The impact of hyperandrogenemia on pregnancy complications and outcomes in patients with PCOS: a systematic review and meta-analysis

References

• Shrivastava S, Conigliaro RL. Polycystic ovarian syndrome. Med Clin North Am. 2023;107(2):227–12. doi: 10.1016/j.mcna.2022.10.004
   PubMed Web of Science ®Google Scholar
• Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 2010;8(1):41. doi: 10.1186/1741-7015-8-41
   PubMed Web of Science ®Google Scholar
• March WA, Moore VM, Willson KJ, et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010;25(2):544–551. doi: 10.1093/humrep/dep399
   PubMed Web of Science ®Google Scholar
• Farhadi-Azar M, Behboudi-Gandevani S, Rahmati M, et al. The prevalence of polycystic ovary syndrome, its phenotypes and cardio-metabolic features in a community sample of Iranian population: Tehran lipid and glucose study. Front Endocrinol (Lausanne). 2022;13:825528. doi: 10.3389/fendo.2022.825528
   PubMed Web of Science ®Google Scholar
• Kollmann M, Klaritsch P, Martins WP, et al. Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions. Hum Reprod. 2015;30(10):2396–2403. doi: 10.1093/humrep/dev187
   PubMed Web of Science ®Google Scholar
• Meier RK. Polycystic ovary syndrome. Nurs Clin North Am. 2018;53(3):407–420. doi: 10.1016/j.cnur.2018.04.008
   PubMed Web of Science ®Google Scholar
• Huddleston HG, Dokras A. Diagnosis and treatment of polycystic ovary syndrome. JAMA. 2022;327(3):274–275. doi: 10.1001/jama.2021.23769
   PubMed Web of Science ®Google Scholar
• Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–47. doi: 10.1093/humrep/deh098
   PubMed Web of Science ®Google Scholar
• Teede HJ, Misso ML, Boyle JA, et al. Translation and implementation of the Australian-led PCOS guideline: clinical summary and translation resources from the International evidence-based guideline for the assessment and management of polycystic ovary syndrome. Medical J Australia. 2018;209(S7):S3–S8. doi: 10.5694/mja18.00656
   PubMedGoogle Scholar
• Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman’s long-term health using data linkage. J Clin Endocrinol Metab. 2015;100(3):911–919. doi: 10.1210/jc.2014-3886
   PubMed Web of Science ®Google Scholar
• Gilbert EW, Tay CT, Hiam DS, et al. Comorbidities and complications of polycystic ovary syndrome: an overview of systematic reviews. Clinical Endocrinol. 2018;89(6):683–699. doi: 10.1111/cen.13828
   PubMed Web of Science ®Google Scholar
• Doherty DA, Newnham JP, Bower C, et al. Implications of polycystic ovary syndrome for pregnancy and for the health of offspring. Obstetrics & Gynecol. 2015;125(6):1397–1406. doi: 10.1097/AOG.0000000000000852
   PubMed Web of Science ®Google Scholar
• Yu HF, Chen HS, Rao DP, et al. Association between polycystic ovary syndrome and the risk of pregnancy complications: a PRISMA-compliant systematic review and meta-analysis. Med (Baltimore). 2016;95(51):e4863. doi: 10.1097/MD.0000000000004863
   PubMed Web of Science ®Google Scholar
• Barker DJ, Gluckman PD, Godfrey KM, et al. Fetal nutrition and cardiovascular disease in adult life. Lancet. 1993;341(8850):938–941. doi: 10.1016/0140-6736(93)91224-A
   PubMed Web of Science ®Google Scholar
• Fauser BC, Tarlatzis BC, Rebar RW, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS consensus workshop group. Fertil Steril. 2012;97(1):28–38.e25. doi: 10.1016/j.fertnstert.2011.09.024
   PubMed Web of Science ®Google Scholar
• Alenezi SA, Khan R, Amer S. The impact of high BMI on pregnancy outcomes and complications in women with PCOS undergoing IVF—A systematic review and meta-analysis. JCM. 2024;13(6):1578. doi: 10.3390/jcm13061578
   Google Scholar
• Christ JP, Gunning MN, Meun C, et al. Pre-conception characteristics predict obstetrical and neonatal outcomes in women with polycystic ovary syndrome. J Clin Endocrinol Metabol. 2019;104(3):809–818. doi: 10.1210/jc.2018-01787
   PubMed Web of Science ®Google Scholar
• De Wilde MA, Lamain-De Ruiter M, Veltman-Verhulst SM, et al. Increased rates of complications in singleton pregnancies of women previously diagnosed with polycystic ovary syndrome predominantly in the hyperandrogenic phenotype. Fertil Steril. 2017;108(2):333–340. doi: 10.1016/j.fertnstert.2017.06.015
   PubMed Web of Science ®Google Scholar
• Mumm H, Jensen DM, Sørensen JA, et al. Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes. Acta Obstet Gynecol Scand. 2015;94(2):204–211. doi: 10.1111/aogs.12545
   PubMed Web of Science ®Google Scholar
• Palomba S, Falbo A, Russo T, et al. Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes. Fertil Steril. 2010;94(5):1805–1811. doi: 10.1016/j.fertnstert.2009.10.043
   PubMed Web of Science ®Google Scholar
• L L, L J, L J. Analysis of different subtypes of polycystic ovary syndrome and pregnancy outcome after in-vitro fertilization and embryo transfer. J Practical Obstet And Gynecol. 2010;26(10):787–790.
   Google Scholar
• Yang W, Yang R, Lin M, et al. Body mass index and basal androstenedione are independent risk factors for miscarriage in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018;16(1):119. doi: 10.1186/s12958-018-0438-7
   PubMedGoogle Scholar
• Wei DM, Zhang ZZ, Wang Z, et al. Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome. Zhonghua Fu Chan Ke Za Zhi. 2018;53(1):18–22. doi: 10.3760/cma.j.issn.0529-567X.2018.01.005
   PubMedGoogle Scholar
• Foroozanfard F, Asemi Z, Bazarganipour F, et al. Comparing pregnancy, childbirth, and neonatal outcomes in women with different phenotypes of polycystic ovary syndrome and healthy women: a prospective cohort study. Gynecol Endocrinol. 2020;36(1):61–65. doi: 10.1080/09513590.2019.1631278
   PubMed Web of Science ®Google Scholar
• Dehghani Firoozabadi A, Dehghani Firouzabadi R, Eftekhar M, et al. Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: a cross-sectional study. Int J Reprod Biomed. 2020;18(5):339–346. doi: 10.18502/ijrm.v13i5.7154
   PubMed Web of Science ®Google Scholar
• Mackens S, Pareyn S, Drakopoulos P, et al. Outcome of in-vitro oocyte maturation in patients with PCOS: does phenotype have an impact? Hum Reprod. 2020;35(10):2272–2279. doi: 10.1093/humrep/deaa190
   PubMed Web of Science ®Google Scholar
• Valdimarsdottir R, Wikström AK, Kallak TK, et al. Pregnancy outcome in women with polycystic ovary syndrome in relation to second-trimester testosterone levels. Reprod Biomed Online. 2021;42(1):217–225. doi: 10.1016/j.rbmo.2020.09.019
   PubMed Web of Science ®Google Scholar
• Rana S, Lemoine E, Granger JP, et al. Preeclampsia: pathophysiology, challenges, and perspectives. Circulat Res. 2019;124(7):1094–1112. doi: 10.1161/CIRCRESAHA.118.313276
   PubMed Web of Science ®Google Scholar
• El-Sayed AAF. Preeclampsia: a review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 2017;56(5):593–598. doi: 10.1016/j.tjog.2017.08.004
   PubMed Web of Science ®Google Scholar
• Hariharan N, Shoemaker A, Wagner S. Pathophysiology of hypertension in preeclampsia. Microvasc Res. 2017;109:34–37. doi: 10.1016/j.mvr.2016.10.002
   PubMed Web of Science ®Google Scholar
• Li F, Hagaman JR, Kim HS, et al. eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. J Am Soc Nephrol. 2012;23(4):652–660. doi: 10.1681/ASN.2011040369
   PubMed Web of Science ®Google Scholar
• Zenclussen AC, Lim E, Knoeller S, et al. Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies. American J Rep Immunol. 2003;50(1):66–76. doi: 10.1034/j.1600-0897.2003.00047.x
   PubMed Web of Science ®Google Scholar
• Lyall F, Barber A, Myatt L, et al. Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function. FASEB J. 2000;14(1):208–219. doi: 10.1096/fasebj.14.1.208
   PubMed Web of Science ®Google Scholar
• Belo L, Gaffney D, Caslake M, et al. Apolipoprotein E and cholesteryl ester transfer protein polymorphisms in normal and preeclamptic pregnancies. Eur J Obstet Gynecol Reprod Biol. 2004;112(1):9–15. doi: 10.1016/S0301-2115(03)00240-9
   PubMed Web of Science ®Google Scholar
• Kulikova GV, Nizyaeva NV, Nagovitsina MN, et al. Specific features of TLR4 expression in structural elements of placenta in patients with preeclampsia. Bull Exp Biol Med. 2016;160(5):718–721. doi: 10.1007/s10517-016-3259-8
   PubMed Web of Science ®Google Scholar
• Xie F, Von Dadelszen P, Nadeau J. CMV infection, TLR-2 and -4 expression, and cytokine profiles in early-onset preeclampsia with HELLP syndrome. Am J Reprod Immunol. 2014;71(4):379–386. doi: 10.1111/aji.12199
   PubMed Web of Science ®Google Scholar
• Barrera D, Díaz L, Noyola-Martínez N, et al. Vitamin D and inflammatory cytokines in healthy and preeclamptic pregnancies. Nutri. 2015;7(8):6465–6490. doi: 10.3390/nu7085293
   Google Scholar
• ACOG practice bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol. 2018;131(2):e49–e64. doi: 10.1097/AOG.0000000000002501
   PubMed Web of Science ®Google Scholar
• Świrska J, Zwolak A, Dudzińska M, et al. Gestational diabetes mellitus - literature review on selected cytokines and hormones of confirmed or possible role in its pathogenesis. Ginekol Pol. 2018;89(9):522–527. doi: 10.5603/GP.a2018.0089
   PubMed Web of Science ®Google Scholar
• Yusuf ANM, Amri MF, Ugusman A, et al. Hyperandrogenism and its possible effects on endometrial receptivity: a review. IJMS. 2023;24(15):12026. doi: 10.3390/ijms241512026
   Google Scholar
• Koster MP, De Wilde MA, Veltman-Verhulst SM, et al. Placental characteristics in women with polycystic ovary syndrome. Hum Reprod. 2015;30(12):2829–2837. doi: 10.1093/humrep/dev265
   PubMed Web of Science ®Google Scholar
• Palomba S, Russo T, Falbo A, et al. Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome: an experimental case-control study. J Clin Endocrinol Metab. 2012;97(7):2441–2449. doi: 10.1210/jc.2012-1100
   PubMed Web of Science ®Google Scholar
• Sun M, Maliqueo M, Benrick A, et al. Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring. Am J Physiol Endocrinol Metab. 2012;303(11):E1373–85. doi: 10.1152/ajpendo.00421.2012
   PubMed Web of Science ®Google Scholar
• Palomba S, Russo T, Falbo A, et al. Macroscopic and microscopic findings of the placenta in women with polycystic ovary syndrome. Hum Reprod. 2013;28(10):2838–2847. doi: 10.1093/humrep/det250
   PubMed Web of Science ®Google Scholar
• Palomba S, Falbo A, Chiossi G, et al. Early trophoblast invasion and placentation in women with different PCOS phenotypes. Reprod Biomed Online. 2014;29(3):370–381. doi: 10.1016/j.rbmo.2014.04.010
   PubMed Web of Science ®Google Scholar
• Bahri Khomami M, Boyle JA, Tay CT, et al. Polycystic ovary syndrome and adverse pregnancy outcomes: Current state of knowledge, challenges and potential implications for practice. Clinical Endocrinol. 2018;88(6):761–769. doi: 10.1111/cen.13579
   PubMed Web of Science ®Google Scholar
• Puttabyatappa M, Cardoso RC, Padmanabhan V. Effect of maternal PCOS and PCOS-like phenotype on the offspring’s health. Mol Cell Endocrinol. 2016;435:29–39. doi: 10.1016/j.mce.2015.11.030
   PubMed Web of Science ®Google Scholar
• Orio F, Palomba JR, Cascella S, et al. The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90(1):2–5. doi: 10.1210/jc.2004-0628
   PubMed Web of Science ®Google Scholar
• Seely EW, Solomon CG. Insulin resistance and its potential role in pregnancy-induced hypertension. J Clin Endocrinol Metab. 2003;88(6):2393–2398. doi: 10.1210/jc.2003-030241
   PubMed Web of Science ®Google Scholar
• Falbo A, Rocca M, Russo T, et al. Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes. J Ovarian Res. 2010;3(1):23. doi: 10.1186/1757-2215-3-23
   PubMedGoogle Scholar