroreport 2000; 11: 3565–3568
  • Todt JC, Yang Y, Lei J, Lauria MR, Sorokin Y, Cotton DB, Yelian FD. Effects of tumor necrosis factor-alpha on human trophoblast cell adhesion and motility. Am J Reprod Immunol 1996; 36: 65–71
  • Hunt JS, Chen HL, Miller L. Tumor necrosis factors: pivotal components of pregnancy?. Biol Reprod 1996; 54: 554–562
  • Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200–1204
  • Friedman SA, Taylor RN, Roberts JM. Pathophysiology of preeclampsia. Clin Perinatol 1991; 18: 661–682
  • Conrad KP, Benyo DF. Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol 1997; 37: 240–249
  • Beckmann I, Efraim SB, Vervoort M, Visser W, Wallenburg HC. Tumor necrosis factor-alpha in whole blood cultures of preeclamptic patients and healthy pregnant and nonpregnant women. Hypertens Pregnancy 2004; 23: 319–329
  • Fukuzawa M, Satoh J, Ohta S, Takahashi K, Miyaguchi S, Qiang X, Sakata Y, Nakazawa T, Takizawa Y, Toyota T. Modulation of tumor necrosis factor-alpha production with anti-hypertensive drugs. Immunopharmacology 2000; 48: 65–74
  • Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis 2000; 148: 209–214
  • Kauma SW, Herman K, Wang Y, Walsh SW. Differential mRNA expression and production of interleukin-6 in placental trophoblast and villous core compartments. Am J Reprod Immunol 1993; 30: 131–135
  • Takacs P, Green KL, Nikaeo A, Kauma SW. Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia. Am J Obstet Gynecol 2003; 188: 740–744
  • Bowen RS, Gu Y, Zhang Y, Lewis DF, Wang Y. Hypoxia promotes interleukin-6 and -8 but reduces interleukin-10 production by placental trophoblast cells from preeclamptic pregnancies. J Soc Gynecol Invest 2005; 12: 428–432

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.