274
Views
14
CrossRef citations to date
0
Altmetric
Articles

Associations of homocysteine status and homocysteine metabolism enzyme polymorphisms with hypertension and dyslipidemia in a Chinese hypertensive population

, , , , , , , , , & show all
Pages 52-60 | Received 10 Sep 2018, Accepted 14 Jan 2019, Published online: 20 Feb 2019

References

  • Weiwei C, Runlin G, Lisheng L, Manlu Z, Wen W, Yongjun W, Zhaosu W, Huijun L, Zhe Z, Lixin J, et al. Outline of the report on cardiovascular diseases in China, 2014. Eur Heart J Suppl. 2016;18(SupplF):F2–F11. doi:10.1093/eurheartj/suw1030. Epub 2016 May 1024.
  • Mora S, Glynn RJ, Ridker PM. High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation. 2013;128(11):1189–97. Epub 002013 Sep 002673. doi:10.1161/CIRCULATIONAHA.113.002671.
  • Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324(17):1149–55. doi:10.1056/NEJM199104253241701.
  • Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1(5):228–37.
  • Tyagi N, Moshal KS, Ovechkin AV, Rodriguez W, Steed M, Henderson B, Roberts AM, Joshua IG, Tyagi SC. Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia. J Cell Biochem. 2005;96(4):665–71. doi:10.1002/jcb.20578.
  • Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14:6. DOI:10.1186/1475-2891-1114-1186.
  • Chen H, Sun Y, Wang X, Si Q, Yao W, Wan Z. Association of cardiometabolic risk profile with prehypertension accompany hyperhomocysteinaemia. Clin Exp Hypertens. 2015;37(3):218–22. doi:10.3109/10641963.2014.939276.
  • Momin M, Fan F, Li J, Qin X, Jia J, Qi L, Zhang Y, Huo Y. Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population. Sci Rep. 2017;7(1):6316. doi:10.1038/s41598-017-06611-3.
  • Momin M, Jia J, Fan F, Li J, Dou J, Chen D, Huo Y, Zhang Y. Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population. Lipids Health Dis. 2017;16(1):54. doi:10.1186/s12944-017-0565-8.
  • Vinukonda G, Mohammad NS, Jain JMN, Chintakindi KP, Akella RRD. Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. Clin Chim Acta. 2009;405(1–2):127–31. doi:10.1016/j.cca.2009.04.015.
  • Tang Z, Xiao L, Wang JQ, Zhang T. Analysis of metabolism-related indicators and MTHFR gene polymorphism in patients with H-type hypertension. Minerva Med. 2017;108(2):103–07. doi:10.23736/S0026-4806.16.04951-X.
  • Li WX, Lv WW, Dai SX, Pan ML, Huang JF. Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study. Lipids Health Dis. 2015;14:101. doi:10.1186/s12944-015-0099-x.
  • Bahadir A, Eroz R, Turker Y. Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients? Anatol J Cardiol. 2015;15(7):524–30. doi:10.5152/akd.2014.5555.
  • Joint Committee for the Development of guidelines for prevention and treatment of dyslipidemia in adults.[Chinese guidelines on prevention and treatment of dyslipidemia in adults]. Zhonghua Xin Xue Guan Bing Za Zhi. 2007:35(5):390–419.
  • Chang Y, Li Y, Guo X, Chen Y, Dai D, Sun Y. The prevalence of hypertension accompanied by high homocysteine and its risk factors in a rural population: A cross-sectional study from Northeast China. Int J Environ Res Public Health. 2017;14(4). doi:10.3390/ijerph14040376.
  • Abudureheman K, Mahemuti A, Xia YN, Hu XM. Association between gene polymorphisms of methylenetetrahydrofolate reductase and plasma homocysteine in Uygur patients with venous thromboembolism. Zhonghua Xin Xue Guan Bing Za Zhi. 2012;40(12):1030–36.
  • Wang Y, Xu X, Huo Y, Liu D, Cui Y, Liu Z, Zhao Z, Xu X, Liu L, Li X, et al. Predicting hyperhomocysteinemia by methylenetetrahydrofolate reductase C677T polymorphism in Chinese patients with hypertension. Clin Appl Thromb Hemost. 2015;21(7):661–66. doi:10.1177/1076029613519849.
  • Markan S, Sachdeva M, Sehrawat BS, Kumari S, Jain S, Mthfr KM. 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem. 2007;302(1–2):125–31. doi:10.1007/s11010-007-9434-5.
  • Chen F, Zhang Y, Wang H, Ouyang J, Munila A, Kalibinuer Y, Yang M. Association of plasma homocysteine level and polymorphism of methione synthase reductase gene with essential hypertension in ethnic Uyghurs and Hans from Xinjiang. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32(4):548–53. doi:10.3760/cma.j.issn.1003-9406.2015.04.022.
  • Han L, Liu Y, Wang C, Tang L, Feng X, Astell-Burt T, Wen Q, Duan D, Lu N, Xu G, et al. Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review. Clin Nutr. 2017;36(5):1215–30. doi:10.1016/j.clnu.2016.11.011.
  • Das M, Ghose M, Borah NC, Choudhury N. A community based study of the relationship between homocysteine and some of the life style factors. Indian J Clin Biochem. 2010;25(3):295–301. doi:10.1007/s12291-010-0044-8.
  • Husemoen LL, Linneberg A, Fenger M, Thuesen BH, Jorgensen T. Changes in lifestyle, biological risk factors and total homocysteine in relation to MTHFR C677T genotype: a 5-year follow-up study. Eur J Clin Nutr. 2009;63(10):1233–40. doi:10.1038/ejcn.2009.59.
  • Li WX, Liao P, Hu CY, Cheng F, Zhang T, Sun YY, Tang L, Wang MM, Liu KS, Liu D, et al. Interactions of methylenetetrahydrofolate reductase gene polymorphisms, folate, and homocysteine on blood pressure in a Chinese hypertensive population. Clin Lab. 2017;63(4):817–25. doi:10.7754/Clin.Lab.2016.160918.
  • Yucel K, Bekci TT, Taner A, Kayrak M, Korucu EN, Unlu A. Homocysteine levels in patients with masked hypertension. Anadolu Kardiyol Derg. 2014;14(4):357–62. doi:10.5152/akd.2014.4689.
  • Li S, Zhu J, Wu L, Peng L, Luo Y, Zhao Y, Dong R, Chen L, Tang X, Liu J. The association between plasma homocysteine and ambulatory blood pressure variability in patients with untreated hypertension. Clin Chim Acta. 2018;477:32–38. doi:10.1016/j.cca.2017.11.042.
  • Dong YF, Zhan BM, Hao QY, Ruan ZH, Xu ZX, Deng M, Chen DW, Zou YQ, Chen J, Li P, et al. Plasma homocysteine levels are associated with circadian blood pressure variation in Chinese hypertensive adults. Am J Hypertens. 2017;30(12):1203–10. doi:10.1093/ajh/hpx116.
  • Qian X, Lu Z, Tan M, Liu H, Lu D. A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension. Eur J Hum Genet. 2007;15(12):1239–45. doi:10.1038/sj.ejhg.5201914.
  • Xu H, Zheng H, Shen Y, Huang J, Luo M. Polymorphism of the methylenetetrahydrofolate reductase gene C677T and its influence on the antihypertensive and vascular protective effects of short-term lercanidipine treatment. Gene. 2012;500(2):207–10. doi:10.1016/j.gene.2012.03.017.
  • Jiang S, Yu Y, Venners SA, Zhang Y, Xing H, Wang X, Xu X. Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients. J Hum Hypertens. 2011;25(3):172–77. doi:10.1038/jhh.2010.50.
  • Lin PT, Cheng CH, Wei JC, Huang YC. Low plasma pyridoxal 5ʹ-phosphate concentration and MTHFR 677C–>T genotypes are associated with increased risk of hypertension. Int J Vitam Nutr Res. 2008;78(1):33–40. doi:10.1024/0300-9831.78.1.33.
  • Fowdar JY, Lason MV, Szvetko AL, Lea RA, Griffiths LR. Investigation of homocysteine-pathway-related variants in essential hypertension. Int J Hypertens. 2012;2012:190923. doi:10.1155/2012/190923.
  • Hirche F, Schroder A, Knoth B, Stangl GI, Eder K. Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats. Ann Nutr Metab. 2006;50(2):139–46. doi:10.1159/000090635.
  • Baszczuk A, Musialik K, Kopczynski J, Thielemann A, Kopczynski Z, Kesy L, Dopierala G. Hyperhomocysteinemia, lipid and lipoprotein disturbances in patients with primary hypertension. Adv Med Sci. 2014;59(1):68–73. doi:10.1016/j.advms.2013.08.001.
  • Raina JK, Sharma M, Panjaliya RK, Bhagat M, Sharma R, Bakaya A, Kumar P. Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region. Indian Heart J. 2016;68(3):421–30. doi:10.1016/j.ihj.2016.02.009.
  • Marosi K, Agota A, Vegh V, Joo JG, Langmar Z, Kriszbacher I, Nagy ZB. [The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension]. Orv Hetil. 2012;153(12):445–53. doi:10.1556/OH.2012.29326.
  • Li Z, Yadav U, Mahemuti A, Tang BP, Upur H. Association of MTHFR genetic polymorphisms with venous thromboembolism in Uyghur population in Xinjiang, China. Int J Clin Exp Med. 2015;8(10):17703–11.
  • Zhang L, Yin RX, Liu WY, Miao L, Wu DF, Aung LH, Hu XJ, Cao XL, Wu JZ, Pan SL. Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 2010;9:123. doi:10.1186/1476-511X-9-123.
  • Liu Y, Li K, Venners SA, Hsu YH, Jiang S, Weinstock J, Wang B, Tang G, Individual XX. Joint associations of methylenetetrahydrofolate reductase C677T genotype and plasma homocysteine with dyslipidemia in a Chinese population with hypertension. Clin Appl Thromb Hemost. 2017;23(3):287–93. doi:10.1177/1076029615609686.
  • Morais CC, Alves MC, Augusto EM, Abdalla DS, Horst MA, Cominetti C. The MTHFR C677T polymorphism is related to plasma concentration of oxidized low-density lipoprotein in adolescents with cardiovascular risk factors. J Nutrigenet Nutrigenomics. 2015;8(3):105–13. doi:10.1159/000439218.
  • Chang YH, Fu WM, Wu YH, Yeh CJ, Huang CN, Shiau MY. Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus. Clin Biochem. 2011;44(17–18):1370–74. Epub 2011 Oct 1378. doi:10.1016/j.clinbiochem.2011.09.020.
  • Huang L, Song XM, Zhu WL, Li Y. Plasma homocysteine and gene polymorphisms associated with the risk of hyperlipidemia in northern Chinese subjects. Biomed Environ Sci. 2008;21(6):514–20. doi:10.1016/S0895-3988(09)60011-8.
  • Jiang S, Zhao R, Pan M, Venners SA, Zhong G, Hsu YH. Associations of MTHFR and MTRR polymorphisms with serum lipid levels in Chinese hypertensive patients. Clin Appl Thromb Hemost. 2014;20(4):400–10. doi:10.1177/1076029612467226.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.