280
Views
96
CrossRef citations to date
0
Altmetric
Original

Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells

, , &
Pages 1259-1272 | Received 14 Jun 2005, Published online: 07 Jul 2009

References

  • McLachlan JA. Environmental signaling: What embryos and evolution teach us bout endocrine disrupting chemicals. Endocr Rev 2001; 22: 319–341
  • Sharpe RM. Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicol Lett 2001; 120: 221–232
  • Richburg JH, Johnson KJ, Schoenfeld HA, Meistrich ML, Dix DJ. Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicol Lett 2002; 135: 167–183
  • Markey CM, Rubin BS, Soto AM, Sonnenschein C. Endocrine disruptors: From Wingspread to environmental developmental biology. J Steroid Biochem Mol Biol 2003; 83: 235–244
  • Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy MP. Inhibition of testicular steroidogenesis by xenoestrogens bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzymes gene expression in rat Leydig cells. Endocrinology. 2004; 145: 592–603
  • Cooke PS, Sato T, Buchanan DL. P450 enzymes: Disruptions of steroids hormone signaling by PCBs. Recent advances in the environmental toxicology and health effects, LW Robertson, LG Hanson. The university press of Kentucky. 2001; 257–263
  • Nessel CS, Gallo MA. Dioxins and related compounds. Environmental toxicants: Human exposure and their health effects, M Lippmann. Van Nostrand-Reinhold, New York 1994; 163–183
  • Whitlock JP. The aromatic hydrocarbon receptor, dioxin action and endocrine homeostasis. Trends Endocrinol Metab 1994; 5: 183–188
  • Li M-H, Hansen LG. Consideration of enzyme and endocrine interactions in the risk assessment of PCBs. Rev Toxicol 1997; 1: 71–156
  • Gray LE, Ostby J, Marshall R, Andrew J. Reproductive and thyroid effects of low level polychlorinated biphenyl (Aroclor 1254) exposure. Fundam Appl Toxicol 1993; 20: 288–294
  • Murugesan P, Senthil kumar J, Balasubramanian K, Aruldhas MM, Arunakaran J. Impact of polychlorinated biphenyl Aroclor 1254 on testicular antioxidant system in adult rats. Hum Exp Toxicol. 2005; 24: 61–66
  • Ahmad SU, Tariq S, Jalali S, Ahmad MM. Environmental pollutant Aroclor 1242 (PCB) disrupts reproduction in adult male rhesus monkeys (Macaca mulatta). Environ Res 2003; 93: 272–278
  • Rozati R, Reddy PP, Reddanna P, Mujtaba R. Role of environmental estrogens in the deterioration of male factor fertility. Fertil Steril 2002; 78: 1187–1194
  • Cooke PS, Zhao YD, Hansen LG. Neonatal polychlorinated biphenyl treatment increase adult testis size and sperm production in the rat. Toxicol Appl Pharmacol 1996; 136: 112–117
  • Simpson ER, Boyd GS. The cholesterol side-chain cleavage system of the adrenal cortex: A mixed-function oxidase. Biochem Biophys Res Commun 1966; 24: 10–17
  • Andric SA, Kostic TS, Stojilkovic SS, Kovacevic RZ. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture Aroclor 1248. Biol Reprod 2000; 62: 1882–1888
  • Kim IS, Ariyaratne HB, Mendis-Handagama SMLC. Effects of continuous and intermitted exposure of lactating mothers to Aroclor 1242 on testicular steroidogenic function in the adult male offspring. Tissue Cell 2001; 33: 169–177
  • Kovacevic R, Milorado VM, Teodorovic I, Andric S. Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vtiro. J Steroid Biochem Mol Biol 1995; 52: 595–597
  • Fridovich I. The biology of oxygen radicals. Science 1978; 201: 875–880
  • Papas AM. Determinants of antioxidant status in humans. Lipids 1996; 31: S77–S82
  • Homsby PJ. Steroid and xenobiotic effects on the adrenal cortex: Mediation by oxidative and other mechanisms. Free Radic Biol Med 1989; 6: 103–115
  • Peltola V, Huhtaniemi I, Metsa-Ketela T, Ahotupa M. Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology 1996; 137: 105–112
  • Georgiou M, Prekins LM, Payne AH. Steroid synthesis dependent oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. Endocrinology 1987; 121: 1390–1399
  • Quinn PG, Payne AH. Oxygen mediated damage of microsomal cytochrome P-450 enzymes in cultured Leydig cells: Role in steroidogenic desensitization. J Biol Chem 1984; 256: 4130–4135
  • Quinn PG, Payne AH. Steroid product-induced oxygen mediated damage of microsomal cytochrome P-450 enzymes in Leydig cell cultures. J Biol Chem 1985; 260: 2092–2099
  • Stocco DM, Wells J, Clark BJ. The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells. Endocrinology 1993; 133: 2827–2832
  • Behrman HR, Preston SL. Luteolytic actions of peroxide in rat ovarian cells. Endocrinology 1989; 124: 2895–2900
  • Endo T, Aten RF, Leykin L, Behrman HR. Hydrogen peroxide evokes antisteroidogenic and antigonadotropic actions in human granulosa luteal cells. J Clin Endocrinol Metab 1993; 76: 337–342
  • Myers RB, Abney TO. The effects of redced O2 and antioxidants on steroidogenic capacity of cultured rat Leydig cells. J Steroid Biochem 1988; 31: 305–309
  • Bartsch H, Nair J. Ultrasensitive and specific detection methods for exocyclic DNA adducts: Markers for lipid peroxidation and oxidative stress. Toxicology 2000; 153: 105–114
  • Halliwell B, Gutteridge JMC. Free radicals in biology and medicine2nd ed. Oxford University press, Oxford 1989
  • Kayanoki Y, Fujii J, Islam KN, Suzuki K, Kawata S, Matsurzawa Y, Taniguchi N. The protective role of glutathione peroxidase in apoptosis induced by reactive oxygen species. J Biochem 1996; 119: 817–822
  • Manna SK, Zhang HJ, Yan T, Oberley LW, Aggarwal BB. Over expression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor- kappa B and activated protein-1. J Biol Chem 1998; 273: 13245–13254
  • Nordberg J, Arner ES. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med 2001; 31: 1287–1312
  • Ren XY, Zhou Y, Zhang JP, Feng WH, Jiao BH. Metallothionein gene expression under different time in testicular Sertoli and spermatogenic cells of rats treated with cadmium. Reprod Toxicol 2003; 17: 219–227
  • Jones DP, Kagan VE, Aust SD, Reed DJ, Omaye ST. Impact of nutrients on cellular lipid peroxidation and antioxidant defense system. Fundam Appl Toxicol 1995; 26: 1–7
  • Diber-Rotheneder M, Puhl H, Waeg G, Striegl G, Esterbauer H. Effect of oral supplementation with Dα- tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 1991; 32: 1325–1332
  • Halliwell B, Wasil M, Grootveld M. Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid.Implications for antioxidant protection in the inflamed rheumatoid joint. FEBS Lett 1987; 213: 15–17
  • Packer JE, Slater TF, Willson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979; 278: 737–738
  • Twaroski TP, Brien ML, Larmonier N, Glauert HP, Robertson LW. Polychlorinated biphenyl induced effects of metabolic enzymes, AP-1 binding, vitamin-E, and oxidative stress in the rat liver. Toxicol Appl Pharmacol 2001; 171: 85–93
  • Twaroski TP, Brien ML, Robertson LW. Effects of selected polychlorinated biphynyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes and selenium status: Implications for oxidative stress. Biochem Pharmacol 2001; 62: 273–281
  • Halliwell B, Gutteridge JMC. Role of free radicals and catalytic metal ions in human diseases: An overview. Methods Enzymol 1990; 186: 1–85
  • Chevion M. A site-specific mechanisms for free radical induced biological damage: The essential role of redox- active transition metals. Free Radic Biol Med 1988; 5: 27–37
  • Zhu BZ, Kitrossky N, Chevion M. Evidence for production of hydroxyl radicals by pentachlorophenol metabolites and hydrogen peroxide: A metal independent organic Fenton reaction. Biochem Biophys Res Commun 2000; 270: 942–946
  • Senthil kumar J, Banudevi S, Sharmila M, Murugesan P, Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran J. Effects of vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Reprod Toxicol 2004; 19: 201–208
  • Murugesan P, Kanagaraj P, Yuvaraj S, Balasubramanian K, Aruldhas MM, Arunakaran J. The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats. Reprod Toxicol 2005; 20: 117–126
  • Greenwood FC, Hunter WM, Glover JS. The preparation of 131I labelled human growth hormone of high specific radioactivity. Biochem J 1963; 89: 114–123
  • Sufi SB, Donaldson A, Jeffcoate SL. Testosterone and estradiol assay. World Health Organization collaborating centre for research and reference service in immunoassay of hormones in human reproduction10th ed. WHO, Geneva 1986; 57–96
  • Rigaudiere N, Loubassou S, Grizard G, Boucher D. Characterization of insulin binding and comparative action of insulin and insulin-like growth factor I on purified Leydig cells from the adult rat. Int J Androl 1988; 11: 165–178
  • Aldred LF, Cooke BA. The effect of cell damage on the density and steroidogenic capacity of rat testis Leydig cells, using an NADH exclusion test for determination of viability. J Steroid Biochem 1983; 18: 411–414
  • Thorell JI, Johansson BG. Enzymatic iodination of polypeptides with 125I to high specific activity. Biochim Biophys Acta 1971; 251: 363–369
  • Bergmeyer MU. Steriod dehydrogenase. Methods of enzymatic analysis. Academic Press, New York 1974; 476–477
  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265–275
  • Devasagayam TP, Tarachand U. Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Commun 1987; 145: 134–138
  • Holland MK, Storey BT. Oxygen metabolism of mammalian spermatozoa. Generation of hydrogen peroxide by rabbit epididymal spermatozoa. Biochem J 1981; 198: 273–280
  • Puntarulo S, Cederbaum AI. Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals. Biochem J 1988; 251: 787–794
  • Marklund S, Marklund G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469–474
  • Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972; 47: 389–394
  • Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588–590
  • Staal GE, Visser J, Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969; 185: 39–48
  • Orlowski M, Meister A. Isolation of γ-glutamyl transpeptidase from hog kidney. J Biol Chem 1965; 240: 338–347
  • Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-Transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130–7139
  • Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol 1979; 62: 3–11
  • Desai ID. Vitamin E analysis methods for animal tissues. Methods Enzymol 1984; 105: 138–147
  • Karanth S, Yu WH, Mastronardi CA, McCann SM. Vitamin E stimulates luteinizing hormone-releasing hormone and ascorbic acid release from medial basal hypothalmi of adult male rats. Exp Biol Med 2003; 228: 779–785
  • Langer P, Tajtakova M, Fodor G, Kocan A, Bohov P, Michalek J, Kreze A. Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. Eur J Endocrinol 1998; 139: 402–409
  • Cheek AO, Kow K, Chen J, McLachlan JA. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin and thyroid- binding globulin. Environ Health Perspect 1999; 107: 273–278
  • Bastomsky CH, Murthy PV, Banovac K. Alterations in thyroxine metabolism produced by cutaneous application of microscope immersion oil: Effects due to polychlorinated biphenyls. Endocrinology 1976; 98: 1309–1314
  • Kolaja KL, Klaassen CD. Dose—response examination of UDP-glucuronosyl-transferase inducers and their ability to increase both TGF-β expression and thyroid follicular cell apoptosis. Toxicol Sci 1998; 46: 31–37
  • Chauhan KR, Kodavanti PR, McKinney JD. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol Appl Pharmacol 2000; 162: 10–21
  • Tsai SC, Lu CC, Lin CS, Wang PS. Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. J Cell Biochem 2003; 90: 1276–1286
  • Hanukoglu I, Rapoport R, Weiner L, Sklan D. Electron leakage from the mitochondrial NADPH-adrenodoxin reductase- adrenodoxin-P450scc (cholesterol side chain cleavage) system. Arch Biochem Biophys 1993; 305: 489–498
  • Girotti AW. Mechanisms of lipid peroxidation. J Free Radic Biol Med 1985; 1: 87–95
  • Ahotupa M, Huhtaniemi I. Impaired detoxification of reactive oxygen and consequent oxidative stress in experimentally crytorchid rat testis. Biol Reprod 1992; 46: 1114–1118
  • Zini A, Schlegel PN. Effect of hormonal manipulation on mRNA expression of antioxidant enzymes in the rat testis. J Urol 2003; 169: 767–771
  • Fridovich I. Superoxide radical and superoxide dismutases. Annu Rev Biochem 1995; 64: 97–112
  • Cheng L, Kellogg EW, 3rd, Packer L. Photoinactivation of catalase. Photochem Photobiol 1981; 34: 125–129
  • Mendis-Handagama SMLC, Zirkin BR, Scallen TJ, Ewing LL. Studies on peroxisomes of the adult rat Leydig cell. J Androl 1990; 11: 270–278
  • Mendis-Handagama SMLC. Peroxisomes and intracellular cholesterol trafficking in adult rat Leydig cells following luteinizing hormone stimulation. Tissue Cell 2000; 32: 102–106
  • Andric NL, Andric SA, Zoric SN, Kostic TS, Stojilkovic SS, Kovacevic RZ. Parallelism and dissociation in the actions of an Aroclor 1260-based transformer fluid on testicular androgenesis and antioxidant enzymes. Toxicology 2003; 194: 65–75
  • Das PC, Das KP, Bagchi H, Dey CD. Evalution of tissue ascorbic acid status in different hormonal states of female rat. Life Sci 1993; 52: 1493–1498
  • Chinoy NJ. Ascorbic acid levels in mammalian tissues and its metabolic significance. Comp Biochem Physiol A 1972; 42: 945–952
  • Tsuji M, Ito Y, Terada N, Mori H. Ovarian aromatase activity in scorbutic mutant rats unable to synthesis ascorbic acid. Acta Endocrinol (Copenh) 1989; 121: 595–602
  • Goralczyk R, Moser UK, Matter U, Weiser H. Regulation of steroid hormone metabolism requires L-ascorbic acid. Ann NY Acad Sci 1992; 669: 349–351
  • Mochizuki H, Oda H, Yokogoshi H. Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls. J Nutr 2000; 130: 873–876
  • Sridhar M, Venkataraman P, Dhanammal S, Arunkumar A, Aruldhas MM, Srinivasan N, Arunakaran J. Impact of polychlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate. Asian J Androl 2004; 6: 19–22
  • Palamanda JR, Kehrer JP. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione. Lipids 1993; 28: 427–431
  • Bagchi D, Hassoun EA, Bagchi M, Stohs SJ. Protective effects of antioxidants against endrin-induced hepatic lipid peroxidation, DNA damage, and excretion of urinary lipid metabolites. Free Radic Biol Med 1993; 15: 217–222
  • Vuchetich PJ, Bagchi D, Bagchi M, Hassoun EA, Tang L, Stohs SJ. Naphthalene-induced oxidative stress in rats and the protective effects of vitamin E succinate. Free Radic Biol Med 1996; 21: 577–590

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.