Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia–reperfusion injury of the liver by limiting free radical-mediated tissue damage

References

• Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia–reperfusion injury. Am J Surg 2001; 181: 160–166
   PubMed Web of Science ®Google Scholar
• Selzner N, Rudiger H, Graf R, Clavien PA. Protective strategies against ischemic injury of the liver. Gastroenterology 2003; 125: 917–936
   PubMed Web of Science ®Google Scholar
• Gujral JS, Bucci TJ, Farhood A, Jaeschke H. Mechanism of cell death during warm hepatic ischemia–reperfusion in rats: Apoptosis or necrosis?. Hepatology 2001; 33: 397–405
   PubMed Web of Science ®Google Scholar
• McCord JM. Oxygen-derived radicals: A link between reperfusion injury and inflammation. Fed Proc 1987; 46: 2402–2406
   PubMedGoogle Scholar
• Jaeschke H, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia–reperfusion injury in rat liver. Am J Physiol 1991; 260: G355–G362
   PubMed Web of Science ®Google Scholar
• Bellavite P. The superoxide-forming enzymatic system of phagocytes. Free Radic Biol Med 1988; 4: 225–261
   PubMed Web of Science ®Google Scholar
• Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000; 28: 1456–1462
   PubMed Web of Science ®Google Scholar
• Feher J, Lengyel G, Blazovics A. Oxidative stress in the liver and biliary tract diseases. Scand J Gastroenterol Suppl 1998; 228: 38–46
   PubMedGoogle Scholar
• Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 1994; 268: 1597–1604
   PubMed Web of Science ®Google Scholar
• Watanabe K, Morinaka Y, Iseki K, Watanabe T, Yuki S, Nishi H. Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone). Redox Rep 2003; 8: 151–155
   PubMed Web of Science ®Google Scholar
• Tabrizchi R. Edaravone Mitsubishi-Tokyo. Curr Opin Investig Drugs 2000; 1: 347–354
   PubMedGoogle Scholar
• Abe S, Kirima K, Tsuchiya K, Okamoto M, Hasegawa T, Houchi H, Yoshizumi M, Tamaki T. The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical. Chem Pharm Bull (Tokyo) 2004; 52: 186–191
   PubMed Web of Science ®Google Scholar
• Ninomiya M, Shimada M, Harada N, Shiotani S, Hiroshige S, Soejima Y, Suehiro T, Sugimachi K. Beneficial effect of MCI-186 on hepatic warm ischemia–reperfusion in the rat. Transplantation 2002; 74: 1470–1472
   PubMed Web of Science ®Google Scholar
• Ninomiya M, Shimada M, Harada N, Soejima Y, Suehiro T, Maehara Y. The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia–reperfusion injury. Br J Surg 2004; 91: 184–190
   PubMedGoogle Scholar
• Suzuki F, Hashikura Y, Ise H, Ishida A, Nakayama J, Takahashi M, Miyagawa S, Ikeda U. MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia–reperfusion injury in rats. Transpl Int 2005; 18: 844–853
   PubMedGoogle Scholar
• Abe T, Unno M, Takeuchi H, Kakita T, Katayose Y, Rikiyama T, Morikawa T, Suzuki M, Matsuno S. A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia–reperfusion in vitro and in vivo. J Gastrointest Surg 2004; 8: 604–615
   PubMed Web of Science ®Google Scholar
• Okatani Y, Wakatsuki A, Enzan H, Miyahara Y. Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 2003; 465: 163–170
   PubMed Web of Science ®Google Scholar
• Rusyn I, Tsukamoto H, Thurman RG. WY-14,643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes. Carcinogenesis 1998; 19: 1217–1222
   PubMedGoogle Scholar
• Kono H, Asakawa M, Fujii H, Maki A, Amemiya H, Yamamoto M, Matsuda M, Matsumoto Y. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 2003; 307: 74–82
   PubMed Web of Science ®Google Scholar
• Zhong Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, Lemasters JJ, Thurman RG. Prevention of hepatic ischemia–reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol 2002; 283: G957–G964
   PubMed Web of Science ®Google Scholar
• Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nagashima K, Nishikawa T, Watanabe N, Omata M, Fujiwara K. Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats. Gastroenterology 2004; 127: 1488–1496
   PubMedGoogle Scholar
• Shimizu H, He W, Guo P, Dziadkoviec I, Miyazaki M, Falk RE. Serum hyaluronate in the assessment of liver endothelial cell function after orthotopic liver transplantation in the rat. Hepatology 1994; 20: 1323–1329
   PubMedGoogle Scholar
• Jaeschke H, Farhood A, Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990; 4: 3355–3359
   PubMed Web of Science ®Google Scholar
• Vollmar B, Menger MD, Glasz J, Leiderer R, Messmer K. Impact of leukocyte–endothelial cell interaction in hepatic ischemia–reperfusion injury. Am J Physiol 1994; 267: G786–G793
   PubMedGoogle Scholar
• Mochida S, Ogata I, Ohta Y, Oka T, Fujiwara K. Method for in situ evaluation of superoxide production by pulmonary macrophages in the rat. Acta Pathol Jpn 1991; 41: 217–220
   PubMedGoogle Scholar
• Arai M, Thurman RG, Lemasters JJ. Ischemic preconditioning of rat livers against cold storage-reperfusion injury: Role of nonparenchymal cells and the phenomenon of heterologous preconditioning. Liver Transpl 2001; 7: 292–299
   PubMedGoogle Scholar
• Kadiiska MB, Hanna PM, Hernandez L, Mason RP. In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: Electron spin resonance spin-trapping investigation. Mol Pharmacol 1992; 42: 723–729
   PubMed Web of Science ®Google Scholar
• Chamulitrat W, Jordan SJ, Mason RP. Fatty acid radical formation in rats administered oxidized fatty acids: In vivo spin trapping investigation. Arch Biochem Biophys 1992; 299: 361–367
   PubMedGoogle Scholar
• Sasaki R, Kurokawa T, Tero-Kubota S. Nature of serum ascorbate radical and its quantitative estimation. Tohoku J Exp Med 1982; 136: 113–119
   PubMedGoogle Scholar
• Sindram D, Porte RJ, Hoffman MR, Bentley RC, Clavien PA. Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: A Kupffer cell-mediated injury. FASEB J 2001; 15: 1230–1232
   PubMed Web of Science ®Google Scholar
• Kohli V, Selzner M, Madden JF, Bentley RC, Clavien PA. Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia–reperfusion injury in the rat liver. Transplantation 1999; 67: 1099–1105
   PubMed Web of Science ®Google Scholar
• Rudiger HA, Clavien PA. Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 2002; 122: 202–210
   PubMed Web of Science ®Google Scholar
• Bajt ML, Farhood A, Jaeschke H. Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature. Am J Physiol Gastrointest Liver Physiol 2001; 281: G1188–G1195
   PubMed Web of Science ®Google Scholar
• Jaeschke H, Smith CW. Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol 1997; 61: 647–653
   PubMed Web of Science ®Google Scholar
• Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A, Nakazawa H. Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res 1996; 24: 361–367
   PubMed Web of Science ®Google Scholar
• Komatsu T, Nakai H, Masaki K, Obata R, Nakai K, Iida N. Pharmacokinetic studies of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186) in rats. Yakubutsudoutai 1996; 11: 463–480
   Google Scholar
• Tsuji K, Kwon AH, Yoshida H, Qiu Z, Kaibori M, Okumura T, Kamiyama Y. Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 2005; 42: 94–101
   PubMedGoogle Scholar