Cervical disc degeneration: important considerations for the manual therapist

References

• Matsumoto M, Fujimura Y, Suzuki N, et al. MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br Vol. 1998;80(1):19–24.
   PubMedGoogle Scholar
• Ernst CW, Stadnik TW, Peeters E, et al. Prevalence of annular tears and disc herniations on MR images of the cervical spine in symptom free volunteers. Eur J Radiol. 2005;55(3):409–414.
   PubMed Web of Science ®Google Scholar
• Siivola SM, Levoska S, Tervonen O, et al. MRI changes of cervical spine in asymptomatic and symptomatic young adults. Eur Spine J. 2002 Aug;11(4):358–363.
   PubMed Web of Science ®Google Scholar
• Nakashima H, Yukawa Y, Suda K, et al. Abnormal findings on magnetic resonance images of the cervical spines in 1211 asymptomatic subjects. Spine (Phila Pa 1976). 2015;40(6):392–398.
   PubMed Web of Science ®Google Scholar
• Lawrence JS. Disc degeneration. Its frequency and relationship to symptoms. Ann Rheum Dis. 1969;28(2):121.
   PubMed Web of Science ®Google Scholar
• Peng B, DePalma MJ. Cervical disc degeneration and neck pain. J Pain Res. 2018;11:2853–2857.
   PubMed Web of Science ®Google Scholar
• Parikh P, Santaguida P, Macdermid J, et al. Comparison of CPG’s for the diagnosis, prognosis and management of non-specific neck pain: a systematic review. BMC Musculoskelet Disord. 2019;20(1):81.
   PubMedGoogle Scholar
• Blanpied PR, Gross AR, Elliott JM, et al. Neck Pain: revision 2017. J Orthop Sports Phys Ther. 2017 Jul;47(7):A1–a83.
   PubMed Web of Science ®Google Scholar
• Institute of M. Clinical practice guidelines we can trust. Washington (DC): The National Academies Press; 2011.
   Google Scholar
• Bialosky JE, Bishop MD, Price DD, et al. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. Manual Ther. 2009;14(5):531–538.
   PubMed Web of Science ®Google Scholar
• Bialosky JE, Beneciuk JM, Bishop MD, et al. Unraveling the mechanisms of manual therapy: modeling an approach. J Orthop Sports Phys Ther. 2018;48(1):8–18.
   PubMed Web of Science ®Google Scholar
• Childs MJD, Fritz JM, Piva SR, et al. Proposal of a classification system for patients with neck pain. J Orthop Sports Phys Ther. 2004;34(11):686–700.
   PubMed Web of Science ®Google Scholar
• Edwards RR, Dworkin RH, Turk DC, et al. Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain. 2016;157(9):1851.
   PubMed Web of Science ®Google Scholar
• Keefe FJ, Main CJ, George SZ. Advancing psychologically informed practice for patients with persistent musculoskeletal pain: promise, pitfalls, and solutions. Phys Ther. 2018;98(5):398–407.
   PubMed Web of Science ®Google Scholar
• Louw A, Nijs J, Puentedura EJ. A clinical perspective on a pain neuroscience education approach to manual therapy. J Man Manip Ther. 2017;25(3):160–168.
   PubMed Web of Science ®Google Scholar
• Shala R, Roussel N, Lorimer Moseley G, et al. Can we just talk our patients out of pain? Should pain neuroscience education be our only tool? J Man Manip Ther. 2021;29(1):1–3.
   PubMed Web of Science ®Google Scholar
• Macnab I, and McCulloch JA. Neck ache and shoulder pain. Baltimore, MD: Lippincott Williams & Wilkins; 1994.
   Google Scholar
• Adams M, McNally D, Dolan P. ‘STRESS’DISTRIBUTIONS INSIDE INTERVERTEBRAL DISCS: THE EFFECTS OF AGE AND DEGENERATION. J Bone Joint Surg Br Vol. 1996;78(6):965–972.
   PubMedGoogle Scholar
• Luxford K. ‘First, do no harm’: shifting the paradigm towards a culture of health. Pt Exp J. 2016;3(2):5–8.
   Google Scholar
• Taylor JR. Point of view: the ligaments and anulus fibrosus of human adult cervical intervertebral discs. Spine (Phila Pa 1976). 1999;24(7):627–628.
   Web of Science ®Google Scholar
• Taylor J, Twomey L, Levander B. Contrasts between cervical and lumbar motion segments. Crit Rev™ Phys Rehabil Med. 2000;12:4.
   Google Scholar
• Mercer S, Bogduk N. The ligaments and anulus fibrosus of human adult cervical intervertebral discs. Spine (Phila Pa 1976). 1999;24(7):619–626.
   PubMed Web of Science ®Google Scholar
• Skrzypiec DM, Pollintine P, Przybyla A, et al. The internal mechanical properties of cervical intervertebral discs as revealed by stress profilometry. Eur Spine J. 2007;16(10):1701–1709.
   PubMed Web of Science ®Google Scholar
• Oda J, Tanaka H, Tsuzuki N. Intervertebral disc changes with aging of human cervical vertebra. From the neonate to the eighties. Spine (Phila Pa 1976). 1988;13(11):1205–1211.
   PubMed Web of Science ®Google Scholar
• Scott JE, Bosworth TR, Cribb AM, et al. The chemical morphology of age-related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposus and annulus fibrosus. J Anat. 1994;184(Pt 1):73.
   PubMed Web of Science ®Google Scholar
• Wu B, Meng C, Wang H, et al. Changes of proteoglycan and collagen II of the adjacent intervertebral disc in the cervical instability models. Biomed Pharmacother. 2016;84:754–758.
   PubMed Web of Science ®Google Scholar
• Peng B, Bogduk N. Cervical discs as a source of neck pain. An analysis of the evidence. Pain Med. 2019;20(3):446–455.
   PubMed Web of Science ®Google Scholar
• Bogduk N, Mercer S. Biomechanics of the cervical spine. I: normal kinematics. Clin Biomech. 2000;15(9):633–648.
   PubMed Web of Science ®Google Scholar
• Yang L, Yang C, Pang X, et al. Mechanoreceptors in diseased cervical intervertebral disc and vertigo. Spine (Phila Pa 1976). 2017;42(8):540–546.
   PubMed Web of Science ®Google Scholar
• Bogduk N, Windsor M, Inglis A. The innervation of the cervical intervertebral discs. Spine (Phila Pa 1976). 1988;13(1):2–8.
   PubMed Web of Science ®Google Scholar
• Mendel T, Wink CS, Zimny ML. Neural elements in human cervical intervertebral discs. Spine (Phila Pa 1976). 1992;17(2):132–135.
   PubMed Web of Science ®Google Scholar
• Cloward RB. Cervical diskography: a contribution to the etiology and mechanism of neck, shoulder and arm pain. Ann Surg. 1959;150(6):1052.
   PubMed Web of Science ®Google Scholar
• Cloward RB. The clinical significance of the sinu-vertebral nerve of the cervical spine in relation to the cervical disk syndrome. J Neurol Neurosurg Psychiatry. 1960;23(4):321.
   PubMed Web of Science ®Google Scholar
• Slipman CW, Plastaras C, Patel R, et al. Provocative cervical discography symptom mapping. Spine J. 2005;5(4):381–388.
   PubMedGoogle Scholar
• Schellhas KP, Smith MD, Gundry CR, et al. Cervical discogenic pain: prospective correlation of magnetic resonance imaging and discography in asymptomatic subjects and pain sufferers. Spine (Phila Pa 1976). 1996;21(3):300–311.
   PubMed Web of Science ®Google Scholar
• Wu B, Yang L, Peng B. Ingrowth of nociceptive receptors into diseased cervical intervertebral disc is associated with discogenic neck pain. Pain Med. 2019;20(6):1072–1077.
   PubMed Web of Science ®Google Scholar
• Milne N. Composite motion in cervical disc segments. Clin Biomech. 1993;8(4):193–202.
   PubMed Web of Science ®Google Scholar
• Pfirrmann CW, Metzdorf A, Zanetti M, et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976). 2001;26(17):1873–1878.
   PubMed Web of Science ®Google Scholar
• Dai L. Disc degeneration and cervical instability: correlation of magnetic resonance imaging with radiography. Spine (Phila Pa 1976). 1998;23(16):1734–1738.
   PubMed Web of Science ®Google Scholar
• Miyazaki M, Hong SW, Yoon SH, et al. Kinematic analysis of the relationship between the grade of disc degeneration and motion unit of the cervical spine. Spine (Phila Pa 1976). 2008;33(2):187–193.
   PubMed Web of Science ®Google Scholar
• Wang B, Liu H, Wang H, et al. Segmental instability in cervical spondylotic myelopathy with severe disc degeneration. Spine (Phila Pa 1976). 2006;31(12):1327–1331.
   PubMed Web of Science ®Google Scholar
• Kirkaldy-Willis W, Farfan H. Instability of the lumbar spine. Clin Orthop Relat Res. 1982;165:110–123.
   PubMed Web of Science ®Google Scholar
• Hino H, Abumi K, Kanayama M, et al. Dynamic motion analysis of normal and unstable cervical spines using cineradiography: an in vivo study. Spine (Phila Pa 1976). 1999;24(2):163–168.
   PubMed Web of Science ®Google Scholar
• Morishita Y, Hymanson H, Miyazaki M, et al. Review Article: kinematic evaluation of the spine: a kinetic magnetic resonance imaging study. J Orthop Surg. 2008;16(3):348–350.
   Google Scholar
• Buonocore E, Hartman JT, Nelson CL. Cineradiograms of Cervical Spine in Diagnosis of Soft-Tissue Injuries. JAMA. 1966;198(1):25–29.
   Web of Science ®Google Scholar
• Amevo B, Aprill C, Bogduk N. Abnormal instantaneous axes of rotation in patients with neck pain. Spine (Phila Pa 1976). 1992;17(7):748–756.
   PubMed Web of Science ®Google Scholar
• Bogduk N, Amevo B, Pearcy M. A biological basis for instantaneous centres of rotation of the vertebral column. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 1995;209( 3):177–183.
   Google Scholar
• Liu B, Liu Z, VanHoof T, et al. Kinematic study of the relation between the instantaneous center of rotation and degenerative changes in the cervical intervertebral disc. Eur Spine J. 2014;23(11):2307–2313.
   PubMed Web of Science ®Google Scholar
• Caridi JM, Pumberger M, Hughes AP. Cervical radiculopathy: a review. HSS J. 2011;7(3):265–272.
   PubMedGoogle Scholar
• Hammer C, Heller J, and Kepler C Epidemiology and pathophysiology of cervical disc herniation. Seminars in Spine Surgery. 2016;28(2): 64–67.
   Google Scholar
• Yamazaki S, Kokubun S, Ishii Y, et al. Courses of cervical disc herniation causing myelopathy or radiculopathy: an analysis based on computed tomographic discograms. Spine (Phila Pa 1976). 2003;28(11):1171–1175.
   PubMed Web of Science ®Google Scholar
• Hartman J. Anatomy and clinical significance of the uncinate process and uncovertebral joint: a comprehensive review. Clin Anat. 2014;27(3):431–440.
   PubMed Web of Science ®Google Scholar
• Demondion X, Lefebvre G, Fisch O, et al. Radiographic anatomy of the intervertebral cervical and lumbar foramina (vessels and variants). Diagn Interv Imaging. 2012;93(9):690–697.
   PubMedGoogle Scholar
• Neuwirth M, Marsicano J. Cervical spondylosis: diagnosis, symptomatology, and treatment. Orthop Nurs. 1996;15(1):31–36.
   PubMedGoogle Scholar
• Bland JH, Boushey DR. Anatomy and physiology of the cervical spine. Semin Arthritis Rheum. 1990;20(1):1–20.
   PubMed Web of Science ®Google Scholar
• Humphreys SC, Hodges SD, Patwardhan A, et al. The natural history of the cervical foramen in symptomatic and asymptomatic individuals aged 20-60 years as measured by magnetic resonance imaging: a descriptive approach. Spine (Phila Pa 1976). 1998;23(20):2180–2184.
   PubMed Web of Science ®Google Scholar
• Wilkinson HA, LeMay ML, Ferris EJ. Clinical-radiographic correlations in cervical spondylosis. J Neurosurg. 1969;30(3part1):213–218.
   PubMedGoogle Scholar
• Lu J, Ebraheim NA, Huntoon M, et al. Cervical intervertebral disc space narrowing and size of intervertebral foramina. In: Clinical orthopaedics and related research. 2000. p. 370.
   Google Scholar
• Hoff JT. Cervical disc disease and cervical spondylosis. Neurosurgery. 1985;3:2230–2239.
   Google Scholar
• Manifold SG, McCann PD. Cervical radiculitis and shoulder disorders. Clin Orthop Relat Res. 1999;368:105–113.
   PubMedGoogle Scholar
• Tanaka Y, Kokubun S, Sato T, et al. Cervical roots as origin of pain in the neck or scapular regions. Spine (Phila Pa 1976). 2006;31(17):E568–E573.
   PubMed Web of Science ®Google Scholar
• Goel A, Dharurkar P, Shah A, et al. Facetal fixation arthrodesis as treatment of cervical radiculopathy. World Neurosurg. 2019;121:e875–e881.
   PubMed Web of Science ®Google Scholar
• Muhle C, Resnick D, Ahn JM, et al. In vivo changes in the neuroforaminal size at flexion-extension and axial rotation of the cervical spine in healthy persons examined using kinematic magnetic resonance imaging. Spine (Phila Pa 1976). 2001;26:13.
   Google Scholar
• Mao H, Driscoll SJ, Li J-S, et al. Dimensional changes of the neuroforamina in subaxial cervical spine during in vivo dynamic flexion-extension. Spine J. 2016;16(4):540–546.
   PubMed Web of Science ®Google Scholar
• Farmer JC, Wisneski RJ. Cervical spine nerve root compression. An analysis of neuroforaminal pressures with varying head and arm positions. Spine (Phila Pa 1976). 1994;19(16):1850–1855.
   PubMed Web of Science ®Google Scholar
• Yang Y, Shi B, Duan Y, et al. Anatomic morphology and clinical significance of intraforaminal ligaments of the cervical spine. Clin Anat. 2019;32(5):654–660.
   PubMed Web of Science ®Google Scholar
• Harrison DE, Cailliet R, Harrison DD, et al. A review of biomechanics of the central nervous system—Part I: spinal canal deformations resulting from changes in posture. J Manipulative Physiol Ther. 1999;22(4):227–234.
   PubMed Web of Science ®Google Scholar
• Harrison DE, Cailliet R, Harrison DD, et al. A review of biomechanics of the central nervous system—Part II: spinal cord strains from postural loads. J Manipulative Physiol Ther. 1999;22(5):322–332.
   PubMed Web of Science ®Google Scholar
• Harrison DE, Cailliet R, Harrison DD, et al. A review of biomechanics of the central nervous system—Part III: spinal cord stresses from postural loads and their neurologic effects. J Manipulative Physiol Ther. 1999;22(6):399–410.
   PubMed Web of Science ®Google Scholar
• Reid JD. Effects of flexion-extension movements of the head and spine upon the spinal cord and nerve roots. J Neurol Neurosurg Psychiatry. 1960;23(3):214.
   PubMed Web of Science ®Google Scholar
• Mimura M, Moriya H, Watanabe T, et al. Three-dimensional motion analysis of the cervical spine with special reference to the axial rotation. Spine (Phila Pa 1976). 1989;14(11):1135–1139.
   PubMed Web of Science ®Google Scholar
• Dugailly P-M, Beyer B, Salem W, et al. Morphometric changes of the cervical intervertebral foramen: a comparative analysis of pre-manipulative positioning and physiological axial rotation. Musculoskeletal Sci Pract. 2018;34:97–102.
   PubMed Web of Science ®Google Scholar
• Smith ZA, Khayatzadeh S, Bakhsheshian J, et al. Dimensions of the cervical neural foramen in conditions of spinal deformity: an ex vivo biomechanical investigation using specimen-specific CT imaging. Eur Spine J. 2016;25(7):2155–2165.
   PubMed Web of Science ®Google Scholar
• Lentell G, Kruse M, Chock B, et al. Dimensions of the cervical neural foramina in resting and retracted positions using magnetic resonance imaging. J Orthop Sports Phys Ther. 2002;32(8):380–390.
   PubMed Web of Science ®Google Scholar
• Ordway NR, Seymour RJ, Donelson RG, et al. Cervical flexion, extension, protrusion, and retraction: a radiographic segmental analysis. Spine (Phila Pa 1976). 1999;24(3):240–247.
   PubMed Web of Science ®Google Scholar
• Liu J, Ebraheim NA, Sanford CG Jr., et al. Quantitative changes in the cervical neural foramen resulting from axial traction: in vivo imaging study. Spine J. 2008 Jul-Aug;8(4):619–623.
   PubMed Web of Science ®Google Scholar
• Wong AM, Leong CP, Chen CM. The traction angle and cervical intervertebral separation. Spine (Phila Pa 1976). 1992;17(2):136–138.
   PubMed Web of Science ®Google Scholar
• Thompson KJ, Dagher AP, Eckel TS, et al. Modic changes on MR images as studied with provocative diskography: clinical relevance—a retrospective study of 2457 disks. Radiology. 2009;250(3):849–855.
   PubMed Web of Science ®Google Scholar
• Modic MT, Steinberg PM, Ross JS, et al. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166(1):193–199.
   PubMed Web of Science ®Google Scholar
• Dudli S, Fields AJ, Samartzis D, et al. Pathobiology of Modic changes. Eur Spine J. 2016;25(11):3723–3734.
   PubMed Web of Science ®Google Scholar
• Teichtahl AJ, Urquhart DM, Wang Y, et al. Modic changes in the lumbar spine and their association with body composition, fat distribution and intervertebral disc height - a 3.0 T-MRI study. BMC Musculoskelet Disord. 2016;17: 92-92.
   Web of Science ®Google Scholar
• Adams MA, Freeman BJC, Morrison HP, et al. Mechanical initiation of intervertebral disc degeneration. Spine (Phila Pa 1976). 2000;25(13):1625–1636.
   PubMed Web of Science ®Google Scholar
• Ferguson SJ, Ito K, Nolte L-P. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech. 2004;37(2):213–221.
   PubMed Web of Science ®Google Scholar
• Torkki M, Majuri M-L, Wolff H, et al. Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus. Eur Spine J. 2016;25(1):207–216.
   PubMed Web of Science ®Google Scholar
• Schroeder GD, Markova DZ, Koerner JD, et al. Are Modic changes associated with intervertebral disc cytokine profiles? Spine J. 2017;17(1):129–134.
   PubMed Web of Science ®Google Scholar
• Dudli S, Boffa DB, Ferguson SJ, et al. Leukocytes enhance inflammatory and catabolic degenerative changes in the intervertebral disc after endplate fracture in vitro without infiltrating the disc. Spine (Phila Pa 1976). 2015;40(23):1799–1806.
   PubMed Web of Science ®Google Scholar
• Kong L, Tian W, Cao P, et al. Predictive factors associated with neck pain in patients with cervical disc degeneration: a cross-sectional study focusing on Modic changes. Medicine (Baltimore). 2017;96:43.
   Web of Science ®Google Scholar
• Teichtahl AJ, Finnin MA, Wang Y, et al. The natural history of Modic changes in a community-based cohort. Joint Bone Spine. 2017;84(2):197–202.
   PubMed Web of Science ®Google Scholar
• Hayashi T, Daubs MD, Suzuki A, et al. Effect of Modic changes on spinal canal stenosis and segmental motion in cervical spine. Eur Spine J. 2014;23(8):1737–1742.
   PubMed Web of Science ®Google Scholar
• Tong T, Gao XD, Li J, et al. Do Modic changes affect cervical sagittal alignment and motion in symptomatic patients? Eur Spine J. 2017 Jul;26(7):1945–1952.
   PubMed Web of Science ®Google Scholar
• Gao X, Li J, Shi Y, et al. Asymmetrical degenerative marrow (Modic) changes in cervical spine: prevalence, correlative factors, and surgical outcomes. J Orthop Surg Res. 2018;13(1):1–7.
   PubMedGoogle Scholar
• Rao RD, Currier BL, Albert TJ, et al. Degenerative cervical spondylosis: clinical syndromes, pathogenesis, and management. JBJS. 2007;89(6):1360–1378.
   PubMedGoogle Scholar
• Brain R. Cervical spondylosis. Ann Intern Med. 1954;41(3):439–446.
   PubMed Web of Science ®Google Scholar
• Cloney M, Smith AC, Coffey T, et al. Fatty infiltration of the cervical multifidus musculature and their clinical correlates in spondylotic myelopathy. J Clin Neurosci. 2018;57:208–213.
   PubMed Web of Science ®Google Scholar
• Alizada M, Li RR, Hayatullah G. Cervical instability in cervical spondylosis patients. Der Orthopäde. 2018;47(12):977–985.
   PubMed Web of Science ®Google Scholar
• Barnes MP, Saunders M. The effect of cervical mobility on the natural history of cervical spondylotic myelopathy. J Neurol Neurosurg. 1984;47(1):17–20.
   Web of Science ®Google Scholar
• Kelly JC, Groarke PJ, Butler JS, et al. The natural history and clinical syndromes of degenerative cervical spondylosis. Adv Orthop. 2012;2012:1–5.
   Google Scholar
• Hou X, Lu S, Wang B, et al. Morphologic characteristics of the deep cervical paraspinal muscles in patients with single-level cervical spondylotic myelopathy. World Neurosurg. 2020;134:e166–e171.
   PubMed Web of Science ®Google Scholar
• Burrows EH. The sagittal diameter of the spinal canal in cervical spondylosis. Clin Radiol. 1963;14(1):77–86.
   PubMedGoogle Scholar
• Morishita Y, Naito M, Hymanson H, et al. The relationship between the cervical spinal canal diameter and the pathological changes in the cervical spine. Eur Spine J. 2009;18(6):877–883.
   PubMed Web of Science ®Google Scholar
• Shedid D, Benzel EC. CERVICAL SPONDYLOSIS ANATOMY: PATHOPHYSIOLOGY AND BIOMECHANICS. Neurosurgery. 2007;60(suppl_1):S1-7-S1-13.
   Web of Science ®Google Scholar
• Edwards WC, LaRocca H. The developmental segmental sagittal diameter of the cervical spinal canal in patients with cervical spondylosis. Spine (Phila Pa 1976). 1983;8(1):20–27.
   PubMed Web of Science ®Google Scholar
• Holmes A, Han ZH, Dang GT, et al. Changes in cervical canal spinal volume during in vitro flexion-extension. Spine (Phila Pa 1976). 1996;21(11):1313–1319.
   PubMed Web of Science ®Google Scholar
• Muhle C, Weinert D, Falliner A, et al. Dynamic changes of the spinal canal in patients with cervical spondylosis at flexion and extension using magnetic resonance imaging. Invest Radiol. 1998;33(8):444–449.
   PubMed Web of Science ®Google Scholar
• Tierney RT, Mattacola CG, Sitler MR, et al. Football equipment influence cervical spinal-cord space during immobilization. J Athl Train. 2002;37(2):185–189.
   PubMed Web of Science ®Google Scholar
• De Lorenzo RA, Olson JE, Boska M, et al. Optimal positioning for cervical immobilization. Ann Emerg Med. 1996 Sep;28(3):301–308.
   PubMed Web of Science ®Google Scholar
• Di Chiro G, Fisher RL. Contrast radiography of the spinal cord. Arch Neurol. 1964;11(2):125–143.
   PubMedGoogle Scholar
• Doppman JL. The mechanism of ischemia in anteroposterior compression of the spinal cord. Invest Radiol. 1975;10(6):543–551.
   PubMed Web of Science ®Google Scholar
• Nordqvist L. The sagittal diameter of the spinal cord and subarachnoid space in different age groups. A roentgenographic post-mortem study. Acta Radiol Diagn (Stockh). 1964;61(227):221–296.
   Google Scholar
• Sherman JL, Nassaux PY, Citrin CM. Measurements of the normal cervical spinal cord on MR imaging. Am J Neuroradiol. 1990;11(2):369–372.
   PubMed Web of Science ®Google Scholar
• White Iii AA, Panjabi MM. Clinical biomechanics of the spine. 1990;
   Google Scholar
• Yuan Q, Dougherty L, Margulies SS. In vivo human cervical spinal cord deformation and displacement in flexion. Spine (Phila Pa 1976). 1998;23(15):1677–1683.
   PubMed Web of Science ®Google Scholar
• Lew PC, Morrow CJ, Lew AM. The effect of neck and leg flexion and their sequence on the lumbar spinal cord: implications in low back pain and sciatica. Spine (Phila Pa 1976). 1994;19(21):2421–2424.
   PubMed Web of Science ®Google Scholar
• Bayley JC, Yoo JU, Kruger DM, et al. The role of distraction in improving the space available for the cord in cervical spondylosis. Spine (Phila Pa 1976). 1995;20(7):771–775.
   PubMed Web of Science ®Google Scholar
• Wuest S, Symons B, Leonard T, et al. Biomechanics of vertebral artery segments C1-C6 during cervical spinal manipulation. J Manipulative Physiol Ther. 2010;33(4):273–278.
   PubMed Web of Science ®Google Scholar
• Herzog W. The biomechanics of spinal manipulation. J Bodyw Mov Ther. 2010;14(3):280–286.
   PubMedGoogle Scholar
• Prescher A. Anatomy and pathology of the aging spine1Dedicated to Professor Dr med D. Graf von Keyserlingk on the occasion of his 60th birthday.1. Eur J Radiol. 1998;27(3):181–195.
   PubMed Web of Science ®Google Scholar
• Sangari SK, Dossous P-M, Heineman T, et al. Dimensions and anatomical variants of the foramen transversarium of typical cervical vertebrae. Anat Res Int. 2015;2015: 391823-391823.
   PubMedGoogle Scholar
• Yilmazlar S, Kocaeli H, Uz A, et al. Clinical importance of ligamentous and osseous structures in the cervical uncovertebral foraminal region. Clin Anat. 2003;16(5):404–410.
   PubMed Web of Science ®Google Scholar
• Kawaguchi T, Fujita S, Hosoda K, et al. Rotational occlusion of the vertebral artery caused by transverse process hyperrotation and unilateral apophyseal joint subluxation: case report. J Neurosurg. 1997;86(6):1031–1035.
   PubMed Web of Science ®Google Scholar
• Ali N, Jinping Y, Sean G, et al., A safe approach to explore/identify the V2 segment of the vertebral artery during anterior approaches to cervical spine and/or arterial repairs: anatomical study. J Neurosurg: Spine SPI. 2010 Jan 01 2010;12:(1)25–32
   PubMed Web of Science ®Google Scholar
• Ebraheim NA, Lu J, Biyani A, et al. Anatomic considerations for uncovertebral involvement in cervical spondylosis. Clin Orthop Relat Res. 1997;339(334):200–206.
   Google Scholar
• Luzzi S, Gragnaniello C, Marasco S, et al. Subaxial Vertebral artery rotational occlusion syndrome: an overview of clinical aspects, diagnostic work-up, and surgical management. Asian Spine J. 2021 6;15(3):392–407.
   PubMed Web of Science ®Google Scholar
• Suzuki A, Daubs MD, Hayashi T, et al. Patterns of cervical disc degeneration: analysis of magnetic resonance imaging of over 1000 symptomatic subjects. Global Spine J. 2018;8(3):254–259.
   PubMed Web of Science ®Google Scholar
• Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10(1):44.
   PubMed Web of Science ®Google Scholar
• Shippel AH, Robinson GK. Radiological and magnetic resonance imaging of cervical spine instability: a case report. J Manipulative Physiol Ther. 1987;10(6):316–322.
   PubMed Web of Science ®Google Scholar
• Kumaresan S, Yoganandan N, Pintar FA, et al. Contribution of disc degeneration to osteophyte formation in the cervical spine: a biomechanical investigation. J Orthop Res. 2001;19(5):977–984.
   PubMed Web of Science ®Google Scholar
• Mann E, Peterson CK, Degenerative Marrow HJ. (Modic) changes on cervical spine magnetic resonance imaging scans: prevalence, inter- and intra-examiner reliability and link to disc herniation. Spine (Phila Pa 1976). 2011;36:14.
   Web of Science ®Google Scholar
• Yang X, Donk R, Arts MP, et al. Are modic vertebral end-plate signal changes associated with degeneration or clinical outcomes in the cervical spine? World Neurosurg. 2019 September 01 2019;129:e881–e889.
   PubMed Web of Science ®Google Scholar
• Di Fabio RP. Manipulation of the cervical spine: risks and benefits. Phys Ther. 1999;79(1):50–65.
   PubMed Web of Science ®Google Scholar
• Klougart N, Leboeuf-Yde C, Rasmussen LR. Safety in chiropractic practice, Part I; The occurrence of cerebrovascular accidents after manipulation to the neck in Denmark from 1978-1988. J Manipulative Physiol Ther. 1996;19(6):371–377.
   PubMedGoogle Scholar
• Kranenburg HA, Schmitt MA, Puentedura EJ, et al. Adverse events associated with the use of cervical spine manipulation or mobilization and patient characteristics: a systematic review. Musculoskeletal Sci Pract. 2017;28:32–38.
   PubMed Web of Science ®Google Scholar
• Puentedura EJ, March J, Anders J, et al. Safety of cervical spine manipulation: are adverse events preventable and are manipulations being performed appropriately? A review of 134 case reports. J Man Manip Ther. 2012;20(2):66–74.
   PubMedGoogle Scholar
• Nagamoto Y, Ishii T, Iwasaki M, et al. Three-dimensional motion of the uncovertebral joint during head rotation. J Neurosurg Spine. 2012;17(4):327–333.
   PubMed Web of Science ®Google Scholar
• Triano JJ, Schultz AB. Motions of the head and thorax during neck manipulations. J Manipulative Physiol Ther. [1994 Nov-Dec]1994;17(9):573–583.
   PubMed Web of Science ®Google Scholar
• Salem W, Klein P. In vivo 3D kinematics of the cervical spine segments during pre-manipulative positioning at the C4/C5 level. Manual Ther. 2013;18(4):321–326.
   PubMedGoogle Scholar
• Wu L-P, Huang Y-Q, Zhou W-H, et al. Influence of cervical spine position, turning time, and cervical segment on cadaver intradiscal pressure during cervical spinal manipulative therapy. J Manipulative Physiol Ther. 2012;35(6):428–436.
   PubMed Web of Science ®Google Scholar
• Li YK, Zhu QA, Zhong SZ. The effect of cervical traction combined with rotatory manipulation on cervical nucleus pulposus pressures. J Manipulative Physiol Ther. 1998;21(2):97–100.
   PubMed Web of Science ®Google Scholar
• Gross A, Miller J, D’Sylva J, et al. Manipulation or mobilisation for neck pain. Cochrane Database Syst Rev. 2010;(1).
   PubMed Web of Science ®Google Scholar
• Young JL, Walker D, Snyder S, et al. Thoracic manipulation versus mobilization in patients with mechanical neck pain: a systematic review. J Man Manip Ther. 2014;22(3):141–153.
   PubMedGoogle Scholar
• Young IA, Pozzi F, Dunning J, et al. Immediate and short-term effects of thoracic spine manipulation in patients with cervical radiculopathy: a randomized controlled trial. J Orthop Sports Phys Ther. 2019 May;49(5):299–309.
   PubMed Web of Science ®Google Scholar
• Romeo A, Vanti C, Boldrini V, et al. Cervical radiculopathy: effectiveness of adding traction to physical therapy—A systematic review and meta-analysis of randomized controlled trials. Phys Ther. 2018;98(4):231–242.
   PubMed Web of Science ®Google Scholar
• Maitland GD. Vertebral manipulation. Edinburgh: Butterworth-Heinemann; 2013.
   Google Scholar
• Kaltenborn FMKT. Manual mobilization of the joints, Vol. 3: traction-manipulation of the extremities and spine. Oslo, Norway: Norli; 2008.
   Google Scholar
• Wang K, Wang H, Deng Z, et al. Cervical traction therapy with and without neck support: a finite element analysis. Musculoskelet Sci Pract. 2017Apr;28:1–9.
   PubMed Web of Science ®Google Scholar
• Gudavalli MR, Potluri T, Carandang G, et al. Intradiscal pressure changes during manual cervical distraction: a cadaveric study. Evid Based Complement Alternat Med. 2013 August 20 2013;2013:954134.
   PubMed Web of Science ®Google Scholar
• Lestini WF, Wiesel SW. The pathogenesis of cervical spondylosis. Clin Orthop Relat Res. 1989;239:69–93.
   PubMed Web of Science ®Google Scholar
• Lundeberg T. Long-term results of vibratory stimulation as a pain relieving measure for chronic pain. Pain. 1984;20(1):13–23.
   PubMed Web of Science ®Google Scholar
• Lundeberg T, Nordemar R, Ottoson D. Pain alleviation by vibratory stimulation. Pain. 1984;20(1):25–44.
   PubMed Web of Science ®Google Scholar
• Lederman E. Fundamentals of manual therapy: physiology, neurology, and psychology. London: Churchill Livingstone; 1997.
   Google Scholar
• Arimi SA, Bandpei MAM, Rezasoltani A, et al. Multifidus muscle size changes at different directions of head and neck movements in females with unilateral chronic non-specific neck pain and healthy subjects using ultrasonography. J Bodyw Mov Ther. 2018;22(3):560–565.
   PubMed Web of Science ®Google Scholar
• Tamai K, Grisdela P, Romanu J, et al. The impact of cervical spinal muscle degeneration on cervical sagittal balance and spinal degenerative disorders. Clin Spine Surg. 2019;32(4):E206–E213.
   PubMed Web of Science ®Google Scholar
• O’Leary S, Falla D, Elliott JM, et al. Muscle dysfunction in cervical spine pain: implications for assessment and management. J Orthop Sports Phys Ther. 2009;39(5):324–333.
   PubMed Web of Science ®Google Scholar
• Creighton D. Therapeutic Exercise: exercise techniques for patients with common orthopedic conditions. Columbus, Ohio: Zip Publications: The Educational Publisher; 2012.
   Google Scholar