Plasminogen Activator Inhibitor-1 and the Circadian Clock in Metabolic Disorders

References

• Vaughan DE, Declerck PJ, Van Houtte E, De Mol M, Collen D. Studies of recombinant plasminogen activator inhibitor-1 in rabbits. Pharmacokinetics and evidence for reactivation of latent plasminogen activator inhibitor-1 in vivo. Circ Res 1990; 67: 1281–1286
   PubMed Web of Science ®Google Scholar
• Mutch NJ, Wilson HM, Booth NA. Plasminogen activator inhibitor-1 and haemostasis in obesity. Proc Nutr Soc 2001; 60: 341–347
   PubMed Web of Science ®Google Scholar
• Eren M, Painter CA, Gleaves LA, Schoenhard JA, Atkinson JB, Brown NJ, Vaughan DE. Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice. J Thromb Haemost 2003; 1: 2389–2396
   PubMed Web of Science ®Google Scholar
• Skurk T, Hauner H. Obesity and impaired fibrinolysis: Role of adipose production of plasminogen activator inhibitor-1. Int J Obes Relat Metab Disord 2004; 28: 1357–1364
   PubMed Web of Science ®Google Scholar
• Vaughan DE. PAI-1 and atherothrombosis. J Thromb Haemost 2005; 3: 1879–1883
   PubMed Web of Science ®Google Scholar
• Mertens I, Van Gaal LF. Visceral fat as a determinant of fibrinolysis and hemostasis. Semin Vasc Med 2005; 5: 48–55
   PubMedGoogle Scholar
• Andreotti F, Kluft C. Circadian variation of fibrinolytic activity in blood. Chronobiol Int 1991; 8: 336–351
   PubMed Web of Science ®Google Scholar
• Curtis AM, Fitzgerald GA. Central and peripheral clocks in cardiovascular and metabolic function. Ann Med 2006; 38: 552–559
   PubMed Web of Science ®Google Scholar
• Reilly DF, Westgate EJ, Fitzgerald GA. Peripheral circadian clocks in the vasculature. Arterioscler Thromb Vasc Biol 2007; 27: 1694–1705
   PubMed Web of Science ®Google Scholar
• Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol 2001; 63: 647–676
   PubMed Web of Science ®Google Scholar
• Wijnen H, Young MW. Interplay of circadian clocks and metabolic rhythms. Annu Rev Genet 2006; 40: 409–448
   PubMed Web of Science ®Google Scholar
• Richter HG, Torres-Farfan C, Rojas-Garcia PP, Campino C, Torrealba F, Seron-Ferre M. The circadian timing system: making sense of day/night gene expression. Biol Res 2004; 37: 11–28
   PubMed Web of Science ®Google Scholar
• Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 2002; 418: 935–941
   PubMed Web of Science ®Google Scholar
• Dardente H, Cermakian N. Molecular circadian rhythms in central and peripheral clocks in mammals. Chronobiol Int 2007; 24: 195–213
   PubMed Web of Science ®Google Scholar
• Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 1994; 264: 719–725
   PubMed Web of Science ®Google Scholar
• Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N. Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats. Biochem Biophys Res Commun 1998; 253: 199–203
   PubMed Web of Science ®Google Scholar
• Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N. Humoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues. Neurosci Lett 1998; 256: 117–119
   PubMed Web of Science ®Google Scholar
• Sakamoto K, Nagase T, Fukui H, Horikawa K, Okada T, Tanaka H, Sato K, Miyake Y, Ohara O, Kako K, Ishida N. Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. J Biol Chem 1998; 273: 27039–27042
   PubMed Web of Science ®Google Scholar
• Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 2002; 109: 307–320
   PubMed Web of Science ®Google Scholar
• Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, Atsumi G, Ohkura N, Azama T, Mesaki M, Yukimasa S, Kobayashi H, Iitaka C, Umehara T, Horikoshi M, Kudo T, Shimizu Y, Yano M, Monden M, Machida K, Matsuda J, Horie S, Todo T, Ishida N. Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J Biol Chem 2003; 278: 41519–41527
   PubMed Web of Science ®Google Scholar
• Oishi K, Shirai H, Ishida N. CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice. Biochem J 2005; 386: 575–581
   PubMed Web of Science ®Google Scholar
• Oishi K, Fukui H, Ishida N. Rhythmic expression of BMAL1 mRNA is altered in Clock mutant mice: differential regulation in the suprachiasmatic nucleus and peripheral tissues. Biochem Biophys Res Commun 2000; 268: 164–171
   PubMed Web of Science ®Google Scholar
• Ripperger JA, Shearman LP, Reppert SM, Schibler U. CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev 2000; 14: 679–689
   PubMed Web of Science ®Google Scholar
• Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell 1999; 96: 57–68
   PubMed Web of Science ®Google Scholar
• Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver Dr, Leslie FM, Zhou QY. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 2002; 417: 405–410
   PubMed Web of Science ®Google Scholar
• Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003; 302: 255–259
   PubMed Web of Science ®Google Scholar
• Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME. CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. J Biol Chem 2000; 275: 36847–36851
   PubMed Web of Science ®Google Scholar
• Manfredini R, Boari B, Smolensky MH, Salmi R, la Cecilia O, Maria Malagoni A, Haus E, Manfredini F. Circadian variation in stroke onset: identical temporal pattern in ischemic and hemorrhagic events. Chronobiol Int 2005; 22: 417–453
   PubMed Web of Science ®Google Scholar
• Nordt TK, Peter K, Ruef J, Kubler W, Bode C. Plasminogen activator inhibitor type-1 (PAI-1) and its role in cardiovascular disease. Thromb Haemost 1999; 82(suppl 1)14–18
   PubMedGoogle Scholar
• Haus E, Cusulos M, Sackett-Lundeen L, Swoyer J. Circadian variations in blood coagulation parameters, alpha-antitrypsin antigen and platelet aggregation and retention in clinically healthy subjects. Chronobiol Int 1990; 7: 203–216
   PubMed Web of Science ®Google Scholar
• Pinotti M, Bertolucci C, Portaluppi F, Colognesi I, Frigato E, Foa A, Bernardi F. Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity. Arterioscler Thromb Vasc Biol 2005; 25: 646–649
   PubMed Web of Science ®Google Scholar
• Undar L, Ertugrul C, Altunbas H, Akca S. Circadian variations in natural coagulation inhibitors protein C, protein S and antithrombin in healthy men: a possible association with interleukin-6. Thromb Haemost 1999; 81: 571–575
   PubMed Web of Science ®Google Scholar
• Schoenhard JA, Smith LH, Painter CA, Eren M, Johnson CH, Vaughan DE. Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J Mol Cell Cardiol 2003; 35: 473–481
   PubMed Web of Science ®Google Scholar
• Wang J, Yin L, Lazar MA. The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1. J Biol Chem 2006; 281: 33842–33848
   PubMed Web of Science ®Google Scholar
• Oishi K, Ohkura N, Kasamatsu M, Fukushima N, Shirai H, Matsuda J, Ishida N. Tissue-specific augmentation of circadian PAI-1 expression in mice with streptozotocin-induced diabetes. Thromb Res 2004; 114: 129–135
   PubMed Web of Science ®Google Scholar
• Oishi K, Ohkura N, Amagai N, Ishida N. Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen activator inhibitor-1 (PAI-1) expression in the mouse heart. FEBS Lett 2005; 579: 3555–3559
   PubMed Web of Science ®Google Scholar
• Ohkura N, Oishi K, Fukushima N, Kasamatsu M, Atsumi GI, Ishida N, Horio S, Matsuda J, et al. Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression. J Thromb Haemost 2006; 4: 2478–2485
   PubMed Web of Science ®Google Scholar
• King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW, Takahashi JS. Positional cloning of the mouse circadian clock gene. Cell 1997; 89: 641–653
   PubMed Web of Science ®Google Scholar
• Oishi K, Shirai H, Ishida N. Identification of the circadian clock-regulated E-box element in the mouse plasminogen activator inhibitor-1 gene. J Thromb Haemost 2007; 5: 428–431
   PubMed Web of Science ®Google Scholar
• van der Bom JG, Bots ML, Haverkate F, Kluft C, Grobbee DE. The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1. Blood 2003; 101: 1841–1844
   PubMed Web of Science ®Google Scholar
• Dimova EY, Kietzmann T. Cell type-dependent regulation of the hypoxia-responsive plasminogen activator inhibitor-1 gene by upstream stimulatory factor-2. J Biol Chem 2006; 281: 2999–3005
   PubMed Web of Science ®Google Scholar
• Nesto RW. Correlation between cardiovascular disease and diabetes mellitus: current concepts. Am J Med 2004; 116(suppl 5A)11S–22S
   PubMed Web of Science ®Google Scholar
• Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444: 875–880
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Saito H. A pathological role of increased expression of plasminogen activator inhibitor-1 in human or animal disorders. Int J Hematol 1998; 68: 371–385
   PubMed Web of Science ®Google Scholar
• Aronson D. Impaired modulation of circadian rhythms in patients with diabetes mellitus: a risk factor for cardiac thrombotic events?. Chronobiol Int 2001; 18: 109–121
   PubMed Web of Science ®Google Scholar
• Anand SS, Yi Q, Gerstein H, Lonn E, Jacobs R, Vuksan V, Teo K, Davis B, Montague P, Yusuf S. Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease. Circulation 2003; 108: 420–425
   PubMed Web of Science ®Google Scholar
• Tsikouris JP, Suarez JA, Meyerrose GE. Plasminogen activator inhibitor-1: physiologic role, regulation, and the influence of common pharmacologic agents. J Clin Pharmacol 2002; 42: 1187–1199
   PubMed Web of Science ®Google Scholar
• Trost S, Pratley R, Sobel B. Impaired fibrinolysis and risk for cardiovascular disease in the metabolic syndrome and type 2 diabetes. Curr Diab Rep 2006; 6: 47–54
   PubMedGoogle Scholar
• Alessi MC, Juhan-Vague I. PAI-1 and the metabolic syndrome: links, causes, and consequences. Arterioscler Thromb Vasc Biol 2006; 26: 2200–2207
   PubMed Web of Science ®Google Scholar
• Samad F, Loskutoff DJ. The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb Haemost 1997; 78: 652–655
   PubMed Web of Science ®Google Scholar
• Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2: 800–803
   PubMed Web of Science ®Google Scholar
• Samad F, Loskutoff DJ. Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol Med 1996; 2: 568–582
   PubMed Web of Science ®Google Scholar
• Oishi K, Ohkura N, Wakabayashi M, Shirai H, Sato K, Matsuda J, Atsumi G, Ishida N. CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression. J Thromb Haemost 2006; 4: 1774–1780
   PubMed Web of Science ®Google Scholar
• Lijnen HR, Alessi MC, Van Hoef B, Collen D, Juhan-Vague I. On the role of plasminogen activator inhibitor-1 in adipose tissue development and insulin resistance in mice. J Thromb Haemost 2005; 3: 1174–1179
   PubMed Web of Science ®Google Scholar
• Alessi MC, Juhan-Vague I. Contribution of PAI-1 in cardiovascular pathology. Arch Mal Coeur Vaiss 2004; 97: 673–678
   PubMedGoogle Scholar
• Oishi K, Ohkura N, Matsuda J, Ishida N. Food deprivation induces adipose PAI-1 expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice. Thromb Haemost 2007; 98: 864–870
   PubMed Web of Science ®Google Scholar
• Oishi K, Atsumi G, Sugiyama S, Kodomari I, Kasamatsu M, Machida K, et al. Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice. FEBS Lett 2006; 580: 127–130
   PubMed Web of Science ®Google Scholar
• Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 2005; 308: 1043–1045
   PubMed Web of Science ®Google Scholar
• Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S. Attenuating Effect of Clock Mutation on Triglyceride Contents in the ICR Mouse Liver under a High-Fat Diet. J Biol Rhythms 2007; 22: 312–323
   PubMed Web of Science ®Google Scholar
• Oishi K, Kasamatsu M, Ishida N. Gene- and tissue-specific alterations of circadian clock gene expression in streptozotocin-induced diabetic mice under restricted feeding. Biochem Biophys Res Commun 2004; 317: 330–334
   PubMed Web of Science ®Google Scholar
• Ando H, Oshima Y, Yanagihara H, Hayashi Y, Takamura T, Kaneko S, Fujimura A. Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice. Biochem Biophys Res Commun 2006; 346: 1297–1302
   PubMed Web of Science ®Google Scholar
• Ando H, Yanagihara H, Hayashi Y, Obi Y, Tsuruoka S, Takamura T, Kaneko S, Fujimura A. Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 2005; 146: 5631–5636
   PubMed Web of Science ®Google Scholar
• Kudo T, Akiyama M, Kuriyama K, Sudo M, Moriya T, Shibata S. Night-time restricted feeding normalises clock genes and Pai-1 gene expression in the db/db mouse liver. Diabetologia 2004; 47: 1425–1436
   PubMed Web of Science ®Google Scholar
• Yanagihara H, Ando H, Hayashi Y, Obi Y, Fujimura A. High-fat feeding exerts minimal effects on rhythmic mRNA expression of clock genes in mouse peripheral tissues. Chronobiol Int 2006; 23: 905–914
   PubMed Web of Science ®Google Scholar
• Shimba S, Ishii N, Ohta Y, Ohno T, Watabe Y, Hayashi M, Wada T, Aoyagi T, Tezuka M. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc Natl Acad Sci USA 2005; 102: 12071–12076
   PubMed Web of Science ®Google Scholar
• Fonseca VA, Reynolds T, Hemphill D, Randolph C, Wall J, Valiquet TR, Graveline I, Fink LM. Effect of troglitazone on fibrinolysis and activated coagulation in patients with non-insulin-dependent diabetes mellitus. J Diabetes Complications 1998; 12: 181–186
   PubMed Web of Science ®Google Scholar
• Ghanim H, Garg R, Aljada A, Mohanty P, Kumbkarni Y, Assian E, Hamouda W, Dandona P. Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. J Clin Endocrinol Metab 2001; 86: 1306–1312
   PubMed Web of Science ®Google Scholar
• Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P. Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab 2004; 89: 2728–2735
   PubMed Web of Science ®Google Scholar
• Aljada A, Garg R, Ghanim H, Mohanty P, Hamouda W, Assian E, Dandona P. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action?. J Clin Endocrinol Metab 2001; 86: 3250–3256
   PubMed Web of Science ®Google Scholar
• Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem 2004; 279: 7091–7097
   PubMed Web of Science ®Google Scholar
• Doi M, Hirayama J, Sassone-Corsi P. Circadian regulator CLOCK is a histone acetyltransferase. Cell 2006; 125: 497–508
   PubMed Web of Science ®Google Scholar