83
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Endothelial NO Synthase (eNOS) phosphorylation regulates coronary diameter during ischemia-reperfusion in association with oxidative stress

, , , , , & show all
Pages 481-489 | Received 19 Jan 2005, Published online: 07 Jul 2009

References

  • Kou R, Greif D, Michel T. Dephosphorylation of endothelial nitric-oxide synthesis by vascular endothelial growth factor. J Biol Chem 2002;277:29669–29673.
  • Michell BJ, Chen Zp, Tiganis T, et al. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001;276:17625–17628.
  • Liu PT, Hock CE, Nagele R, et al. Formation of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury in rats. Am J Physiol 1997;272: H2327—H2336.
  • Nakazawa H, Fukuyama N, Takizawa S, Tsuji C, Yoshitake M, Ishida H. Nitrotyrosine formation and its role in various pathological conditions. Free Radic Res 2000;33:771–784.
  • Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Chin Invest 2002;109:817–826.
  • Muramatsu K, Numaguchi K, Egashira K, et al. Effects of N-nitro-L-arginine on coronary artery tone and hyper-perfusion after brief coronary occlusion in conscious dogs. Coron Art Dis 1994;5:815–820.
  • Tsunoda R, Okumura K, Ishizaka H, et al. Enhancement of myocardial hyper-perfusion with manganese-superoxide dis-mutase: Role of endothelium-derived nitric oxide. Cardiovasc Res 1996;31:537–545.
  • Reffelmann T, Hale SL, Dow JS, Kloner RA. No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion. Circulation 2003;108:2911–2917.
  • Maczewski M, Beresewicz A. The role of endothelin, protein kinase C and free radicals in the mechanism of the post-ischemic endothelial dysfunction in guinea-pig hearts. J Mol Cell Cardiol 2000;32:297–310.
  • Hink U, Li H, Mollnau H, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001;88:E14—E22.
  • Zulueta JJ, Yu FS, Hertig IA, Thannickal VJ, et al. Release of hydrogen peroxide in response to hypoxia-reoxygenation: Role of an NAD(P)H mddase-like enzyme in endothelial cell plasma membrane. Am J Respir Cell Mol Biol 1995;12:41–49.
  • Waypa GB, Marks JD, Mack MM, et al. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 2002;91:719–726.
  • Kawata H, Yoshida K, Kawamoto A, et al. Preconditioning upregulates vascular endothelial growth factor mRNA expression and neovascularization via nuclear translocation of protein kinase C epsilon in the rat ischemic myocardium. Circ Res 2001;88:696–704.
  • Dimmler S, Fleming I, Fisslthaler B, et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601 — 605 .
  • Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of P13-kinase, Akt, and endothelial nitric oxide synthase phosphoryl-ation. Circulation 2002;105: 1497–1502.
  • Isenovic ER, Divald A, Milivojevic N, Grgurevic T, Fisher SE, Sowers JR. Interactive effects of insulin-like growth factor-1 and beta-estradiol on endothelial nitric oxide synthase activity in rat aortic endothelial cells. Metabolism 2003; 52:482–487.
  • Thomas SR, Chen K, Keaney Jr, JF. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordi-nated phosphorylation and dephosphorylation via a phosphoi-nositide 3-kinase-dependent signaling pathway. J Biol Chem Feb 22 2002;277:6017–6024.
  • Fleming I, Fisslthaler B, Dimmeler S, et al. Phosphorylation of Thr (495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 2001;88:E68—E75.
  • Reffelmann T, Hale SL, Dow JS, Kloner RA. No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion. Circulation 2003;108:2911–2917.
  • Seo JH, Ahn Y, Lee SR, Yeo CY, Hur KC. The major target of the endogenously generated reactive oxygen species in response to insulin stimulation phosphatase and tensin homolog and not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway. Mol Biol Cell 2005; 16(1):348–357.
  • Kurzelewski M, Czarnowska E, Beresewicz A. Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart. Eur J Pharmacol 2002;434:95–107.
  • Wang QD, Uriuda Y, Pernow J, et al. Myocardial release of endothelin (ET) and enhanced ET (A) receptor-mediated coronary vasoconstriction after coronary thrombosis and thrombolysis in pigs. J Cardiovasc Pharmacol 1995;26: 770–776.
  • Tsuyama S, Yamazaki E, Tomita T, et al. Characterization of a novel monoclonal antibody that senses nitric oxide-dependent activation of soluble guanylate cyclase. FEBS Lett 1999;455:291–294.
  • Yoshida K, Hirata T, Akita Y, et al. Translocation of protein kinase C-alpha, delta and epsilon isoforms in ischemic rat heart. Biochim Biophys Acta 1996;1317:36–44.
  • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680–685.
  • Towbin FIT, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350–4354.
  • Chilian WM. Coronary microcirculation in health and disease. Summary of an NHLBI workshop. Circulation 1997;95:522–528.
  • Frey RS, Rahman A, Kefer JC, et al. PKC 4 regulates TNF-ek-induced activation of NADPH oxidase in endothelial cells. Circ Res 2002;90:1012–1019.
  • Mollnau H, Wendt M, Szocs K, et al. Effects of Angiotensin II infusion on the expression and function of NAD(P)H oxidase and uncomponents of nitric oxide/cGMP signaling. Circ Res 2002;90:e58—e65.
  • Frangogiannis NG, Lindsey ML, Michael LH, Youker KA, Bressler RB, Mendoza LH, Spengler RN, Smith CW, Entman ML. Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion. Circu-lation 1998;98(7):699–710.
  • Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M. Normalizing mitochondrial super-oxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404(6779):787–790.
  • Dantas AP, Franco Mdo C, Silva-Antonialli MM, Tostes RC, Fortes ZB, Nigro D, Carvalho MH. Gender differences in superoxide generation in microvessels of hypertensive rats: Role of NAD(P)H-oxidase. Cardiovasc Res 2004;61:22–29.
  • Jernigan NL, Walker BR, Resta TC. Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2004;287: L801 —L808.
  • Ikeda Y, Young LH, Scalia R, Ross CR, Lefer AM. PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardiopro-tective effects in myocardial ischemia-reperfusion. Cardiovasc Res 2001;49: 69–77.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.