Modulation of LDL Oxidation by 7,8-Dihydroneopterin

References

• Chisholm, G.M. and Penn, M.S. (1996) In: Fuster, V, Ross, R. and Topol, E.J., eds, Oxidized Lipoproteins and Atherosclerosis (Raven Press, New York) 19, pp 129–149.
   Google Scholar
• Steinberg, D. (1997) "Low density lipoprotein oxidation and its pathobiological significance", J. Biol. Chem. 272, 20963–20966.
   PubMed Web of Science ®Google Scholar
• Berliner, J.A., Navab, M., Fogelman, AM., Frank, J.S., Demer, L.L., Edwards, P.A., Watson, A.D. and Lusis, A.J. (1995) "Atherosclerosis: basic mechanisms. Oxidation, inflam-mation, and genetics", Circulation 91, 2488–2496.
   PubMed Web of Science ®Google Scholar
• Witztum, J.L. and Hörkkö, S. (1997) "The role of oxidized LDL in atherogenesis: immunological response and anti-phospho-lipid antibodies", Ann. NY Acad. Sci. 811, 88–96.
   PubMed Web of Science ®Google Scholar
• Heinecke, J.W. (1998) "Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis", Atherosclerosis 141, 1–15.
   PubMed Web of Science ®Google Scholar
• Muller, K., Carpenter, K.L. and Mitchinson, M.J. (1998) "Cell-mediated oxidation of LDL: comparison of different cell types of the atherosclerotic lesion", Free Radic. Res. 29, 201–220.
   Google Scholar
• Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G. and Jörgens, G. (1990) "Biochemical, structural and func-tional properties of oxidized low density lipoprotein", Chem. Res. Toxicol. 3, 77–92.
   PubMed Web of Science ®Google Scholar
• Jörgens, G., Lang, J. and Esterbauer, H. (1986) "Modification of human low density lipoprotein (LDL) by the lipid peroxidation product 4-hydroxy-nonenal", Biochim. Biophys. Acta 875, 103–114.
   PubMedGoogle Scholar
• Jörgens, G., Ashy, A. and Esterbauer, H. (1990) "Detection of new epitopes formed upon oxidation of low density lipoprotein, lipoprotein(a) and very low density lipoprotein. Use of an antiserum against 4-hydroxynonenal modified low density lipoprotein", Biochem. J. 265, 605–608.
   PubMedGoogle Scholar
• Esterbauer, H., Gebicki, J., Puhl, H. and Jörgens, G. (1992) "The role of lipid permddation and antioxidants in oxidative modification of LDL", Free Radic. Biol. Med. 13, 341–390.
   PubMed Web of Science ®Google Scholar
• Kodama, T., Doi, T., Suzuki, H., Takahashi, K., Wada, Y. and Gordon, S. (1996) "Collagenous macrophage scavenger receptors", Curr. Opin. Lipidol. 7, 287–291.
   PubMedGoogle Scholar
• Chisholm, G.M., Hazen, S.L., Fox, P.L. and Cathcart, M.K. (1999) "The Oxidation of lipoproteins by monocytes-macrophages", J. Biol. Chem. 274, 25959–25962.
   PubMedGoogle Scholar
• Yang, F.M., Friedrichs, W.E., Cupples, R.L., Bonifacio, M.J., Sanford, J.A., Horton, W.A. and Bowman, B.H. (1990) "Human ceruloplasmin. Tissue-specific expression of tran-scripts produced by alternative splicing", J. Biol. Chem. 265, 10780–10785.
   PubMedGoogle Scholar
• Fleming, R.E., Whitman, I.P. and Gitlin, J.D. (1991) "Induction of ceruloplasmin gene expression in rat lung during inflammation and hyperoxia", Am. J. Physiol. 260, L68—L74.
   Google Scholar
• Mukhopadhyay, C.K. and Fox, P.L. (1998) "Ceruloplasmin copper induces oxidant damage by a redox process utilizing cell-derived superoxide as reductant", Biochemistry 37, 14222–14229.
   PubMed Web of Science ®Google Scholar
• Ehrenwald, E. and Fox, EL. (1996) "Role of endogenous ceruloplasmin in low density lipoprotein oxidation by human U937 monocytic cells", J. Clin. Investig. 97, 884–890.
   PubMed Web of Science ®Google Scholar
• Cathcart, M.K., McNally, A.K., Morel, D.W. and Chisolm, G.M. (1989) "Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin", J. Immunol. 142, 1963–1969.
   PubMed Web of Science ®Google Scholar
• Huber, C., Batchelor, J.R., Fuchs, D., Hausen, A., Lang, A., Niederwieser, D., Reibnegger, G., Swetly, P., Troppmair, J. and Wachter, H. (1984) "Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon gamma", J. Exp. Med. 160, 310–316.
   PubMed Web of Science ®Google Scholar
• Wachter, H., Fuchs, D., Hausen, A., Reibnegger, G. and Werner, E.R. (1989) "Neopterin as a marker for activation of cellular immunity: immunologic basis and clinical appli-cation", Adv. Clin. Chem. 27, 81–141.
   PubMed Web of Science ®Google Scholar
• Samsonov, M.Y., TiIz, G.P., Egorova, 0., Reibnegger, G., Balabanova, R.M., Nassonov, E.L., Nassonova, V.A., Wachter, H. and Fuchs, D. (1995) "Serum soluble markers of immune activation and disease activity in systemic lupus erythe-matosus", Lupus 4, 29–32.
   Google Scholar
• Weiss, G., Kronberger, P., Conrad, E, Bodner, E., Wachter, H. and Reibnegger, G. (1993) "Neopterin and prognosis in patients with adenocarcinoma of the colon", Cancer Res. 53,260–265.
   PubMed Web of Science ®Google Scholar
• Fuchs, D., Hausen, A., Reibnegger, G., Werner, E.R., Dierich, M.P. and Wachter, H. (1988) "Neopterin as a marker for activated cell-mediated immunity: application in HIV infection", Immunol. Today 9, 150–155.
   PubMedGoogle Scholar
• Fahey, J.L., Taylor, J.M., Detels, R., Hofmann, B., Melmed, R., Nishanian, P. and Giorgi, J.V. (1990) "The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1", New Engl. J. Med. 322, 166–172.
   PubMed Web of Science ®Google Scholar
• Reibnegger, G., Aichberger, C., Fuchs, D., Hausen, A., Spielberger, M., Werner, E.R., Margreiter, R. and Wachter, H. (1991) "Posttransplant neopterin excretion in renal allograft recipients-a reliable diagnostic aid for acute rejection and a predictive marker of long-term graft survival", Transplan-tation 52, 58–63.
   PubMed Web of Science ®Google Scholar
• Gieseg, S.P., Reibnegger, G., Wachter, H. and Esterbauer, H. (1995) "7,8-Dihydroneopterin inhibits low density lipo-protein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant", Free Radic. Res. 23, 123–136.
   PubMed Web of Science ®Google Scholar
• Herpfer, I., Greilberger, J., Ledinski, G., Widner, B., Fuchs, D. and Jiirgens, G. (2002) "Neopterin and 7,8-dihydroneopterin interfere with low density lipoprotein oxidation mediated by peroxynitrite and/or copper", Free Radic. Res. 36, 509–520.
   PubMed Web of Science ®Google Scholar
• Jiirgens, G., Taddei-Peters, W.C., Költringer, P., Petek, W., Chen, Q., Greilberger, J., Macomber, P.F., Butman, B.T., Stead, A. and Ransom, J.H. (1995) "Lipoprotein(a) serum concentration and apolipoprotein(a) phenotype correlate with severity and presence of ischemic cerebrovascular disease", Stroke 26, 1841–1848.
   PubMedGoogle Scholar
• el-Saadani, M., Esterbauer, H., el-Sayed, M., Goher, M., Nassar, A.Y. and Jiirgens, G. (1989) "A spectrophotometric assay for LPO in serum lipoproteins using a commercially available reagent", J. Lipid Res. 30, 627–630.
   PubMed Web of Science ®Google Scholar
• Oettl, K., Greilberger, J., Zangger, K., Haslinger, E., Reibnegger, G. and Jiirgens, G. (2001) "Radical-scavenging and iron-chelating properties of carvedilol, an antihyper-tensive drug with antimddative activity", Biochem. Pharmcol. 62, 241–248.
   PubMed Web of Science ®Google Scholar
• Oettl, K., Wirleitner, B., Baier-Bitterlich, G., Grammer, T., Fuchs, D. and Reibnegger, G. (1999) "Formation of oxygen radicals in solutions of 7,8-dihydroneopterin", Biochem. Biophys. Res. Commun. 264, 262–267.
   PubMed Web of Science ®Google Scholar
• Oettl, K., Greilberger, J., Plank, H., Jiirgens, G. and Reibnegger, G. (2001) "Interactions of 7,8-dihydroneopterin with copper stability and radical formation (abstract)", Pteridines 12, 16.
   Google Scholar
• Reibnegger, G., Greilberger, J., Horejsi, R. and Oettl, K. (2001) "7,8-dihydroneopterin and free radicals—a short overview of a fascinating story (abstract)", Pteridines 12, 18.
   Google Scholar
• Headlam, H.A. and Davies, M.J. (2003) "Cell-mediated reduction of protein and peptide hydroperoxides to reactive free radicals", Free Radic. Biol. Med. 34, 44–55.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay, C.K., Fox, Pi., "Ceruloplasmin copper induces oxidant damage by a redox process utilizing cell-derived superoxide as reductant", Biochemistry 37, 1422 2–14229.
   Google Scholar
• Greilberger, J., Wang, X., Ledinski, G., Chen, Q. and Jörgens, G. (1999) "Presence of aldehydic epitopes on a minor low-density lipoprotein fraction", Free Radic. Biol. Med. 26, 1489–1494.
   PubMedGoogle Scholar
• Sevanian, A., Bittolo-Bon, G., Cazzolato, G., Hodis, H., Hwang, J., Zamburlini, A., Maiorino, M. and Ursini, F. (1997) "LDL- is a lipid hydropermdde-enriched circulating lipo-protein", J. Lipid Res. 38, 419–428.
   PubMed Web of Science ®Google Scholar