Renal sympathetic denervation attenuates left ventricle hypertrophy in spontaneously hypertensive rats by suppressing the Raf/MEK/ERK signaling pathway

References

• Chien KL, Hsu HC, Sung FC, Su TC, Chen MF, Lee YT. Incidence of hypertension and risk of cardiovascular events among ethnic Chinese: report from a community-based cohort study in Taiwan. J Hypertens. 2007;25(7):1355–61.doi:10.1097/HJH.0b013e3280d94313.
   PubMed Web of Science ®Google Scholar
• Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, et al. American heart association statistics C, Stroke statistics S. Heart disease and stroke statistics–2007 update: a report from the American heart association statistics committee and stroke statistics subcommittee. Circulation. 2007;115:e69–171.doi:10.1161/CIRCULATIONAHA.106.179918.
   PubMed Web of Science ®Google Scholar
• Bombelli M, Facchetti R, Carugo S, Madotto F, Arenare F, Quarti-Trevano F, Capra A, Giannattasio C, Dell’Oro R, Grassi G, et al. Left ventricular hypertrophy increases cardiovascular risk independently of in-office and out-of-office blood pressure values. J Hypertens. 2009;27(12):2458–64.doi:10.1097/HJH.0b013e328330b845.
   PubMed Web of Science ®Google Scholar
• Mao Y, Tokudome T, Kishimoto I, Otani K, Nishimura H, Yamaguchi O, Otsu K, Miyazato M, Kangawa K. Endogenous ghrelin attenuates pressure overload-induced cardiac hypertrophy via a cholinergic anti-inflammatory pathway. Hypertension. 2015;65(6):1238–44.doi:10.1161/HYPERTENSIONAHA.114.04864.
   PubMed Web of Science ®Google Scholar
• Olsen MH, Wachtell K, Ibsen H, Lindholm LH, Dahlof B, Devereux RB, Kjeldsen SE, Oikarinen L, Okin PM. Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE study. J Hypertens. 2016;12(4):775–81.doi:10.1097/01.hjh.0000217862.50735.dc.
   Google Scholar
• Krum H, Schlaich MP, Sobotka PA, Bohm M, Mahfoud F, Rocha-Singh K, Katholi R, Esler MD. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet. 2014;383:622–29.doi:10.1016/S0140-6736(13)62192-3.
   PubMed Web of Science ®Google Scholar
• Bohm M, Mahfoud F, Ukena C, Hoppe UC, Narkiewicz K, Negoita M, Ruilope L, Schlaich MP, Schmieder RE, Whitbourn R, et al. First report of the global SYMPLICITY registry on the effect of renal artery denervation in patients with uncontrolled hypertension. Hypertension. 2015;65(4):766–74.doi:10.1161/HYPERTENSIONAHA.114.05010.
   PubMed Web of Science ®Google Scholar
• Eriguchi M, Tsuruya K. Renal sympathetic denervation in rats. Methods Mol Biol. 2016;1397:45–52.
   PubMedGoogle Scholar
• Polimeni A, Curcio A, Indolfi C. Renal sympathetic denervation for treating resistant hypertension. Circ J. 2013;77(4):857–63.doi:10.1253/circj.CJ-13-0297.
   PubMed Web of Science ®Google Scholar
• Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275–81.doi:10.1016/S0140-6736(09)60566-3.
   PubMed Web of Science ®Google Scholar
• Manna PR, Stocco DM. The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis. J Signal Transduct. 2011;2011:821615.doi:10.1155/2011/821615.
   PubMedGoogle Scholar
• Martinez-Soto D, Ruiz-Herrera J. Functional analysis of the MAPK pathways in fungi. Rev Iberoam Micol. 2017;34:192–202.doi:10.1016/j.riam.2017.02.006.
   PubMed Web of Science ®Google Scholar
• De Luca A, Maiello MR, D’Alessio A, Pergameno M, The NN.RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets. 2012;16(Suppl 2):S17–27.doi:10.1517/14728222.2011.639361.
   PubMed Web of Science ®Google Scholar
• Roberts RE. The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension. J Exp Pharmacol. 2012;4:77–83.doi:10.2147/JEP.S28907.
   PubMedGoogle Scholar
• Lorenz K, Schmitt JP, Vidal M, Lohse MJ. Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling. Int J Biochem Cell Biol. 2009;41(12):2351–55.doi:10.1016/j.biocel.2009.08.002.
   PubMed Web of Science ®Google Scholar
• Zhang P, Mende U. Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circ Res. 2011;109:320–33.doi:10.1161/CIRCRESAHA.110.231423.
   PubMed Web of Science ®Google Scholar
• Wang L, Lu CZ, Zhang X, Luo D, Zhao B, Yu X, Xia DS, Chen X, Zhao XD. [The effect of catheter based renal synthetic denervation on renin-angiotensin-aldosterone system in patients with resistant hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2013;41:3–7.
   PubMedGoogle Scholar
• Jiang W, Tan L, Guo Y, Li X, Tang X, Yang K. Effect of renal denervation procedure on left ventricular hypertrophy of hypertensive rats and its mechanisms. Acta Cir Bras. 2012;27(11):815–20.doi:10.1590/S0102-86502012001100012.
   PubMed Web of Science ®Google Scholar
• Ahnstedt H, Mostajeran M, Blixt FW, Warfvinge K, Ansar S, Krause DN, Edvinsson L. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015;35(3):454–60.doi:10.1038/jcbfm.2014.217.
   PubMed Web of Science ®Google Scholar
• Folkow B, Hallback M, Lundgren Y, Weiss L. Background of increased flow resistance and vascular reactivity in spontaneously hypertensive rats. Acta Physiol Scand. 1970;80(1):93–106.doi:10.1111/j.1748-1716.1970.tb04773.x.
   PubMedGoogle Scholar
• Kodavanti UP, Schladweiler MC, Ledbetter AD, Watkinson WP, Campen MJ, Winsett DW, Richards JR, Crissman KM, Hatch GE, Costa DL. The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled emission particulate matter. Toxicol Appl Pharmacol. 2000;164(3):250–63.doi:10.1006/taap.2000.8899.
   PubMed Web of Science ®Google Scholar
• Li P, Huang PP, Yang Y, Liu C, Lu Y, Wang F, Sun W, Kong XQ. Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. J Appl Physiol (1985). 2017;122(1):121–29.doi:10.1152/japplphysiol.01019.2015.
   PubMed Web of Science ®Google Scholar
• Azizi M, Schmieder RE, Mahfoud F, Weber MA, Daemen J, Davies J, Basile J, Kirtane AJ, Wang Y, Lobo MD, et al. Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial. Lancet. 2018;391(10137):2335–45.doi:10.1016/S0140-6736(18)31082-1.
   PubMed Web of Science ®Google Scholar
• Katayama T, Sueta D, Kataoka K, Hasegawa Y, Koibuchi N, Toyama K, Uekawa K, Mingjie M, Nakagawa T, Maeda M, et al. Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome. J Am Heart Assoc. 2013;2(4):e000197.doi:10.1161/JAHA.113.000197.
   PubMed Web of Science ®Google Scholar
• Taddei S, Nami R, Bruno RM, Quatrini I, Nuti R. Hypertension, left ventricular hypertrophy and chronic kidney disease. Heart Fail Rev. 2011;16(6):615–20.doi:10.1007/s10741-010-9197-z.
   PubMed Web of Science ®Google Scholar
• Lepor NE, Hypertension KA. Left ventricular hypertrophy and cardiac function in patients with resistant hypertension. Rev Cardiovasc Med. 2013;14:69–71.
   PubMedGoogle Scholar
• Gosse P.Left ventricular hypertrophy–the problem and possible solutions. J Int Med Res. 2005;33(Suppl 1):3A–11A.doi:10.1177/14732300050330S102.
   PubMed Web of Science ®Google Scholar
• Ozcakar ZB, Yalcinkaya F, Tutar E, Cakar N, Ucar T, Elhan A, Acar B, Yuksel S, Uncu N, Kara N, et al. Hypertension and left ventricular hypertrophy in pediatric peritoneal dialysis patients: ambulatory blood pressure monitoring and echocardiographic evaluation. Nephron Clin Pract. 2006;104(2):c101–6.doi:10.1159/000093997.
   PubMedGoogle Scholar
• Andersen K, Hennersdorf M, Cohnen M, Blondin D, Modder U, Poll LW. Myocardial delayed contrast enhancement in patients with arterial hypertension: initial results of cardiac MRI. Eur J Radiol. 2009;71(1):75–81.doi:10.1016/j.ejrad.2008.03.009.
   PubMed Web of Science ®Google Scholar
• Lee Y, Kim BK, Lim YH, Kim MK, Choi BY, Shin J. The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy. PLoS One. 2013;8(7):e70246.doi:10.1371/journal.pone.0070246.
   PubMed Web of Science ®Google Scholar
• Tawa M, Yamamoto S, Ohkita M, Matsumura Y. Endothelin-1 and norepinephrine overflow from cardiac sympathetic nerve endings in myocardial ischemia. Cardiol Res Pract. 2012;2012:789071.doi:10.1155/2012/789071.
   PubMedGoogle Scholar
• Cohn JN. Plasma norepinephrine and mortality. Clin Cardiol. 1995;18(S1):I9–12.doi:10.1002/clc.4960181304.
   PubMedGoogle Scholar
• Li J, He Q, Wu W, Li Q, Huang R, Pan X, Lai W. Role of the renal sympathetic nerves in renal sodium/potassium handling and renal damage in spontaneously hypertensive rats. Exp Ther Med. 2016;12(4):2547–53.doi:10.3892/etm.2016.3669.
   PubMed Web of Science ®Google Scholar
• Brandt MC, Mahfoud F, Reda S, Schirmer SH, Erdmann E, Bohm M, Hoppe UC. Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension. J Am Coll Cardiol. 2012;59(10):901–09.doi:10.1016/j.jacc.2011.11.034.
   PubMed Web of Science ®Google Scholar
• Holtwick R, van Eickels M, Skryabin BV, Baba HA, Bubikat A, Begrow F, Schneider MD, Garbers DL, Kuhn M. Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. J Clin Invest. 2003;111(9):1399–407.doi:10.1172/JCI17061.
   PubMed Web of Science ®Google Scholar
• Hobbs RE, Mills RM. Endogenous B-type natriuretic peptide: a limb of the regulatory response to acutely decompensated heart failure. Clin Cardiol. 2008;31(9):407–12.doi:10.1002/clc.20304.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhang YZ, Gao M, Liu BC. Elevation of B-type natriuretic peptide is a sensitive marker of left ventricular diastolic dysfunction in patients with maintenance haemodialysis. Biomarkers. 2010;15(6):533–37.doi:10.3109/1354750X.2010.493973.
   PubMed Web of Science ®Google Scholar
• Sheridan DJ, Autelitano DJ, Wang B, Percy E, Woodcock EA, Du XJ. Beta(2)-adrenergic receptor overexpression driven by alpha-MHC promoter is downregulated in hypertrophied and failing myocardium. Cardiovasc Res. 2000;47:133–41.doi:10.1016/S0008-6363(00)00065-1.
   PubMed Web of Science ®Google Scholar
• Pandya K, Kim HS, Smithies O. Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proc Natl Acad Sci U S A. 2006;103:16864–69.
   PubMed Web of Science ®Google Scholar
• Di Domenico M, Casadonte R, Ricci P, Santini M, Frati G, Rizzo A, Carratelli CR, Lamberti M, Parrotta E, Quaresima B, et al. Cardiac and skeletal muscle expression of mutant beta-myosin heavy chains, degree of functional impairment and phenotypic heterogeneity in hypertrophic cardiomyopathy. J Cell Physiol. 2012;227(10):3471–76.doi:10.1002/jcp.24047.
   PubMed Web of Science ®Google Scholar
• Ding X, Xu X, Yan Y, Song X, Liu S, Wang G, Su D, Jing Q, Qin Y. Effects of renal sympathetic denervation and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy. Comparison in spontaneously hypertensive rats. Herz. 2015;40(4):695–701.doi:10.1007/s00059-014-4110-5.
   PubMed Web of Science ®Google Scholar
• Jing L, Zhang JZ, Zhao L, Wang YL, Guo FY. High-expression of transforming growth factor beta1 and phosphorylation of extracellular signal-regulated protein kinase in vascular smooth muscle cells from aorta and renal arterioles of spontaneous hypertension rats. Clin Exp Hypertens. 2007;29:107–17.doi:10.1080/10641960701195447.
   PubMed Web of Science ®Google Scholar
• Yang L, Zou X, Liang Q, Chen H, Feng J, Yan L, Wang Z, Zhou D, Li S, Yao S, et al. Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway. Exp Mol Med. 2007;39(1):65–73.doi:10.1038/emm.2007.8.
   PubMed Web of Science ®Google Scholar
• Cho HJ, Kang JH, Kwak JY, Lee TS, Lee IS, Park NG, Nakajima H, Magae J, Chang YC. Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. Carcinogenesis. 2007;28:1104–10.doi:10.1093/carcin/bgl217.
   PubMed Web of Science ®Google Scholar
• McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta. 2007;1773:1263–84.doi:10.1016/j.bbamcr.2006.10.001.
   PubMed Web of Science ®Google Scholar
• Freitas RR, Lopes KL, Carillo BA, Bergamaschi CT, Carmona AK, Casarini DE, Furukawa L, Heimann JC, Campos RR, Dolnikoff MS. Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. Am J Hypertens. 2007;20(6):692–98.doi:10.1016/j.amjhyper.2007.01.014.
   PubMed Web of Science ®Google Scholar
• Dahlof B. Left ventricular hypertrophy and angiotensin II antagonists. Am J Hypertens. 2001;14(2):174–82.doi:10.1016/S0895-7061(00)01257-7.
   PubMed Web of Science ®Google Scholar
• Kang -N-N, Fu L, Xu J, Han Y, Cao J-X, Sun J-F, Zheng M. Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. Arch Cardiovasc Dis. 2012;2012(2):68–76.doi:10.1016/j.acvd.2011.12.002.
   Google Scholar
• Guo L, Wang M, Zhang ZY, Hao L, Lou BY, Li XY, Loo WT, Jin L, Cheung MN. Angiotensin II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor. Arch Oral Biol. 2011;56(3):205–11.doi:10.1016/j.archoralbio.2010.09.016.
   PubMed Web of Science ®Google Scholar
• Dai Z, Yu S, Zhao Q, Meng Y, He H, Tang Y, Wang X, Xiao J, Wang X, Huang C. Renal sympathetic denervation suppresses ventricular substrate remodelling in a canine high-rate pacing model. EuroIntervention. 2014;10(3):392–99.doi:10.4244/EIJV10I3A65.
   PubMed Web of Science ®Google Scholar