301
Views
9
CrossRef citations to date
0
Altmetric
Research Article

Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals

, , , , , & show all
Pages 56-62 | Received 26 Apr 2020, Accepted 18 Jul 2020, Published online: 16 Aug 2020

References

  • Singh JP, Larson MG, Manolio TA, O’Donnell CJ, Lauer M, Evans JC, Levy D. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham Heart Study Circulation. 1999;99:1831–36. doi:10.1161/01.CIR.99.14.1831.
  • Miyai N, Arita M, Miyashita K, Morioka I, Shiraishi T, Nishio I. Blood pressure response to heart rate during exercise test and risk of future hypertension. Hypertension. 2002;39:761–66. doi:10.1161/hy0302.105777.
  • Sharman JE, Hare JL, Thomas S, Davies JE, Leano R, Jenkins C, Marwick TH. Association of masked hypertension and left ventricular remodeling with the hypertensive response to exercise. Am J Hypertens. 2011;24:898–903. doi:10.1038/ajh.2011.75.
  • Kato S, Onishi K, Yamanaka T, Takamura T, Dohi K, Yamada N, Wada H, Nobori T, Ito M. Exaggerated hypertensive response to exercise in patients with diastolic heart failure. Hypertens Res. 2008;31:679–84. doi:10.1291/hypres.31.679.
  • Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Systolic blood pressure response to exercise stress test and risk of stroke. Stroke. 2001;32:2036–41. doi:10.1161/hs0901.095395.
  • Schultz MG, Otahal P, Cleland VJ, Blizzard L, Marwick TH, Sharman JE. Exercise-induced hypertension, cardiovascular events, and mortality in patients undergoing exercise stress testing: a systematic review and meta-analysis. Am J Hypertens. 2013;26:357–66. doi:10.1093/ajh/hps053.
  • Weiss SA, Blumenthal RS, Sharrett AR, Redberg RF, Mora S. Exercise blood pressure and future cardiovascular death in asymptomatic individuals. Circulation. 2010;121:2109–16. doi:10.1161/CIRCULATIONAHA.109.895292.
  • Stewart KJ, Sung J, Silber HA, Fleg JL, Kelemen MD, Turner KL, Bacher AC, Dobrosielski DA, DeRegis JR, Shapiro EP, et al. Exaggerated exercise blood pressure is related to impaired endothelial vasodilator function. Am J Hypertens. 2004;17:314–20.
  • Olson KM, Augeri AL, Seip RL, Tsongalis GJ, Thompson PD, Pescatello LS. Correlates of endothelial function and the peak systolic blood pressure response to a graded maximal exercise test. Atherosclerosis. 2012;222:202–07. doi:10.1016/j.atherosclerosis.2012.01.027.
  • Tsioufis C, Dimitriadis K, Thomopoulos C, Tsiachris D, Selima M, Stefanadi E, Tousoulis D, Kallikazaros I, Stefanadis C. Exercise blood pressure response, albuminuria, and arterial stiffness in hypertension. Am J Med. 2008;121:894–902. doi:10.1016/j.amjmed.2008.05.035.
  • Thanassoulis G, Lyass A, Benjamin EJ, Larson MG, Vita JA, Levy D, Hamburg NM, Widlansky ME, O’Donnell CJ, Mitchell GF, et al. Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study. Circulation. 2012;125:2836–43.
  • Jae SY, Fernhall B, Heffernan KS, Kang M, Lee MK, Choi YH, Hong KP, Ahn ES, Park WH. Exaggerated blood pressure response to exercise is associated with carotid atherosclerosis in apparently healthy men. J Hypertens. 2006;24:881–87. doi:10.1097/01.hjh.0000222758.54111.e2.
  • Michishita R, Ohta M, Ikeda M, Jiang Y, Yamato H. An exaggerated blood pressure response to exercise is associated with nitric oxide bioavailability and inflammatory markers in normotensive females. Hypertens Res. 2016;39:792–98. doi:10.1038/hr.2016.75.
  • Lim PO, MacFadyen RJ, Clarkson PB, MacDonald TM. Impaired exercise tolerance in hypertensive patients. Ann Intern Med. 1996;124:41–55. doi:10.7326/0003-4819-124-1_Part_1-199601010-00008.
  • Le VV, Mitiku T, Sungar G, Myers J, Froelicher V. The blood pressure response to dynamic exercise testing: a systematic review. Prog Cardiovasc Dis. 2008;51:135–60. doi:10.1016/j.pcad.2008.07.001.
  • Umemura S, Arima H, Arima S, Asayama K, Dohi Y, Hirooka Y, Horio T, Hoshide S, Ikeda S, Ishimitsu T, et al. The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2019). Hypertens Res. 2019;42:1235–81.
  • Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res. 2002;25:359–64. doi:10.1291/hypres.25.359.
  • Hickson SS, Butlin M, Mir FA, Graggaber J, Cheriyan J, Khan F, Grace AA, Yasmin, Cockcroft JR, Wilkinson IB, et al.The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveform. J Hypertens. 2009;27:1784–88.
  • Cameron JD, Stevenson I, Reed E, McGrath BP, Dart AM, Kingwell BA. Accuracy of automated auscultatory blood pressure measurement during supine exercise and treadmill stress electrocardiogram-testing. Blood Press Monit. 2004;9:269–75. doi:10.1097/00126097-200410000-00007.
  • Miyai N, Shiozaki M, Yabu M, Utsumi M, Morioka I, Miyashita K, Arita M. Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors. Hypertens Res. 2013;36:534–39. doi:10.1038/hr.2012.215.
  • Karvonen J, Vuorimaa T. Heart rate and exercise intensity during sports activities. Practical application. Sports Med. 1988;5:303–11. doi:10.2165/00007256-198805050-00002.
  • Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a “set up” for vascular disease. Circulation. 2003;107:139–46. doi:10.1161/01.CIR.0000048892.83521.58.
  • Suzuki E, Kashiwagi A, Nishio Y, Egawa K, Shimizu S, Maegawa H, Haneda M, Yasuda H, Morikawa S, Inubushi T, et al. Increased arterial wall stiffness limits flow volume in the lower extremities in type 2 diabetic patients. Diabetes Care. 2001;24:2107–14.
  • Chung H, Kim JY, Lee BK, Min PK, Yoon YW, Hong BK, Rim SJ, Kwon HM, Choi EY. Arterial stiffness, sex, and age difference on hypertensive response to supine bicycle exercise. J Clin Hypertens. 2017;19:1260–68. doi:10.1111/jch.13106.
  • Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV, Sakkinen PA, Lyles MF, Spurgeon HA, Lakatta EG, Kuller LH. Correlates of aortic stiffness in elderly individuals: a subgroup of the cardiovascular health study. Am J Hypertens. 2002;15:16–23. doi:10.1016/S0895-7061(01)02228-2.
  • Ballermann BJ, Stan RV. Resolved: capillary endothelium is a major contributor to the glomerular filtration barrier. J Am Soc Nephrol. 2007;18:2432–38. doi:10.1681/ASN.2007060687.
  • Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int. 2007;71:504–13. doi:10.1038/sj.ki.5002041.
  • Garg JP, Bakris GL. Microalbuminuria: marker of vascular dysfunction, risk factor for cardiovascular disease. Vasc Med. 2002;7:35–43. doi:10.1191/1358863x02vm412ra.
  • Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, Quyyumi AA. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation. 1994;90:2853–58. doi:10.1161/01.CIR.90.6.2853.
  • Knight EL, Kramer HM, Curhan GC. High-normal blood pressure and microalbuminuria. Am J Kidney Dis. 2003;41:588–95. doi:10.1053/ajkd.2003.50120.
  • Miyai N, Arita M, Morioka I, Takeda S, Miyashita K. Ambulatory blood pressure, sympathetic activity, and left ventricular structure and function in middle-aged normotensive men with exaggerated blood pressure response to exercise. Med Sci Monit. 2005;11(CR):478–84.
  • Kayrak M, Bacaksiz A, Vatankulu MA, Ayhan SS, Kaya Z, Ari H, Sonmez O, Gok H. Exaggerated blood pressure response to exercise – a new portent of masked hypertension. Clin Exp Hypertens. 2010;32:560–68. doi:10.3109/10641963.2010.503298.
  • Mitchell GF. Arterial stiffness and wave reflection: biomarkers of cardiovascular risk. Artery Res. 2009;3:56–64. doi:10.1016/j.artres.2009.02.002.
  • Eryonucu B, Bilge M, Güler N, Uygan I. The effect of autonomic nervous system activity on exaggerated blood pressure response to exercise: evaluation by heart rate variability. Acta Cardiol. 2000;55:181–85. doi:10.2143/AC.55.3.2005737.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.