The Neural Network Basis for Abnormalities of Attention and Executive Function in Major Depressive Disorder: Implications for Application of the Medical Disease Model to Psychiatric Disorders

REFERENCES

• Nemeroff CB, Kilts CD, Berns GS. Functional brain imaging: twenty-first century phrenology or psychobiological advance for the millennium? Am J Psychiatry 1999;156:671–3.
   PubMed Web of Science ®Google Scholar
• Andreasen NC. Linking mind and brain in the study of men- tal illnesses: a project for a scientific psychopathology. Sci- ence 1997;275:1586–93.
   PubMed Web of Science ®Google Scholar
• Pearlson GD, Petty RG, Ross CA, Tien AY. Schizophrenia: a disease of heteromodal association cortex? Neuropsycho- pharmacology 1996;14:1–17.
   PubMed Web of Science ®Google Scholar
• Drevets WC. Neuroimaging studies of mood disorders. Biol Psychiatry 2000;48:813–29.
   PubMed Web of Science ®Google Scholar
• Brody AL, Barsom MW, Bota RG, Saxena S. Prefrontal- subcortical and limbic circuit mediation of major depressive disorder. Semin Clin Neuropsychiatry 2001;6:102–12.
   PubMedGoogle Scholar
• Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 1997; 9:471–81.
   PubMed Web of Science ®Google Scholar
• Madden JJ, Luhan JA, Kaplan LA, Manfredi HM. Non- dementing psychoses in older persons. JAMA 1952;150:1567–70.
   PubMed Web of Science ®Google Scholar
• Cassens G, Wolfe L, Zola M. The neuropsychology of depres- sions. J Neuropsychiatry Clin Neurosci 1990;2:202–13.
   PubMedGoogle Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Ameri- can Psychiatric Association, 1994.
   Google Scholar
• Burt DB, Zembar MJ, Niederehe G. Depression and memory impairment: a meta-analysis of the association, its pattern, and specificity. Psychol Bull 1995;117:285–305.
   PubMed Web of Science ®Google Scholar
• Mega MS, Cummings JL. Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 1994;6:358–70.
   PubMed Web of Science ®Google Scholar
• Cohen R, Lohr I, Paul R, Boland R. Impairments of attention and effort among patients with major affective disorders. J Neuropsychiatry Clin Neurosci 2001;13:385–95.
   Google Scholar
• Mirsky AF, Anthony BJ, Duncan CC, Ahearn MB, Kellam SG. Analysis of the elements of attention: a neuropsychologi- cal approach. Neuropsychol Rev 1991;2:109–45.
   PubMedGoogle Scholar
• Thomas P, Goudemand M, Rousseaux M. Divided attention in major depression. Psychiatry Res 1998;81:309–22.
   PubMed Web of Science ®Google Scholar
• MacQueen GM, Tipper SP, Young LT, Joffe RT, Levitt AJ. Im- paired distractor inhibition on a selective attention task in unmedicated, depressed subjects. Psychol Med 2000;30:557–64.
   Google Scholar
• Schatzberg AF, Posener JA, DeBattista C, Kalehzan BM, Rothschild AJ, Shear PK. Neuropsychological deficits in psy- chotic versus nonpsychotic major depression and no mental illness. Am J Psychiatry 2000;157:1095–100.
   PubMed Web of Science ®Google Scholar
• Jeste DV, Heaton SC, Paulsen JS, Ercoli L, Harris J, Heaton RK. Clinical and neuropsychological comparison of psychotic depression with nonpsychotic depression and schizophrenia. Am J Psychiatry 1996;153:490–6.
   PubMed Web of Science ®Google Scholar
• Wolfe J, Granholm E, Butters N, Saunders E, Janowsky D. Verbal memory deficits associated with major affective disor- ders: a comparison of unipolar and bipolar patients. J Affect Disord 1987;13:83–92.
   PubMed Web of Science ®Google Scholar
• Savard RJ, Rey AC, Post RM. Halstead-Reitan Category Test in bipolar and unipolar affective disorders: relationship to age and phase of illness. J Nerv Ment Dis 1980;168:297–304.
   PubMed Web of Science ®Google Scholar
• Tarbuck AF, Paykel ES. Effects of major depression on the cognitive function of younger and older subjects. Psychol Med 1995;25:285–95.
   PubMed Web of Science ®Google Scholar
• Merriam EP, Thase ME, Haas GL, Keshavan MS, Sweeney JA. Prefrontal cortical dysfunction in depression determined by Wisconsin Card Sorting Test performance. Am J Psychia- try 1999;156:780–2.
   PubMed Web of Science ®Google Scholar
• Spitzer RL, Endicott J, Robins E. Research diagnostic crite- ria: rationale and reliability. Arch Gen Psychiatry 1978;35:773–82.
   PubMed Web of Science ®Google Scholar
• Broca P. Perte de la parole, ramollisement chronique et de- struction partiale du lobe ante´rieur gauche du cerveau. Bull Soc Anthropol Paris 1861;2:235–8.
   Google Scholar
• Broca P. Nouvelle observation d’aphe´mie produite par une le´sion de la moitie´ poste´rieure des deuxie`me et troisie`me circonvolutions frontales. Bull Soc Anat Paris 1861;6:398–407.
   Google Scholar
• Broca P. Sur le sie`ge de la faculte´ du langage articule´. Bull Soc Anthropol Paris 1865;6:337–93.
   Google Scholar
• Wernicke C. Der aphasische Symptomencomplex: eine psy- chologische Studie auf anatomischer Basis. Breslau: Cohn, 1874.
   Google Scholar
• Geschwind N. Specializations of the human brain. Sci Am 1979;241:180–99.
   PubMed Web of Science ®Google Scholar
• Anderson JM, Gilmore R, Roper S, Crosson B, Bauer RM, Nadeau S, et al. Conduction aphasia and the arcuate fascicu- lus: a reexamination of the Wernicke-Geschwind model. Brain Lang 1999;70:1–12.
   PubMed Web of Science ®Google Scholar
• Wilkins RH, Brody IA. Wernicke’s sensory aphasia. Arch Neurol 1970;22:279–82.
   Google Scholar
• Schacter DL, Alpert NM, Savage CR, Rauch SL, Albert MS. Conscious recollection and the human hippocampal forma- tion: evidence from positron emission tomography. Proc Natl Acad Sci USA 1996;93:321–5.
   PubMed Web of Science ®Google Scholar
• Savage CR, Deckersbach T, Heckers S, Wagner AD, Schacter DL, Alpert NM, et al. Prefrontal regions supporting sponta- neous and directed application of verbal learning strategies: evidence from PET. Brain 2001;124:219–31.
   PubMed Web of Science ®Google Scholar
• Rauch SL, Savage CR, Brown HD, Curran T, Alpert NM, Kendrick A, et al. A PET investigation of implicit and explicit sequence learning. Hum Brain Map 1995;3:271–86.
   Web of Science ®Google Scholar
• Mendez MF. Delirium. In: Bradley WG, Daroff RB, Fenichel GM, Marsden CD, eds. Neurology in clinical practice, vol 1. 2nd ed. Boston: Butterworth-Heinemann, 1996:29–38.
   Google Scholar
• Mialet JP, Pope HG, Yurgelun-Todd D. Impaired attention in depressive states: a non-specific deficit? Psychol Med 1996; 26:1009–20.
   PubMed Web of Science ®Google Scholar
• Posner MI, Dehaene S. Attentional networks. Trends Neu- rosci 1994;17:75–9.
   PubMed Web of Science ®Google Scholar
• Lemelin S, Baruch P, Vincent A, Everett J, Vincent P. Dis- tractibility and processing resource deficit in major depres- sion: evidence for two deficient attentional processing mod- els. J Nerv Ment Dis 1997;185:542–8.
   PubMed Web of Science ®Google Scholar
• Vanderploeg RD. The interpretation process. In: Vanderploeg RD, ed. Clinician’s guide to neuropsychological assessment. Mahwah, New Jersey: Erlbaum, 2000:111–54.
   Google Scholar
• Mesulam MM. A cortical network for directed attention and unilateral neglect. Ann Neurol 1981;10:309–25.
   PubMed Web of Science ®Google Scholar
• Nobre AC, Sebestyen GN, Gitelman DR, Mesulam MM, Frackowiak RS, Frith CD. Functional localization of the sys- tem for visuospatial attention using positron emission to- mography. Brain 1997;120:515–33.
   PubMed Web of Science ®Google Scholar
• Tzourio N, Massioui FE, Crivello F, Joliot M, Renault B, Ma- zoyer B. Functional anatomy of human auditory attention studied with PET. Neuroimage 1997;5:63–77.
   Google Scholar
• Lezak MD. Neuropsychological assessment. New York: Ox- ford University Press, 1976.
   Google Scholar
• Aronson H, Vroonland JP. The residual cognitive competence of elderly females. J Clin Psychol 1993;49:724–31.
   Google Scholar
• Lysaker P, Bell M, Beam-Goulet J. Wisconsin Card Sorting Test and work performance in schizophrenia. Psychiatry Res 1995;56:45–51.
   PubMed Web of Science ®Google Scholar
• Milner B. Effects of different brain lesions on card sorting: the role of the frontal lobes. Arch Neurol 1963;9:90–100.
   Web of Science ®Google Scholar
• Drewe EA. The effect of type and area of brain lesion on Wis- consin Card Sorting Test performance. Cortex 1974;10:159–70.
   PubMedGoogle Scholar
• Berman KF, Ostrem JL, Randolph C, Gold J, Goldberg TE, Coppola R, et al. Physiological activation of a cortical net- work during performance of the Wisconsin Card Sorting Test: a positron emission tomography study. Neuropsychologia 1995;33:1027–46.
   PubMed Web of Science ®Google Scholar
• Baker SC, Rogers RD, Owen AM, Frith CD, Dolan RJ, Frack- owiak RSJ, et al. Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia 1996;34:515–26.
   Google Scholar
• Bench CJ, Frith CD, Grasby PM, Friston KJ, Paulesu E, Frackowiak RSJ, et al. Investigations of the functional anat- omy of attention using the Stroop Test. Neuropsychologia 1993;31:907–22.
   PubMed Web of Science ®Google Scholar
• Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 1986;9:357–81.
   PubMed Web of Science ®Google Scholar
• Masterman DL, Cummings JL. Frontal-subcortical circuits: the anatomic basis of executive, social and motivated behav- iors. J Psychopharmacol 1997;11:107–14.
   PubMed Web of Science ®Google Scholar
• Martin PD, Ono T. Effects of reward anticipation, reward presentation, and spatial parameters on the firing of single neurons recorded in the subiculum and nucleus accumbens of freely moving rats. Behav Brain Res 2000;116:23–38.
   Google Scholar
• Spreen O, Strauss E. A compendium of neuropsychological tests: administration, norms, and commentary. 2nd ed. New York: Oxford University Press, 1998.
   Google Scholar
• Weschler D. A standardized memory scale for clinical use. J Psychol 1945;19:87–95.
   Web of Science ®Google Scholar
• Weschler D. Weschler Adult Intelligence Scale—Revised: manual. New York: Harcourt Brace Jovanovich, 1981.
   Google Scholar
• Gerton BK, Brown TT, Meyer-Lindenberg A, Holt JL, Ber- man KF. Shared and distinct neurophysiological components of the Digits Forward and Backward tasks as revealed by PET. Presented at the 5th International Conference on Func- tional Mapping of the Human Brain, Du¨ sseldorf, Germany, June 1999.
   Google Scholar
• Stuss DT, Bisschop SM, Alexander MP, Levine B, Katz D, Izukawa D. The Trail Making Test: a study in focal lesion patients. Psychol Assess 2001;13:230–9.
   PubMed Web of Science ®Google Scholar
• Rosvold HE, Mirsky AF, Sarason I, Bransome ED Jr, Beck LH. A Continuous Performance Test of brain damage. J Con- sult Psychol 1956;20:343–50.
   PubMed Web of Science ®Google Scholar
• Nuechterlein KH, Parasuraman R, Jiang Q. Visual sustained attention: image degradation produces rapid sensitivity dec- rement over time. Science 1983;220:327–9.
   PubMed Web of Science ®Google Scholar
• Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer- Kimling L. The Continuous Performance Test, Identical Pairs version (CPT-IP), I: New findings about sustained at- tention in normal families. Psychiatry Res 1988;26:223–38.
   PubMed Web of Science ®Google Scholar
• Van den Bosch RJ, Rombouts RP, Van Asma MJO. What determines Continuous Performance Task performance? Schizophr Bull 1996;22:643–51.
   PubMed Web of Science ®Google Scholar
• Coull JT, Frith CD, Frackowiak RSJ, Grasby PM. A fronto- parietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neu- ropsychologia 1996;34:1085–95.
   PubMed Web of Science ®Google Scholar
• Bench CJ, Friston KJ, Brown RG, Frackowiak RSJ, Dolan RJ. Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions. Psychol Med 1993;23:579–90.
   PubMed Web of Science ®Google Scholar
• Pardo JV, Pardo PJ, Janer KW, Raichle ME. The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm. Proc Natl Acad Sci USA 1990;87:256–9.
   PubMed Web of Science ®Google Scholar
• Bush G, Luu P, Posner MI. Cognitive and emotional influ- ences in anterior cingulate cortex. Trends Cogn Sci 2000; 4:215–22.
   PubMed Web of Science ®Google Scholar
• Shallice T. Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci 1982;298:199–209.
   Google Scholar
• Pihlajama¨ ki M, Tanila H, Ha¨ nninen T, Ko¨no¨nen M, Laakso M, Partanen K, et al. Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study. Ann Neurol 2000;47:470–6.
   Google Scholar
• Grant MM, Thase ME, Sweeney JA. Cognitive disturbance in outpatient depressed younger adults: evidence of modest impairment. Biol Psychiatry 2001;50:35–43.
   PubMed Web of Science ®Google Scholar
• Williams RA, Hagerty BM, Cimprich B, Therrien B, Bay E, Oe H. Changes in directed attention and short-term memory in depression. J Psychiatr Res 2000;34:227–38.
   PubMed Web of Science ®Google Scholar
• Fossati P, Amar G, Raoux N, Ergis AM, Allilaire JF. Execu- tive functioning and verbal memory in young patients with unipolar depression and schizophrenia. Psychiatry Res 1999;89:171–87.
   PubMed Web of Science ®Google Scholar
• Brown RG, Scott LC, Bench CJ, Dolan RJ. Cognitive function in depression: its relationship to the presence and severity of intellectual decline. Psychol Med 1994;24:829–47.
   PubMed Web of Science ®Google Scholar
• Channon S, Baker JE, Robertson MM. Working memory in clinical depression: an experimental study. Psychol Med 1993;23:87–91.
   PubMed Web of Science ®Google Scholar
• Martin DJ, Oren Z, Boone K. Major depressives’ and dysthy- mics’ performance on the Wisconsin Card Sorting Test. J Clin Psychol 1991;47:684–90.
   PubMed Web of Science ®Google Scholar
• Bornstein RA, Baker GB, Douglass AB. Depression and memory in major depressive disorder. J Neuropsychiatry Clin Neurosci 1991;3:78–80.
   PubMedGoogle Scholar
• Danion JM, Willard-Schroeder D, Zimmermann MA, Grange D, Schlienger JL, Singer L. Explicit memory and repetition priming in depression: preliminary findings. Arch Gen Psy- chiatry 1991;48:707–11.
   PubMed Web of Science ®Google Scholar
• Richards PM, Ruff RM. Motivational effects on neuropsycho- logical functioning: comparison of depressed versus nonde- pressed individuals. J Consult Clin Psychol 1989;57:396–402.
   PubMed Web of Science ®Google Scholar
• Nelson EB, Sax KW, Strakowski SM. Attentional perfor- mance in patients with psychotic and nonpsychotic major de- pression and schizophrenia. Am J Psychiatry 1998;155:137–9.
   PubMed Web of Science ®Google Scholar
• Van den Bosch RJ, Rombouts RP. Causal mechanisms of sub- jective cognitive dysfunction in schizophrenic and depressed patients. J Nerv Ment Dis 1998;186:364–8.
   PubMed Web of Science ®Google Scholar
• Paradiso S, Lamberty GJ, Garvey MJ, Robinson RG. Cogni- tive impairment in the euthymic phase of chronic unipolar depression. J Nerv Ment Dis 1997;185:748–54.
   PubMed Web of Science ®Google Scholar
• Lemelin S, Baruch P. Clinical psychomotor retardation and attention in depression. J Psychiatr Res 1998;32:81–8.
   Google Scholar
• Cornell DG, Suarez R, Berent S. Psychomotor retardation in melancholic and nonmelancholic depression: cognitive and motor components. J Abnorm Psychol 1984;93:150–7.
   PubMed Web of Science ®Google Scholar
• Moffoot APR, O’Carroll RE, Bennie J, Carroll S, Dick H, Eb- meier KP, et al. Diurnal variation of mood and neuropsycho- logical function in major depression with melancholia. J Af- fect Disord 1994;32:257–69.
   Google Scholar
• Porterfield T, Cook M, Deary IJ, Ebmeier KP. Neuropsycho- logical function and diurnal variation in depression. J Clin Exp Neuropsychol 1997;19:906–13.
   PubMed Web of Science ®Google Scholar
• Hartlage S, Alloy LB, Va´ zquez C, Dykman B. Automatic and effortful processing in depression. Psychol Bull 1993;113:247–78.
   Google Scholar
• Cohen RM, Weingartner H, Smallberg SA, Pickar D, Murphy DL. Effort and cognition in depression. Arch Gen Psychiatry 1982;39:593–7.
   PubMed Web of Science ®Google Scholar
• Silberman EK, Weingartner H, Targum SD, Byrnes S. Cogni- tive functioning in biological subtypes of depression. Biol Psychiatry 1985;20:654–61.
   Google Scholar
• El Massioui F, Lese`vre N. Attention impairment and psycho- motor retardation in depressed patients: an event-related po- tential study. Electroencephalogr Clin Neurophysiol 1988; 70:46–55.
   PubMedGoogle Scholar
• David AS. Spatial and selective attention in the cerebral hemispheres in depression, mania, and schizophrenia. Brain Cogn 1993;23:166–80.
   PubMed Web of Science ®Google Scholar
• Degl’Innocenti A, A° gren H, Ba¨ ckman L. Executive deficits in major depression. Acta Psychiatr Scand 1998;97:182–8.
   PubMed Web of Science ®Google Scholar
• Lemelin S, Baruch P, Vincent A, LaPlante L, Everett J, Vin- cent P. Attention disturbance in clinical depression: deficient distractor inhibition or processing resource deficit? J Nerv Ment Dis 1996;184:114–21.
   Google Scholar
• Trichard C, Martinot JL, Alagille M, Masure MC, Hardy P, Ginestet D, et al. Time course of prefrontal lobe dysfunction in severely depressed in-patients: a longitudinal neuropsy- chological study. Psychol Med 1995;25:79–85.
   PubMed Web of Science ®Google Scholar
• Jones BP, Henderson M, Welch CA. Executive functions in unipolar depression before and after electroconvulsive ther- apy. Int J Neurosci 1988;38:287–97.
   PubMed Web of Science ®Google Scholar
• Purcell R, Maruff P, Kyrios M, Pantelis C. Neuropsychologi- cal function in young patients with unipolar major depres- sion. Psychol Med 1997;27:1277–85.
   PubMed Web of Science ®Google Scholar
• Elliott R, Baker SC, Rogers RD, O’Leary DA, Paykel ES, Frith CD, et al. Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychol Med 1997;27:931–42.
   PubMed Web of Science ®Google Scholar
• Watts FN, MacLeod AK, Morris L. Associations between phe- nomenal and objective aspects of concentration problems in depressed patients. Br J Psychol 1988;79:241–50.
   PubMed Web of Science ®Google Scholar
• Ilsley JE, Moffoot APR, O’Carroll RE. An analysis of mem- ory dysfunction in major depression. J Affect Disord 1995; 35:1–9.
   PubMed Web of Science ®Google Scholar
• Smith MJ, Bre´bion G, Banquet JP, Allilaire JF. Experimental evidence for two dimensions of cognitive disorders in de- pressives. J Psychiatr Res 1994;28:401–11.
   PubMedGoogle Scholar
• Dougherty D, Rauch SL. Neuroimaging and neurobiological models of depression. Harvard Rev Psychiatry 1997;5:138–59.
   PubMed Web of Science ®Google Scholar
• Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. Hippocampal volume reduction in major depression. Am J Psychiatry 2000;157:115–8.
   PubMed Web of Science ®Google Scholar
• Mervaala E, Fo¨hr J, Ko¨no¨nen M, Valkonen-Korhonen M, Vai- nio P, Partanen K, et al. Quantitative MRI of the hippocam- pus and amygdala in severe depression. Psychol Med 2000; 30:117–25.
   Google Scholar
• Sheline YI, Gado MH, Price JL. Amygdala core nuclei vol- umes are decreased in recurrent major depression. Neuro- report 1998;9:2023–8.
   Google Scholar
• Krishnan KR, McDonald WM, Escalona PR, Doraiswamy PM, Na C, Husain MM, et al. Magnetic resonance imaging of the caudate nuclei in depression: preliminary observa- tions. Arch Gen Psychiatry 1992;49:553–7.
   Google Scholar
• Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, et al. Quantitative cerebral anatomy in de- pression: a controlled magnetic resonance imaging study. Arch Gen Psychiatry 1993;50:7–16.
   PubMed Web of Science ®Google Scholar
• Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997;386:824–7.
   PubMed Web of Science ®Google Scholar
• Austin MP, Dougall N, Ross M, Murray C, O’Carroll RE, Mof- foot A, et al. Single photon emission tomography with 99mTc- exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. J Af- fect Disord 1992;26:31–43.
   Google Scholar
• Mayberg HS, Lewis PJ, Regenold W, Wagner HN Jr. Paralim- bic hypoperfusion in unipolar depression. J Nucl Med 1994; 35:929–34.
   PubMed Web of Science ®Google Scholar
• Galynker II, Cai J, Ongseng F, Finestone H, Dutta E, Serseni D. Hypofrontality and negative symptoms in major de- pressive disorder. J Nucl Med 1998;39:608–12.
   PubMed Web of Science ®Google Scholar
• Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME. A functional anatomical study of unipolar depression. J Neurosci 1992;12:3628–41.
   PubMed Web of Science ®Google Scholar
• Baxter LR Jr, Phelps ME, Mazziotta JC, Schwartz JM, Gerner RH, Selin CE, et al. Cerebral metabolic rates for glu- cose in mood disorders: studies with positron emission to- mography and fluorodeoxyglucose F 18. Arch Gen Psychiatry 1985;42:441–7.
   Google Scholar
• Dolan RJ, Bench CJ, Brown RG, Scott LC, Friston KJ, Frack- owiak RSJ. Regional cerebral blood flow abnormalities in de- pressed patients with cognitive impairment. J Neurol Neuro- surg Psychiatry 1992;55:768–73.
   Google Scholar
• Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RS, Dolan RJ. The anatomy of melancholia—focal abnormalities of cerebral blood flow in major depression. Psychol Med 1992;22:607–15.
   PubMed Web of Science ®Google Scholar
• Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, et al. Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry 1994;36:381–8.
   PubMed Web of Science ®Google Scholar
• Hurwitz TA, Clark C, Murphy E, Klonoff H, Martin WRW, Pate BD. Regional cerebral glucose metabolism in major de- pressive disorder. Can J Psychiatry 1990;35:684–8.
   PubMed Web of Science ®Google Scholar
• Baxter LR Jr, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry 1989;46:243–50.
   Google Scholar
• Baxter LR, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive-compulsive disorder: a comparison with rates in unipolar depression and in normal controls. Arch Gen Psy- chiatry 1987;44:211–8.
   PubMed Web of Science ®Google Scholar
• Beck AT. Cognitive therapy and the emotional disorders. New York: International Universities Press, 1976.
   Google Scholar
• Weingartner H, Silberman E. Models of cognitive impair- ment: cognitive changes in depression. Psychopharmacol Bull 1982;18:27–42.
   PubMedGoogle Scholar
• Elliott R, Sahakian BJ, Michael A, Paykel ES, Dolan RJ. Ab- normal neural response to feedback on planning and guess- ing tasks in patients with unipolar depression. Psychol Med 1998;28:559–71.
   Google Scholar
• Tourney G. History of biological psychiatry in America. Am J Psychiatry 1969;126:29–42.
   Google Scholar
• Gabbard GO. Psychodynamic psychiatry in clinical practice: the DSM-IV edition. Washington, DC: American Psychiatric Press, 1994.
   Google Scholar
• Mesulam MM. From sensation to cognition. Brain 1998; 121:1013–52.
   PubMed Web of Science ®Google Scholar
• Siegel DJ. Contributions of the psychological sciences: per- ception and cognition. In: Sadock BJ, Sadock VA, eds. Kaplan & Sadock’s comprehensive textbook of psychiatry, vol 7th ed. Philadelphia: Lippincott Williams & Wilkins, 2000:386–402.
   Google Scholar
• Gerson SN, Benson DF, Frazier SH. Diagnosis: schizophre- nia versus posterior aphasia. Am J Psychiatry 1977;134:966–9.
   PubMed Web of Science ®Google Scholar
• Benson DF. Psychiatric aspects of aphasia. Br J Psychiatry 1973;123:555–66.
   PubMed Web of Science ®Google Scholar
• Barta PE, Pearlson GD, Powers RE, Richards SS, Tune LE. Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am J Psychiatry 1990;147:1457–62.
   PubMed Web of Science ®Google Scholar
• Shenton ME, Kikinis R, Jolesz FA, Pollak SD, LeMay M, Wible CG, et al. Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. N Engl J Med 1992;327:604–12.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed. Washington, DC: Ameri- can Psychiatric Association, 1980.
   Google Scholar
• Janicak PG, Davis JM, Preskorn SH, Ayd FJ Jr. General principles. In: Principles and practice of psychopharmaco- therapy. 2nd ed. Baltimore: Williams & Wilkins, 1997:1–7.
   Google Scholar
• Faraone SV, Tsuang MT. Measuring diagnostic accuracy in the absence of a “gold standard.” Am J Psychiatry 1994; 151:650–7.
   PubMed Web of Science ®Google Scholar