Neutrophil count is a useful marker to predict the severity of preeclampsia

References

• Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124(7):1094–112. doi:10.1161/CIRCRESAHA.118.313276.
   PubMed Web of Science ®Google Scholar
• Sibai BM, and Stella CL. Diagnosis and management of atypical preeclampsia-eclampsia. Am J Obstet Gynecol. 2009;200(5):481. doi:10.1016/j.ajog.2008.07.048.
   PubMed Web of Science ®Google Scholar
• Jimmy E , Alex V , Christian M P , Hyagriv S, ACOG Practice Bulletin No. 202: gestational Hypertension and Preeclampsia. Obstet Gynecol. 2019, 133 (1), 1 doi:10.1097/AOG.0000000000003018.
   Web of Science ®Google Scholar
• Gezer C, Ekin A, Ertas IE, Ozeren M, Solmaz U, Mat E, Taner CE . High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia. Ginekol Pol. 2016;87(6):431–35. doi:10.5603/GP.2016.0021.
   PubMed Web of Science ®Google Scholar
• Goel A, Maski MR, Bajracharya S, Wenger JB, Zhang D, Salahuddin S, Shahul SS, Thadhani R, Seely EW, Karumanchi SA, et al. Epidemiology and mechanisms of de novo and persistent Hypertension in the postpartum period. Circulation. 2015;132(18):1726–33. doi:10.1161/CIRCULATIONAHA.115.015721.
   PubMed Web of Science ®Google Scholar
• Hypertension in pregnancy. Report of the american college of obstetricians and Gynecologists’ Task force on hypertension in pregnancy. Obstet Gynecol. 2013;122(5):1122–31. doi:10.1097/01.AOG.0000437382.03963.88.
   PubMed Web of Science ®Google Scholar
• Teirila L, Heikkinen-Eloranta J, Kotimaa J, Meri S, Lokki AI. Regulation of the complement system and immunological tolerance in pregnancy. Semin Immunol. 2019;45:101337. doi:10.1016/j.smim.2019.101337.
   PubMed Web of Science ®Google Scholar
• Ives CW, Sinkey R, Rajapreyar I, Tita A, Oparil S. Preeclampsia-Pathophysiology and clinical presentations: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;76(14):1690–702. doi:10.1016/j.jacc.2020.08.014.
   PubMed Web of Science ®Google Scholar
• Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, Park J-E, Stephenson E, Polański K, Goncalves A, et al. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018;563(7731):347–53. doi:10.1038/s41586-018-0698-6.
   PubMed Web of Science ®Google Scholar
• Clark P, Boswell F, Greer IA. The neutrophil and preeclampsia. Semin Reprod Endocrinol. 1998;16(1):57–64. doi:10.1055/s-2007-1016253.
   PubMedGoogle Scholar
• Tsukimori K, Fukushima K, Tsushima A, and Nakano H. Generation of reactive oxygen species by neutrophils and endothelial cell injury in normal and preeclamptic pregnancies. Hypertension. 2005;46(4):696–700. doi:10.1161/01.HYP.0000184197.11226.71.
   PubMed Web of Science ®Google Scholar
• Hu Y, Li H, Yan R, Wang C, Wang Y, Zhang C, Liu M, Zhou T, Zhu W, Zhang H, et al. Increased Neutrophil Activation and Plasma DNA Levels in Patients with Pre-Eclampsia. Thromb Haemost. 2018;118(12):2064–73. doi:10.1055/s-0038-1675788.
   PubMed Web of Science ®Google Scholar
• Kirbas A, Ersoy AO, Daglar K, Turkan D, Ebru HB, Ozgur K, Nuri D . Prediction of preeclampsia by first trimester combined test and simple complete blood count parameters. J Clin Diagn Res 2015;9:C20–C23.
   Web of Science ®Google Scholar
• Wang F, Zhang L, Zhang F, Wang J, Wang Y, Man D. First trimester serum PIGF is associated with placenta accreta. Placenta. 2020;101:39–44. doi:10.1016/j.placenta.2020.08.023.
   PubMed Web of Science ®Google Scholar
• Mellembakken JR, Aukrust P, Olafsen MK, Ueland T, Hestdal K, Videm V. Activation of leukocytes during the uteroplacental passage in preeclampsia. Hypertension. 2002;39(1):155–60. doi:10.1161/hy0102.100778.
   PubMed Web of Science ®Google Scholar
• Leik CE, Walsh SW. Neutrophils infiltrate resistance-sized vessels of subcutaneous fat in women with preeclampsia. Hypertension. 2004;44(1):72–77. doi:10.1161/01.HYP.0000130483.83154.37.
   PubMed Web of Science ®Google Scholar
• Aneman I, Pienaar D, Suvakov S, Simic TP, Garovic VD, McClements L. Mechanisms of key innate immune cells in Early- and late-onset preeclampsia. Front Immunol. 2020;11:1864. doi:10.3389/fimmu.2020.01864.
   PubMed Web of Science ®Google Scholar
• Williamson RD, McCarthy FP, Kenny LC, and McCarthy CM. 2019. Activation of a TLR9 mediated innate immune response in preeclampsia. Sci Rep. 9(1):5920. doi:10.1038/s41598-019-42551-w.
   PubMedGoogle Scholar
• Xie F, Hu Y, Turvey SE, Magee LA, Brunham RM, Choi K-C, Krajden M, Leung PCK, Money DM, Patrick DM, et al. Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia. Bjog. 2010;117(1):99–108. doi:10.1111/j.1471-0528.2009.02428.x.
   PubMed Web of Science ®Google Scholar
• Bounds KR, Newell-Rogers MK, Mitchell BM. Four pathways involving innate immunity in the pathogenesis of preeclampsia. Front Cardiovasc Med. 2015;2:20. doi:10.3389/fcvm.2015.00020.
   PubMedGoogle Scholar
• Gupta AK, Hasler P, Holzgreve W, Gebhardt S, Hahn S. Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia. Hum Immunol. 2005;66(11):1146–54. doi:10.1016/j.humimm.2005.11.003.
   PubMed Web of Science ®Google Scholar
• Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 2018;18(2):134–47. doi:10.1038/nri.2017.105.
   PubMed Web of Science ®Google Scholar
• Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z, Gröne H-J, Brinkmann V, Jenne DE . Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009;15(6):623–25. doi:10.1038/nm.1959.
   PubMed Web of Science ®Google Scholar
• Gupta AK, Joshi MB, Philippova M, Erne P, Hasler P, Hahn S, Resink TJ . Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death. Febs Lett. 2010;584(14):3193–97. doi:10.1016/j.febslet.2010.06.006.
   PubMed Web of Science ®Google Scholar
• Moodley M, Moodley J, Naicker T. The role of neutrophils and their extracellular traps in the synergy of pre-eclampsia and HIV Infection. Curr Hypertens Rep. 2020;22(6):41. doi:10.1007/s11906-020-01047-z.
   PubMed Web of Science ®Google Scholar
• Marder W, Knight JS, Kaplan MJ, Somers EC, Zhang X, O’Dell AA, Padmanabhan V, Lieberman RW . Placental histology and neutrophil extracellular traps in lupus and pre-eclampsia pregnancies. Lupus Sci Med. 2016;3(1):e134. doi:10.1136/lupus-2015-000134.
   Web of Science ®Google Scholar
• Konecna B, Tothova L, Repiska G. Exosomes-Associated DNA-New marker in pregnancy complications? Int J Mol Sci. 2019;20(12):2890. doi:10.3390/ijms20122890.
   PubMed Web of Science ®Google Scholar
• Zhong XY, Laivuori H, Livingston JC, Ylikorkala O, Sibai BM, Holzgreve W, Hahn S . Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol. 2001;184(3):414–19. doi:10.1067/mob.2001.109594.
   PubMed Web of Science ®Google Scholar
• Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019;366:l2381. doi:10.1136/bmj.l2381.
   PubMed Web of Science ®Google Scholar
• Guerby P, Tasta O, Swiader A, Pont F, Bujold E, Parant O, Vayssiere C, Salvayre R, Negre-Salvayre A . Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia. Redox Biol. 2021;40:101861.
   PubMed Web of Science ®Google Scholar
• Ritter A, Roth S, Kreis NN, Friemel A, Hoock SC, Steglich Souto A, Eichbaum C, Neuhoff A, Chen Q, Solbach C, et al. Primary Cilia in trophoblastic cells: potential involvement in preeclampsia. Hypertension. 2020;76(5):1491–505. doi:10.1161/HYPERTENSIONAHA.120.15433.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest. 1997;99(9):2152–64. doi:10.1172/JCI119388.
   PubMed Web of Science ®Google Scholar
• Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, et al. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 2012;484(7393):246–50. doi:10.1038/nature10897.
   PubMed Web of Science ®Google Scholar
• Fisher SJ. Why is placentation abnormal in preeclampsia? Am J Obstet Gynecol. 2015;213(4):S115–S122. doi:10.1016/j.ajog.2015.08.042.
   PubMed Web of Science ®Google Scholar
• Mancia G, Hall JE. Introduction to a compendium on the pathophysiology and treatment of Hypertension. Circ Res. 2019;124(7):967–68. doi:10.1161/CIRCRESAHA.119.314953.
   PubMed Web of Science ®Google Scholar
• Aouache R, Biquard L, Vaiman D, Miralles F. Oxidative stress in preeclampsia and placental diseases. Int J Mol Sci. 2018;19(5):1496. doi:10.3390/ijms19051496.
   PubMed Web of Science ®Google Scholar
• Redman CW, Sargent IL. Placental stress and pre-eclampsia: a revised view. Placenta. 2009;30(Suppl A):S38–S42. doi:10.1016/j.placenta.2008.11.021.
   PubMed Web of Science ®Google Scholar
• Goulopoulou S, Davidge ST. Molecular mechanisms of maternal vascular dysfunction in preeclampsia. Trends Mol Med. 2015;21(2):88–97. doi:10.1016/j.molmed.2014.11.009.
   PubMed Web of Science ®Google Scholar
• Tenorio MB, Ferreira RC, Moura FA, Bueno NB, de Oliveira A, Goulart M. Cross-Talk between oxidative stress and inflammation in preeclampsia. Oxid Med Cell Longev. 2019;2019:8238727. doi:10.1155/2019/8238727.
   PubMed Web of Science ®Google Scholar
• Aratani Y. Myeloperoxidase: its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys. 2018;640:47–52. doi:10.1016/j.abb.2018.01.004.
   PubMed Web of Science ®Google Scholar
• Bachawaty T, Washington SL, Walsh SW. Neutrophil expression of cyclooxygenase 2 in preeclampsia. Reprod Sci. 2010;17(5):465–70. doi:10.1177/1933719110361960.
   PubMed Web of Science ®Google Scholar
• Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med. 2011;17(11):1410–22.
   PubMed Web of Science ®Google Scholar
• Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339(6116):161–66. doi:10.1126/science.1230719.
   PubMed Web of Science ®Google Scholar
• Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, et al. Meta-Analysis of leukocyte diversity in atherosclerotic mouse aortas. Circ Res. 2020;127(3):402–26. doi:10.1161/CIRCRESAHA.120.316903.
   PubMed Web of Science ®Google Scholar
• Imano H, Sato S, Kitamura A, Kiyama M, Ohira T, Shimamoto T, Iso H. Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men. Atherosclerosis.2007;195(1):147–52. doi:10.1016/j.atherosclerosis.2006.09.002.
   PubMed Web of Science ®Google Scholar
• Gogoi P, Sinha P, Gupta B, Firmal P, Rajaram S. Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia. Int J Gynaecol Obstet. 2019;144(1):16–20. doi:10.1002/ijgo.12701.
   PubMed Web of Science ®Google Scholar